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http://www.neurodiscovery.harvard.edu/research/neurobehavior_laboratory.html

Core facility that provides the following services: Surgery/necropsy service. Mouse models have become a popular and successful approach to elucidating the physiological and pathological roles of individual genes and are truly crucial to accelerate the development of effective treatments and cures for Alzheimer''''s, Parkinson''''s, ALS, MS and other neurodegenerative diseases. The increasing demand for mouse behavioral studies within the neuroscience community has led the Harvard NeuroDiscovery Center to develop a major new, state of the art mouse behavior laboratory, located in the Longwood medical area and carefully designed to meet the exacting standards required for this type of work. The NeuroBehavior Laboratory (NBL) will provide the Harvard community and other investigators access to a broad range of reliable behavioral/cognitive tests necessary to analyze and interpret the impact of a genetic, surgical or pharmacologic manipulation on specific behaviors. They can provide: * Assistance with experimental design. * Support for grant applications that have a significant component of mouse neurobehavioral research. * Full, fee-for-service, mouse behavioral testing services. * Training in all aspects of mouse neurobehavioral testing. * Assistance with data analysis and interpretation.

Proper citation: HNDC NeuroBehavior Laboratory Core (RRID:SCR_012396) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/embryonic-stem-cell-core

The Murine Embryonic Stem Cell Core has been created to help you create mutations in murine embryonic stem cells. The core has several missions including development of state-of-the-art reagents for the production of targeted mutations in embryonic stem cells, the creation of quality-controlled embryonic stem cell lines, and the teaching of methods for embryonic stem cell culture and manipulation. The core utilizes quality-controlled cells developed here at Washington University.

Proper citation: WUSTL School of Medicine Embryonic Stem Cell Core (RRID:SCR_012441) Copy   

•   Source: SciCrunch Registry

http://cancer.dartmouth.edu/res/transgenics_genetic.html

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 12,2026.Core facility that provides the following services: Cigarette smoke exposure analysis service, Oocyte injection for transgenic animal production, Transgenic mice consultation, Generation of chimeric mice from ES cells, Transgenic lines establishment, Genotyping service, Tail biopsies and other services, Humanized mice production. The mission of the TGCSR is to support the generation and utilization of genetically modified mice by members of the Dartmouth research community. The support starts with intellectual support in planning and designing transgenic experiments provided by consultation with the TGCSR director. The TGCSR is now able to offer not only assistance with design of genetic constructs but also the production of genetic constructs for use in transgenic animal production through recombineering in either yeast or E. coli. TGCSR provides a full range of ES cell manipulation services. The tasks of manipulating the mouse embryo are fully provided by the TGCSR either in house or through an established relationship with the University of Vermont. Jackson labs is now providing cryopreservation services to protect and preserve valuable transgenic mouse lines. The TGCSR can also provide genotyping and mouse husbandry services. As currently organized, the TGCSR can provide the full range of services required to design, generate and maintain transgenic mouse lines. TGCSR currently maintains two specialized transgenic lines that express Cre or Flp in the germline for genetic manipulation of transgene/knockouts in vivo. TGCSR has a fully equipped embryo manipulation laboratory in the Borwell animal facility and an adjoining 4 room suite of mouse husbandry rooms.

Proper citation: Dartmouth Transgenics and Genetic Constructs Shared Resource (RRID:SCR_012443) Copy   

•   Source: SciCrunch Registry

https://research.wustl.edu/core-facilities/mouse-cardiovascular-phenotyping-core/

Core that was established in 1998 and currently provides approximately 3,000 surgical, imaging and functional cardiovascular physiology services annually to its academic and industry partners throughout the world. With an experienced staff of 4 dedicated investigators, each with over 10 years of animal physiology experience, the MCPC provides a focused, systematic approach to the study of the basal physiology and pathophysiology of the mouse cardiovascular system.

Proper citation: WUSTL Mouse Cardiovascular Phenotyping Core (RRID:SCR_012673) Copy   

•   Source: SciCrunch Registry

http://www.baderc.org/cores/transgenicCore.html

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 23,2024.Transgenic core which generates transgenic and gene knockout mouse models relevant to obesity, diabetes and nutrition research. It also provides consultation on all aspects of making transgenic and gene knockout mice.

Proper citation: Boston Area Diabetes Endocrinology Research Center Transgenic (RRID:SCR_015074) Copy   

•   Source: SciCrunch Registry

http://www.einstein.yu.edu/centers/liver-research/research-cores/special-animals-core.aspx

Core that provides resources, technologies and scientific expertise to advance translational applications of animal and human liver cells. It also provides bred animals for research, isolation and culture of animal and human liver cells, as well as provision of cell culture additives and materials.

Proper citation: Marion Bessin Liver Research Center Animal Models Stem Cells and Cell Therapy (RRID:SCR_015181) Copy   

•   Source: SciCrunch Registry

http://drc.ucsf.edu/mouse-genetics-core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on November 5,2024. Core that provides a shared resource for the establishment of mutant mouse models for DRC research. It coordinates DRC members with contacts to a number of UCSF-wide facilities for knock-out/knock-in and transgenic mouse generation.

Proper citation: University of California San Francisco Diabetes Research Center Mouse Genetics Core Facility (RRID:SCR_015109) Copy   

•   Source: SciCrunch Registry

http://derc.yale.edu/cores/physiology.aspx

Fee-for-service core facility for DRC members to facilitate in vivo diabetes-related research dealing with biological outcomes in normal, diabetic, and genetically manipulated rodents and mice. Physiology Core is divided into two Sub-cores: the Animal Surgery and Experimental Procedure Sub-core, which provides assistance with in vivo rodent studies the Analytical Sub-core, which assists with measurement of various analytes in rat and mouse samples.

