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http://www.uwgnotobiotics.org/

Core at University of Washington (UW) is managed by Department of Comparative Medicine and open to investigators with research needs to maintain mice free of any microorganisms (germ-free), or with known population of microorganisms (gnotobiotic).Services provided include Rederivation, Germ-Free (GF) Mice, Isolator Maintenance of GF Mice, Experimental Study Support, Diet Sterility Testing, Technical Procedures.

Proper citation: University of Washington Gnotobiotic Animal Core Facility (RRID:SCR_017887) Copy   

•   Source: SciCrunch Registry

https://bds.berkeley.edu/facilities/cell-culture

Core provides cell cultures (mammalian and insect), media, supplies and expertise and consultation regarding cell culture needs, media, and experimental design.Provides tested media, serum, and cell lines at exceptionally low prices, large scale production of cells, expansion and harvesting of hybridoma lines,cryopreservation of cell lines, Cell Authentication by STR analysis provided in conjunction with DNA Sequencing Facility, Mycoplasma screeening,Use of 2 laminar flow hoods for mammalian or insect cell manipulation.

Proper citation: University of California, Berkeley Biosciences Divisional Services Cell Culture Core Facility (RRID:SCR_017924) Copy   

•   Source: SciCrunch Registry

https://nyumc.ilab.agilent.com/service_center/show_external/4296?name=experimental-pathology-research-laboratory

Core provides services, access to instruments, and training to facilitate production of animal tissue samples for morphological and molecular analyses. Supports multiplex immunofluorescence staining, RNA in situ hybridization (ISH), and imaging analysis. Services include tissue preparation, processing, and sectioning, as well as histochemistry and immunohistochemistry of fresh, frozen, and fixed animal tissues, can optimize and validate commercial or proprietary antibodies for chromogenic or fluorescence-based immunohistochemistry including seven-color multiplexing.Provides access to database listing antibodies that have been tested in lab to date and are currently in stock.Offers basic imaging resources and digital whole-slide scanning of stained tissue sections, which allows researchers to view their slides online at their convenience.Researchers can also rent our self-service instruments. These include embedding station, microtome, cryostat, and vibratome. Provides access to brightfield and fluorescence upright and dissecting microscopes,laser capture microdissection scope, and high-throughput multispectral imaging system.To reserve time on instrument, faculty, staff, and investigators must be registered in iLab.

Proper citation: New York University School of Medicine Langone Health Experimental Pathology Research Laboratory Core Facility (RRID:SCR_017928) Copy   

•   Source: SciCrunch Registry

http://www.chori.org/Services/Elemental_Analysis_Facility/elemental_analysis.html

Core provides sample preparation, metal extraction, dissolved solids measurement, analytic consultation, and technical writing assistance) in support of wide range of clinical and biomedical research projects.Instruments include Agilent 5100 SVDV Inductively-Coupled Plasma-Optical Emission Spectrometer, SPS3 Robotic Autosampler,MARS5 Microwave Sample Digestion Oven,ICPExpert Advanced Workstation.Analytic Capabilities:Simultaneous, multi-element quantitation over wide dynamic range;Broad elemental detection capability with high precision and sensitivity;Compatible with range of clinical, nutritional, basic research, and pharmaceutical samples;Tolerant of high total dissolved solids and complex matrix components;NIST-traceable calibrants, standards, and other QA/QC controls included in analyses.

Proper citation: Children's Hospital Oakland Research Institute Elemental Analysis Core Facility (RRID:SCR_017927) Copy   

•   Source: SciCrunch Registry

http://www.uwtransgenics.org/

Core facility that creates transgenic and gene-targeted mice using pronuclear microinjection, targeted ES cell microinjection, and CRISPR/Cas9 gene editing. Offers mouse rederivation services to create specific pathogen free mice or to rederive cryopreserved mouse lines. Additionally, embryo and sperm cryopreservation services are available to provide long-term storage of valuable mouse strains or stocks. Services include:Pronuclear Microinjection,ES Cell Microinjection,ES Cell Electroporation CRISPR/Cas9,In Vitro Fertilization,Sperm Cryopreservation,Embryo Cryo,Embryo Rederivation.

Proper citation: University of Washington Transgenic Resources Program Core Facility (RRID:SCR_017863) Copy   

•   Source: SciCrunch Registry

http://nic.ucsf.edu/

Core provides light microscopy instrumentation, microscopy training and education and can provide assistance with experiment design, data acquisition, and image analysis. Provides training for users.Services include:Fluorescence imaging (up to 5 colors) Brightfield, phase contrast, and DIC imaging;High speed imaging (over 100 frames per second);Automated imaging, including multiwell plates;Super-resolution imaging (SIM / STORM / PALM);Single molecule imaging;3D confocal imaging;Gigapixel image stitching;Live cell time lapse imaging;Photoactivation and photobleaching;Light sheet imaging of cleared tissues.

