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http://dartmouth.eagle-i.net/i/00000135-59ea-7c4f-a5f8-842480000000

Core facility that provides the following services: Multi-photon imaging. This SynergyT1 Shared Resource Core includes two microscopes sharing two femtosecond pulsed Ti:Sapphire lasers (tunable between 690 and 1080 nm) for imaging fluorescently-tagged molecules in tissues in vivo and in vitro.

Proper citation: Dartmouth Multi-Photon Imaging (RRID:SCR_009767) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000012a-24fd-03f4-d8a1-249280000000

Core facility that provides the following services: Electron micrscopy facility access.

The EM Facility is an institutional resource to meet the electron microscopy needs of faculty, staff and students of the Dartmouth College community, including the College, Thayer School of Engineering, the Dartmouth Medical School, and the Dartmouth-Hitchcock Medical Center. The instruments are housed in the EM wing of Remsen. Because the facility is intended to provide service to all the campus, yet has limited personnel, a major effort is made to provide training in the use of appropriate instruments to enable users to do their own microscopy. In addition to this training, there will be service assistance available for those unable to spend time on the microscopes, and for processing of biopsy samples from DHMC.

Proper citation: Dartmouth Electron Microscope Facility (RRID:SCR_009762) Copy   

•   Source: SciCrunch Registry

http://dms.dartmouth.edu/dgml

Core facility that provides the following services: Illumina Bead Array service, Affymetrix Microarray service.

The Genomics Shared Resource provides technologies to the Norris Cotton Cancer Center and Dartmouth community investigators that enable profiling of gene expression, miRNA, GpC Island, and CGH on a whole-genome scale. The long-term goal of the Genomics Shared Resource is to provide an efficient and affordable fee-for-service operation that will provide high quality genomics and microarray data for the growing number of Cancer Center investigators who require this service.

Proper citation: Dartmouth Genomics Shared Resource (RRID:SCR_009763) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000012b-43eb-535f-bd3e-55f580000000

Core facility that provides the following services: Cigarette smoke exposure analysis service.

Our lab is interested in the innate immune system at the mucosal surfaces of the female reproductive and respiratory tracts. A special focus of this work is to determine the effects of cigarette smoke on changes in immune protection. The relationship of cigarette smoke exposure to increased risk of infection is well established, however the mechanisms involved are not. Our research shows that cigarette smoke exposure reduces production of a key antimicrobial chemokine, CCL20. Ongoing research in the lab seeks to determine if similar responses to cigarette smoke exposure underlie increased rates of infection and how cigarette smoke exposure associated infection is linked to the development of cancer. Consulting; training; planning; experimental management assistance. Banked tissue samples available for preliminary studies. Small animal cigarette exposure.

Proper citation: Dartmouth Cigarette Smoke Exposure Analysis Laboratory (RRID:SCR_009761) Copy   

•   Source: SciCrunch Registry

http://core.iddrc.org/molecular-genetics/

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 8,2024. Core facility that provides the following services: DNA sequencing (standard) service, Taqman gene expression service, Taqman SNP genotyping, Digital PCR service, Genomic mapping facility standard service, DNA purification from blood and saliva, RNA purification service, Master 96-well plate sample preparation, Gene expression service, SNP genotyping service, Bioanalysis of RNA and DNA, Next-generation sequencing service, Sequenom SNP genotyping, SNP and qPCR 7900HT instrument access. The Molecular Genetics Core Facility (MGCF) is a non-profit core laboratory in the Program in Genomics and Genetics Division of Children''s Hospital Boston offering genomics services for academic research institutions. The majority of MGCF users are investigators from Children''s Hospital Boston and the surrounding Harvard affiliates, but the MGCF also serves laboratories throughout the entire United States. The MGCF is comprised of a compilation of smaller cores partially supported by private and federal funds. Funding is provided in part through The Intellectual and Developmental Disabilities Research Center, The Manton Center for Orphan Disease Research, The Wellstone Center for Muscular Dystrophy, and The Neuromuscular Disease Project of the Program in Genomics at Children''s Hospital Boston. The overall objective of the MGCF is to provide a location where researchers can have access to high quality, low cost genomic technology services and expertise in a timely, affordable manner. The services offered include DNA sequencing, Next-Gen sequencing, Affymetrix and Illumina whole-genome expression and genotyping microarray technology, microsatellite genotyping, high-throughput qPCR and SNP services on the Fluidigm Biomark System, multiplex SNP genotyping on the Sequenom MassARRAY, and sample extraction and banking. The MGCF also assists investigators with project design and collaborates on linkage and association study analysis.

