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http://jaxmice.jax.org/list/ra1642.html
Produce new neurological mouse models that could serve as experimental models for the exploration of basic neurobiological mechanisms and diseases. The impetus for the program resulted from the recognition that: * The value of genomic data would remain limited unless more information about the functionality of its individual components became available. * The task of linking genes to specific behavior would best be accomplished by employing a combination of different approaches. In an effort to complement already existing programs, the Neuroscience Mutagenesis Facility decided to use: a random, genome-wide approach to mutagenesis, i.e.N-ethyl-N-nitrosourea (ENU) as the mutagen; a three-generation back-cross breeding scheme to focus on the detection of recessive mutations; behavioral screens selective for the detection of phenotypes deemed useful for the program goals. The resulting mutant mouse lines have been available to the scientific community for the last five years and over 700 NMF mice have been sent to interested investigators for research; these mutant mouse lines will remain available as frozen embryos (which can be re-derived on request) and can be ordered through the JAX customer service at 1-800-422-6423 (or 207-288-5845). The results of the work of the Neuroscience Mutagenesis Facility and that of two other neurogenesis centers, i.e. The Neurogenomics Project at Northwestern University, and the Neuromutagenesis Project of the Tennessee Mouse Genome Consortium, can also be seen at Neuromice.org, a common web site of these three research centers; in addition, information about all mutants produced by these groups has been recorded in MGI.
Proper citation: JAX Neuroscience Mutagenesis Facility (RRID:SCR_007437) Copy
Project focused on cerebral aneurysms and provides integrated decision support system to assess risk of aneurysm rupture in patients and to optimize their treatments. IT infrastructure has been developeded for management and processing of vast amount of heterogeneous data acquired during diagnosis.
Proper citation: aneurIST (RRID:SCR_007427) Copy
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 23,2022. A metagenomic open reading frame (ORF) finding tool for the prediction of protein coding genes in short, environmental DNA sequences with unknown phylogenetic origin. The resource is based on a two-stage machine learning approach that uses linear discriminants to extract features from the ORFs. An artificial neural network then combines the features and computes a gene probability for each ORF fragment.
Proper citation: Orphelia (RRID:SCR_000119) Copy
Understanding the mechanisms underlying the expression and perception of auditory communication in nonhuman primates provides important insights for understanding the neural systems that mediate nonverbal auditory communication in humans. Our research is devoted to understanding the changes in vocal behavior that are associated with maturation and social experience under normative conditions, and to investigating neural systems to define their roles in auditory communication. The anterior cingulate gyrus, in the frontal cerebral cortex, is an essential neural system for the expression of the primate isolation call, a structural and functional equivalent of the cry sounds of humans. Bilateral removal of this structure in adult squirrel monkeys resulted in a long-lasting inability to emit isolation calls. Partial recovery, often over many weeks, initially took the form of production of short, faint and uninflected versions of the typical isolation call. Humans suffering infarct damage to this region likewise show an initial recovery in the form of short, faint, monosyllabic sounds, suggesting that the anterior cingulate gyrus of nonhuman primates is the evolutionary precursor of a neural structure involved in human affective expression and speech. Our working model of isolation call production is that the anterior cingulate gyrus is the site where the command to produce this vocalization is initiated. Since the anterior cingulate region also has reciprocal connections with temporal lobe auditory cortex, a presumptive feedback pathway exists for registering commands to initiate vocalization with the temporal lobe cortex, which plays a major role in perceiving and decoding the acoustic details of species-specific vocalizations. At present, we do not know the role of the anterior cingulate gyrus in the production of infant vocalizations. However, we have found that neonatal removal of the amygdala, an important forebrain component of the limbic system, or portions of the inferotemporal gyrus, which sends projections to the amygdala, result in significant changes in the vocal behavior of infant rhesus macaques. Vocal development is a dynamic process, and a pattern shared by several nonhuman primates has emerged regarding the nature of this process. Infants are highly vocal during periods of brief separation from their caregiver, and we take advantage of this to document the range of vocalizations produced by infants of different ages. In the neonatal period, infants of 3 species of nonhuman primate (rhesus macaque, squirrel monkey and common marmoset) all produce sounds that vary widely in their acoustic structure. Many of these bear a striking similarity to sounds used in a variety of social settings by adults, suggesting that neural systems responsible for generating adult vocalizations are already in place during early infancy. As infants mature, their vocal behavior during brief periods of social separation becomes much more stereotyped. It isn't until much later in development, as individuals engage in a variety of social interactions with peers and adults, that the sounds expressed in early infancy begin to re-appear in adult contexts. The role of individual experience during development is currently being explored to determine the mechanisms leading to the acquisition of adult vocal skills.