Proper citation: University of California at San Francisco, Nikon Imaging Center Core Facility (RRID:SCR_017862) Copy   

•   Source: SciCrunch Registry

http://dmpi.duke.edu/molecular-genomics-shared-resource

Core offers variety of experimental platforms to facilitate genomics research. Accredited as Duke Shared Resource facility offers experience with genetic, genomic and epigenomic study design and technology, working closely with researchers to customize experiments to meet their needs. Applications include 10x Genomics NGS library generation for both single cell and gDNA experiments, DNA methylation microarrays, SNP genotyping and copy number microarrays, and Taqman targeted SNP genotyping.

Proper citation: Duke University Molecular Genomics Core Facility (RRID:SCR_017860) Copy   

•   Source: SciCrunch Registry

https://www.unmc.edu/vcr/cores/vcr-cores/electron-microscopy/index.html

Core provides instrumentation and technical assistance to research programs utilizing Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM). Available for consultation and service.

Proper citation: Nebraska University Medical Center Electron Microscopy Core Facility (RRID:SCR_017864) Copy   

•   Source: SciCrunch Registry

http://www.umass.edu/ials/genomics

Core provides services and advanced instrumentation support for nucleic acid (DNA and RNA) analysis, high-throughput next-generation sequencing, including solutions for sample processing such as nucleic-acid isolation, nucleic-acid quantitative and qualitative analysis, NGS library preparation, quantitative-PCR analysis, etc. Provides sample processing and library preparation such as whole genome sequencing, shotgun metagenomics, metatranscriptomics, targeted amplicon sequencing, RNA-Seq, ChIP-Seq, Exome Sequencing, Methyl-seq, Single Cell Genomics, etc. Facility accepts samples and will perform requested analysis. Offers training to users to conduct experimentation.

Proper citation: University of Massachusetts Amherst Genomics Resource Laboratory Core Facility (RRID:SCR_017907) Copy   

•   Source: SciCrunch Registry

http://imserc.facilities.northwestern.edu/

Core provides access to NMR, mass spectrometry, X-Ray crystallography instruments and education on use of instrumentation needed for molecular structure characterization.

Proper citation: Northwestern University Integrated Molecular Structure Education and Research Center Core Facility (RRID:SCR_017874) Copy   

•   Source: SciCrunch Registry

http://www.cti.northwestern.edu/

Core is Northwestern Radiology research facility providing translational imaging capabilities that promote pre-clinical and clinical research efforts. CTI occupies space in basement of Olson building housing imaging equipment along with research staff. Services include Cardiovascular Imaging for development, analysis and application of MRI methods providing insights into structure and function of cardiovascular system,NeuroImaging for functional MRI using spectroscopy and diffusion-weighted imaging to studying human anatomy and physiology during development and disease,Small Animal Imaging for molecular and functional imaging of biological processes in living animal models to study diseases and responses to intervention.

Proper citation: Northwestern University Center for Translational Imaging Core Facility (RRID:SCR_017878) Copy   

•   Source: SciCrunch Registry

https://www.biotech.iastate.edu/metabolomics/

Core facility that conducts fee for service mass spectrometry-based non-targeted and targeted metabolomic studies. The facility serves and partners with both on- and off-campus clients.

Proper citation: Iowa State University W.M. Keck Metabolomics Research Laboratory Core Facility (RRID:SCR_017911) Copy   

•   Source: SciCrunch Registry

https://www.mccormick.northwestern.edu/materials-science/clammp/

Core provides mechanical testing machines and accessories for conducting educational, research, and outreach experiments on most solid materials.

Proper citation: Northwestern University Central Laboratory for Materials Mechanical Properties Core Facility (RRID:SCR_017877) Copy   

•   Source: SciCrunch Registry

http://mhpl.facilities.northwestern.edu/

Core provides assistance with standard and customized research specific histology services for variety of tissues (i.e., mouse, rat, sheep, pig, zebrafish, etc.) for routine histology, and immunohistochemistry. Provides Pathologist consultation to help develop strategies to elucidate phenotypes and gain mechanistic insight regarding biologic actions of targeted molecule(s) or toxicity of exogenously administered substances.Provides training opportunities for learning histology techniques and phenotyping analysis.Services include Immunohistochemistry (IHC) . Using tyramide signal amplification (TSA) and ABC methods (automated), with DAB chromogenic substrate; Immunofluorescence (IF)- Single and multiple staining;TUNEL assay; Freezing and embedding of tissues for histology;Frozen sections;Paraffin block processing and Paraffin sections;Hematoxylin and Eosin staining of sections;Specialized histochemical staining of sections (e.g. Trichrome, PAS, Luxol fast blue, Cresyl violet, and many other stains);Dissection and tissue collection;Histopathology (slide interpretation);Histopathology toxicity evaluation;Training in necropsy techniques including perfusion of mice and special tissue dissection;Assistance with development of animal pathology protocols.

