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https://www.ohsu.edu/research-cores/massively-parallel-sequencing-shared-resource-mpssr

As of January 1, 2024, the Integrated Genomics Laboratory is one shared resource comprising the former Massively Parallel Sequencing Shared Resource, the Gene Profiling Shared Resource, and the DNA Services Core. Please be aware that the reorganization is an ongoing process, particularly regarding our iLab integration.Provides RNA-sequencing for gene expression analysis, DNA resequencing for single nucleotide polymorphism discovery, DNA resequencing for copy number variation discovery, ChiP-sequencing for promoter analysis, DNA methylation analysis, De novo sequencing for unique genomes, Sequence capture service. Offers sequencing including genome resequencing, transcriptome analysis, miRNA analysis, and prometer analysis via ChIP-seq.

Proper citation: OHSU Massively Parallel Sequencing Shared Resource Core Facility (RRID:SCR_009984) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000012f-c755-f030-a63c-45b480000000

THIS RESOURCE IS NO LONGER IN SERVICE.Documented on December 6,2022. Core facility that provides the following services: Mouse breeding service, Behavioral testing procedures service, Mouse breeding. Three of the MARC''s research components (5, 6, and 8) include experiments with lines of mice bred to have special genetic traits. The animal core supports these components by purchasing, testing, breeding, maintaining, and distributing these animals within the center. The core will breed special mouse lines F1 and F2 that are descendents of C57BL/6J (B6) and DBA/2J (D2) inbred strains. For Components 5 and 6, the animal core will also produce independent sets of replicated mouse lines selected for high and low tendencies toward methamphetamine drinking and for high and low methamphetamine-induced sensitization. In addition, the core is developing new behavioral-testing procedures and maintaining a database that will track individual animals and post their trait data for all MARC investigators to utilize.

Proper citation: OHSU Methamphetamine Abuse Research Center Animal Core Component (RRID:SCR_009985) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/00000131-1efe-8036-a944-114f80000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 6,2022. Core facility that provides the following services: Use of IOIC facility, In vivo optical imaging training service. The IOIC is located in Cardiac Imaging Laboratory on the first floor of the Biomedical Research Building (BRB). The laboratory was established through a Shared Instrument Grant (PI: Michael Deininger) but is maintained through user fees. The core facility includes the IVIS Spectrum optical imaging camera housed in a light-tight housing, rat and mouse imaging platforms for multi-subject simultaneous acquisition, an integrated inhaled anesthesia system, and advanced analysis software. A key component of the IOIC is the ability to operate either independently or under the guidance and supervision of core personnel. Independent use of the system requires that investigators undergo training that is offered every 2 months or on an ad hoc basis. All analysis will be charged on an hourly basis and is graduated according to the level of service (independent or supervised).

Proper citation: OHSU In Vivo Optical Imaging Center (RRID:SCR_009982) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000012a-24ff-956f-d994-629180000000

THIS RESOURCE IS NO LONGER IN SERVICE.Documented on December 6,2022. Core facility that provides the following services: Immunological study design and implementation, Flow cytometry assays service, High-throughput analysis service, Economies-of-scale reagent purchasing, Flow cytometry sorting service. The CIU offers all the study organization and technical expertise developed at the (Louis) Picker Lab to researchers whose questions require obtaining and processing monkey immunological samples, and/or utilizing cytometry to assay phenotype of CFC/ICS information. The CIU was originally developed as part of the Bill & Melinda Gates foundation CAVD (Collaboration for AIDS Vaccine Discovery) consortium.

Proper citation: OHSU Immunology Support Core Cellular Immunology Unit (RRID:SCR_009980) Copy   

•   Source: SciCrunch Registry

http://montana.eagle-i.net/i/0000012b-00be-16ed-df3b-3fdc80000000

Core facility that provides the following services: Lab animal technician services, Animal husbandry service.

The Mission of the Animal Resources Center is to provide healthy animals for use in IACUC-approved research, educational and testing protocols at Montana State University,ensure that University research animals are cared for in a humane and appropriate manner by the provision of modern, well maintained facilities, trained personnel, technical support, veterinary care and monitoring of animal care and use, provide resources, technical assistance, and information for University researchers and educators in meeting the requirements of animal-related protocols, and ensure observance of ethical standards and federal regulations pertaining to the care and use of animals for research, education and testing at Montana State University.

