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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
GC/GCF
 
Resource Report
Resource Website
1+ mentions
GC/GCF (RRID:SCR_009075) software resource, software application Software application where GC implements the genomic control models. GCF implements the basic Genomic Control approach, but adjusts the p-values for uncertainty in the estimated effect of substructure. This approach is preferable if a large number of tests will be evaluated because it provides a more accurrate assessment of the significance level for small p-values. (entry from Genetic Analysis Software) gene, genetic, genomic, r, linux is listed by: Genetic Analysis Software nlx_154072, SCR_000846, nlx_154584 SCR_009075 R/GCF, R/GC, Genomic Control 2026-08-12 10:49:54 1
Homeobox Genes DataBase
 
Resource Report
Resource Website
1+ mentions
Homeobox Genes DataBase (RRID:SCR_007723) HoxPro data or information resource, database THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 11th,2023. The database HOX Pro contains information about organization, functions and evolution of gene ensembles, key roles in which play homeobox-genes. It is aimed at: 1. analysis and classification of regulatory and coding regions in diverse homeobox and related genes; 2. describing mutations and knock-outs of hox-genes, as well as hereditary diseases related to these genes; 3. graphical representation, comparisons and classification of hox-genes expression patterns and profiles (sea urchin blastula, Drosophila blastoderm and imaginal discs, vertebrate limbs, mammalian brain, human EC cells); 4. comparative analysis of organization of hox-based genetic networks the nematode Caenorhabditis elegans the sea urchins Strongylocentrotus purpuratus and other echinids, the fruit flies Drosophila melanogaster and D.virilis, the vertebrates chicken and mouse; 5. analysis of phylogeny and evolution of homeobox genes and clusters. homeobox, homeobox-genes, hox genes THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-20854, SCR_008115, nif-0000-02982 SCR_007723 2026-08-12 10:49:44 1
The Loom
 
Resource Report
Resource Website
1+ mentions
The Loom (RRID:SCR_006877) Loom data or information resource, narrative resource, blog The Loom is a blog about life, past and future. Written by DISCOVER contributing editor and columnist Carl Zimmer. Carl Zimmer writes about science regularly for the New York Times and magazines such as Discover, where he is a contributing editor and columnist. has parent organization: Discover Magazine nlx_83062 SCR_006877 2026-08-12 10:49:33 1
Sapienta
 
Resource Report
Resource Website
1+ mentions
Sapienta (RRID:SCR_006993) SAPIENTA software application, software resource, source code Software to help researchers process scientific papers faster and get the information they are interested in out of them. This is achieved by automating the recognition of core scientific concepts such as Motivation, Method, Result, Conclusion in papers and uses them to generate automatic summaries. This SAPIENTA tool adds additional functionality to the SAPIENT tool, an annotation tool implemented as a web application which enables experts to annotate scientific papers, sentence by sentence manually, according to the Core Scientific Concept (CSC) schema. semantic mark up, semantic, annotation, annotation software is listed by: FORCE11 JISC nlx_151311 SCR_006993 SAPIENTA - Automating the Semantic Annotation of Papers, Semantic Annotation of Papers: Interface & ENrichment Tool Automated 2026-08-12 10:49:36 1
GOstat
 