Proper citation: CHB Molecular Genetics Core Facility (RRID:SCR_009715) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000130-0977-e10a-de5a-673e80000000

Core facility that provides the following services: Lipoprotein analysis, Biliary lipid concentrations analysis, Biliary particle analysis, Quantitative real-time PCR, Sequential ultracentrifugation for lipoproteins, Radiolabeling of lipoproteins, Fluorescence labeling of lipoproteins, Purification of biliary lipid aggregatesfrom model biles, Preparation of recombinant proteins, Protein identification from gel bands, Protein Identification from complex mixtures. The Molecular and Cellular Biochemistry Core is dedicated to providing HDDC investigators and their trainees with access to a variety of methods to determine the compositions of tissues, as well as their cellular and subcellular specimens. The Core Scientists offer a broad range of analyses and preparatory services including Proteomics. Importantly, the Core also provides training in the application of state-of-the-art techniques in molecular analysis of proteins, lipids and nucleic acids. The main Core laboratory is located at Brigham and Women?s Hospital (BWH) and the satellite Core laboratory is located at Children?s Hospital Boston (CHB). We perform a broad array of biochemical and analytical assays that are not typically available within laboratories of HDDC members. These have generally been adapted so that they may be performed in large numbers on microplates. These include quantification of lipids, mRNA and protein and a full array of mass spectroscopy services for protein analysis (and soon to be expanded for lipidomics). We also offer both analytical and preparatory separations by a variety of methods.

Proper citation: CHB Molecular and Cellular Biochemistry Core (RRID:SCR_009716) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-a575-496e-4882-b08d80000000

Core facility that provides the following services: Magnetic resonance imaging (MRI) access. Magnetic Resonance Imaging (MR or MRI) at Children''s Hospital Boston performs pediatric MRIs in a friendly, child-centered environment designed to make your child''s experience as pleasant as possible. Our dedicated staff has years of experience imaging children and teens. Physicians order MRI studies to rule out or diagnose diseases. The technology produces incredibly detailed pictures of your child''s organs, bones and tissues without using ionizing radiation (X-rays). Instead, it uses strong magnets, radiofrequency waves and powerful computers to generate 2- and 3-dimensional images of a given organ or body part. We use protocols and procedures developed specifically for babies and children, which means age-appropriate care for your child and the best possible images for the radiologist.

Proper citation: CHB Magnetic Resonance Imaging (RRID:SCR_009714) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-b8ed-227f-4882-b08d80000000

Within Children''s Hospital Boston''s Department of Radiology, Diagnostic Radiology offers standard radiography (conventional X-rays) and fluoroscopy, an imaging technique that uses X-rays to create real-time images of the body. We perform more than 135,000 exams each year in Boston and at our satellite locations, which makes us one of the country''s largest general diagnostic centers for children.

Proper citation: CHB Diagnostic Radiology Core (RRID:SCR_009711) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2517-1d49-5617-794280000000

Core facility that provides the following services: Data acquisition service, Data storage service.

The Research Electronic Data Collection Core can help you capture research data by supporting all aspects of data acquisition, storage and retrieval. The core is designed to significantly improve the efficiency, cost structure and overall quality of research data collection. The Data Collection Core will provide expert services including: study forms design and implementation; training in all aspects of using TELEform software; database construction and exporting / preparing data for statistical applications such as SAS and SPSS; and technical assistance with scanners and computers running electronic form capture process.

Proper citation: BIDMC eData Collection Core (RRID:SCR_009679) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2512-776b-5617-794280000000

Computed Tomography (CT) at Children''s Hospital Boston helps doctors quickly answer urgent questions about your child''s health. In just seconds or minutes, CT scans can produce incredibly detailed, three-dimensional images of your child''s bone, tissue and blood vessels. CT exams in our powerful multi-detector scanners are quick, painless and non-invasive. Located at two locations: Boston and Waltham. Should be contacted about scanner technology, image acquisition, etc., but not for actual access to the facility.

Proper citation: CHB Computed Tomography Core Imaging Facilities (RRID:SCR_009710) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2519-e7a3-5617-794280000000

Core facility that provides the following services: Mouse breeding service, Mouse genotyping service, Tail vein injections service, Tissue service, Cancer mouse model service, Human tumor xenografts service.

