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http://cccb.dfci.harvard.edu

Core facility that provides the following services: Microarray and other genomic data analysis, MiSeq. The Center provides broad-based support for the generation, analysis, and interpretation of genomic and other large-scale data in the context of basic, clinical and translational research. The CCCB has three primary elements. * The CCCB sequencing facility offers a wide range of services to assist in the design and execution of next-generation sequencing projects. Utilizing the Illumina (Solexa) sequencing technology, they currently support a number of applications inlcuding ChIP-Seq, RNA-Seq, whole genome, whole exome, and targeted re-sequencing. * The analytical services and support platform aims to provide state-of-the-art assistance in the collection, management, analysis, and interpretation of large-scale data with a focus on data generated using ''''omic technologies. In addition, they offer software, services, and training designed to assist investigators in advancing their research. * The CCCB research program is focused on development of new methods for improving analysis and interpretation of genomic data through integration of diverse data types with the goal of creating open-source software tools to be made freely-available to the research community.

Proper citation: DFCI Center for Cancer Computational Biology (RRID:SCR_012688) Copy   

•   Source: SciCrunch Registry

http://ocs.med.nyu.edu/immunohistochemistry

The Immunohistochemistry Core, a component of the Experimental Pathology Shared Resource, is located in Bellevue Hospital within the NYULMC Department of Pathology''s Anatomic Pathology clinical space. The laboratory serves as an immunohistochemical antibody repository with a catalog of over 900 antibodies. Antibodies are in stock and available for use in the core laboratory for the collection of experimental immunohistochemistry data. The laboratory develops immunohistochemical protocols for new antibodies (commercial or proprietary) that have not been tested in fresh, frozen, fixed human or animal tissues and cells. In addition to performing manual labeling, the laboratory is equipped with two Ventana NEXES and one Discovery automated immunohistochemical staining instruments. The laboratory uses human and animal tissue micro-arrays for validation and employs a wide variety of antigen retrieval methods for protocol development. The core offers tyramide and polymer amplification methods (manual) and single or two color chromogenic immunohistochemistry. The laboratory has also commenced developing protocols and validating antibodies for immunoflorescence in frozen and FFPE tissue samples. The laboratory faculty and staff are available to provide hands-on informal training, as well as guidance and support for the design and execution of experiments involving histopathology and immunohistochemistry of human and animal cells and tissues. In conjunction with the Histopathology Core Laboratory, the Immunohistochemistry Laboratory can also assist investigators with routine and advanced histopathologic services for tissue and cell specimens (including guidance on initial processing steps: grossing/tissue preparation, processing, embedding, paraffin/frozen microtomy) for samples destined for histopathological interpretation and analysis. In addition, we offer extensive options for special and routine histochemical and immunohistochemical labeling of both human and animal model cells and tissues.

Proper citation: NYU Immunohistochemistry Core (RRID:SCR_012721) Copy   

•   Source: SciCrunch Registry

http://www.ohri.ca/stemcore/Default.aspx

StemCore Laboratories is a high-throughput genomics facility within the Ottawa Hospital Research Institute (OHRI). Core is capable of facilitating large-scale scientific research and biotechnology projects.Provides infrastructure for genomics, bioinformatics, and proteomics.

Proper citation: Ottawa Hospital Research Institute StemCore Laboratories Core Facility (RRID:SCR_012601) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/specialist-device-fabrication

THIS RESOURCE IS NO LONGER IN SERVCE, documented September 22, 2016. The ANFF provides leading-edge research capability and supports excellence in science. The capability provided by ANFF enables users to process hard materials (metals, composites and ceramics) and soft materials (polymers and polymer-biological moieties) and transform these into structures that have application in sensors, medical devices, nanophotonics and nanoelectronics. It has a strong emphasis on service provision to the research community. ANFF seeks to enhance national and international collaborations and enable world-class-research.

