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Project aggregates and provides experimental gene expression data from genito-urinary system. International consortium providing molecular atlas of gene expression for developing organs of GenitoUrinary (GU) tract. Mouse strains to facilitate developmental and functional studies within GU system. Experimental protocols and standard specifications. Tutorials describing GU organogenesis and primary data via database. Data are from large-scale in situ hybridization screens (wholemount and section) and microarray gene expression data of microdissected, laser-captured and FACS-sorted components of developing mouse genitourinary (GU) system.
Proper citation: GenitoUrinary Development Molecular Anatomy Project (RRID:SCR_001554) Copy
The Center develops conceptual models, computational infrastructure, an integrated knowledge repository, and query and analysis tools that enable scientists to effectively access and integrate the wealth of biological data. The National Center for Integrative Biomedical Informatics (NCIBI) was founded in October 2005 and is one of seven National Centers for Biomedical Computing (NCBC) in the NIH Roadmap. NCIBI is based at the University of Michigan as a part of the Center for Computational Medicine and Biology (CCMB). NCIBI is composed of biomedical researchers, computational biologists, computer scientists, developers and human-computer interaction specialists organized into seven major core functions. They work in interdisciplinary teams to collectively develop tools that are not only computationally powerful but also biologically relevant and meaningful. The four initial Driving Biological Projects (prostate cancer progression, Type 1 and type 2 diabetes and bipolar disorder) provide the nucleation point from which tool development is informed, launched, and tested. In addition to testing tools for function, a separate team is dedicated to testing usability and user interaction that is a unique feature of this Center. Once tools are developed and validated the goal of the Center is to share and disseminate data and software throughout the research community both internally and externally. This is achieved through various mechanisms such as training videos, tutorials, and demonstrations and presentations at national and international scientific conferences. NCIBI is supported by NIH Grant # U54-DA021519.
Proper citation: National Center for Integrative Biomedical Informatics (RRID:SCR_001538) Copy
NEI established NEHEP to increase awareness among healthcare professionals and the public of scientifically based health information that can be applied to preserving sight and preventing blindness. NEHEP works in partnership with a variety of public and private organizations that conduct eye health education programs. Program activities are designed to promote the importance of early detection and timely treatment of eye disease and the use of vision rehabilitation services using strategies that are culturally appropriate, health-literate, and evidence-based. NEHEP ensures that vision is a health priority by translating eye and vision research into public and professional education programs. NEHEP supports collaboration among eye health professionals, healthcare providers, patients, and the public. NEHEP programs provide healthcare professionals with information, materials, and resources to educate patients and the public about eye health and the importance of comprehensive dilated eye examinations. NEHEP is supported by a Planning Committee and a Partnership, which bring a vast array of knowledge about eye health and experience with populations at higher risk for eye disease. NEHEP Programs *Diabetic Eye Disease: The NEHEP Diabetic Eye Disease (DED) Education Program is designed to increase awareness about DED among people with diabetes, particularly those at higher risk. *Glaucoma: The NEHEP Glaucoma Education Program provides information about glaucoma to people at higher risk as well as those living with the disease. *Low Vision: The NEHEP Low Vision Education Program is designed to create awareness among adults, their families and friends, and the general public about vision rehabilitation services. *Ojo con su Vision: Ojo con su visin or Watch out for your vision is the Spanish-language program of NEHEP that targets the Hispanic/Latino community. Healthy Vision Program Healthy People 2010, the health promotion and disease prevention framework for the Nation, identifies the most significant risks to health and establishes national goals to reduce those risks. Focus area 28 of Healthy People 2010, Vision and Hearing, includes 10 vision objectives known as Healthy Vision. The Healthy Vision objectives identify national eye health concerns, and encourage individuals, organizations, and businesses to help address these concerns in their communities. *Healthy Vision 2010 Focusing on examination and prevention, eye diseases, injury and safety, and vision rehabilitation, Healthy Vision 2010 is designed to help you determine what you can do in your home, community, business, or state to help improve the Nation's eye health. *Healthy Vision Community Awards Program The Healthy Vision Community Awards Program provides awards of up to 10,000 for community-based eye health education programs. The program objectives address examinations and prevention, eye diseases, injury and safety, and vision rehabilitation. *Healthy Vision Month May is Healthy Vision Month, a national eye health observance sponsored by NEI and the National Eye Health Education Program Partnership. Healthy Vision Month is devoted to elevating vision as a public health priority. Each year focuses on a specific eye health topic. *Healthy Vision Community Programs Database The Healthy Vision Community Programs Database is a searchable collection of community-based vision health programs from the different U.S. states and territories. It stimulates ideas for creative eye health education projects and promotes networking among interested groups. Outlook Newsletter: Outlook is the electronic newsletter of the National Eye Health Education Program (NEHEP). Outlook provides quarterly updates on eye health education, disease prevention activities, and NEHEP activities and materials. Related Research: NEHEP represents an extension of the support that NEI provides to vision research, where results are disseminated to health professionals, patients, and the public.
