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http://harvard.eagle-i.net/i/0000012e-9652-3f24-55da-381e80000000

Core facility that provides the following services: Double- and triple-labeling experiments, Acquisition of high-resolution images: 2048 x 2048 pixels, Single molecule visualization, allowing dynamic observation and functional analyses of both in vivo and living cells, Total internal reflection fluorescence experiments (TIRF).

This Core consists of a Zeiss LSM 5 Pascal laser confocal microscope with a Zeiss RGB vario laser module and Nikon C1 Confocal/TIRF System with 3 PMT. A Zeiss Axiovert 200 fully motorized light microscope is available with fluorescence, bright-field, phase-contrast and Nomarski (DIC) capabilities. Image acquisition and analyses are performed using Zeiss LSM 5 Pascal Confocal Microscopy Software (Release 3.2) on 2 workstations. Zeiss Physiology software is available also. Live cell imaging is available using a Zeiss temperature controller with custom chamber and heating stage. The Nikon C1 Confocal/TIRF System fully motorized Nikon Eclipse Ti microscope is available with fluorescence, bright-field and TIRF capabilities. Imaging acquisition and analyses are performed using EZ-C1 and NIC-Elements Software.

Proper citation: MGH Confocal Microscope Core (RRID:SCR_009921) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-ee0d-d869-b2b9-4d8780000000

Core facility that provides the following services: DNA sequencing service, High volume DNA sequencing, Plasmid verification and primer walking service, PCR purification service, Microsatellite analysis.

The DNA Sequencing Core at the Massachusetts General Hospital functions both as a small-scale sequencing facility and a high-throughput center for large-scale sequencing projects.

Proper citation: MGH CCIB DNA Sequencing Core (RRID:SCR_009915) Copy   

•   Source: SciCrunch Registry

http://montana.eagle-i.net/i/0000012a-2502-98a0-f94c-e32480000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 22, 2025. Core facility that provides the following services: Microscopy facility training and access.

The Center for Biofilm Engineering Microscopy Facility is a research-only facility on the MSU campus, located on the third floor of the EPS building. The Microscopy Facilities Manager trains and assists faculty, research staff and students with capturing images of samples via optical microscopy and fluorescent confocal microscopy. The microscopy facilities include three separate laboratories - the Optical Microscopy Lab, the Confocal Microscopy Lab, and the Microscope Resource Room and Digital Imaging Lab. Large inventory of fluorescent stains. Inquire for availability, applications and collaborations.

Proper citation: MSU Microscopy Core Facility (RRID:SCR_009943) Copy   

•   Source: SciCrunch Registry

https://www.ohsu.edu/flow-cytometry-core

Core facility that provides the following services: Analytical flow cytometry service, Cell sorting service, Flow cytometry data analysis service, Grant preparation support service, Flow cytometry instrument training, Flow cytometry consultation service. The OHSU Flow Cytometry Shared Resource (FCSR) has operated as a core resource for OHSU Knight Cancer Institute members since 1996 and provides advanced flow cytometry instrumentation, technical expertise and technical services. The FCSR also provides training in data interpretation, experiment design and routine operation to researchers, offering an additional cost-saving option of doing some of the work themselves. Finally, this resource saves valuable investigator time by analyzing specimens and preparing them, if needed.

Proper citation: OHSU Flow Cytometry and Monoclonal Antibody Shared Resource Core Facility (RRID:SCR_009974) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000013c-e05d-718e-6d01-360380000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 6,2022. Core facility provides the following services: Data Management Consultation, Research Databases: REDCap & Customized Databases, Functional Genomics Consultation: Microarray Proteomics. The Biomedical Informatics Program (BMIP) provides investigators with informatics tools and methodologies to support translational researchers. Using a hybrid of collaborative and service approaches, BMIP is continually developing and deploying an array of informatics tools for bench research (bioinformatics), bedside research (clinical research informatics), and translation to practice (medical informatics). BMIP also provides a platform for collaborative and multidisciplinary informatics education and research. The Biomedical Informatics Program includes two major areas of emphasis: Translational Bioinformatics - Novel methodology development, Statistical Genetics, Functional Genomics, Clinical Research Informatics, Research Data Warehouse - Using Epic and other clinical data for research, Clinical research data management software, Epic as an interventional tool for research

Proper citation: Oregon Clinical and Translational Research Institute Biomedical Informatics Program (RRID:SCR_009965) Copy   

•   Source: SciCrunch Registry

https://www.ohsu.edu/pharmacokinetics-core

Core for analysis of drugs and their metabolites and bio-molecules such as simple peptides, oligonucleotides, carbohydrates, lipids, fatty acids and steroids. Provides open access to laboratory where users prepare and analyze their own samples by HPLC, GC/MS or LC/MS on equipment maintained by core personnel. Provides analysis of samples including development of analytical methods, sample preparation, and data analysis for clinical trials as well as basic science investigations.

