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http://harvard.eagle-i.net/i/0000012e-58c7-d44f-55da-381e80000000

Core to provide gene expression data analysis service. Activities range from the provision of services to fully collaborative grant funded investigations.

Proper citation: Harvard Partners HealthCare Center for Personalized Genetic Medicine Bioinformatics Core Facility (RRID:SCR_000882) Copy   

•   Source: SciCrunch Registry

http://flowcytometry.sysbio.med.harvard.edu/

Core facility that provides the following services: Sorting and analysis services. The facility houses two state-of-the-art BD analyzers with high-throughput capability, a Stratedigm benchtop analyzer, a high-speed BD cell sorter, and both Mac and PC workstations for data analysis. Sorting services are offered through the facility, as well as instrument and software training.

Proper citation: HMS Systems Biology Flow Cytometry Facility (RRID:SCR_012696) Copy   

•   Source: SciCrunch Registry

http://www.neurodiscovery.harvard.edu/resources/atrc.html

Core facility that provides provides state-of-the-art molecular pathology resources to the Harvard community including laser capture microscopy, DNA/RNA/miRNA quality/expression analysis, Luminex FlexMap 3D multiplex bead cytometry, and real-time PCR. The ATRC is a fee-for-use facility. For NeuroDiscovery members, the first 10 hours of training, consultation and instrument use is free. This initial period is intended to provide a first time user with preliminary data/proof of concept regarding their project, and is generally sufficient when investigators work under the aegis of ATRC staff. Thereafter, the base fee varies depending on activity and the extent of your proposed work. Project-based charge-back agreements for large projects can be negotiated with the ATRC Director, Dr. Charles Vanderburg. Although priority is given to NeuroDiscovery members investigating neurodegenerative diseases and the CNS, the facility is also available to any academic investigators within the Harvard medical community and the greater-Boston research community. Under special arrangements the facility may also be made available to the commercial sector. Please contact ATRC Director, Dr. Charles Vanderburg, for details.

Proper citation: HNDC Advanced Tissue Resource Center (RRID:SCR_012670) Copy   

•   Source: SciCrunch Registry

http://bioinformatics.hms.harvard.edu/

Core facility that offers consultations on basic questions in research computing, bioinformatics and computational biology during the initial stages of study design and grant proposals as well as for ongoing, funded studies requiring external expertise. Core has experience in large-scale data management, database design and software development. Staff members can provide assistance in quality assurance and analysis of gene expression arrays, genome-wide SNP arrays, CNV studies and different aspects of second-generation sequencing technologies such as ChIP-seq, RNA-Seq or resequencing efforts. Services also include provision of external information generated from public database, data curation and assistance on choosing the right data format and annotation standard to ensure best practices in data management and submission are being maintained.

Proper citation: Harvard Chan Bioinformatics Core (RRID:SCR_012655) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/microarray-and-bioinformatics-core-mmc

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 22,2024. Core facility that provides the following services: RNA quality analysis service, qRT-PCR service, Microarray service, Bioinformatics data analysis service. The Core provides state of the art training, instrumentation, services and bioinformatics-driven data analysis to the Meharry Community in microarray experimental design, manipulation, and gene expression analysis. They also aid investigators and trainees in validation of microarray results using RNA QA/QC and real time PCR results. Finally, this Core Resource aids Meharry investigators and trainees with high performance computation in proteomics as well as genomics. Gene and protein pathways analysis and shotgun proteomics (mass spectrometry) analysis are just two more of the services that we provide. It is their aim to keep this facility up to date computationally and intellectually with state of the art Omics services to support education and research in microarray, genomics and proteomics data analysis, computational biology, and systems biology.

Proper citation: Meharry Microarray and Bioinformatics Core (RRID:SCR_012229) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/martinos-center-for-biomedical-imaging-core-facility-harvard

Core facility that provides the following services: Positron emission tomography service.

The Martinos Center''''s dual mission includes translational research and technology development. The core technologies being developed and used at the center are magnetic resonance imaging (MRI) and spectroscopy (MRS), magnetoencephalography (MEG) and electroencephalograpy (EEG), near infra-red spectroscopy (NIRS) and diffuse optical tomography (DOT), Positron Emission Tomography (PET), electrophysiology, molecular imaging, and computational image analysis. A particular area of innovation at the Center is Multimodal Functional Neuroimaging which involves the integration of imaging technologies. They are also world leaders in the development of primate neuroimaging techniques. Major areas of research at the center include, psychiatric, neurologic and neurovascular disorders, basic and cognitive neuroscience, cardiovascular disease, cancer and more. With an extensive and expanding inventory of state-of-the-art imaging facilities, a world class team of investigators and collaborators, and important government, industry and private supporters, the Martinos Center is leading the way to new advances and applications in biomedical imaging.