Proper citation: National Eye Health Education Program (RRID:SCR_002049) Copy
http://www.worldpdcongress.org
A nonprofit organization dedicated to providing an international forum for the latest scientific discoveries, medical practices and caregiver initiatives related to Parkinson's disease. It hosts the annual World Parkinson Congress, an event which focuses on bringing physicians, scientists, allied health professionals, caregivers and people diagnosed with Parkinson's disease together, in order to create a global dialogue that will help expedite treatment practices and the discovery of a cure .
Proper citation: World Parkinson Congress (RRID:SCR_002034) Copy
THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. The World Parkinson's Disease Association is an alliance of members from all over the world who have come together to share information about Parkinson's disease. In order to further Parkinson's research and better the condition of those diagnosed with the disease, the Association: establishes computerized connections; takes part in and/or finances research activities; urges pharmaceutical companies and government institutions of the various countries to support the guidelines recommended by the associations of Parkinson's patients; and coordinates and promotes interchange of information among its members with the aim of solving problems of mutual interest.
Proper citation: World Parkinson Disease Association (RRID:SCR_002035) Copy
The UCLA-DOE Institute for Genomics and Proteomics carries out research in bioenergy, structural biology, genomics and proteomics, consistent with the research mission of the United States Department of Energy. Major interests of the 12 Principal Investigators and 9 Associate Members include systems approaches to organisms, structural biology, bioinformatics, and bioenergetic systems. The Institute sponsors 5 Core Technology Centers, for X-ray and NMR structural determination, bioinformatics and computation, protein expression and purification, and biochemical instrumentation. Services offered by this Institute: - Databases: * DIP (The Database of Interacting Proteins): The DIPTM database catalogs experimentally determined interactions between proteins. It combines information from a variety of sources to create a single, consistent set of protein-protein interactions. * ProLinks Database of Functional Linkages: The Prolinks database is a collection of inference methods used to predict functional linkages between proteins. These methods include the Phylogenetic Profile method which uses the presence and absence of proteins across multiple genomes to detect functional linkages; the Gene Cluster method, which uses genome proximity to predict functional linkage; Rosetta Stone, which uses a gene fusion event in a second organism to infer functional relatedness; and the Gene Neighbor method, which uses both gene proximity and phylogenetic distribution to infer linkage. - Data-to-Structure Servers: * SAVEs Structure Verification Server * Merohedral Twinning Test Server * SER Surface Entropy Reduction Server * VERIFY3D Structure Verification Server * ERRAT Structure Verification Server - Structure-to-Function Servers: * ProKnow Protein Functionator * Hot Patch Functional Site Locator
Proper citation: University of California at Los Angeles - Department of Energy Institute for Genomics and Proteomics (RRID:SCR_001921) Copy
National marine phytoplankton collection, maintaining over 2700 strains from around the world, most are marine phytoplankton but they also have benthic, macrophytic, freshwater and heterotrophic organisms - now incorporating bacteria and viruses. Strain records have (when available): * collection and isolation information * culturing medium recipes and growth conditions * photographs * GenBank accession link * collection site map * link to the taxonomic database Micro*scope The deposition of new strains are welcome if the strains are a valuable addition to the collection. Examples include strains that are referred to in publications, contain interesting molecular, biochemical or physiological properties, are the basis for taxonomic descriptions, are important for aquaculture, or are from an unusual geographical location or ecological habitat. The NCMA offers a course in phytoplankton culturing techniques and facilities for visiting scientists are available at the new laboratories in East Boothbay, Maine. Services include: Mass Culturing DNA and RNA, Purification, Private Holdings, Culture Techniques Course, Visiting Scientists, Single Cell Genomics, Flow Cytometry, Corporate Alliances and Technology Transfer.
