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http://www.scienceexchange.com/facilities/center-for-structural-biology

The CSB provides an integrated platform of expertise, infrastructure and education to foster a wider use of structural biology by the UNC community. The CSB mission is to make structural biology available as a general tool to any researcher. Structures of macromolecules at atomic resolution have helped to revolutionize modern biology. Structural insight is often crucial for understanding the functions of biological macromolecules, including their interactions with small ligands (such as substrates, inhibitors, drugs) and other macromolecules (nucleic acids and/or proteins). Consequently, structural biology represents one of the pillars of basic biomedical research; it is indispensable for deciphering the details of life processes and for understanding the differences between natural and diseased states. Building on such insights, structural biology can assist in devising novel therapies, e.g., through structure-based or structure-aided drug design. The enormous information content available in high-resolution, three-dimensional structures has sparked the desire of non-structural biologists to examine the structures of the macromolecules that they study. Structural biology is technically demanding, and it requires highly specialized expertise. The CSB removes or reduces these barriers that usually prevent general researchers from engaging in structural biology-based projects by themselves.

Proper citation: UNC School of Medicine Center for Structural Biology (RRID:SCR_012430) Copy   

•   Source: SciCrunch Registry

https://unclineberger.org/tissueculture/

Supply center and provides UNC Lineberger members and UNC colleagues with tissue culture products including stocks media, media supplements, serum, salt solutions, antibiotics, cell culture flasks and dishes, and many other in vitro cell culture and molecular biology-related items, kits and cell lines. Cell lines include normal and transformed mammalian, avian, insect, amphibian/reptile, and hybridoma cells. Services include checking Fetal Bovine Serum for quality and efficacy. TCF partners with Genetica Cell Line Services to offer qPCR-based Mycoplasma contamination testing for cell or DNA samples. Utilizes Genetica Cell Line Services for STR profiling of cell lines.

Proper citation: University of North Carolina Lineberger Comprehensive Cancer Center Tissue Culture Core Facility (RRID:SCR_012432) Copy   

•   Source: SciCrunch Registry

http://microscopy.dfci.harvard.edu

Core facility that provides state-of-the-art imaging microscopy technology for fixed and live cells, tissues and multi-photon animal imaging along with scientific and technical expertise to assist in experimental design and optimal image collection. Imaging techniques available include Standard fluorescence, Live-cell long term imaging, Confocal, Deconvolution, Fluorescence spectral detection, TIRF, FRET, Calcium imaging, Multi-photon, and Fluorescence lifetime imaging. Available equipment includes: Yokogawa spinning disk confocal microscope (Andor), Leica SP5 laser scanning confocal with a white light laser, Zeiss 710 confocal/multi-photon, Nikon inverted widefield fluorescence microscope. Other services include training on all equipment, consultation about various imaging techniques and assistance with image analysis. In addition, staff are available to assist with troubleshooting regarding microscopes in individual research labs. All services are available on a fee basis, and equipment is available for either assisted use or unassisted use after training by core staff. NEW: The core has established a collaboration with Rockland Immunochemicals to provide free, trial-size samples of primary and secondary antibodies that may be useful in your experiments.

Proper citation: DFCI Confocal and Light Microscopy Core Facility (RRID:SCR_012314) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/genomics-core--3

An Core facility

Proper citation: UT Arlington Genomics Core (RRID:SCR_012436) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/bone-histomorphometry-lab

Evaluations at the tissue level are critical to musculoskeletal research. The Bone Histomorphometry Lab in the Department of Orthopedics has a rich history of conducting such in situ evaluations in both human and animal tissue. The primary expertise of the Bone Histo Lab is the processing of skeletal tissue in its calcified state for the preparation of histology slides.

Proper citation: Mayo Clinic Bone Histomorphometry Lab (RRID:SCR_012439) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/electron-microprobe-laboratory

An electron microprobe is an electron microscope designed for the non-destructive x-ray microanalysis and imaging of solid materials. It is capable of high spatial resolution (1 micron beam size) and relatively high analytical sensitivity. The analytical facilities'''' JEOL JXA-8600 can acquire digital secondary-electron and backscattered-electron images as well as elemental x-ray maps. It is equipped with 4 wavelength-dispersive spectrometers and an energy-dispersive spectrometer. Most of the periodic table can in principle be analyzed (Be through U), subject to several important considerations. The quality of analyses performed depends essentially on the quality of sample preparation, character of the sample material, and availability of appropriate primary and secondary calibration standards for the desired elements. A precision usually less than 0.5% relative depending on element abundance, and accuracy as good as 1-2% can be obtained with this instrument. The analytical sensitivity ranges from a low of ~50 parts per million for optimum cases, to a typical detection limit of several hundred ppm, but can be as high as several weight percent for problem elements. The volume sampled is typically a few cubic microns, corresponding to a weight of a few picograms.

