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https://physiology.case.edu/media/eq_manuals/eq_manual_beckman_optima-l_series_instruction_manual_ll-im-12ab.pdf

Ultracentrifuge is used for centrifugation of subcellular particles, virus isolations, and high purity plasmid DNA.

Proper citation: Beckman Coulter: L-90K Ultracentrifuge (RRID:SCR_019651) Copy   

•   Source: SciCrunch Registry

https://www.beckmancoulter.com/en/products/hematology/dxh-800

DxH 800 hematology analyzer utilizes data about individual cell size, shape and structure to provide high quality results.

Proper citation: Beckman Coulter: DxH 800 Hematology Analyzer (RRID:SCR_019635) Copy   

•   Source: SciCrunch Registry

https://www.thelabworldgroup.com/beckman-du-530-spectrophotometer

This spectrophotometer functions with single cell module and supports alternative cell holders, like 16 mm test tube, 1 cm standard, 10cm rectangular turbidity, and 50uL microcell.

Proper citation: Beckman Coulter: DU 530 Spectrophotometer (RRID:SCR_019631) Copy   

•   Source: SciCrunch Registry

https://www.beckmancoulter.com/en/products/immunoassay/diasorin-liaison-xl?id=C55910

Chemiluminescence Immunoassay Analyzer closes care gap and addresses challenges with blood viruses and infectious diseases.

Proper citation: Beckman Coulter: DiaSorin LIAISON XL Chemiluminescence Immunoassay Analyzer (RRID:SCR_019630) Copy   

•   Source: SciCrunch Registry

http://griffin.cbrc.jp/

Griffin (G-protein-receptor interacting feature finding instrument) is a high-throughput system to predict GPCR - G-protein coupling selectively with the input of GPCR sequence and ligand molecular weight. This system consists of two parts: 1) HMM section using family specific multiple alignment of GPCRs, 2) SVM section using physico-chemical feature vectors in GPCR sequence. G-protein coupled receptors (GPCR), which is composed of seven transmembrane helices, play a role as interface of signal transduction. The external stimulation for GPCR, induce the coupling with G-protein (Gi/o, Gq/11, Gs, G12/13) followed by different kinds of signal transduction to inner cell. About half of distributed drugs are intending to control this GPCR - G-protein binding system, and therefore this system is important research target for the development of effective drug. For this purpose, it is necessary to monitor, effectively and comprehensively, of the activation of G-protein by identifying ligand combined with GPCR. Since, at present, it is difficult to construct such biochemical experiment system, if the answers for experimental results can be prepared beforehand by using bioinformatics techniques, large progress is brought to G-protein related drug design. Previous works for predicting GPCR-G protein coupling selectivity are using sequence pattern search, statistical models, and HMM representations showed high sensitivity of predictions. However, there are still no works that can predict with both high sensitivity and specificity. In this work we extracted comprehensively the physico-chemical parameters of each part of ligand, GPCR and G-protein, and choose the parameters which have strong correlation with the coupling selectivity of G-protein. These parameters were put as a feature vector, used for GPCR classification based on SVM.

Proper citation: G protein receptor interaction feature finding instrument (RRID:SCR_008343) Copy   

•   Source: SciCrunch Registry

http://www.usa.philips.com/healthcare/product/HCNMRB617/dti-fibertrak-mr-software

Instrument and software tool used to visualize, trace, analyze, and process white matter fiber tracts of Diffusion Tensor Imaging (DTI) data in real-time. It supports pre-operative surgical planning, post-surgery evaluation, and general evaluation of fiber tracts around tumors and lesions in connection with functional areas.

Proper citation: DTI FiberTrak MR Clinical application (RRID:SCR_015521) Copy   

•   Source: SciCrunch Registry

https://www.thermofisher.com/order/catalog/product/4376600

Equipment and software system that is a real-time thermal cycler for intuitive data analysis of polymerase chain reactions. It comes with analysis software, instrument control software, and a LED-based 4-color optical recording feature.