Proper citation: National Center for Marine Algae and Microbiota (RRID:SCR_002120) Copy
http://www.gladstone.ucsf.edu/gladstone/site/gind/
GIND provides a highly interactive academic environment and state-of-the-art research facilities that are ideal for training in neuroscience and biomedical research. GIND Investigators hold university appointments at UCSF and participate in educational activities, including the teaching and training of graduate students and postdoctoral fellows. Additionally, GIND is actively engaged in efforts to translate scientific discoveries into better treatments for major diseases of the nervous system. Sponsors: Support for GIND comes from the University of California at San Francisco.
Proper citation: Gladstone Institute of Neurological Disease (RRID:SCR_008072) Copy
An interdisciplinary group of scientists and clinicians who study the human brain using a variety of imaging, recording, and computational techniques. Their primary goal is to bridge non-invasive imaging technologies to the underlying neurophysiology of brain neuronal circuits for a better understanding of healthy human brain function, and mechanisms of disruption of this function in diseases such as Alzheimer's, epilepsy and stroke. The other goal of the MMIL is to develop and apply advanced imaging techniques to understanding the human brain and its disorders. In order to ground these methodological developments in their underlying neurobiology, invasive studies in humans and animals involving optical and micro physiological measures are also performed. These methodologies are applied to understanding normal function in sleep, memory and language, development and aging, and diseases such as dementia, epilepsy and autism.
Proper citation: Multimodal Imaging Laboratory (RRID:SCR_008071) Copy
UK’s national facility for mouse genetics and use of mouse models for preclinical study of human disease.Offers services to researchers around the world. Services include free archiving of mouse lines to protect them for future use, distribution of mouse lines from the Archive, breeding and phenotyping of genetically altered mice, and genome engineering services to generate new mouse models.Offers archiving and distribution of mouse lines to safeguard germplasm collected from unique strains and make it readily available to the scientific community.
Proper citation: Medical Research Council Harwell: An International Centre for Mouse Genetics (RRID:SCR_008013) Copy
http://www-bird.jst.go.jp/index_e.html
BIRD''s mission is to aid the progress of bioinformatics and promote creation of new biology, which has computational, deductive, predictive, and theoretical features. (most of this site is in Japanese) To carry out its responsibilities, BIRD: * Promotes appropriate development of bioinformatics research and development, such as what kinds of databases and analysis software should be developed and what kind of computer facilities are needed for that development. * Maintains the computer environment and network and functions as a funding agency to further promotion plans. * Develops basic databases: genome sequence database, protein 3D structure database, gene expression profile database, molecular interaction database, etc. * Conducts and coordinates integration, enhancement, and standardization of the basic databases. * Develops computing tools for analyzing various kinds of biological and experimental data, data mining from databases, computer simulation of living systems and so on. * Develops ontologies necessary for data and knowledge description of databases storing biological functions and integration of the basic databases. * Conducts and coordinates research and development of innovative and creative technologies and theories which move toward understanding life as an information system, especially approaches by collaboration of computer scientists and experimental scientists. * Provides computer facilities for developing databases and software and making them publicly available. * Sets up training courses for teaching utilization of databases and tools for novices in bioinformatics and sponsors scientific meetings. * Provides community space with high performance computing facilities where innovative ideas are cultivated by free discussion and "trial and error" with the computer in order to promote development of young scientists who will create new biological discoveries based on bioinfomatics and become leaders in the field.