Proper citation: CU Boulder Electron Microprobe Laboratory (RRID:SCR_012321) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/embryonic-stem-cell-core

The Murine Embryonic Stem Cell Core has been created to help you create mutations in murine embryonic stem cells. The core has several missions including development of state-of-the-art reagents for the production of targeted mutations in embryonic stem cells, the creation of quality-controlled embryonic stem cell lines, and the teaching of methods for embryonic stem cell culture and manipulation. The core utilizes quality-controlled cells developed here at Washington University.

Proper citation: WUSTL School of Medicine Embryonic Stem Cell Core (RRID:SCR_012441) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/histopathology-and-tissue-shared-resource-georgetown

The HTSR offers a full complement of histology services through our combined Human Tissue Bank, histology, and IHC departments. The Human Tissue Bank supports tissue procurement and the retrieval of fresh frozen and archival paraffin blocks. The Histology laboratory provides processing, embedding and microtomy services both for fresh frozen and fixed tissues. The Histology lab also provides numerous routine and non-routine histological stains. The Immunohistochemistry (IHC) laboratory supports colorimetric and fluorescent IHC staining for established antibodies as well as the development of protocols for new antibodies. The IHC lab also supports TUNEL labeling and novel labeling techniques.

Proper citation: Georgetown Histopathology and Tissue Shared Resource (RRID:SCR_012489) Copy   

•   Source: SciCrunch Registry

https://rtsf.natsci.msu.edu/genomics/gene-expression-analysis/index.aspx

RTSF Genomics Core offers services for investigators looking to utilize gene expression for their research. Our range of applications includes solutions for quantifying gene expression levels in nearly any species regardless of sample size. Services include Next Generation Sequencing using Illumina instruments, qPCR using the ABI QuantStudio 7 Flex Real-Time PCR System, and gene expression using NanoString nCounter system.

Proper citation: Michigan State University RTSF Genomics Core Facility (RRID:SCR_012406) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/division-of-comparative-pathology-miami

The Division of Comparative Pathology is a full service veterinary pathology laboratory with both clinical pathology and histology services. Routine hematology and serum biochemistry testing is available for multiple species; we work well with low volume samples. Specialized testing is available or can be implemented as needed. Routine histology services including processing, embedding, and sectioning are available with many routine and special staining options.

Proper citation: UM Miller School of Medicine Division of Comparative Pathology (RRID:SCR_012492) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/institute-for-behavioral-genetics

The Institute for Behavioral Genetics (IBG) is an organized research unit of the University of Colorado Graduate School dedicated to conducting and facilitating research on the genetic and environmental bases of individual differences in behavior. Founded in 1967, IBG is one of the top research facilities in the world for genetic research on behavior. Data collection and analysis is ongoing for several internationally renowned studies including the Colorado Adoption Project, the Colorado Twin Registry, the National Youth Survey Family Study, the Colorado Learning Disabilities Research Center, and the National Longitudinal Study of Adolescent Health. IBG is home to one of the nation''''s largest DNA repositories for research on human behavior, as well as housing a wide array of behaviorally and genetically defined lines of selected, recombinant inbred, transgenic, and knockout-gene mice. Current research includes studies of aging ( The Johnson Lab, The Link Lab), psychopathology, reading disability, cognition, substance abuse, behavioral development, and evolution. In addition to our research, we provide training opportunities for graduate students in affiliated programs at the University of Colorado campuses in Boulder and Denver. IBG receives funding from several federal agencies, principally through the National Institutes of Health, as well as a broad spectrum of Associations, Foundations and Programs. Welcome to our site, please feel free to contact us with any questions about our research or programs.

Proper citation: CU Boulder Institute for Behavioral Genetics (RRID:SCR_012495) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/experimental-pathology-core-laboratory-uark

The Experimental Pathology Shared Resource Laboratory is a non-profit laboratory that provides investigators with centralized, comprehensive histological services. The laboratory currently works with over 70 investigators at the University of Arkansas, regionally, and nationally. By providing a centralized laboratory, we offer convenient access to all services within one facility, save costs for investigators and the institution, increase efficiency of sample processing, eliminate duplication of services and equipment, and maintain stringent quality control standards. The laboratory director, consultants, and technicians have extensive experience in routine histology and immunohistochemistry involving both human and animal tissues.

Proper citation: UAMS Experimental Pathology Core Laboratory (RRID:SCR_012373) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/genoseq-core-facility-ucla

THIS RESOURCE IS NO LONGER IN SERVCE, documented January 23, 2019. Core is involved in a broad range of scientific research. Medical research performed at the GenoSeq Core includes studies of human neurological disorders, such as: autism, bipolar disorder, and epilepsy; cancers of breast, colon, lung, and prostate; cardiac disease; and digestive disorders. Core also carries out studies of the genetics of non-human organisms. The GenoSeq Core is closely linked to the UCLA Bioinformatics Core in Gonda Center, which provides the computing power and sophisticated software needed to analyze and interpret the unprecedented volume of genetic data being generated with modern laboratory automation.