Proper citation: MGH Martinos Center for Biomedical Imaging Core Facility (RRID:SCR_012324) Copy   

•   Source: SciCrunch Registry

http://www.schepens.harvard.edu/graphics

Core facility that provides the following services: Web and graphic services, Web design and content management service, Photography service. Peter Mallen is a designer and illustrator who manages a full-service web and graphics studio in a moderately sized scientific research facility, Schepens Eye Research Institute. He provides a full range of graphic design, scientific illustration, web design and development, content management, and general design and production services. His products are utilized by: faculty and scientific staff (books, scientific publications, slide shows, grant applications); professional staff (Administration, Development & Public Affairs; brochures, books, pamphlets); the general public (Institute websites) as well as clients of our 250-seat state-of-the-art conference center, Starr Center for Scientific Communications.

Proper citation: Harvard SERI Graphic Services Core (RRID:SCR_012309) Copy   

•   Source: SciCrunch Registry

http://www.massgeneral.org/psychiatry/research/pngu_home.aspx

Core facility that provides the following services: SNP genotyping, qPCR for CNV detection / confirmation, Genetic analysis services, DNA extraction, quantification, sample preparation, tracking, and storage. This resource provides custom genotyping (SNP, other), qPCR for CNV detection/confirmation, DNA extraction, quantification, sample preparation, tracking, and storage, and related services to further the PNGU mission of identifying and characterizing the genetic basis of psychiatric, behavioral, and neurodevelopmental disorders and to translate these discoveries to improvements in clinical care and public health.

Proper citation: MGH Psychiatric and Neurodevelopmental Genetics Unit Core Lab (RRID:SCR_012301) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000012b-00c3-e398-6a59-ec4e80000000

Core facility that provides the following services: Custom design and development of equipment, tools and instruments for scientific research.

Proper citation: Dartmouth Department of Physics: Apparatus Shop Core Laboratory (RRID:SCR_009738) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-7276-7824-55da-381e80000000

Core facility that provides the following services: Whole genome amplification service, Genotyping service using Illumina GoldenGate and Infinium technologies, SNP Analysis using OpenArray Genotyping, SNP Analysis using Taqman, Custom Illumina GoldenGate genotyping, Illumina Infinium genotyping.

The mission of the High-Throughput Polymorphism Detection Core is to provide services to investigators conducting molecular analyses of somatic DNA collected as part of a wide range of investigations. This Core provides high-throughput assays of specific gene mutations and polymorphisms (SNPs) in the many situations where previously defined specific nucleotide alterations are of interest.

Proper citation: DF/HCC High-Throughput Polymorphism Detection Core (RRID:SCR_009736) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-c90c-c8fc-4882-b08d80000000

Core facility that provides the following services: Hematopoietic progenitor cell (HPC) components processing, Tumor cell vaccine generation, Dendritic cell vaccine generation, Validation consultation.

The (Connell and O''Reilly Families) Cell Manipulation Core Facility (CMCF), at Dana-Farber Cancer Institute (DFCI) was created in 1996 to be the manufacturing facility that produces safe and effective novel cellular component therapy that meets regulatory guidelines for clinical use and also facilitates research to be translated from the bench to the bedside. The goal of this facility is to assist DF/HCC investigators in developing new cell-based therapies for cancer and to support clinical research studies designed to evaluate the toxicity and efficacy of these novel treatments. In November 2004, CMCF moved to a newly constructed 6,700 square feet facility on the third floor and ground floor of the Jimmy Fund Building (JFB) at DFCI. The new facility is dedicated to the production of clinical grade cellular products for patients who participate in clinical trials conducted by DF/HCC investigators. All procedures are performed in environmentally controlled conditions according to current Good Manufacturing Practices (cGMP) for cell and tissue processing. The third floor accommodates all of the production areas while space on the ground floor is devoted to the long-term storage of cellular products, tissues and samples in liquid nitrogen and mechanical freezers. The CMCF is available to both clinical and laboratory investigators at all DF/HCC institutions and will provide services to patients at all DF/HCC affiliated hospitals. The staff of the CMCF are committed to working with DF/HCC investigators at all levels of clinical trial development and execution, including pre-clinical development, trial design, DF/HCC and FDA review, data management, quality control, internal and external audits as well as reports and publications. The Cell Manipulation Core Facility (CMCF) has been accredited by the Foundation for the Accreditation of Cellular Therapy (FACT). The CMCF services as a Regulatory Core for Center for Human Cell Therapy and is also a member of the Joint Program in Transfusion Medicine.

