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https://www.benaroyaresearch.org/our-research/core-labs/genomics-core

Core provides services for genomics analysis, from sample processing through data generation. Available technologies focus on Illumina RNA and DNA sequencing. RNA-seq can be performed from a variety of sample types, including purified total RNA, cell populations (including low input samples of 50-1000 cells), or single cells (either plate-sorted rare populations or high-throughput 10x single-cell analyses). DNA-seq pipelines can also be performed, including bulk CUT and Tag/CUT and RUN, and ATAC-seq and single cell ATACseq and multiome capture. Custom prepared libraries can also be submitted for sequencing. Core laboratory houses Illumina sequencers, NextSeq2000 instruments and Miseq, plus 10x Chromium X and 10x CytAssist. Additional equipment includes ThermoFisher Kingfisher Flex, for extracting nucleic acid from variety of sample types using magnetic bead technology with throughput of up to 96 samples. Qiagen QIAcube Connect instruments automate extraction of nucleic acid using spin column technology. Ancillary equipment for sample processing includes Formulatrix Mantis Liquid Handler, Agilent TapeStation 4200 and Tecan NanoQuant.

Proper citation: Benaroya Research Institute Genomics Core Facility (RRID:SCR_026658) Copy   

•   Source: SciCrunch Registry

https://cvm.ncsu.edu/research/labs/flow-cytometry-and-cell-sorting/

Core provides flow cytometry services. Staff members will help with experimental design, instrument training, sample acquisition, data analysis with software provided, and conventional/spectral cell sorting.

Proper citation: North Carolina State University College of Veterinary Medicine Flow Cytometry and Cell Sorting Core Facility (RRID:SCR_026657) Copy   

•   Source: SciCrunch Registry

https://www.lerner.ccf.org/cores/electronics/

Electronics Core is electronics design, development and repair facility which specializes in proof-of-concept design and prototyping, and early stage development of medical devices and laboratory research instrumentation. Services include system design, schematic capture, printed circuit board layout, board fabrication, assembly and testing.

Proper citation: Cleveland Clinic Lerner Research Institute Electronics Core Facility (RRID:SCR_026870) Copy   

•   Source: SciCrunch Registry

https://www.ucl.ac.uk/life-sciences/lmcb/facilities-and-platforms/light-microscopy

Core provides imaging systems for advanced microscopy including confocal, multi-photon and super-resolution modalities, enabling users to address research questions in living systems across temporal and spatial scales. Staff offers training to use equipment, expertise about experimental strategy, design, image processing and analysis.

Proper citation: University College London LMCB Light Microscopy Core Facility (RRID:SCR_026871) Copy   

•   Source: SciCrunch Registry

https://www.ifom.eu/en/cancer-research/technological-units/functional-genomics-screening-unit.php

Core specializes in high-throughput CRISPR screening using pooled or arrayed libraries in diverse cellular models. This technology assesses the effects of thousands of genetic perturbations at single-cell resolution with CRISPR knockout (CRISPR KO), CRISPR interference (CRISPRi), and CRISPR activation (CRISPRa). It also utilizes base and prime editing to investigate specific mutations, such as those relevant to cancer development and progression.

Proper citation: Cancer Research Institute IFOM FGS Functional Genomic Screening Core Facility (RRID:SCR_026867) Copy   

•   Source: SciCrunch Registry

https://www.ifom.eu/en/cancer-research/technological-units/imaging.php

Core Facility provides technological platforms in the field of light microscopy. A team of highly qualified and experienced professionals supports IFOM's research activities, assisting in sample preparation and acquisition, data post-processing and image analysis.

Proper citation: Cancer Research Institute IFOM ALM Advanced Light Microscopy Core Facility (RRID:SCR_026866) Copy   

•   Source: SciCrunch Registry

https://syntheticbiology.northwestern.edu/research/biofoundry/

Core facility for synthetic biology experimentation including pilot-scale fermentation, high throughput automation, biological sample analysis, and cell-free protein synthesis.

Proper citation: Northwestern University SynBio Foundry Core Facility (RRID:SCR_026869) Copy   

•   Source: SciCrunch Registry

https://facs.iq.msu.edu/

Core provides access to analytical flow cytometry instrumentation and cell sorting services, as well as training and experimental consultation.

Proper citation: Michigan State University Flow Cytometry Core Facility (RRID:SCR_026903) Copy   

•   Source: SciCrunch Registry

https://sites.lsa.umich.edu/isopaleolab/facilities/

Core specializes in precise measurements of rare isotopologues such as “clumped” isotopes of carbonate and CO2 and triple oxygen isotope distributions in waters, carbonates, phosphates and recently organics. Houses Nu Perspective IRMS mass spectrometers, EuroVector EA3000 and HT-PyrOH, NuCarb device for traditional carbon and oxygen isotopes, Thermo Fisher ISQ 7000 GC-MS, fully automated clumped isotope preparation line, semi-automated triple oxygen isotope preparation line, manual water fluorination line, multi-purpose vacuum extraction line, and ovens, balances, glassware, fume hoods, and other equipment used in experiments and sample preparation.

Proper citation: University of Michigan Isopaleo Lab Core Facility (RRID:SCR_026763) Copy   

•   Source: SciCrunch Registry

https://mhl.engin.umich.edu/

Research facility dedicated to the study and testing of various marine and hydrodynamic phenomena. It is part of the Department of Naval Architecture and Marine Engineering at the University of Michigan. Conducts research and experiments related to fluid dynamics, ship design, offshore engineering, and other areas relevant to marine and naval architecture.