Proper citation: OHSU Bioanalytical Shared Resource Pharmacokinetics Core Facility (RRID:SCR_009963) Copy   

•   Source: SciCrunch Registry

https://www.ohsu.edu/advanced-imaging-research-center/about-advanced-imaging-research-center

Provides magnetic resonance instruments including Siemens 3 Tesla Prisma, Siemens Magnetom 7 Tesla, and Bruker 11.75 Tesla to support research investigating normal physiology, brain development and aging, and disease pathophysiology with high performance non invasive imaging capabilities.

Proper citation: OHSU Advanced Imaging Research Center Core Facility (RRID:SCR_009960) Copy   

•   Source: SciCrunch Registry

https://www.ohsu.edu/proteomics-shared-resource

Core facility that provides the following services: Protein identification and partial sequencing, Determination of whole protein mass, Targeted SRM analysis of known proteins, Protein quantitation assay, Gel electrophoresis. The OHSU Protemics Shared Resource facility was established to make state-of-the-art mass spectrometry based protein analysis analytical capabilities available to the biomedical research community at OHSU.

Proper citation: OHSU Proteomics Shared Resource Core Facility (RRID:SCR_009991) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013f-52ff-7e24-a468-831a80000000

The MR Sub-Core of the SAIF provides the instrumentation and expertise necessary to perform a broad spectrum of magnetic resonance imaging and spectroscopy studies on a wide range of biological samples including small animals (cats, rabbits, rats, mice), tissue specimens, cultured cells and tissue extracts. This facility includes a conveniently located, well equipped surgery room used for preparing the animals for MR exams and a wide assortment of supporting equipment, i.e. anesthesia machines, MR compatible vital signs monitors (SA Instruments), infusion pumps (Harvard), heating pads, etc. A variety of perishable supplies used in animal preparation are provided by the facility.

Proper citation: Penn Small Animal Imaging Facility: MRI/MRS Sub-Core (RRID:SCR_010032) Copy   

•   Source: SciCrunch Registry

http://www.med.upenn.edu/gtp/vectorcore/

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. Core whose main aim is to provide vector technology for preclinical studies and other basic research applications. Its services include rovision of AAV, adenoviral and lentiviral based vectors, consultation and advice in the design of custom vectors and in vector serotype/pseudotype selection, and design, cloning and production of plasmid DNA for the production of custom vectors.

Proper citation: University of Pennsylvania Center for Molecular Therapy for Cystic Fibrosis Vector Core Facility (RRID:SCR_010038) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-7ce8-c10b-fbab-3b8480000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on June 1,2023. Core facility that provides the following services: Flow cytometry analysis service, Cell sorting and analysis service, Flow cytometer analyzer access, Introductory flow cytometry training, Advanced and customized flow cytometry training, Flow cytometry consultation service, FACSAria training, Flow cytometry data analysis, BSL2+ biohazardous human cell sorting, BSL2+ murine biohazardous cell sorting, BSL2+ murine cell sorting access, Non-infectious cell sorting access. The Flow Cytometry and Cell Sorting Resource Laboratory is currently recognized as one of the largest and most comprehensive flow cytometry laboratories in the US. In 2010 it was designated a laboratory of exceptional merit by the National Cancer Institute. Using state-of-the-art technology, the resource provides a broad array of, instrumentation, support, education and consultation to the research community at the University of Pennsylvania. A wide variety of cell sorting applications are supported, from high-speed multicolor (up to 14 colors) cell sorting to low-speed, large nozzle, improved viability sorting. Additionally, a wide variety of cell analysis services (up to 20 parameters) are offered, from traditional analog, easier to use tabletop analyzers to many-laser, many-color, high-speed, fully-digital modern instrumentation. Currently the facility offers 6 cell sorters and 19 analytical instruments. A very active training and consultation program is in place to support these activities. The Scientific Director, Dr. Jonni Moore, and the Technical Director, each have over 25 years experience in the field of cytomics. Researchers at the University of Pennsylvania are increasingly engaged in research projects that require 8-plus-parameter cell sorting of infectious cells and primary human tissues. Investigators using the Flow Cytometry and Cell Sorting Shared Resource have access to virtually any type of cytometric services required for a vast array of applications.

Proper citation: Penn Flow Cytometry and Cell Sorting Resource Laboratory (RRID:SCR_010011) Copy   

•   Source: SciCrunch Registry

http://upr.eagle-i.net/i/0000012a-250b-efe2-43fb-601a80000000

These laboratories house large, relatively expensive research instruments, which are shared among the faculty, students and staff on campus.