Proper citation: Yale Diabetes Research Center Physiology Core Facility (RRID:SCR_015147) Copy   

•   Source: SciCrunch Registry

http://diabetesresearchcenter.dom.wustl.edu/diabetes-models-phenotyping-core/

Core facility that provides services to multiple funded research projects in the area of diabetes and its complications so that rigorous experiments performed in model systems have the potential to yield compelling results that can be translated to a clinical context.

Proper citation: Washington University School of Medicine Diabetes Research Center Diabetes Models Phenotyping Core Facility (RRID:SCR_015156) Copy   

•   Source: SciCrunch Registry

https://labnodes.vanderbilt.edu/tmescsr

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 30,2025.Core facility that provides services, consultation and collaboration to enable the generation, storage and regeneration of genetically altered mice at Vanderbilt.

Proper citation: Vanderbilt Diabetes Research and Training Center Transgenic Mouse and ES Cell Shared Resource (RRID:SCR_015154) Copy   

•   Source: SciCrunch Registry

http://drtc.bsd.uchicago.edu/physiology-core-about/

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on November 7,2024. Core whose goal is to facilitate the use of model organisms in diabetes and metabolism-related research. The Core provides access to resources, technology, equipment and services for the generation and study of genetically modified mice and other model organisms; consultation on experimental design and analysis; technology development; and opportunities for collaboration and training.

Proper citation: University of Chicago Diabetes Research and Training Center Animal Models and Physiology Core (RRID:SCR_015134) Copy   

•   Source: SciCrunch Registry

http://www.cancer.iu.edu/research-trials/facilities/in-vivo-core/index.shtml

Core facility which maintains on-site breeding colonies of mouse strains essential for study of murine and human hematopoietic cells in vivo. It also provides specialized core services and consultation to CHSCC investigators and serves as an educational resource for CHSCC laboratories.

Proper citation: Indiana University Cooperative Center of Excellence in Hematology Experimental Mouse Resources Core (RRID:SCR_015342) Copy   

•   Source: SciCrunch Registry

http://www.mmpc.org/shared/showCenterCore.aspx?id=47

Core whose services include in vivo physiological assessments encompassing glucose homeostasis (glucose tolerance, insulin tolerance, hyperinsulinemic/euglycemic clamps), energy homeostasis (indirect calorimetry by CLAMS, dietary challenge), ultradian hormone secretion (Culex platform for serial biological fluid sampling from unrestrained mice), behavioral measurements (locomotor activity, meal pattern analysis, operant conditioning) and generation of bariatric surgery models.

Proper citation: MMPC-University of Michigan Medical School Metabolism Bariatric Surgery and Behavior Core (RRID:SCR_015354) Copy   

•   Source: SciCrunch Registry

http://mmpc.ucdavis.edu/core.php?coreID=29

Core that provides phenotyping services for the assessment of endocrine function and metabolic pathways in mouse models of obesity, diabetes, and related metabolic diseases including dyslipidemia and fatty liver disease.

Proper citation: MMPC-University of California Davis Endocrinology and Metabolism Core (RRID:SCR_015359) Copy   

•   Source: SciCrunch Registry

http://www.mmpc.org/shared/showCenterCore.aspx?id=27

Core that provides importation/exportation, colony management, customized mouse models, rederivation and creation of genetically-modified mutant mice (e.g. CRISPR), and re-animation of a variety of models cryopreserved within the KOMP or MMRRC repositories. It also provides ancillary services and procedures, including blood sampling for in vivo testing for glucose tolerance tests and insulin tolerance tests.

Proper citation: MMPC-University of California Davis Animal Care Surgery and Pathology Core (RRID:SCR_015356) Copy   

•   Source: SciCrunch Registry

http://zfrhmaps.tch.harvard.edu/cemh/CoreA.htm

Core facility which generates genetically modified mice with gene knockout/knockin lines for analysis gene function in hematopoiesis.

Proper citation: Boston Children's Hospital Center of Excellence in Molecular Hematology Mouse Embryonic Stem(ES) Cell and Gene Targeting Core (RRID:SCR_015350) Copy   

•   Source: SciCrunch Registry

http://www.baltimorepkdcenter.org/mouse/index.shtml

Core facility which provides mouse models and a biobank of tissues and other materials for research.

Proper citation: Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Mouse Models and Biobank (RRID:SCR_015319) Copy   

•   Source: SciCrunch Registry

http://www.baltimorepkdcenter.org/cell/index.shtml

Core faiclity that provides researchers with cell culturing and engineering services.

Proper citation: Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Cell Culture and Engineering (RRID:SCR_015323) Copy   

•   Source: SciCrunch Registry

http://www.utsouthwestern.edu/research/core-facilities/obrien-kidney/core-services/animal-core.html

Core that generates and distributes several kidney-specific Cre recombinase and tetracycline-inducible activator and repressor lines to be crossed to floxed or tet responder lines provided by co-investigators.

Proper citation: George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center Animal Models Core (RRID:SCR_015292) Copy   

•   Source: SciCrunch Registry

http://www.utsouthwestern.edu/research/core-facilities/obrien-kidney/core-services/physiology-core.html

Core that provides measurement of serum and or urine Creatinine by Capillary Electrophoresis, measurement of serum and urine citrate by capillary electrophoresis, Microanalysis of serum and urine electrolytes by: Flame photometry, Atomic absorption or Ion-Selective Electrode, and Klotho IP-IB Assay.

Proper citation: George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center Physiology Core (RRID:SCR_015266) Copy   

•   Source: SciCrunch Registry