Resource Report
Resource Website
100+ mentions
GOstat (RRID:SCR_008535) GOstat production service resource, data analysis service, analysis service resource, service resource GOstat is a tool that allows you to find statistically overrepresented Gene Ontologies within a group of genes. The Gene-Ontology database (GO: http://www.geneontology.org) provides a useful tool to annotate and analyze the function of large numbers of genes. Modern experimental techniques, as e.g. DNA microarrays, often result in long lists of genes. To learn about the biology in this kind of data it is desirable to find functional annotation or Gene-Ontology groups which are highly represented in the data. This program (GOstat) should help in the analysis of such lists and will provide statistics about the GO terms contained in the data and sort the GO annotations giving the most representative GO terms first. Run GOstat: * Go to search form - Computes GO statistics of a list of genes selected from a microarray. * GOstat Display - You can store results from a previously run and view them here, either by uploading them as a file or putting them on a selected URL. * Upload Custom GO Annotations - This allows you to upload your own GO annotation database and use it with GOstat. Variants of GOstat: * Rank GOstat - Takes input from all genes on microarray instead of using a fixed cutoff and uses ranks using a Wilcoxon test or either ranks or pvalues to score GOs using Kolmogorov-Smirnov statistics. * Gene Abundance GOstats - Takes input from all genes on microarray and sums up the gene abundances for each GO to compute statistics. * Two list GOstat - Compares GO statistics in two independent lists of genes, not necessarily one of them being the complete list the other list is sampled from. Platform: Online tool, THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. gene, gene ontology, annotation, statistical analysis, FASEB list is listed by: Gene Ontology Tools
is related to: Gene Ontology
has parent organization: Walter and Eliza Hall Institute of Medical Research; Victoria; Australia
DFG PMID:14962934 THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-30625 SCR_008535 2026-08-12 10:49:47 159
Pythonxy
 
Resource Report
Resource Website
10+ mentions
Pythonxy (RRID:SCR_006903) Python-xy, Python(x, y) software development tool, software application, software resource, source code Scientific and engineering development software for numerical computations, data analysis and data visualization based on Python programming language, Qt graphical user interfaces and Spyder interactive scientific development environment. Used to interpreted languages (such as MATLAB or IDL) or compiled languages (C/C++ or Fortran) to switch to Python. program, language, python, computation, data analysis, data visualization, plugin is related to: Spyder Free, Available for download, Freely available nlx_149232 http://www.pythonxy.com, https://code.google.com/p/pythonxy/wiki/Welcome SCR_006903 pythonxy - Scientific-oriented Python Distribution based on Qt and Spyder, Python(x, y) - Scientific oriented Python Distribution based on Qt and Spyder 2026-08-12 10:49:34 10
IRESite
 
Resource Report
Resource Website
50+ mentions
IRESite (RRID:SCR_007753) data or information resource, database Database of experimentally verified IRES structures. Presents information about experimentally studied Internal Ribosome Entry Site segments. bio.tools, experimentally verified IRES structures, Internal Ribosome Entry Site segments, IRES structures, IRES segments is listed by: bio.tools
is listed by: Debian
has parent organization: Charles University; Prague; Czech Republic
nif-0000-03047, nif-0000-03046, SCR_007754, biotools:iresite https://bio.tools/iresite http://ifr31w3.toulouse.inserm.fr/IRESdatabase/ SCR_007753 IRESdb, , IRESdb - the Internal Ribosome Entry Site database, Internal Ribosome Entry Site 2026-08-12 10:49:44 52
GeneTerm Linker
 
Resource Report
Resource Website
1+ mentions
GeneTerm Linker (RRID:SCR_006385) GTLinker production service resource, data analysis service, analysis service resource, service resource Web application that filters and links enriched output data identifying sets of associated genes and terms, producing metagroups of coherent biological significance. The method uses fuzzy reciprocal linkage between genes and terms to unravel their functional convergence and associations. It can also be accessed through its web service. gene, functional annotation, function, functional metagroup, p-value, annotation, web service is listed by: OMICtools
is related to: Gene Ontology
is related to: KEGG
is related to: InterPro
has parent organization: Spanish National Research Council; Madrid; Spain
PMID:21949701 Acknowledgement requested OMICS_02227 SCR_006385 GeneTerm Linker - post enrichment functional association by non-redundant reciprocal linkage 2026-08-12 10:49:25 2
Atlas of Genetics and Cytogenetics in Oncology and Haematology
 