Proper citation: University of California Los Angeles GenoSeq Core Facility (RRID:SCR_012411) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/genomics-and-epigenomics-shared-resource-gesr-georgetown

The Genomics & Epigenomics Shared Resource (GESR) provides services for various high throughput experiments including gene expression profiling, SNP genotyping, CNV analysis, DNA methylation, microRNA expression profiling, siRNA screening, DNA/RNA isolation, RNA quality assessment, DNA plating and assay preparation, DNA sequencing, and fragment analysis. GESR uses state-of-the-art instruments and assays to provide these services. These include Affymetrix Microarray System, Agilent Microarray System, Applied Biosystems TaqMan assays, Illumina BeadXpress, Qiagen PyromarkMD, Qiagen Qiacube, Agilent Bioanalyzer, Beckman Multimek NXP Robotic Liquid Handling System, and Applied Biosystems Sequence Analyzer. In addition, GESR houses several user-operated specialized instruments for which the shared resource personnel provide technical support and training.

Proper citation: Georgetown Genomics and Epigenomics Shared Resource (RRID:SCR_012498) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/microarray-resource-core-bu

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 22,2024. Microarray Resource Core offers the full line of microarray products available from Affymetrix. This includes expression profiling, miRNA, exon, genotyping, resequencing, and tiling arrays. As part of our standard service, the resource provides assistance with experimental design and data analysis. Arrays for other organisms are available; please contact us for with specific requests.

Proper citation: Boston University Microarray Resource Core (RRID:SCR_012491) Copy   

•   Source: SciCrunch Registry

https://genomics.umn.edu/

Provides genomic technologies and services to researchers and clinicians. Services include Next Generation Sequencing, Epigenomics, SARS-CoV-2 services, GBS, Third Generation Sequencing, NGS Library Creation, Sanger Sequencing, DNA and RNA Extraction, Gene Expression.

Proper citation: University of Minnesota Genomics Center Core Facility (RRID:SCR_012413) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/animal-and-food-sciences-department-udel

We offer a wide range of disciplines including virology, physiology, nutrition, microbiology, immunology, molecular biology, engineering, and genomics. Our research addresses contemporary and future scientific challenges by using cutting edge technologies with the goal of assisting stakeholders in the poultry, livestock, and food industries.

Proper citation: UD Animal and Food Sciences Department (RRID:SCR_012415) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/center-of-biomedical-analysis-tsinghua-university

The center of biomedical analysis (CBA) is a multiple discipline platform. CBA is bound to provide the best services and support to our investigators in all research fields. We welcome any suggestions and recommendations. In consultation with the Advisory Committee for each facility, the facility manager sets up the fee structures and makes decision on equipment purchase and upgrade.

Proper citation: Tsinghua University Center of Biomedical Analysis (RRID:SCR_012382) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/dna-microarray-core-facility-duke

The Duke Microarray Facility provides services for the analysis of gene expression. The facility is operated jointly with the Duke Cancer Institute and provides: Affymetrix Microarrays Agilent Microarrays Real-Time PCR RNA Quality Check with Agilent Bioanalyzer The Microarray Facility also maintains a comprehensive database server to manage the massive amounts of data generated by microarray analysis. The facility provides data analysis support through various software packages as well as gene annotation support.

Proper citation: Duke DNA Microarray Core Facility (RRID:SCR_012629) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/w-m-keck-biomedical-mass-spectrometry-laboratory-virginia

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 15,2024. W.M. Keck Biomedical Mass Spectrometry Laboratory within the Biomolecular Research Facility identifies and analyzes proteins from gels and solution using current mass spectrometry techniques. There are techniques to compare samples which have different amounts of the same proteins. Analyses available: - Protein identification and sequencing from gel or solution by either peptide mass fingerprinting or ESI-LC/MS/MS at the low femtomole level. - Analysis of protein mixtures such as tissue and media analysis of tissue samples prepared by Laser Capture Microdissection - Proteomics, comparison of proteins in tissue samples using chemical/isotopic labels or label free analysis - Absolute quantitation of proteins using labeled peptides and selective reaction monitoring - Identification of phosphorylation sites using titanium dioxide enrichment - Identification of post-translational modifications (deamination, ubiquitination, etc) - De Novo (manual) sequence analysis of novel proteins to obtain sufficient sequence data for cloning - High resolution, high mass accuracy measurements of peptides and small proteins - Confirmation of peptide identity by MALDI mass measurements - Identification of binding partners Equipment Our current mass spectrometers: - Thermo Scientific LTQ Orbitrap Velos for high accuracy, high sensitivity analysis - Bruker Microflex for mass analysis by MALDI - Thermo Scientific TSQ Quantum Access MAX triple quadrupole instrument Sample types analyzed: - gel bands, stained with Coomassie, silver, fluorescent stains - proteins in solution - tissue samples - media - Laser Capture Microdissection tissue samples.

Proper citation: UVa W.M. Keck Biomedical Mass Spectrometry Laboratory (RRID:SCR_012589) Copy   

•   Source: SciCrunch Registry