Proper citation: UPR RCMI Program Shared Instrumentation Laboratories (RRID:SCR_010132) Copy   

•   Source: SciCrunch Registry

http://uccaribe.eagle-i.net/i/00000135-c95d-a6f3-a272-8ee780000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 26,2026. Core facility that provides the following services: Research support, Research Training. The DMSRSU provides study design, data management, quality assurance, and statistical analysis support for UCC researchers. The DMSRSU has a strong infrastructure which includes the following subunits: Data Abstraction and Management; Data Entry; Quality Control; Data Analysis and Consultant; and Administrative and Computer Systems. Each of these subunits consists of experienced professionals readily available to assist researchers and to provide data management and statistical research support to investigators. In addition, the DMSRSU counts on a highly experienced and reliable consulting team.

Proper citation: UCC Data Management and Statistical Research Support Unit (RRID:SCR_010074) Copy   

•   Source: SciCrunch Registry

http://atlasgeneticsoncology.org/

Online journal and database devoted to genes, cytogenetics, and clinical entities in cancer, and cancer-prone diseases. Its aim is to cover the entire field under study and it presents concise and updated reviews (cards) or longer texts (deep insights) concerning topics in cancer research and genomics.

Proper citation: Atlas of Genetics and Cytogenetics in Oncology and Haematology (RRID:SCR_007199) Copy   

•   Source: SciCrunch Registry

http://eaa.mpi-bn.mpg.de/

Service that allows you to process CEL files from Affymetrix, Inc. GeneChip Exon 1.0 ST Arrays to identify alternative splicing.

Proper citation: Exon Array Analyzer (RRID:SCR_008684) Copy   

•   Source: SciCrunch Registry

http://obomap.bioontology.org/

THIS RESOURCE IS NO LONGER IN SERVCE, documented September 2, 2016. Service that determines the Suspected Overlap Among OBO Foundry Candidate Ontologies.

Proper citation: PROTOTYPE - Suspected Overlap Among OBO Foundry Candidate Ontologies (RRID:SCR_008834) Copy   

•   Source: SciCrunch Registry

http://edboyden.org/05.09.boyden.html

Laser tool that enables neurons to be optically silenced by pulses of yellow light, the light-activated chloride pump halorhodopsin (Halo), in a paper entitled Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution. Temporally precise, noninvasive control of activity in well-defined neuronal populations is a long-sought goal of systems neuroscience. We adapted for this purpose the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons. We demonstrate reliable, millisecond-timescale control of neuronal spiking, as well as control of excitatory and inhibitory synaptic transmission. This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers. The quest to determine how precise neural activity patterns mediate computation, behavior, and pathology would be greatly aided by a set of tools for reliably activating and inactivating genetically targeted neurons, in a temporally precise and rapidly reversible fashion. Having earlier adapted a light-activated cation channel, 1channelrhodopsin-2 (ChR2), for allowing neurons to be stimulated by blue light, we searched for a complementary tool that would enable optical neuronal inhibition, driven by light of a second color. Here we report that targeting the 1codon-optimized form of the light-driven chloride pump halorhodopsin from the archaebacterium Natronomas pharaonis (hereafter abbreviated Halo) to genetically-specified neurons enables them to be silenced reliably, and reversibly, by millisecond-timescale pulses of yellow light. We show that trains of yellow and blue light pulses can drive high-fidelity sequences of hyperpolarizations and depolarizations in neurons simultaneously expressing yellow light-driven Halo and blue light-driven ChR2, allowing for the first time manipulations of neural synchrony without perturbation of other parameters such as spiking rates. The Halo/ChR2 system thus constitutes a powerful toolbox for multichannel photoinhibition and photostimulation of virally or transgenically targeted neural circuits without need for exogenous chemicals, enabling systematic analysis and engineering of the brain, and quantitative bioengineering of excitable cells.

Proper citation: Channelrhodopsin-2 enables optical activation of neurons (RRID:SCR_008833) Copy   

•   Source: SciCrunch Registry

http://www.functionalneurogenesis.com/blog/

A blog focusing on the function of adult neurogenesis in the dentate gyrus of the hippocampus, including discussion of scientific research papers, methods and protocols, and other trends or observations about the field.

Proper citation: Functional Neurogenesis (RRID:SCR_008830) Copy   

•   Source: SciCrunch Registry

http://chgr.mc.vanderbilt.edu/page/gist

Software package to test if a marker can account in part for the linkage signal in its region. There are two versions of the software: Windows and Linux/Unix.

Proper citation: Genotype-IBD Sharing Test (RRID:SCR_006257) Copy   

•   Source: SciCrunch Registry

http://biobehavioural.blogspot.com/

THIS RESOURCE IS NO LONGER IN SERVCE, documented September 6, 2016. Biobehavioral blog on research and medicine as a continuum from biological mechanisms to behavioural phenomena., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: Biobehavioral (RRID:SCR_008710) Copy   

•   Source: SciCrunch Registry