Resource Report
Resource Website
10+ mentions
Atlas of Genetics and Cytogenetics in Oncology and Haematology (RRID:SCR_007199) data or information resource, atlas, database Online journal and database devoted to genes, cytogenetics, and clinical entities in cancer, and cancer-prone diseases. Its aim is to cover the entire field under study and it presents concise and updated reviews (cards) or longer texts (deep insights) concerning topics in cancer research and genomics. gene, cytogenetic, cancer, cancer research, genomic, online journal, bio.tools, FASEB list is listed by: Debian
is listed by: bio.tools
PMID:23161685 Freely available, Available to the scientific community nif-0000-30129, biotools:atlasgeneticsoncology https://bio.tools/atlasgeneticsoncology SCR_007199 Genetics and Cytogenetics Atlas 2026-08-12 10:49:35 43
Exon Array Analyzer
 
Resource Report
Resource Website
1+ mentions
Exon Array Analyzer (RRID:SCR_008684) Exon Array Analyzer production service resource, data analysis service, analysis service resource, service resource Service that allows you to process CEL files from Affymetrix, Inc. GeneChip Exon 1.0 ST Arrays to identify alternative splicing. is listed by: OMICtools OMICS_00754 SCR_008684 2026-08-12 10:49:45 4
PROTOTYPE - Suspected Overlap Among OBO Foundry Candidate Ontologies
 
Resource Report
Resource Website
1+ mentions
PROTOTYPE - Suspected Overlap Among OBO Foundry Candidate Ontologies (RRID:SCR_008834) PROTOTYPE Suspected Overlap Among OBO Foundry Candidate Ontologies production service resource, data analysis service, analysis service resource, service resource THIS RESOURCE IS NO LONGER IN SERVCE, documented September 2, 2016. Service that determines the Suspected Overlap Among OBO Foundry Candidate Ontologies. has parent organization: National Center for Biomedical Ontology THIS RESOURCE IS NO LONGER IN SERVICE nlx_144632 SCR_008834 2026-08-12 10:49:48 2
Channelrhodopsin-2 enables optical activation of neurons
 
Resource Report
Resource Website
1+ mentions
Channelrhodopsin-2 enables optical activation of neurons (RRID:SCR_008833) Channelrhodopsin-2 enables optical activation of neurons production service resource, resource, material service resource, service resource Laser tool that enables neurons to be optically silenced by pulses of yellow light, the light-activated chloride pump halorhodopsin (Halo), in a paper entitled Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution. Temporally precise, noninvasive control of activity in well-defined neuronal populations is a long-sought goal of systems neuroscience. We adapted for this purpose the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons. We demonstrate reliable, millisecond-timescale control of neuronal spiking, as well as control of excitatory and inhibitory synaptic transmission. This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers. The quest to determine how precise neural activity patterns mediate computation, behavior, and pathology would be greatly aided by a set of tools for reliably activating and inactivating genetically targeted neurons, in a temporally precise and rapidly reversible fashion. Having earlier adapted a light-activated cation channel, 1channelrhodopsin-2 (ChR2), for allowing neurons to be stimulated by blue light, we searched for a complementary tool that would enable optical neuronal inhibition, driven by light of a second color. Here we report that targeting the 1codon-optimized form of the light-driven chloride pump halorhodopsin from the archaebacterium Natronomas pharaonis (hereafter abbreviated Halo) to genetically-specified neurons enables them to be silenced reliably, and reversibly, by millisecond-timescale pulses of yellow light. We show that trains of yellow and blue light pulses can drive high-fidelity sequences of hyperpolarizations and depolarizations in neurons simultaneously expressing yellow light-driven Halo and blue light-driven ChR2, allowing for the first time manipulations of neural synchrony without perturbation of other parameters such as spiking rates. The Halo/ChR2 system thus constitutes a powerful toolbox for multichannel photoinhibition and photostimulation of virally or transgenically targeted neural circuits without need for exogenous chemicals, enabling systematic analysis and engineering of the brain, and quantitative bioengineering of excitable cells. hardware, instrument, equipment has parent organization: Massachusetts Institute of Technology; Massachusetts; USA; Anonymous donor ;
MIT Media Lab ;
Helen Hay Whitney Foundation
PMID:17375185 nlx_144630 http://channelrhodopsin.org SCR_008833 2026-08-12 10:49:52 3
Functional Neurogenesis
 