Proper citation: MSU Animal Resource Center (RRID:SCR_009936) Copy   

•   Source: SciCrunch Registry

http://msm.eagle-i.net/i/0000012b-00c2-e053-353c-df7f80000000

The Analytical Chemistry and Protein Profiling Core is comprised of three primary labs: * Analytical Chemistry * Protein Profiling/2D Gel * 2D Gel Electrophoresis Lab

Proper citation: MSM Analytical Chemistry and Protein Profiling Core (RRID:SCR_009933) Copy   

•   Source: SciCrunch Registry

http://msm.eagle-i.net/i/0000012b-00c2-b0bd-353c-df7f80000000

THIS RESOURCE IS NO LONGER IN SERVCE, documented January 25, 2019. Core focuses on integration of MSM and affiliated health information systems into an interoperable repository. The long-term goal is to establish an integrated standards-based informatics platform to support MSM clinical and translational research investigators in their own work and in sharing research information with collaborators and other investigators in parallel fields.

Proper citation: Morehouse School of Medicine Biomedical Informatics Unit (RRID:SCR_009934) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-86f9-8ca4-8463-ad4580000000

The Visualization Core Laboratory / GIS Remote Core Laboratories were established to bond existing capabilities and talents in the areas of Geographic Information Systems (GIS), Remote Sensing (RS) and Scientific Visualization (Sci-Viz) and co-locate them in a centralized facility. This created an infrastructure of technology, data, people and institutional linkages that enables the discovery, evaluation and application of geospatial and visual data for adding value to research across various areas and disciplines. The GIS/RS laboratories support the development, enhancement and transfer of GIS/RS applications, make geospatial data available and accessible and promote research and development innovation among users. The Sci-Viz laboratory supports the need of scientists and researchers relative to modeling, program application development and production of high quality advanced visualizations for all fields or disciplines. The TLGVRC addresses human resource development to ensure a skilled workforce which is vital for sustenance of any high level technology activity.

Proper citation: JSU Remote Sensing Core Laboratory (RRID:SCR_009898) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000131-6bd2-db1d-75a1-b5a380000000

Core facility that provides the following services: Recombinant protein expression and purification in yeast Pichia pastoris, Large-scale production of immunotoxins for cell depletion studies, Large scale production of recombinant cytokines, Cost effective small-scale production using E.coli system.

The Recombinant Protein Expression and Purification (RPrEP) Core was established in 2009 to provide a cost-effective resource to the MGH and DF/ HCC community for expression and purification of recombinant proteins necessary for pre-clinical studies as well as for basic mechanistic studies by immunologists and cancer biologists. Recombinant Proteins can be manufactured by this Core for a variety of applications according to MGH-DF/ HCC investigator needs. In addition to large-scale production of recombinant proteins in yeast Pichia pastoris, a cost effective small-scale production service will be provided using E.coli or yeast Pichia pastoris expression system (e.g. for small animal studies, use as immunogens, ELISAs, or high throughput microarray platforms).

Proper citation: MGH Recombinant Protein Expression and Purification Core (RRID:SCR_009931) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-6de9-a291-55da-381e80000000

Core facility that provides the following services: Sperm Cryoperservation - Standard Mouse Backgrounds; including quality test (QC), 129 or Hybrid ES Cell transfection package for conventional or BAC vector (from DNA transfection to DNA preparation) ~200 colonies, C57BL/6 (JM8A) ES Cell transfection package for conventional or BAC vector (from DNA transfection to DNA preparation) ~200 colonies, Microinjection of one targeted 129, JM8A, or hybrid ES Cell clone, Microinjection of one targeted C57BL/6 (JM8 & others) ES Cell clone, Transgenic / DNA pronuclear Microinjection, Transgenic/ BAC DNA pronuclear Microinjection to hybrid mouse strain, Mice colony breeding, Mice ID tag & tail biopsy, Mice tail DNA preparation, Sperm Cryoperservation - Non-Standard Mouse Backgrounds; including quality test(QC), Recovery live born pups for testing following QC, IVF recovery of one mouse line from cryopreserved sperm for most strains (~10 pups provided), Recovery of cryopreserved mice embryos (up to 80 embryos), Special DNA Prep.