Proper citation: BIRD - Bio Info R and D (RRID:SCR_008010) Copy
THIS RESOURCE IS NO LONGER IN SERVICE, documented on May 16, 2016. The establishment of open access literature makes it possible for knowledge to be extracted from scholarly articles and included in other resources. BioLit aims to extract database identifiers and rich meta-data from open access articles in the life sciences and integrate that information with existing biological databases. We have begun prototyping this effort using a clone of the RCSB Protein Data Bank, a database of macromolecular structures. Cyberinfrastructure is integral to all aspects of conducting experimental research and distributing those results. However, it has yet to make a similar impact on the way we communicate that information. Peer-reviewed publications have long been the currency of scientific research as they are the fundamental unit through which scientists communicate with and evaluate each other. However, in striking contrast to the data, publications have yet to benefit from the opportunities offered by cyberinfrastructure. While the means of distributing publications has vastly improved, publishers have done little else to capitalize on the electronic medium. In particular, semantic information describing the content of these publications is sorely lacking, as is the integration of this information with data in public repositories. This is confounding considering that many basic tools for marking-up and integrating publication content in this manner already exist, such as a centralized literature database, relevant ontologies, and machine-readable document standards. We believe that the research community is ripe for a revolution in scientific communication and that the current generation of scientists will be the one to push it forward. These scientists, generally graduate students and new post-docs and have grown up with cyberinfrastructure as a part of their daily lives, not just a specialized aspect of their profession. They have a natural ability to do science in an electronic environment without the need for printed publications or static documents and, in fact, can feel quite limited by the traditional format of a publication. Perhaps most importantly, they appreciate that the sheer amount of data and the number of publications is prohibitive to the traditional methods of keeping current with the literature. Fink, L., Bourne, P. Reinventing Scholarly Communication for the Electronic Age, CTWatch Quarterly, Volume 3, Number 3, August 2007., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
Proper citation: BioLit (RRID:SCR_008270) Copy
http://psychiatry.ucsd.edu/Neuroembryologylab/index.htm
Dr. Eric Turner''s laboratory studies the mechanisms underlying the development of the nervous system. The vertebrate brain is comprised of a tremendous variety of neurons, each class exhibiting a unique phenotype characterized by the expression of specific neurotransmitter receptors, ion channels, patterns of axonal growth, and synapse formation. The research we conduct focuses on the critical role transcription factors play in the specification of neuronal cell type during development. We are particularly interested in transcription factors of the homeodomain family that bind to DNA and in doing so activate or repress gene expression. One area of study is the role of POU-domain transciption factor Brn3a in axon growth and survival. The primary research areas are: * Neuronal cell fate determination: The expression of regulatory genes is manipulated in living chick embryos using microsurgery and electroporation and the effects on neural marker genes studied. * Molecular mechanisms of gene regulation: Target DNA binding sites of neural transcription factors are biochemically characterized and findings coordinated with sequence data from the mouse and human genomes. * Targeted misexpression of regulatory genes: Transgenic and knockout mouse technology is used to misexpress genes of interest, and the effects on neural marker genes, axonal growth, and cell survival studied. * Global analysis of neural gene expression: Micro-arrays (GeneChips) are employed in conjunction with other areas of study to understand the coordinated regulation of gene expression in the nervous system. Dr. Turner is a member of the University of California, San Diego''s Graduate Program in Neuroscience and Biomedical Sciences Program and accepts students from these two programs. Interesting rotation projects are available using methods ranging from biochemistry and molecular biology to embryology. Additionally, Dr. Turner is also the Director of this NIMH-funded training program for research-oriented psychiatrists, psychologists, and basic neuroscientists working in areas relevant to psychiatry. Typically Fellows spend two years in the program, during which they develop a research project under the close supervision of one of the highly productive members of the UCSD Department of Psychiatry, or another investigator in the La Jolla (UCSD/Salk/Scripps) research community.