Proper citation: NICHD Developmental Neuroethology - Laboratory of Comparative Ethology (RRID:SCR_000416) Copy
Website resource for researchers to order and send Drosophilia specimens to each other. This community-driven supplier also works with the FlyBase Drosophilia database to search for synonyms for fly species.
Proper citation: Drososhare (RRID:SCR_014976) Copy
http://www.northernspalting.com/workshops-and-materials/buy-fungi/
Supplier of non-toxic, pure-culture fungi through Oregon State University which are kept active in the lab. All organisms arrive in an aggressive, pigmenting state. It's website also features scientific information on spalting, DIY guides, lists of upcoming spalting events, and a menagerie of other spalting resources.
Proper citation: Northern Spalting - Applied Mycology Lab (RRID:SCR_014945) Copy
http://www.alohaculturebank.com/about.html#.WKzBohIrL-Y
Producer and supplier of organic medicinal mushrooms and medicinal mushroom products. Its product line includes raw materials and private label products for pharmaceutical and nutraceutical use, as well as its own branded line of "Condition Specific" dietary supplements available to the public.
Proper citation: Aloha Medicinals (RRID:SCR_014943) Copy
http://www.archerfarmsinc.com/
Producer and supplier of swine and sheep for research purposes. Archer Farms delivers its specimens directly to research facilities throughout the East Coast.
Proper citation: Archer Farms (RRID:SCR_014948) Copy
Supplier of laboratory-reared and field-collected freshwater, marine, and estuarine organisms. Invertebrates and vertebrates are available, and seasonal and unlisted organisms can be requested. Its test organisms are available for environmental and biomedical research.
Proper citation: Aquatic Research Organisms (RRID:SCR_014946) Copy
Developer of specialized and appropriate hamster models for research on human diseases. These specialized hamsters have features similar to those seen in certain human diseases. Bio Breeders provides these specialized hamsters to the biomedical community worldwide.
Proper citation: Bio Breeders (RRID:SCR_014951) Copy
Foundation to support research in and diagnosis of adrenal diseases. The portal provides basic information about adrenal diseases as well as a community for patients.
Proper citation: National Adrenal Diseases Foundation (RRID:SCR_015007) Copy
http://brownfamilyenterprises.com/
Research facility and licensed commercial research animal breeder that specializes in custom polyclonal antibody production, contract research, animal models for research, and animal tissue procurement. Brown Family Enterprises can make and distribute custom polyclonal antibodies using rabbits, goats, sheep, and horses.
Proper citation: Brown Family Enterprises (RRID:SCR_014953) Copy
Genebank of wild relatives, monogenic mutants and miscellaneous genetic stocks of tomato. TGRC offers seed samples for free to researchers worldwide.
Proper citation: C.M. Rick Tomato Genetic Resources Center (RRID:SCR_014954) Copy
https://www.niddk.nih.gov/research-funding/research-programs/kidney-disease-centers
A portal with detailed information about various research centers that focus on kidney disease and translational research funded by NIDDK.
Proper citation: Polycystic Kidney Disease Research and Translation Centers (RRID:SCR_015305) Copy
Project to house templates used to build other projects. It is also known as the NeuroImaging and Analysis Group, which employs various physiological, functional and structural neuroimaging methodologies in both research and clinical domains.
Proper citation: Template Project (RRID:SCR_015516) Copy
Commercial provider of purpose-bred animals for biomedical research. They provide dogs, pigs, ferrets, mice, and guinea pigs in physically and psychologically healthy condition.
Proper citation: Marshall BioResources (RRID:SCR_015489) Copy
https://www.med.upenn.edu/idom/
NIDDK center that serves diabetes-oriented investigators from University of Pennsylvania as well as additional institutions from the mid-Atlantic region. The Penn DRC represents many basic science and clinical departments at Penn and the other institutions, and supports research in diabetes and obesity via Scientific Cores, a Pilot and Feasibility Grant Program, and a series of seminars, retreats, and other academic enrichment activities.
Proper citation: University of Pennsylvania Diabetes Research Center (RRID:SCR_015732) Copy
https://funricegenes.github.io/
Dataset of functionally characterized rice genes and members of different gene families. The dataset was created by integrating data from available databases and reviewing publications of rice functional genomic studies.
Proper citation: funRiceGenes (RRID:SCR_015778) Copy
https://github.com/ABCD-STUDY/eprime-data-clean
Software to convert E-Prime (software tool for psychology computerized experiment design, data collection, and analysis) generated files to CSV files without errors during conversion. The ABCD project is using E-Prime to run behavioral tests.
Proper citation: eprime-data-clean (RRID:SCR_016020) Copy
Supplier of Frogs and Tadpoles for the scientific community.
Proper citation: Xenopus Express (RRID:SCR_016373) Copy
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