Proper citation: DF/HCC Cell Manipulation Core Facility (RRID:SCR_009734) Copy   

•   Source: SciCrunch Registry

http://cdrewu.eagle-i.net/i/00000135-20a3-3d3f-f836-7d1b80000000

The AXIS Biomedical Informatics function is dedicated to providing investigators at Charles Drew University (CDU) with state-of-the-art informatics solutions for their research projects. AXIS Biomedical Informatics comprises a multi-disciplinary team of researchers with backgrounds and interest in clinical medicine, biomedical informatics, medical geography and geographical information systems, computer science, sociotechnical theories and qualitative methods.

Proper citation: CDU AXIS Biomedical Informatics function (RRID:SCR_009699) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-f066-ba26-2162-17a280000000

Core facility that provides the following services: Metabolite identification service, PK data analysis and interpretation service.

The Cancer Pharmacology Core provides DF/HCC investigators with the necessary expertise and resources to design and undertake pharmacokinetic studies in the context of phase I and phase II clinical trials, and preclinical investigations. The core has the ability to implement and validate previously developed analytical methods to quantify drugs and their metabolites in biological fluids as well as the capability to modify or develop entirely new assays when warranted. The core also offers comprehensive analysis of pharmacokinetic data as an additional service, including the estimation of pharmacokinetic parameters and identifying their relationship to pathophysiological variables and pharmacodynamic effects.

Proper citation: DF/HCC Cancer Pharmacology Core (RRID:SCR_009732) Copy   

•   Source: SciCrunch Registry

http://ccny-cuny.eagle-i.net/i/00000137-568a-3b40-bb24-040880000000

LSR II A State-of-the-Art RCMI Flow Cytometry Core is located in MR613 with full time technical support, provided by the Flow Technician Mr. Jeffrey Walker. Mr. Walker is BD trained and certified in both analysis and sorting and has extensive experience in sorting both lymphocytes and larger epithelial cells, as well as with specialized applications including cell cycle analysis and calcium flux. Mr. Walker provides training for regular users wishing to perform independent analysis, and is responsible for all sorting.

Proper citation: CCNY Fluorescence Activated Cell Sorting (RRID:SCR_009696) Copy   

•   Source: SciCrunch Registry

http://cau.eagle-i.net/i/00000135-abf1-2607-ecf8-187780000000

CCRTD houses several major instruments to support structural studies of biological molecules, cells, modern cell, and molecular visualization applications. We have an Inverted Digitized Microscope (Zeiss) of general use, plus an advanced Fluorescence-enabled Inverted Digitized Microscope with Z-stacking and Live Cell Imaging modules (Zeiss). For advanced applications including In Situ Hybridization (ISH) and Immunohistochemistry (IHC), in addition to Zeiss microscope above we offer Confocal Fluorescent Microscope (Nikon). The latter is currently undergoing a major upgrade of computer system, software, and optics including addition of lasers.

Proper citation: CAU CCRTD-Structural Biology (RRID:SCR_009694) Copy   

•   Source: SciCrunch Registry

http://cau.eagle-i.net/i/00000135-abe7-77c7-ecf8-187780000000

CCRTD Core Facilities house major equipment for DNA and RNA-based applications. We offer polymerase chain reaction ( PCR ) instruments including Real-Time PCR machine (I-Cycle, Bio-Rad), Liquid Scintillation Counter (Beckman Coulter), Lyophilizer and Freeze-Dryer for biological samples, Cell Porator, high-speed and ultra-high-speed Centrifuges, ultra-sensitive Balances, and other supporting equipment. DNA and RNA quantification can be carried out on Spectrophotometers, both single-cuvette (DU650, Beckman Coulter) and 96-well plate based. DNA and RNA can be visualized, digitized, and quantified using Gel Documentation system (Bio-Rad) or Multi-Mode Imager Typhoon 9410, in fluorescent, luminescent, UV, or visible wavelengths; time-resolved fluorescence option is available on BioTek Plate Imager. For X-Ray imaging, we maintain an Automated X-Ray processor and Dark Room; radioisotope imaging is also supported on Typhoon 9410.