Proper citation: ANFF Specialist Device Fabrication (RRID:SCR_012689) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/high-throughput-screening-service-uc-irvine

With the completion of the genome sequence, that offers us a variety of new genes to study, and advances in combinatorial chemistry, that delivers large numbers of synthetic compounds to test, high__������throughput screening (HTS) is becoming a necessary research endeavor. We specialize in HTS of G protein__������coupled receptors (GPCRs). Ligand recognition is quantified in binding experiments or monitored by second messenger responses. One technology that we use is the FLIPR technology that allows for real__������time fluorescent measurements.

Proper citation: UC Irvine High Throughput Screening Service (RRID:SCR_012725) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/macromolecular-x-ray-crystallography-core-facility

The Macromolecular X-ray Crystallography Core Facility of Scripps FL offers state-of-the-art equipment and resources to scientists inside and outside of the Scripps FL campus by providing crystallographic analysis of their chosen biological macromolecules. The core facility offers and operates as a full service core by performing protein crystallization, X-ray diffraction data collection (both in-house and at Argonne National Laboratory) and processing, phasing, crystallographic refinement, model building, and visualization. The structural data obtained by the core will provide scientists with a wealth of information including but not limited to biological functions, 3D-folding, ligand binding (small molecule or protein), or mutational effect of target macromolecules of their interests.

Proper citation: Scripps Florida Macromolecular X-ray Crystallography Core Facility (RRID:SCR_012727) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/high-resolution-plant-phenomics-centre-hrppc-csiro

The High Resolution Plant Phenomics Centre (HRPPC) is the Canberra node of the Australian Plant Phenomics Facility and is located in Canberra at CSIRO Plant Industry and the Australian National University. This centre focuses on _������_deep phenotyping_���� (delving into metabolism and physiological processes within the plant) and _������_reverse phenomics_���� (dissecting traits to discover their mechanistic basis). Next generation research tools are applied to probe plant function and performance, under controlled conditions and in the field. Recent advances in robotics, imaging and computing are used in applying these technologies and scaling them from the single plant to the ecosystem level. Two levels of service are provided in the HRPPC. First, projects can be housed in the _������_Research Hotel_���� environment where screening systems can be developed using facility staff and resources then deployed in the facility and in the user''''s home institution. Second, users_������_ material can be screened for specific attributes using one or more of the modules housed at CSIRO or the ANU. The HRPPC''''s focus is on flexibility from cereals to dicots and woody perennials at all stages of development.

Proper citation: CSIRO High Resolution Plant Phenomics Centre (RRID:SCR_012570) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/penn-microarray-core-facility-upenn

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 2,2024. Penn Microarray Facility provides instrumentation and expertise for RNA transcript profiling. DNA microarrays provide a highly parallel means of measuring the abundance of RNA for targeted genes in a biological sample. The Facility supports two microarray formats: oligonucleotide arrays synthesized by Affymetrix Inc. and arrays of probes printed in-house on glass slides. This reflects our goal of offering a range of cost and performance options suitable for a variety of experimental questions.

Proper citation: Penn Microarray Core Facility (RRID:SCR_012610) Copy   

•   Source: SciCrunch Registry

https://www.ualberta.ca/chemistry/facilities-and-resources/mass-spectrometry-facility.html

There are currently eleven mass spectrometers housed in the mass spectrometry laboratory covering most ionisation techniques from electron impact to MALDI. 8 or more samples submitted at the same time and run under identical conditions qualify for a 25% discount for GC-coupled, LC-coupled and in-gel digest LC/MS/MS experiments Variable rate for high molecular weight samples (i.e., more than 3000 u), depending on the instrument and operator time required for the analysis. There will be a 50% surcharge for all RUSH orders (queue jumping).

Proper citation: UAlberta Mass Spectrometry Facility - Department of Chemistry (RRID:SCR_012613) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/nucleic-acids-core-facility

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 15,2024. Nucleic Acids Core Facility offers automated DNA sequencing with data analysis, custom DNA synthesis, genome project services, gene amplification services, and robotic application custom projects. These services are provided to researchers at the HSC and others in the surrounding scientific community. Our mission is to offer high quality synthesis and sequencing services to researchers through cutting edge instrumentation and a service-oriented and knowledgeable staff.

