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http://www.montana.edu/massspec/index.html

Provides access to mass spectrometers and mass spectrometry expertise. The facility currently maintains the following equipment Waters Synapt-XS Q-IMS-TOF with Waters I-Class UHPLC; Agilent 6538 Q-TOF with Agilent 1290 UHPLC;Agilent 7800 Inductively Coupled Plasma with Laser Ablation (193 nm);Bruker micrOTOF with Agilent 1290 UHPLC; Agilent 6490 Triple Quadrupole Mass Spectrometer; Bruker MALDI Autoflex; Agilent GC-MS; Waters Synapt G2S-i Q-TOF with Ion Mobility.

Proper citation: Montana State University Mass Spectrometry Core Facility (RRID:SCR_012482) Copy   

•   Source: SciCrunch Registry

https://www.urmc.rochester.edu/research/flow-core.aspx

Provides investigators with instrumentation along with expertise. Core instrumentation includes traditional analytical cytometers, full spectrum cytometer, cell sorters, imaging cytometers, small(nano) particle detection system, metabolomics instrument, and mass cytometer.

Proper citation: University of Rochester Medical Center Flow Cytometry Core Facility (RRID:SCR_012360) Copy   

•   Source: SciCrunch Registry

https://research.ku.edu/ku-core-research-labs

COBRE Protein Production Group focuses on the cloning, expression and purification of prokaryotic and eukaryotic proteins for COBRE and other investigators in Kansas and the region. The laboratory maintains a variety of equipment to support the production of properly folded proteins in quantities suitable for structural studies (X-ray and NMR), functional studies (catalytic or biological), label-free binding studies (SPR) and/or high throughput (HTP) screening studies.

Proper citation: University of Kansas Protein Production Group Core Facility (RRID:SCR_012484) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/multiphoton-microscopy-core-rochester

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 16,2024.The mission of the URSMD Multiphoton Core Facility is to provide state-of-the-art multiphoton imaging capabilities to further the biomedical and bio-optical research at the URSMD and the University of Rochester with emphasis on intravital imaging and systems physiology. The Multiphoton Core Facility provides access to an Olympus Fluoview 1000 AOM-MPM imaging system and a Spectra-Physics MaiTai HP DeepSee Ti:Sa laser system with dispersion compensation. Further capabilities include engineering applications for opto-electronics and spectroscopy. Initial meeting with the director regarding the design of the experiments begins the process. Imaging will be initially performed by highly skilled staff to make sure all features of software are added for the study, thereafter, the investigator is trained until they are able to operate the microscope independently. Also offered is a blood gas analysis machine and supporting equipment.

Proper citation: URMC Multiphoton Microscopy Core (RRID:SCR_012362) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/crocker-nuclear-laboratory-uc-davis

Crocker Nuclear Laboratory hosts a diverse group of research programs, nearly all of which are related to applied science programs. Constructed in the mid-sixties, CNL, houses a low energy particle accelerator. The accelerator, an isochronous cyclotron, is one of the few of this design remaining in productive operation. The Crocker Nuclear Labortory''''s Isochronous Cyclotron began operating in 1965, accelerating protons, alpha particles, and other light ions into various targets to study nuclear structure. Instead of the uniform magnetic fields used in the earlier cyclotrons, the isochronous design employed tailored sectors with a varying magnetic field. This design compensated for increases in the mass of ions as they accelerated, both focusing their paths and keeping them in resonance at high energies. In its day, this design was considered a major technological breakthrough.

Proper citation: UC Davis Crocker Nuclear Laboratory (RRID:SCR_012486) Copy   

•   Source: SciCrunch Registry

https://www.moffitt.org/research-science/shared-resources/tissue/

Biorepository resource with mission of proper collection, handling, processing and storage of irreplaceable biological specimens to support spectrum of related basic science, translational and clinical research. Provides expertise in nucleic acid extractions, quantification, aliquoting and quality assurance; liquid specimen centrifugation, processing and aliquoting; histological tissue processing, immunohistochemistry and tissue microarray microtomy; pathologist consultation services. Tissue Core operations are divided into four distinct pillars of service that work collaboratively to ensure specimen quality is maintained from procurement to preservation.

Proper citation: Moffitt Cancer Center Tissue Core Facility (RRID:SCR_012364) Copy   

•   Source: SciCrunch Registry

https://www.urmc.rochester.edu/research/electron-microscope.aspx

Electron Microscopy Resource supports ultra-structural interrogation of tissues, biologic solutions and nanomaterials for investigators utilizing transmission electron microscopy (TEM), scanning electron microscopy (SEM) and cryo-TEM.

Proper citation: University of Rochester Medical Center Electron Microscopy Core Facility (RRID:SCR_012366) Copy   

•   Source: SciCrunch Registry

https://www.ohio.edu/research/sharedequipment/ohio-university-genomics-facility

Facility offers Next-Generation Sequencing services, Sanger sequencing, Fragment Analysis, qPCR, data analysis. Provided services include DNA sequencing, fragment analysis, RNA, DNA, protein and cell cytometry through various equipment.