The MGH Transgenic and Gene Targeting Facility generates transgenic and knockout or knock-in mice to study gene function in embryonic stem cell and somatic cell systems. Services include: microinjection of DNA into fertilized embryos for the creation of transgenic mice, transfection of DNA into ES cells for the generation of recombinant ES cell clones, injection of gene-targeted ES cell clones into host blastocysts for the generation of gene knockout or knock-in mice, and other related ES cell based services. The facility is also equipped to perform in vitro fertilization projects, cryopreservation of mouse sperm and embryos, recovery of cryopreserved mouse sperm and embryos, and derivation of ES cell lines from a variety of genetic backgrounds. The facility provides consultation within reason on experimental design and vectors for gene targeting-related projects. The facility can also provide advice for the preparation of DNA, recombinant ES clones, mouse genotyping, handling and husbandry. The facility supports innovative and experimental approaches involving transgenic and knockout or knock-in mice to better help investigators study gene regulation and function, and develop appropriate animal models to study human genetic disorders.

Proper citation: MGH Transgenic and Gene Targeting Facility (RRID:SCR_009932) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-c931-8969-0055-c4eb80000000

Core facility that provides the following services: Genomics service, Proteomics services, Functional assays service, Cell culture services, Stress enzyme analysis. The specific aims of the MCB Core Laboratory are: To provide a variety of services and technical support in molecular biology and DNA technology by offering equipment access, expert advice, demonstration of techniques, operation of equipment, participation in discussion and data interpretation, and hands-on-training in molecular biology and cell culture; to increase faculty training in recombinant DNA technology to strengthen faculty development and technology transfer; to provide a research environment and instrumentation for investigators to pursue biomedical research opportunities and enhance overall research productivity; to foster collaborative research relationships among RCMI investigators and other MCB core users at JSU and other research intensive institutions.

Proper citation: JSU Molecular and Cellular Biology Core Laboratory (RRID:SCR_009896) Copy   

•   Source: SciCrunch Registry

http://xula.eagle-i.net/i/00000135-81af-5452-a9f8-d64580000000

Core facility that provides the following services: Mass spectrometry services. The mission of Proteomics Core Facility is to help researchers advance their biomedical research programs. The Facility is equipped with gel electrophoresis units, image analyzers and digitizers, and robotics for mass spectrometry sample preparation. Currently, a Matrix-Assisted Laser Desorption/Ionization Mass Spectrometer instrument implements protein identification. The various applications include the studies of protein expression profile, posttranslational modifications, and partial sequencing of novel proteins. The staff also consult with researchers about their particular research interests and assist with the development of specific applications and solution to problems.

Proper citation: LCRC Proteomics Core Facility (RRID:SCR_009894) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012b-00bb-9e00-3984-bcfb80000000

Core facility that provides the following services: Nanoindenter strain test service, UTM strain test service, Topography transmission electron microscopy service, Topography environmental scanning electron microscope service, Electron microscopy sample preparation service. The specific aims of the Electron Microscope Core Laboratory are: To provide investigators with access to microscopy instruments necessary for ultrastructural research in all the STEM areas; to train faculty, staff, and students on relevant methods in ultrastructural research; to help faculty, staff, and students on relevant approaches to address research questions involving morphological characterization; to improve JSU competitiveness in the innovative field of electron microscopy-based research.

Proper citation: JSU Electron Microscope Core Laboratory (RRID:SCR_009892) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-c928-8ae0-0055-c4eb80000000

Core facility that provides the following services: Electron paramagnetic resonance (EPR) spectroscopy service. The specific aims of the MMR are to: 1. Provide high field FT-NMR spectrometers for all RCMI investigators and other researchers who need structural determination tools in their research. High field NMR spectrometers are key instruments in organic chemistry including biomedical and environmental research. Two high field FT-NMR spectrometers in the MMR Core Facility are made available for JSU researchers and off-campus users. 2. To offer technical support to users who need to apply NMR technology in their research but lack expertise. The sophisticated technology in NMR spectroscopy will be available for organic chemists as well as novice users and researchers from the biomedical and environmental areas. The MMR Core facility will host numerous workshops for new users including faculty and new graduate students.

Proper citation: JSU Molecular Magnetic Resonance Core Laboratory (RRID:SCR_009893) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9c78-6bed-55da-381e80000000

Core facility that provides the following services: Synthesis of Radiopharmaceuticals for PET, PET scanning/imaging service.

The PET Core Laboratory provides a full range of technical and professional services for the design and execution of programs using Positron Emission Tomography (PET). The PET Core Facility provides the required facilities and personnel on a per study basis to allow investigators to use PET without requiring them to acquire the needed special expertise and equipment.