Resource Report
Resource Website
1+ mentions
Functional Neurogenesis (RRID:SCR_008830) Functional Neurogenesis data or information resource, narrative resource, blog A blog focusing on the function of adult neurogenesis in the dentate gyrus of the hippocampus, including discussion of scientific research papers, methods and protocols, and other trends or observations about the field. adult, neurogenesis, dentate gyrus, hippocampus, brain, neuron, anxiety, depressive disorder, memory, plasticity nlx_144587 SCR_008830 Functional Neurogenesis - New neurons in the adult brain. How they work and what they are good for. 2026-08-12 10:49:52 2
Genotype-IBD Sharing Test
 
Resource Report
Resource Website
100+ mentions
Genotype-IBD Sharing Test (RRID:SCR_006257) GIST resource, software application, software resource Software package to test if a marker can account in part for the linkage signal in its region. There are two versions of the software: Windows and Linux/Unix. identical by descent, genotype, gene, genetic, genomic, unix, ms-windows, linux, linkage disequilibrium, linkage, association is listed by: Genetic Analysis Software
has parent organization: Vanderbilt University; Tennessee; USA
Vanderbilt Diabetes Center ;
NHGRI HG00376;
NIDDK DK62370;
NHGRI N01-HG-15465
PMID:14872409 nlx_154133 http://phg.mc.vanderbilt.edu/content/gist SCR_006257 2026-08-12 10:49:22 120
Biobehavioral
 
Resource Report
Resource Website
10+ mentions
Biobehavioral (RRID:SCR_008710) data or information resource, narrative resource, blog THIS RESOURCE IS NO LONGER IN SERVCE, documented September 6, 2016. Biobehavioral blog on research and medicine as a continuum from biological mechanisms to behavioural phenomena., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. THIS RESOURCE IS NO LONGER IN SERVICE nlx_11905 SCR_008710 Biobehavioral 2026-08-12 10:49:45 14
MEDIE
 
Resource Report
Resource Website
1+ mentions
MEDIE (RRID:SCR_006254) MEDIE production service resource, data analysis service, analysis service resource, service resource An intelligent search engine to retrieve biomedical correlations from MEDLINE, based on indexing by Natural Language Processing and Text Mining techniques. You can find abstracts/sentences in MEDLINE by specifying semantics of correlations; for example, What activates p53 and What causes colon cancer. Semantic search uses a semantic query for finding biomedical correlations. Input a subject, a verb, and an object of a concept (or either of them) into a form. Results of the query will be shown in a second. (E.g., What does p53 activate? (subject=p53, verb=activate)) Reference: Miyao, Yusuke, Tomoko Ohta, Katsuya Masuda, Yoshimasa Tsuruoka, Kazuhiro Yoshida, Takashi Ninomiya and Jun''''ichi Tsujii (2006) Semantic Retrieval for the Accurate Identification of Relational Concepts in Massive Textbases. Proceedings COLING-ACL 2006. Sydney, Australia, pp. 1017--1024. natural language processing, text mining, semantic search, computational linguistics, search engine is used by: BioLexicon
is listed by: OMICtools
is listed by: FORCE11
is related to: MEDLINE
has parent organization: University of Tokyo; Tokyo; Japan
has parent organization: National Centre for Text Mining
nif-0000-06682, OMICS_01188 http://www-tsujii.is.s.u-tokyo.ac.jp/medie/, https://www.force11.org/node/4643 SCR_006254 2026-08-12 10:49:24 3
GeneTrail
 