Proper citation: Thermo Fisher: StepOnePlus Real-Time PCR System (RRID:SCR_015805) Copy   

•   Source: SciCrunch Registry

http://actimetrics.com/products/limelight/

A video tracking system designed for high-throughput behavioral experiments. LimeLight can track up to 4 arenas at once and can collect images at up to 30 frames per second for one animal or up to 8 frames per second when tracking 4 arenas at once. The tracking system has 2 different hardware configurations: the 1-camera system can be used to record 1 to 4 animals at once, while for multiple animals, each one is placed in a separate arena in one quadrant of the image. The software contains productivity features such as flexible arena setup, user-defined behavior scoring, stimulus control, and various analytical functions for quantifying behavior. The program is designed for experiments such as Open Field, Plus Maze, Radial Arm Maze, Zero Maze, Novel Object Recognition, Conditioned Place Preference, and Barnes Maze.

Proper citation: Limelight (RRID:SCR_014254) Copy   

•   Source: SciCrunch Registry

https://www.agilent.com/cs/library/brochures/5990-5596EN.pdf

Agilent 3100 OFFGEL Fractionator performs isoelectric focusing of proteins or peptides in immobilized pH gradient (IPG) gel strips.

Proper citation: Agilent: 3100 OFFGEL Fractionator (RRID:SCR_018433) Copy   

•   Source: SciCrunch Registry

http://tools.thermofisher.com/content/sfs/manuals/cms_040970.pdf

Automated PCR instrument for automated amplification of nucleic acids with Polymerase Chain Reaction. It has reaction volumes of up to 50 uL and sample temperature range of 4 to 99.9 C.

Proper citation: Thermo Fisher: Applied Biosystems: GeneAmp 9700 PCR Thermocycler System (RRID:SCR_018436) Copy   

•   Source: SciCrunch Registry

https://www.rankinbiomed.com/product/refurbished-american-optical-860-sliding-micrtome/

THIS REOURCE IS NO LONGER IN SERVICE. Documented on September 29,2023. Sliding microtome used for cutting hard objects such as bone, wood, frozen celloidin, and paraffin preparations. Cutting thickness is adjustable from 1 to 40 microns.

Proper citation: American Optical: 860 Sliding Microtome (RRID:SCR_018434) Copy   

•   Source: SciCrunch Registry

https://atagousa.corecommerce.com/PAL-10S-p358.html

Digital hand held pocket refractometer that measures urine specific gravity. It has measurement temperature of 10 to 35 C and sample volume of 0.3ml.

Proper citation: Atago: PAL-10S Pocket Refractometer (RRID:SCR_018439) Copy   

•   Source: SciCrunch Registry

https://www.sutter.com/manuals/P-2000_OpMan.pdf

Microprocessor controlled, CO2 laser based micropipette puller.Default configuration allows fabrication of micropipettes for intracellular recording, patch clamping, microinjection and microperfusion.Can store up to 100 separate programs, each consisting of up to 8 command lines. The five parameters set in each command line allow exquisite control of the micropipette taper geometry. Allows the use of wide range of glass diameters from 0.125 to 1.2 mm.

Proper citation: Sutter: P-2000 Laser Micropipette Puller (RRID:SCR_018640) Copy   

•   Source: SciCrunch Registry

https://github.com/PIEFoundry/Microfabrication/wiki/Parylene-MEA-Fabrication

Parylene MEA Fabrication is related to SPARC. Repository for standard fabrication procedure for Parylene C microelectrode arrays and similar devices.