Proper citation: MGH PET Core (RRID:SCR_009927) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000013b-3d48-24a1-e81d-064c80000000

Core facility that provides the following services: 3D Imaging, Normative data comparison, Scan review. The High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) Core Facility offers measurements of the microscopic internal structure of cortical and trabecular bone in the distal radius and tibia. Additionally, the HR-pQCT Core Facility offers Finite Element Analysis to estimate key biomechanical properties of the bone including failure load and stiffness. By scanning the distal radius and tibia, the HR-pQCT Core can measure a variety of important parameters reflecting the integrity or cortical and trabecular bone. This information cannot be determined using standard clinical imaging techniques such as dual-energy x-ray absorptiometry (DXA). A scanning appointment is a 30 minute addition to a clinical research visit and involves less radiation exposure than traditional bone densitometry. With applications for both cross-sectional and longitudinal research, investigators have employed our facilities and expertise to study a variety of bone-related diseases with participants ranging in age from children to the elderly. The goal of the HR-pQCT Core is to provide facilities and personnel on a per study basis, allowing investigators access to important information about bone structure and function without requiring special expertise and equipment. Getting Started: To begin organizing a cohort for HR-pQCT studies or to inquire further, please contact the Core Director, Dr. Joel Finkelstein.

Proper citation: MGH High Resolution Peripheral Quantitative Computed Tomography Core Facility (RRID:SCR_009924) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-a1bd-151b-55da-381e80000000

Core facility that provides the following services: 4.7T/7T MRI, PET-CT, SPECT, FMT, BLI, Animal housing service, Multimodality imaging and image fusion, Quantitative image analysis and processing, Animal surgical services, Radiochemistry, Histopathology, Data Management, In vivo confocal microscopy.

The Mouse Imaging Program (MIP) at the Center for Systems Biology is a uniquely integrated imaging resource providing the larger Harvard/MIT research community with access to state-of-the-art in vivo imaging technologies. The program offers magnetic resonance imaging (MRI), positron emission tomography (PET-CT), single photon emission computed tomography (SPECT-CT), computed tomography (CT), bioluminescence (BLI), fluorescence mediated tomography (FMT), and various other fluorescence imaging technologies. The fully integrated program also provides mouse holding facilities for serial imaging, surgery, anesthesia and veterinary care. Image reconstruction, 3D display, fusion, quantitative image analysis and online data access are also available. The program performs its own research, aimed at continuously improving existing imaging technologies and has deep knowledge of cardiovascular, oncology and neurological mouse models of disease. A list of publications made possible by utilizing MIP resources is available on the Program web site. Imaging requests may be submitted through the MIP website.

Proper citation: MGH Mouse Imaging Program (RRID:SCR_009925) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9143-a911-55da-381e80000000

Core facility that provides the following services: Offline assisted or self-performed analysis.

The HSCI-CRM Flow Cytometry Core Facility seeks to provide high quality, accessible cytometry sorting and analysis services to laboratories in the Center for Regenerative Medicine, Harvard Stem Cell Institute, and MGH research communities at an affordable rate. The Core''s equipment and highly trained operators provide an advanced level of sorting and analysis services to its investigators. Additionally, the Core is dedicated to training users on all aspects of flow cytometry, including practical issues, information about specific applications, and critical interpretation of sorting results. The Core''s three full-time staff members strive to ensure that each investigator''s visit benefits their individual experiments to the greatest extent possible. To ensure the best availability to all users, the Core offers an online scheduling system, and provides extended sorting hours until late evening. HSCI faculty have reduced pricing for use of the Core''s services.

Proper citation: MGH HSCI-CRM Flow Cytometry Core Facility (RRID:SCR_009923) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-c96b-3791-4882-b08d80000000

The Clinical Genetic Research Facility (CGRF) offers clinical investigators a convenient, modern research-dedicated facility for outpatient studies involving genetics. Our outpatient exam rooms and phlebotomy rooms are fully equipped and offer investigators an experienced medical assistant to facilitate the visit. Since the CGRF?s primary mission is to support and promote genetic clinical research, the facility?s investigators performing genetic studies supported by non-commercial sponsors are given priority. The CGRF also considers genetic studies sponsored by industry, as well as studies without a genetic component, on a space-available basis.

Proper citation: MGH CHGR Clinical Genetic Research Facility (RRID:SCR_009917) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9766-17f0-55da-381e80000000

Core facility that provides the following services: DNA extraction from blood and cell lines.

This facility provides processing of cell lines, human blood and tissue samples for DNA, plasma and buffy coat storage and for initiation of lymphoblast and fibroblast cell lines in furtherance of the CHGR mission to promote the use of genetic strategies in basic and clinical research.

Proper citation: MGH CHGR DNA and Tissue Culture Resource (RRID:SCR_009918) Copy   

•   Source: SciCrunch Registry