Proper citation: UTHSCSA Nucleic Acids Core Facility (RRID:SCR_012614) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/ontario-cancer-biomarker-network

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 14,2024. OCBN is a not-for-profit corporation that was established in 2005 with a grant from the Ontario Institute for Cancer Research and the Ontario Ministry of Research and Innovation for the purpose of advancing biomarker research. The OCBN is designed to enable the co-ordination and amplification of the proteomic and genomic biomarker research efforts throughout the province of Ontario to better service academia and industry, whether provincially, nationally or internationally. As such, OCBN is much more than simply an academic research consortium. Residing at the core of the network is the OCBN Central Facility, located at the MaRS Incubator www.marsdd.com in the heart of the biomedical research community in Toronto, one of the most vibrant research hubs in the world. The Central Facility functions as the nexus for the network and its academic and industry partners by providing numerous support services for their clinical and basic research scientists in the conduct of their research.

Proper citation: Ontario Cancer Biomarker Network (RRID:SCR_012616) Copy   

•   Source: SciCrunch Registry

https://planttransformationlab.wordpress.ncsu.edu/

Provides innovative solutions, technologies, expertise, training, and services for research and applications related to plant transformation. The PTL staff and facilities are available for research collaborations; core resources are available for user-driven projects with cost recovery; fee-based plant transformation services can be provided for the NCSU community and external partners.

Proper citation: North Carolina State University Plant Transformation Laboratory Core Facility (RRID:SCR_012706) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/histology-core-wustl

The Histology Core has all the requisite equipment and reagents to enable a variety of tissue processing, embedding and sectioning protocols, including epon/araldite, glycol and methyl methacrylate, polyethylene glycol (PEG), paraffin and cryosectioning. Users of the Histology Core can choose to submit full service jobs and allow core personnel to embed, section and counterstain fixed tissue samples or they can sign up to use a microtome and cut the tissue themselves. Training on any aspect of the histologic process is available on request. All core services are equally available to core members and non-members on a first-come first-served basis.

Proper citation: WUSTL Histology Core (RRID:SCR_012700) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/center-for-organic-photonics-and-electronics-cope-georgia-tech

The Georgia Tech Center for Organic Photonics and Electronics (COPE) is a premier national research and educational resource center that creates flexible organic photonic and electronic materials and devices that serve the information technology, telecommunications, energy, and defense sectors. COPE creates the opportunity for disruptive technologies by developing new materials with emergent properties and by providing new paradigms for device design and fabrication. This helps enable a new generation of devices and systems that meet the challenges that these sectors and our ever-changing society face in this decade and the future.

Proper citation: Georgia Tech Center for Organic Photonics and Electronics (RRID:SCR_012702) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/immune-monitoring-core-facility-usc

The mission of the USC Arnold and Mabel Beckman Center for Immune Monitoring is to provide the USC community and external customers with the highest quality support for clinical trials for immunotherapy of human cancers; facilitate basic, translational, and clinical research with an immunological monitoring component; and provide immunological assay training and education. The IM core provides quality assessments of immunological function necessary for the study of pathogenesis, treatment, and prevention of cancer and other human diseases. Supporting clinical trials for immunotherapy of human cancer: For physicians involved in clinical trials for immunotherapy of human cancer, the Beckman Center for Immune Monitoring Core offers several assays to assess patient immune responses. Such assays provide a highly sensitive and quantitative means of measuring the efficacy of an experimental treatment as a surrogate endpoint or as a correlative to clinical responses. It can help establish proof of principle that a treatment works, and suggest changes to adapt a standard treatment protocol to individual patient needs. Besides the Gold Standard of Immune monitoring: the ELISPOT assay for detection of cytokines released by activated T cells, we also perform intracellular cytokine staining and can detect tumor specific T cells by MHC tetramer analysis. Helper and killer T cells can be separated, and proliferative and cytotoxic responses are quantified in radioactive assays. The monitoring protocol of choice is tailor made to fit the needs and the possibilities of each treatment protocol. The core offers freezing and storage capacity for clinical samples and full analytical support for monitoring assays. It is also possible to send in samples for post-assay analysis using our state-of-the-art ELISPOT reader. Facilitating research with an immune monitoring component: For researchers within travel distance of our facility, we offer equipment and technical assistance for performance and/or analysis of ELISPOT assays, flow cytometry-based assays, radioisotope-based proliferation and cytotoxicity assays, multiplexing ELISA assays, and molecular-based quantitative PCR assays. Our lab has equipment for controlled rate freezing and storage of cryopreserved peripheral blood cells, tissue culture facilities and an ELISPOT reader to analyze your 96 well plates. Assays and technical support are also available to support translational projects that utilize in-vitro systems and in vivo animal models.