Proper citation: CAU CCRTD-Molecular Biology (RRID:SCR_009692) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000013a-8f55-ae5a-0802-e06e80000000

Core facility that provides the following services: Mouse Long Bone Scans, Mouse Vertebrae Scans. The Harvard School of Dental Medicine under the direction of The Office of Research operates a core facility composed of two micro CT machines.

Proper citation: HSDM Micro CT Core (RRID:SCR_009693) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-b447-d309-9cd7-d7e280000000

Core facility that provides the following services: DNA sequencing service, Oligonucleotide synthesis portal to IDT service, Oligonucleotide purification service, DNA fragment analysis service. The Nucleic Acid/Protein Research Core Facility, located on the 9th floor of the Abramson Building, provides a centralized source for specialized services, technical expertise and reagents to support investigators'' molecular biology research needs. These services include DNA sequencing analysis, fluorescent fragment analysis (microsatellite genotyping), oligonucleotide synthesis, microarray services, denaturing high-performance liquid chromatography, Affymetrix GeneChip expression analysis, SNP analysis and RNA analysis.

Proper citation: CHOP Nucleic Acid/Protein Core (RRID:SCR_009728) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013b-9b4b-434b-83a0-df0880000000

Core facility that provides the following services: Tissue microarray construction service, Unstained slides preparation service, H&E staining (on unstained slide) service, Special stain (from slide) service, TUNEL labeling service, IHC stain from slide service, In situ hybridization RNAscope service, New antibody workup service, Decalcification service, Laser capture service, Histopathology-related techniques training, Histopathology technical consultation service, Basic imaging workstation access, Laser capture microdissection microscope access. The Pathology Core Laboratory at the Children''s Hospital of Philadelphia Research Institute provides basic histopathology, research immunohistochemistry, tissue microarray, and laser capture microdissection services to researchers at Children''s Hospital and within the surrounding academic community. We are located on the 7th Floor of the Leonard and Madlyn Abramson Pediatric Research Center in room 706. The Pathology Core Laboratory unites three core components in a single core facility: histopathology, tissue microarray and laser capture microdissection. The core offers a full range of histopathology services including tissue processing, embedding, and cutting, for both paraffin and frozen tissue. We also perform most standard stains as well as immunohistochemistry, antibody workup, fluorescence, in situ hybridization and TUNEL. Tissue microarrays can be constructed using a Beacher Arrayer. Sophisticated imaging instrumentation is available for virtual microscopy (ScanScope from Aperio) and image analysis (Image ProPlus, Volocity). Specialized software is available to image and analyze tissue microarrays, and to manage and store array data.

Proper citation: CHOP Pathology Core Laboratories (RRID:SCR_009729) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000139-02ae-1aca-eb5b-b63c80000000

Core facility that provides the following services: Flow cytometer access, Non-infectious cell sorting, BSL2 biohazardous cell sorting, FlowJo workstation access, Flow cytometry online scheduling service, Sample processing and flow cytometry analysis service, Functional flow cytometry assay service, Cytometric Bead Array service, Flow cytometry data analysis service, Flow cytometer training, Flow cytometry consultation service. The Research Flow Cytometry Core Laboratory of the Children''s Hospital of Philadelphia Research Institute is located on the 12th floor of the Leonard and Madlyn Abramson Pediatric Research Center in room 1207. The laboratory offers state of the art instrumentation and professional technical assistance for performing flow cytometry analyses. We focus on providing services to members of the research community of The Children''s Hospital of Philadelphia and the University of Pennsylvania but users from outside the campus are welcome to our lab. The facility is equipped with three analyzers (LSRFortessa, Accuri C6 and FACSCalibur) and one cell sorter (MoFlo XDP). The analyzers are available 24 hours a day to users carrying a CHOP ID. Users not affiliated with CHOP may access the facility during business hours. Cell sorting services are offered on a fee-for-service basis. The core lab also offers full-service flow cytometry testing, including sample processing and immunophenotyping of blood samples from clinical studies as well as functional flow cytometry assays. The core is under the direction of Dr. Florin Tuluc and the daily activities in the lab are supervised by Eric Riedel.

Proper citation: CHOP Flow Cytometry Core Laboratory (RRID:SCR_009726) Copy   

•   Source: SciCrunch Registry