Proper citation: BIDMC Preclinical Murine Pharmacogenetics Core (RRID:SCR_009675) Copy   

•   Source: SciCrunch Registry

http://bidmc.org/Research/CoreFacilities/MassSpectrometryCore.aspx

Core facility that provides the following services: Mapping of post-translational modifications by LC/MS/MS, Protein (complex) identification by LC/MS/MS, Relative quantification of peptides by LC/MS/MS, SILAC, iTRAQ, and Isotope-free ratio quantification service, Metabolomics profiling service.

The Mass Spectrometry Core Facility has been serving the BIDMC community since 2004. We specialize in a targeted mass spectrometry based proteomics approach for isolated proteins and protein complexes, especially phosphorylation and other post-translational modifications involved in cellular signaling using cutting edge instrumentation. Our trained staff offers the highest quality and reliable service with meticulous attention to detail for each sample. We routinely provide services including protein identification, post-translational modification mapping, and relative peptide/protein quantification by stable isotope labeling and label free methods using highly sensitive microcapillary LC/MS/MS techniques at nanoliter flow rates. Several different types of mass spectrometry are utilized depending upon the needs of the researcher including a fast scanning and highly sensitive 2D linear ion trap and a high resolution/high mass accuracy LTQ-Oribitrap mass spectrometer acquired in 2007. In 2005, in agreement with Harvard Medical School''s Pathology Dept., the BIDMC Mass Spectrometry Core became part of the NRB Mass Spectrometry and Proteomics Core, expanding its services and became part of the Cancer Proteomics Core for the Dana Farber Harvard Cancer Center. We serve all institutions regardless of affiliation and have an interest in samples related to many diseases such as cancer and diabetes.

Proper citation: BIDMC Mass Spectrometry Core (RRID:SCR_009672) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000131-09f6-d7d6-6a45-990480000000

Core facility that provides the following services: Multi-Gene transcriptional profiling (MGTP) service.

Multi-Gene Transcriptional Profiling (MGTP) is a real-time PCR based technique, developed in our lab, for quantifying mRNA copy numbers per cell with high reproducibility and accuracy. Primary Goals of the MGTP Core: * To make MGTP services available to investigators, and assist them in advancing their research and obtaining grants; * To assist studies of molecular signaling mechanisms and pathways, discovery of biomarkers, and development of clinical assays; and * To share the resources of our primer library, which currently includes about 2400 pre-validated human, and mouse genes. The MGTP Core makes these unique and powerful capabilities available to biomedical researchers. Thousands of pre-validated primers are available for use, and others can be designed on demand.

Proper citation: BIDMC Multi-Gene Transcriptional Profiling Core (RRID:SCR_009673) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2513-1465-5617-794280000000

Core facility that provides the following services: User-based microscopy service, Microscopy training service. The Imaging Core provides access to standard digital and laser scanning confocal microscopy, multiphoton microscopy, unbiased stereology, and automated confocal microscopy for large scale genome-wide screens. In addition, the Core has substantial capabilities in quantitative and three-dimensional volumetric image reconstruction.

Proper citation: CHB Cellular Imaging Core (RRID:SCR_009671) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00c7-c357-db6e-7a3f80000000

Core facility that provides the following services: Rapid golgi staining service, Luxol fast blue service, Electron microscopy service, Electron microscopy embedding service, Electron microscopy sectioning service, H&E and cresyl violet staining service, Golgi Cox service, Cryostat, vibratome, and microtome usage service, Ultramicrotome usage service. The core allows investigators to perform diverse types of histological studies at several levels, including light and electron microscopy. Furthermore, since mental retardation may not be associated with structural abnormalities visible at the light microscopic level, analysis of protein expression by immunohistochemistry and gene expression by in situ hybridization are also facilitated by this Core.