Proper citation: Department of Psychiatry, Turner Laboratory (RRID:SCR_008067) Copy
http://www.jax.org/imr/index.html
THIS RESOURCE IS NO LONGER IN SERVICE, documented on June 08, 2012. The function of the IMR is to select, import, cryopreserve, maintain, and distribute these important strains of mice to the research community. To improve their value for research, the IMR also undertakes genetic development of stocks, such as transferring mutant genes or transgenes to defined genetic backgrounds and combining transgenes and/or targeted mutations to create new mouse models for research. The function of the IMR is to: * select biomedically important stocks of transgenic, chemically induced, and targeted mutant mice * import these stocks into the Jackson Laboratory by rederivation procedures that rid them of any pathogens they might carry * cryopreserve embryos from these stocks to protect them against accidental loss and genetic contamination * backcross the mutation onto an inbred strain, if necessary * distribute them to the scientific community More than 1000 mutant stocks have been accepted by the IMR from 1992 through December 2006. Current holdings include models for research on cancer; breast cancer; immunological and inflammatory diseases; neurological diseases; behavioral, cardiovascular and heart diseases; developmental, metabolic and other diseases; reporter (e.g., GFP) and recombinase (e.g., cre/loxP) strains. About eight strains a month are being added to the IMR holdings. Research is being conducted on improved methods for assisted reproduction and speed congenic production. Most of the targeted mutants arrive on a mixed 129xC57BL/6 genetic background, and as many of these as possible are backcrossed onto an inbred strain (usually C57BL/6J). In addition, new mouse models are being created by intercrossing carriers of specific transgenes and/or targeted mutations. Simple sequence length polymorphism DNA markers are being used to characterize and evaluate differences between inbred strains, substrains, and embryonic stem cell lines.
Proper citation: Induced Mutant Resource (RRID:SCR_008366) Copy
http://www.transgenic-hydra.org/
The Transgenic Hydra Facility is a non-profit facility in the laboratory of Thomas Bosch at the University of Kiel that assists scientists to use and to develop transgenic Hydra polyps. Our mission is to provide investigators access to the latest technology for the efficient production of transgenic polyps. We particularly encourage scientists from laboratories lacking the infrastructure for transgenic Hydra technologies to use our services. Abstract: Understanding the evolution of development in large part relies on the study of phylogenetically old organisms. Cnidarians, such as Hydra, have become attractive model organisms for these studies. However, despite long-term efforts, stably transgenic animals could not be generated, severely limiting the functional analysis of genes. Here we report the efficient generation of transgenic Hydra lines by embryo microinjection. One of these transgenic lines expressing EGFP revealed remarkably high motility of individual endodermal epithelial cells during morphogenesis. We expect that transgenic Hydra will become important tools to dissect the molecular mechanisms of development at the base of the Metazoan tree. Sponsors: Financial support for this research was provided by the German Research Foundation [Deutsche Forschungsgemeinschaft Grants B0848/13 and SFB617.
Proper citation: Transgenic Hydra Facility (RRID:SCR_008641) Copy
http://www.sanger.ac.uk/PostGenomics/S_pombe/
The laboratory studies global gene expression programs in fission yeast (S. pombe). They apply a wide range of integrated approaches to analyse regulatory networks during cell proliferation, differentiation and quiescence including genetic and environmental perturbations. They are also interested in genetic diversity, genome evolution, and the complex interactions between genotypes, phenotypes, and the environment. The relative simplicity of the yeast cell promises a deeply satisfying, systems-level understanding of its inner workings within our life time Sponsors: This research is mainly funded by Cancer Research UK and the EC FP7 PhenOxiGEn project. Keywords: Gene, Expression, S.pombe, Yeast, Cell, Proliferation, Differentiation, Environmental, Genetic, Diversity, Genome, Evolution, Genotype, Phenotype, Environment,
Proper citation: Bahler Laboratory: Genome Regulation (RRID:SCR_008422) Copy
THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. The brain is made of billions of neurons, which together form the world''s most powerful information-processing machine. Despite decades of research, the fundamental principle by which these cells work together is still unknown. Many theories for brain function have been proposed over the last century. But only in the last few years has it become possible to record simultaneously from large enough numbers of neurons to put these theories to the test experimentally. This is an unprecedented opportunity, but it opens up a new question: how do we go from the gigabytes of experimental data that we now have, to concise conclusions about the function of the brain? The data processing methods traditionally used in neuroscience are not sophisticated enough to exploit this new flood of information. Fortunately, modern statistics and machine learning theory is making great strides in precisely the type of techniques needed to process these large multivariate databases. By applying these methods to neuronal data, we can now test long-standing hypotheses about brain function. The Cell Assembly The main focus of our