Proper citation: HORNET CENTER FOR AUTONOMIC NERVE RECORDING AND STIMULATION SYSTEMS (RRID:SCR_023681) Copy   

•   Source: SciCrunch Registry

http://edboyden.org/05.09.boyden.html

Laser tool that enables neurons to be optically silenced by pulses of yellow light, the light-activated chloride pump halorhodopsin (Halo), in a paper entitled Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution. Temporally precise, noninvasive control of activity in well-defined neuronal populations is a long-sought goal of systems neuroscience. We adapted for this purpose the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons. We demonstrate reliable, millisecond-timescale control of neuronal spiking, as well as control of excitatory and inhibitory synaptic transmission. This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers. The quest to determine how precise neural activity patterns mediate computation, behavior, and pathology would be greatly aided by a set of tools for reliably activating and inactivating genetically targeted neurons, in a temporally precise and rapidly reversible fashion. Having earlier adapted a light-activated cation channel, 1channelrhodopsin-2 (ChR2), for allowing neurons to be stimulated by blue light, we searched for a complementary tool that would enable optical neuronal inhibition, driven by light of a second color. Here we report that targeting the 1codon-optimized form of the light-driven chloride pump halorhodopsin from the archaebacterium Natronomas pharaonis (hereafter abbreviated Halo) to genetically-specified neurons enables them to be silenced reliably, and reversibly, by millisecond-timescale pulses of yellow light. We show that trains of yellow and blue light pulses can drive high-fidelity sequences of hyperpolarizations and depolarizations in neurons simultaneously expressing yellow light-driven Halo and blue light-driven ChR2, allowing for the first time manipulations of neural synchrony without perturbation of other parameters such as spiking rates. The Halo/ChR2 system thus constitutes a powerful toolbox for multichannel photoinhibition and photostimulation of virally or transgenically targeted neural circuits without need for exogenous chemicals, enabling systematic analysis and engineering of the brain, and quantitative bioengineering of excitable cells.

Proper citation: Channelrhodopsin-2 enables optical activation of neurons (RRID:SCR_008833) Copy   

•   Source: SciCrunch Registry

https://edspace.american.edu/openbehavior/project/automated-mouse-homecage-two-bottle-choice-test/

Project related to assessing preferences by mice among fluids in their homecages.Provided system includes homecage fitted apparatus for automated, photobeam based detection of licks in two bottle choice task. Used for automated mouse homecage two bottle choice test.

Proper citation: Automated mouse homecage two bottle choice test project (RRID:SCR_021457) Copy   

•   Source: SciCrunch Registry

https://edspace.american.edu/openbehavior/project/rad/

Project related to tracking and recording activity in rodent home cages.Provides device that utilizes passive infrared (PIR) sensor to detect movement in cages and logs data to microSD card. Device is wireless and battery powered, and can record data for about 3 weeks on charge.

Proper citation: Rodent Activity Detector project (RRID:SCR_021451) Copy   

•   Source: SciCrunch Registry

https://edspace.american.edu/openbehavior/project/homecage-2bottle-choice/

Project related to studies of liquid ingestive behaviors used in neuroscience to investigate reward related behavior, metabolism, and circadian biology. Provides automated home cage sipper device for monitoring liquid ingestive behavior in rodents developed by Washington University, St. Louis scientists. Homecage fitted apparatus for automated, photobeam based detection of licks in two bottle choice task.

Proper citation: Automated Home Cage Rodent Two bottle Choice Test project (RRID:SCR_021445) Copy   

•   Source: SciCrunch Registry

http://www.rockefeller.edu/bioimaging/

Provide members of University and their visitors with wide spectrum of optical microscopy equipment and extensive training in its use.

Proper citation: Rockefeller University Bio-Imaging Resource Center Core Facility (RRID:SCR_017791) Copy   

•   Source: SciCrunch Registry

https://biophy.uchicago.edu/

Core provides access to biophysics equipment, integral to research community at University of Chicago.Provides tools, training, and assistance for quantitative analysis of macromolecules and their interactions. Instruments include Seahorse XFe-96 Extracellular Flux Analyzer,Jasco J-1500 CD Spectrometer,Synergy Neo HST Plate Reader,Wyatt DAWN HELEOS II SLS,Wyatt DynaPro Plate Reader DLS,Wyatt DynaPro NanoStar DLS,HORIBA Fluorolog-3,Microcal iTC200,Molecular Imager,Bio-Rad ProteOn XPR to Biacore 8K,Agilent 8453 Spectrophotometer. Core provides staff assistance in conducting experiments.

Proper citation: Chicago University Biophysics Core Facility (RRID:SCR_017915) Copy   

•   Source: SciCrunch Registry