Proper citation: University of Michigan Marine Hydrodynamics Lab Core Facility (RRID:SCR_026765) Copy   

•   Source: SciCrunch Registry

https://medresearch.umich.edu/office-research/about-office-research/our-units/central-biorepository

Core provides annotated biospecimens for basic, clinical, and translational research. Helps researchers access, collect, manage, and protect biospecimens using automated processes and quality control. Offers safe and monitored management of biospecimens including temperature-controlled storage, preparation of derivatives from these specimens, aliquoting, distribution, and production of specimen collection kits.

Proper citation: University of Michigan Medical School Central Biorepository Core Facility (RRID:SCR_026845) Copy   

•   Source: SciCrunch Registry

https://www.lerner.ccf.org/cores/biorobotics/

Core provides biomechanical testing of biological structures and biomaterials. Allows investigators to conduct research of mechanical properties of existing biological structures and constructs, as well as to quantify potential for new technologies and clinical advancements. Robotic simulators are built around the simVITRO software platform and are designed for in vitro simulation of major joints including knee, spine, foot, ankle, hip, shoulder, elbow, wrist and more. Provides testing capabilities for range of biomechanical modalities and will offer expert advice and support for development of new test protocols, innovative techniques for instrumentation and data collection. Modalities include tissues, joints, and multi-articular units, such as foot or spine segments.

Proper citation: Cleveland Clinic Lerner Research Institute BioRobotics and Mechanical Testing Core Facility (RRID:SCR_026849) Copy   

•   Source: SciCrunch Registry

https://www.unmc.edu/eppley/cmtdd/cores/scst.html

Core offers spatial omics processing on many different tissue types. Facility provides instrumnets including Bruker's GeoMx DSP ready for launch with anticipated launch of 10x Visium. Offers expert collaboration from project design to data handoff. Core has established workflows with additional shared resources on UNMC campus to allow for expertise throughout entire project.

Proper citation: University of Nebraska Medical Center Single Cell and Spatial Transcriptomics Core Facility (RRID:SCR_026860) Copy   

•   Source: SciCrunch Registry

https://www.ifom.eu/en/cancer-research/technological-units/electron-microscopy.php

Core performs routine transmission and scanning Electron Microscopy and all kinds of immune Electron Microscopy, correlative light electron microscopy, three-dimensional EM (3DEM), quantitative stereological evaluation of data and more.

Proper citation: Cancer Research Institute IFOM EMCT Electron Microscopy Cells & Tissues Core Facility (RRID:SCR_026863) Copy   

•   Source: SciCrunch Registry

https://www.ifom.eu/en/cancer-research/technological-units/mechanomedicine.php

Core focuses on development of innovative biomedical technologies and devices for cancer research as well as biomedical applications using microfabrication and 3D printing.

Proper citation: Cancer Research Institute IFOM CERD Cancer Engineering R&D Core Facility (RRID:SCR_026862) Copy   

•   Source: SciCrunch Registry

https://www.ifom.eu/en/cancer-research/technological-units/preclinical-models.php

Specialized laboratory designed for growth, maintenance, and experimentation of living cells under controlled conditions. This facility is used in various fields such as biomedical research, drug development, and supports the culture of primary cells, immortalized cell lines, human-induced pluripotent stem cells (hiPSCs), and organoids, among others.

Proper citation: Cancer Research Institute IFOM CPM Cellular And Preclinical Models Core Facility (RRID:SCR_026864) Copy   

•   Source: SciCrunch Registry

https://www.lerner.ccf.org/cores/mechanical-prototyping/

Mechanical Core provides variety of fabrication, customization and repair services for mechanical devices and equipment. Offers precision machining of metals and plastics, welding of structural and exotic metals, instrument refurbishing and mechanical repair.

Proper citation: Cleveland Clinic Lerner Research Institute Mechanical Prototyping Core Facility (RRID:SCR_026824) Copy   

•   Source: SciCrunch Registry

https://imb.uq.edu.au/microscopy

Microscopy Facility supports cancer research, cell and developmental biology, and cross-disciplinary studies spanning molecular mechanisms to translational applications. Houses imaging platforms including widefield, confocal, multi-photon, super-resolution, spinning disk, and light sheet systems. Enables advanced modalities such as TIRF, FRET, STED, SHG/THG, and FLIM for detailed exploration of cell behaviour and microenvironments. Facility staff offer training, expert consultation, image analysis support, and troubleshooting.

Proper citation: University of Queensland Institute for Molecular Bioscience Advanced Microscopy Core Facility (RRID:SCR_026841) Copy   

•   Source: SciCrunch Registry

https://bibraincancer.umich.edu/core/high-plex-immunocytochemistry-core/

Core utilizes Akoya PhenoCycler-Fusion to enable high-plex spatial phenotyping of whole tissue slides at single-cell resolution.

Proper citation: University of Michigan Bioinnovation in Brain Cancer High-Plex Immunocytochemistry Core Facility (RRID:SCR_026843) Copy   

•   Source: SciCrunch Registry

https://www.rogelcancercenter.org/research/shared-resources-and-cores/single-cell-analysis-core-overview

Provides expertise through experimental design consultations,cell isolation,single cell analytics (RNA, DNA, protein),biomarker validation,novel statistical and bioinformatics analyses. Services include Single cell targeted gene expression, Single cell RNA Seq, Single cell DNA Seq, Tissue sectioning, Tissue spatial analysis, Spatial transcriptomics and proteomics.

Proper citation: University of Michigan Rogel Cancer Center Single Cell Spatial Analysis Shared Resource Core Facility (RRID:SCR_026842) Copy   

•   Source: SciCrunch Registry