research is an experimental search for cell assemblies. Before describing what a cell assembly is, it will be useful to describe what it is not. The brain is often thought of as a feed-forward system. In this scheme, sensory information is processed by successive levels of cortical analyzers, each of which transforms the results of previous levels, until sensory information is in a suitable form to guide the animals behavior. In support of this idea, the pattern of connections in the cortex does appear to respect a hierarchical organization, with the output of low-level areas corresponding to a single sensory modality being integrated into high-level multi-modal areas. Responses in higher-level sensory areas appear to have more complex responses to sensory stimuli, in agreement with increased abstraction as the hierarchy is traversed. However, there are several levels at which this feed-forward picture is incomplete. At the circuit diagram level, there more connections projecting across and down the hierarchy, than there are feed-forward projections. What''s more, if information were processed in a strictly feed-forward manner, one would expect a neuron to respond identically to repeated presentations of the same sensory stimulus. Although this is a fairly good approximation in primary sensory areas of cortex, in high-level structures responses are often more variable than expected from strict sensory control. Finally, although feed-forward processing can describe how an animal could perform simple stimulus-response behaviors, it cannot explain more complex top-down behaviors such as memory or thought. An alternative point of view, put forward over 50 years ago by Canadian psychologist Donald Hebb, holds that recurrent and feedback connections play an essential role in brain function. The principal actor in this view is the cell assembly, an anatomically distributed subset of neurons, amongst which mutually excitatory connections have been strengthened by repeated co-activation, allowing the assembly to later maintain its activity through reverberation without direct sensory stimulation. This theory allows for sensory-response behavior, and also behavior resulting purely from internally generated cognitive activity, by the sequential activation of a series of assemblies, leading in turn to the production of motion. In our research, we search for signatures of assembly activity in simultaneous recordings from multiple neurons, and aim to characterize the properties of assembly activity in ways not possible from theory alone. Software for Automatic Clustering KlustaKwik is a program developed in the lab for automatic cluster analysis, specifically designed to run fast on large data sets. In order facilitate open-source development, it is now located at klustakwik.sourceforge.net. This study was supported by NIH grants MH073245 and DC009947; NSF grant SBE-0542013 to the Temporal Dynamics of Learning Center, an NSF Science of Learning Center; a National Institute on Deafness and Other Communication Disorders, NIH, grant DC-005787-01A1; and a Spanish grant FIS 2006-09294. K.D.H. is an Alfred P. Sloan fellow. We would like to dedicate this work to the memory of D. J. Amit.
Proper citation: Rutgers University Quantitative Neuroscience Laboratory (RRID:SCR_008541) Copy
http://www.brl.ntt.co.jp/cs/human/index.html
This site provides information about the NTT Human and Information Science Laboratory. Technologies that enable users to get along well with information and technologies that can handle information properly on computers and networks are the keys to secure and high-quality information distribution services in a network society. In realizing those technologies, a comprehensive understanding of how human beings, the creators and the recipients of information, process information and novel principles for handling information are indispensable. From this viewpoint, the NTT Human and Information Science Laboratory has been pursuing scientific research in two areas: Sensory and Emotion Research, and Sensory and Motor Research. Sponsors: This resource is supported by NTT Communication Science Laboratories.
Proper citation: Human and Information Science Laboratory (RRID:SCR_008329) Copy
http://www.usc.edu/schools/medicine/departments/psychiatry_behavioralsciences/research/gsc/
The USC Geriatric Studies Center includes the State of California Alzheimer's Research Center of California and the National Institute of Aging funded clinical program of the USC Alzheimer's Disease Research Center. It is staffed by USC faculty and physicians with expertise in Alzheimer's disease and age related memory loss. The Center provides evaluation, diagnosis and treatment recommendations, referral to caregiver services and support groups, and the opportunity to participate in clinical drug trials for memory problems.
Proper citation: USC Geriatric Studies Center/Alzheimer's Disease Research Center (RRID:SCR_008725) Copy
Center for the study of non-human primates. Its mission is the study and use of non-human primates as models for studies of social and biological interactions and for the discovery of methods of prevention, diagnosis and treatment of diseases that afflict humans. Through the stewardship of three unique facilities—Cayo Santiago Field Station, Sabana Seca Field Station, and the Laboratory of Primate Morphology supports a diverse range of research programs that enhance understanding of primate biology and behavior, with direct applications in biomedical and translational research.
Proper citation: Caribbean Primate Research Center (RRID:SCR_008345) Copy
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