Proper citation: CHB Cellular Neuroscience Core Laboratory (RRID:SCR_009708) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-9ff6-5676-4882-b08d80000000

Core facility that provides the following services: Flow cytometry analysis service, Cell cycle analysis, Cell sorting service, Side population cell sorting, Zebrafish cell sorting and analysis. The Stem Cell Core Facility has been part of the IDDRC center for more than 30 years fostering collaboration and innovation among IDDRC investigators and members of the academic research community. It was used to develop chromosome sorting for human chromosome specific recombinant libraries and these techniques were utilized by others to generate large scale libraries for the early genome project. The facility was the first to develop cell sorting of fetal cells in the maternal circulation as a means to detect fetal genetic abnormalities. Throughout its history the Stem Cell Core has provided careful and accurate cell cycle analysis via DNA content analysis using Hoechst dye uptake. This service is still used today by investigators. The facility was among the first to take advantage of the ability to express GFP in cells transfected with vectors and induced to express GFP in transgenic animals conditionally expressing a specific gene promoter. This ability allowed IDDRC investigators to isolate neurons, muscle cells and other cell types which express GFP from those which do not. IDDRC investigators were among the first to subsequently culture sorted neurons. Based on the extensive experience of the core using Hoechst dye for cell cycle analysis, the core was able to help IDDRC investigators prepare side population cells (tissue derived potential multipotent progenitor cells) based on Hoechst dye efflux. These methods have allowed the isolation of different muscle side population cells and have facilitated experiments that aim to use the cells for treating muscle disease. The interactive and collaborative nature of the core has fostered these developments, and the interests of the core director, advisory committee, manager and IDDRC investigators will continue to make this core as innovative in the future as it has been in the past. The overall goal of the Stem Cell Core Facility is to provide both IDDRC and non-IDDRC researchers comprehensive analytical flow cytometry and cell sorting services in a timely, dependable and cost-effective manner., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: CHB Cell Sorter Core (RRID:SCR_009706) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2513-a940-5617-794280000000

Core facility that provides the following services: Gene targeting service, Transgenics service. The Transgenic Core centralizes the production of genetically altered mice for MRRC investigators in a cost-effective and efficient manner. The Core also provides expert assistance in the additional areas required for generating genetically altered mice, including transgene and targeting construct production, and transgenic mouse colony management. Core personnel are available to train investigators in all of the techniques required for the generation of genetically modified mice.

Proper citation: CHB Transgenic Core Laboratory (RRID:SCR_009707) Copy   

•   Source: SciCrunch Registry

http://cdrewu.eagle-i.net/i/00000135-82ef-5677-1a88-e81c80000000

Core facility that provides the following services: Assay analysis consulting services, Sandwich immunoassays, Competitive immunoassays, Hormone immunoassay service, Inflammation marker immunoassay service, Oxidative stress immunoassay service, Cancer marker immunoassay service, Kidney function immunoassay service, Cardiovascular immunoassay service, DNA damage/repair assay service, Metabolic profile assay service, Apoptosis/ survival pathways assay service. Since its inception fifteen years ago, the Technology Core Laboratory has surpassed its goals in new assay development and assay refinement. It has provided top-quality services, been innovative in developing new assays, and has encouraged collaborations between molecular biologists and clinical investigators. This core laboratory has an outstanding record of accomplishments and has supported many high-impact, peer-reviewed publications.

Proper citation: CDU Metabolic and Oxidative Stress Core Laboratory (RRID:SCR_009702) Copy   

•   Source: SciCrunch Registry

http://cdrewu.eagle-i.net/i/00000135-82f1-6b82-1a88-e81c80000000

A 3,000 square foot Exercise Physiology Lab is located in the ERC Business Park approximately one mile from KDMC. It is fully equipped with Keiser pneumatic resistance training equipment, free weights, treadmills, stationary exercise cycles, as well as state-of-the-art, computerized equipment for measuring muscle performance, cardiopulmonary response, and body composition. These tools are available for utilization by investigators working the field of health disparities related to endocrine metabolism and exercise physiology.

Proper citation: CDU Exercise Physiology Laboratory (RRID:SCR_009700) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-020d-f054-b2b9-4d8780000000

Core facility that provides the following services: DNA extraction from whole blood, saliva, isolated cell pellet, RNA extraction from whole blood with PaxGene tubes, Lymphoblast transformation, Isolation and cryo-preservation of white blood cells. The BioSample Services Facility (BSF) provides sample handling and preparation resources to investigators in the Partners research community. Our goal is to efficiently and effectively process specimens enabling the generation of high quality data via down stream processes. All projects containing subject samples and submitted to the BSF for handling must be IRB approved in advance. All specimens must be entered into our Laboratory Information Management System (GIGPAD) prior to delivery to the BSF. Our staff will work with you to design an implementation plan that would best fit your research needs.

Proper citation: Harvard PCPGM Biosample Services Facility (RRID:SCR_009856) Copy   

•   Source: SciCrunch Registry