Proper citation: Ohio University Genomics Core Facility (RRID:SCR_012487) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/centre-for-translational-and-applied-genomics-ctag

PHSA Laboratories'''' Centre for Translational and Applied Genomics (CTAG) is a a CAP Accredited genomics and molecular pathology core facility supported by a world class team of molecular pathologists with diverse clinical and research interests and technical skills. CTAG operates at PHSA agencies including the BC Cancer Agency, BC Centre for Disease Control, BC Children''''s Hospital and BC Women''''s Hospital & Health Centre. CTAG offers a broad range of analytical services to the public and private sectors. As a division of PHSA Laboratories, CTAG''''s mission is to develop novel laboratory tests to improve the management of a diverse spectrum of disorders including cancer, infectious diseases, and inherited syndromes.

Proper citation: PHSA Centre for Translational and Applied Genomics (RRID:SCR_012446) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/macromolecular-x-ray-crystallography-core-facility--2

X-ray crystallography is the principal technique used to determine three-dimensional structures of biological macromolecules. The central goal of the UNC Crystallography Core Facility is to provide the support and infrastructure necessary to enable individual investigators of any experience level to initiate and successfully complete a structural biology project. The facility is state of the art, offering a variety of services in these three areas: crystallization, x-ray diffraction, structure determination. The primary mission of the MX Facility is to work with researchers here at UNC, however, we are also able to work with researchers at non-UNC academic institutions and commercial companies.

Proper citation: UNC School of Medicine Macromolecular X-Ray Crystallography Core Facility (RRID:SCR_012327) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/magnetic-resonance-laboratory-georgia-tech

The Nanomedicine Research Institute Magnetic Resonance Laboratory at Georgia Tech operates a Bruker Pharmascan 7T with a magnet bore of 160 mm. We have a large expertise in the use of MRI as a tool in Biomedical and Chemical Engineering. Previous research projects were concerned with: MRI of anatomical preparations; evaluation of tumor growth; bio-compatibility of implants; cardiac MRI; Diffusion Tensor Imaging; pharmacokinetics; fluid ingress and distribution in complex substrates; flow MRI; 1H, 19F and 13P in vivo spectroscopy and relaxometry; development of MRI contrast agents; solid-state MRI.

Proper citation: Georgia Tech Magnetic Resonance Laboratory (RRID:SCR_012326) Copy   

•   Source: SciCrunch Registry

https://www.med.unc.edu/csb/pep/

Core specializes in production of pure, functional proteins for structural, biophysical, and biochemical studies. Has ability to produce and purify milligram amount of protein.

Proper citation: University of North Carolina at Chapel Hill School of Medicine Protein Expression and Purification Core Facility (RRID:SCR_012328) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/antibody-core-facility

The primary objective of our facility is to produce monoclonal antibody-producing hybridoma cell lines for UNC investigators. The core develops monoclonal antibodies in mice, rats and hamsters. The core can assist in the screening of hybridomas of interest by ELISA or flow cytometry. The facility can also produce large amounts of crude antibody in vitro for investigators as well as purify both polyclonal and monoclonal antibodies from tissue culture media or ascites.

Proper citation: UNC School of Medicine Antibody Core Facility (RRID:SCR_012330) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/athymic-animal-and-xenograft-core-facility-cwru

The Athymic Animal and Xenograft Core Facility provides facilities for breeding and housing of athymic nude mice (NCRnu/nu) and rats, and other immunodeficient mice. The core provides pathogen-free facilities for experimentation using immunodeficient animal hosts and normal human cells and human tumor cell xenografts. Core staff maintain and monitor animals housed in the facility, and provide users with a variety of services, including transportation, health reports, animal handling, and experimental procedures. The staff will also train users in animal handling and experimental procedures. Entry to the animal facilities is controlled by key card access and is limited to employees who are listed on an IACUC-approved protocol, have enrolled in an animal contact Occupational Health program, and have completed access training. Experimental procedures, listed below, are provided either at the Case facility or in the Animal Tumor Core (ATC) at the Cleveland Clinic Taussig Cancer Institute. The Taussig Cancer Institute ATC was established in 2002 to help principal investigators at the Cleveland Clinic and CWRU perform tumor experiments, angiogenesis studies, and pharmacokinetic studies in mice. The ATC conducts syngeneic murine tumor experiments, and human xenograft (athymic nude mouse) tumor experiments. In addition, the ATC has developed several orthotopic human carcinoma models: HT-29 colon, HCT-116 colon, SW480 colon (all metastasize to liver), ACHN renal, A549 lung, multiple prostate, bladder, melanoma and ovarian tumors. ATC services utilize murine models to facilitate in vivo cancer drug screening, drug evaluation, and drug development. The core''''s goal is to help in evaluation of new pharmacologic agents by providing data on tumor growth, metastasis, angiogenesis, and gene expression. The facility also provides consultation services to assist the investigator in all aspects of animal tumor model development.