Resource Report
Resource Website
100+ mentions
GeneTrail (RRID:SCR_006250) GeneTrail production service resource, data analysis service, analysis service resource, service resource A web-based application that analyzes gene sets for statistically significant accumulations of genes that belong to some functional category. Considered category types are: KEGG Pathways, TRANSPATH Pathways, TRANSFAC Transcription Factor, GeneOntology Categories, Genomic Localization, Protein-Protein Interactions, Coiled-coil domains, Granzyme-B clevage sites, and ELR/RGD motifs. The web server provides two statistical approaches, "Over-Representation Analysis" (ORA) comparing a reference set of genes to a test set, and "Gene Set Enrichment Analysis" (GSEA) scoring sorted lists of genes., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. pathway, microarray, enrichment, genomic, proteomic, function, transcription factor, genomic localization, protein-protein interaction, coiled-coil domain, granzyme-b clevage site, motif, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is related to: KEGG
is related to: TRANSPATH
is related to: TRANSFAC
is related to: Gene Ontology
has parent organization: Saarland University; Saarbrucken; Germany
PMID:17526521 THIS RESOURCE IS NO LONGER IN SERVICE biotools:genetrail, OMICS_02236 https://bio.tools/genetrail SCR_006250 2026-08-12 10:49:23 114
Neurocritic
 
Resource Report
Resource Website
1+ mentions
Neurocritic (RRID:SCR_006528) Neurocritic data or information resource, narrative resource, blog The Neurocritic is a blog deconstructing the most sensationalistic recent findings in Human Brain Imaging, Cognitive Neuroscience, and Psychopharmacology. Born in West Virginia in 1980, The Neurocritic embarked upon a roadtrip across America at the age of thirteen with his mother. She abandoned him when they reached San Francisco and The Neurocritic descended into a spiral of drug abuse and prostitution. At fifteen, The Neurocritic''s psychiatrist encouraged him to start writing as a form of therapy. human, brain imaging, cognitive neuroscience, psychopharmacology, brain, imaging, neuroimaging nlx_144592 SCR_006528 The Neurocritic 2026-08-12 10:49:28 2
Single Nucleotide Polymorphism Spectral Decomposition (SNPSpD)
 
Resource Report
Resource Website
10+ mentions
Single Nucleotide Polymorphism Spectral Decomposition (SNPSpD) (RRID:SCR_008621) SNPSpD production service resource, data analysis service, analysis service resource, service resource SNPSpD is a method of correcting for non-independance of single nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD) with each other, on the basis of the spectral decomposition (SpD) of matrices of LD between SNP''s. Additionally, output from SNPSpD includes eigenvalues, principal-component coefficients, and factor loadings after varimax rotation, enabling the selection of a subset of SNPs that optimize the information in a genomic region. bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: Queensland Institute of Medical Research
National Health and MRC Australia 241916 PMID:14997420 biotools:snpspd, nif-0000-31985 https://bio.tools/snpspd http://genepi.qimr.edu.au/general/daleN/SNPSp SCR_008621 Single Nucleotide Polymorphism Spectral Decomposition 2026-08-12 10:49:44 18
Lists2Networks
 
Resource Report
Resource Website
1+ mentions
Lists2Networks (RRID:SCR_006323) L2N production service resource, data analysis service, analysis service resource, service resource A web-based software system that allows users to upload lists of mammalian genes/proteins onto a server-based program for integrated analysis. The system includes web-based tools to manipulate lists with different set operations, to expand lists using existing mammalian networks of protein-protein interactions, co-expression correlation, or background knowledge co-annotation correlation, as well as to apply gene-list enrichment analyses against many gene-list libraries of prior biological knowledge such as pathways, gene ontology terms, kinase-substrate, microRNA-mRAN, and protein-protein interactions, metabolites, and protein domains. Such analyses can be applied to several lists at once against many prior knowledge libraries of gene-lists associated with specific annotations. The system also contains features that allow users to export networks and share lists with other users of the system. high-throughput sequencing, analysis, gene, protein is listed by: OMICtools
has parent organization: Icahn School of Medicine at Mount Sinai; New York; USA
PMID:20152038 Free, Public, Account required OMICS_02231 http://www.lists2networks.org SCR_006323 Lists2Networks: Integrated analysis of gene/protein lists 2026-08-12 10:49:24 3

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