Proper citation: USC Immune Monitoring Core Facility (RRID:SCR_012672) Copy   

•   Source: SciCrunch Registry

https://med.virginia.edu/bioinformatics-core/

Core serves as a centralized resource for providing expert and timely bioinformatics consulting and data analysis solutions. The core offers services to investigators both within and outside UVA on both grant-funded and chargeback-based projects for management and analysis of large-scale biological datasets produced by high-throughput genomics experiments. The Core's mission is to build and maintain an infrastructure that enables the application of strong bioinformatics analysis with a measurable impact on the ability of UVa investigators to both publish their work and obtain new funding.

Proper citation: University of Virginia Bioinformatics Core (RRID:SCR_012718) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/bwh-confocal-microscopy-core-facility-harvard

Our facility provides equipment and training for researchers interested in using widefield & confocal microscopy, photobleaching, and live cell imaging studies.

Proper citation: BWH Confocal Microscopy Core Facility (RRID:SCR_012679) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/flow-cytometry-core-harvard

The cell sorting and analysis lab provides access to the most sophisticated flow cytometers presently available. The core is able to analyze and physically separate cells based upon features detectable with fluorescently labeled monoclonal antibodies. The Simches site is located in the newly constructed space located in room 3.434 in the Simches Building. Major Equipment (Simches): Analytic Seven Laser LSR configured with 355 nm, 407 nm, 488 nm, 532 nm, 594 nm, 633 nm, and 780 nm air cooled lasers providing a wide range of excitation possibilities. Modified Digital Vantage cell sorter with 2 water-cooled argon, 2 krypton and one air cooled 633 nm laser. The CNY site is located in the newly constructed space located in room 6.307 in Building 149, 13th Street, Charlestown Navy Yard. Major Equipment (CNY): Analytic three Laser LSR II configured with 405 nm, 488 nm, and 633 nm air cooled lasers providing a wide range of excitation possibilities. A four laser FACS Aria II cell sorter configured with 405 nm, 488 nm, 594 nm and 633 nm air cooled lasers providing a wide range of excitation and sorting possibilities.

Proper citation: MGH Flow Cytometry Core (RRID:SCR_012678) Copy   

•   Source: SciCrunch Registry

http://www.neurodiscovery.harvard.edu/research/lddn_2.html

Core facility that provides the following services: Assay design and development service. The NeuroDiscovery Center''''s Laboratory for Drug Discovery in Neurodegeneration (LDDN) was established to discover chemical agents from which we and others will develop a new generation of drugs to treat neurodegenerative diseases (including degenerative diseases of the eye and ear). To accomplish this goal, LDDN has recruited a permanent staff of industry-seasoned scientists with expertise in assay development, laboratory automation, informatics, and medicinal chemistry, to work in close collaboration with principal investigators from the academic neuroscience community. In this way, LDDN helps transform discoveries in the basic biology of neurodegeneration into opportunities for drug discovery. (While priority is given to members investigating neurodegenerative diseases and the central nervous system, we welcome inquiries from all investigators.)

Proper citation: HNDC Drug Discovery in Neurodegeneration (RRID:SCR_012680) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/brains-on-line

Our mission at Brains On-Line is to provide preclinical research services to facilitate the development of new drugs that target the central nervous system. Brains On-Line benefits from its intimate connections with academia, as well as with several associated contract research organizations (CRO). Using our expertise, we aim to give full insight in the possibilities of your compound.

Proper citation: Brains On-Line (RRID:SCR_012565) Copy   

•   Source: SciCrunch Registry