Proper citation: CWRU Athymic Animal and Xenograft Core Facility (RRID:SCR_012459) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/analytical-ultracentrifugation-facility

The Analytical Ultracentrifugation Facility located at the University of Connecticut engages in collaborative research as well as training scientists, technicians, and students. The Facility has three Beckman XL-I ultracentrifuges along with associated instruments, hardware and computers. In addition, University scientists are on hand to provide user support and advice.

Proper citation: UConn Analytical Ultracentrifugation Facility (RRID:SCR_012340) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/sequencing-core-institute-of-bioscience-biotechnology-research

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 24,2024. IBBR DNA Sequencing Facility currently offers its customers NextGen sequencing.

Proper citation: UMD Sequencing Core - Institute of Bioscience and Biotechnology Research (RRID:SCR_012428) Copy   

•   Source: SciCrunch Registry

https://azgc.arizona.edu

Core provides molecular biotechnology services and current molecular genetic methods. Services include DNA and RNA Extraction, transgenic mouse genotyping, Human Cell line Authentication, Sanger DNA Sequencing, Next-Generation sequencing platforms, Microsatellite DNA Typing, Agena multiplex SNP Genotyping, Real-time PCR, NanoString Gene Expression Analysis. Specializes in custom workflows that couple services with specific research needs.

Proper citation: Arizona Genetics Core (RRID:SCR_012429) Copy   

•   Source: SciCrunch Registry

http://www.neurodiscovery.harvard.edu/research/neurobehavior_laboratory.html

Core facility that provides the following services: Surgery/necropsy service. Mouse models have become a popular and successful approach to elucidating the physiological and pathological roles of individual genes and are truly crucial to accelerate the development of effective treatments and cures for Alzheimer''''s, Parkinson''''s, ALS, MS and other neurodegenerative diseases. The increasing demand for mouse behavioral studies within the neuroscience community has led the Harvard NeuroDiscovery Center to develop a major new, state of the art mouse behavior laboratory, located in the Longwood medical area and carefully designed to meet the exacting standards required for this type of work. The NeuroBehavior Laboratory (NBL) will provide the Harvard community and other investigators access to a broad range of reliable behavioral/cognitive tests necessary to analyze and interpret the impact of a genetic, surgical or pharmacologic manipulation on specific behaviors. They can provide: * Assistance with experimental design. * Support for grant applications that have a significant component of mouse neurobehavioral research. * Full, fee-for-service, mouse behavioral testing services. * Training in all aspects of mouse neurobehavioral testing. * Assistance with data analysis and interpretation.

Proper citation: HNDC NeuroBehavior Laboratory Core (RRID:SCR_012396) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/center-for-structural-biology

The CSB provides an integrated platform of expertise, infrastructure and education to foster a wider use of structural biology by the UNC community. The CSB mission is to make structural biology available as a general tool to any researcher. Structures of macromolecules at atomic resolution have helped to revolutionize modern biology. Structural insight is often crucial for understanding the functions of biological macromolecules, including their interactions with small ligands (such as substrates, inhibitors, drugs) and other macromolecules (nucleic acids and/or proteins). Consequently, structural biology represents one of the pillars of basic biomedical research; it is indispensable for deciphering the details of life processes and for understanding the differences between natural and diseased states. Building on such insights, structural biology can assist in devising novel therapies, e.g., through structure-based or structure-aided drug design. The enormous information content available in high-resolution, three-dimensional structures has sparked the desire of non-structural biologists to examine the structures of the macromolecules that they study. Structural biology is technically demanding, and it requires highly specialized expertise. The CSB removes or reduces these barriers that usually prevent general researchers from engaging in structural biology-based projects by themselves.

Proper citation: UNC School of Medicine Center for Structural Biology (RRID:SCR_012430) Copy   

•   Source: SciCrunch Registry

https://unclineberger.org/tissueculture/

Supply center and provides UNC Lineberger members and UNC colleagues with tissue culture products including stocks media, media supplements, serum, salt solutions, antibiotics, cell culture flasks and dishes, and many other in vitro cell culture and molecular biology-related items, kits and cell lines. Cell lines include normal and transformed mammalian, avian, insect, amphibian/reptile, and hybridoma cells. Services include checking Fetal Bovine Serum for quality and efficacy. TCF partners with Genetica Cell Line Services to offer qPCR-based Mycoplasma contamination testing for cell or DNA samples. Utilizes Genetica Cell Line Services for STR profiling of cell lines.

Proper citation: University of North Carolina Lineberger Comprehensive Cancer Center Tissue Culture Core Facility (RRID:SCR_012432) Copy   

•   Source: SciCrunch Registry