Proper citation: Northwestern University Mouse Histology and Phenotyping Laboratory Core Facility (RRID:SCR_017870) Copy   

•   Source: SciCrunch Registry

http://www.med.unc.edu/csb/unc-peptides

Core offers services for: High quality synthetic peptides, stable isotope labeled peptides, peptides with PTM and fluorescent and affinity tags, synthesis of peptide libraries. Analysis of synthetic peptides. Purification, lyophilization and aliquoting of synthetic peptides.

Proper citation: North Carolina University at Chapel Hill School of Medicine High Throughput Peptide Synthesis and Array Core Facility (RRID:SCR_017837) Copy   

•   Source: SciCrunch Registry

http://einstein.yu.edu/shRNA

Core Facility was closed in November 2016. Services of shRNA Core were redistibuted to other existing facilities at Einstein.Gene Modulation Services: CRISPR, RNAi and ORF. CRISPR-Cas9 services for cell lines will now be performed in Gene Modification Facility. Gene Modification Facility already offers CRISPR services for genetic modification of mice and will utilize this scientific expertise to provide CRISPR services for the gene modification of cell lines as well. You can access these services through core's site in iLab.The human and mouse whole genome shRNA library has been relocated to the Molecular Cytogenetic Core. The core staff will pull requested shRNA and ORF clones from our collection for investigators. You can access this service through the core's site in iLab.Access and operation of the Operetta instrument for high-content imaging will now be coordinated through the Macromolecular Therapeutics Development Facility (MTDF). You can access this service through the core's site in iLab. Lentivirus prep from shRNA and CRSPR constructs can be obtained from our Gene Therapy Core from clones obtained from the Molecular Cytogenetic Core. You can access this service through the core's site in iLab.

Proper citation: Albert Einstein College of Medicine shRNA Core Facility (RRID:SCR_017846) Copy   

•   Source: SciCrunch Registry

http://crl.berkeley.edu/molecular-imaging-center/

Microscopy core specializing in laser based fluorescence techniques. Offers training and expertise in 20 different microscope systems, including live cell and in vivo imaging, laser scanning (LSM) and spinning disk (SDC) confocal, multi-photon (2p), fluorescent lifetime imaging (FLIM), light-sheet microscopy (SPIM), super resolution (Airyscan), slide scanning and patterned illumination for optogenetic manipulation and readout. Provides offline computer analysis workstations for image processing, visualization and analysis, including GPU workstations. MIC operates in 3 different buildings on campus, with primary locations in Life Sciences Addition (LSA), North-side core in Barker Hall, and small outpost in Li Ka Shing Center for Biomedical and Health Sciences (LKS).Provides equipment in categories:Confocal and multi photon laser scanning microscopes,Spinning disk confocal microscopes,Lightsheet (SPIM) microscopes,Epifluorescence/widefield scopes and Computer workstations.

Proper citation: University of California at Berkeley Cancer Research Laboratory Molecular Imaging Center Core Facility (RRID:SCR_017852) Copy   

•   Source: SciCrunch Registry

http://www.uwhistologyandimaging.org

Core provides servises including:Immunohistochemistry,Image analysis,Quantitative microscopy,Histology,Luminex cell based multiplex assay,Comparative pathology consultation.Offers experience, expertise and instrumentation across all platforms. HIC utilizes automated immunohistochemistry stainers which provide efficiency and consistency as well as standardization of protocols across studies of all sizes.

Proper citation: University of Washington Histology and Imaging Core Facility (RRID:SCR_017855) Copy   

•   Source: SciCrunch Registry

https://med.miami.edu/centers-and-institutes/hihg/research-centers/center-for-genome-technology/sequencing-core

Core Facility offers services utilizing Illumina Novaseq X Plus, Pacific Biosciences Revio, ONT Promethion, and 10x Genomics platforms. The core has extensive knowledge of DNA/RNA library preparation for short-read, long-read and single cell sequencing. Sample preparation is fully automated on Perkin Elmer robotic workstations and tracked via the Clarity LIMS. Services include, but are not limited to, whole genome, exome and custom capture protocols, as well as, bulk RNAseq, small RNAseq, and single cell RNA sequencing.

Proper citation: University of Miami Hussman Institute for Human Genomics Sequencing Core Facility (RRID:SCR_017828) Copy   

•   Source: SciCrunch Registry

https://www.microscopyu.com/museum/eclipse-e600

Microscope equipped with CFI60 infinity optical system, providing images in all applications. Incorporates specifications adopted for CFI60 series objectives, including 60 millimeter parfocal distance, 25 millimeter thread size, and standard 22 millimeter field of view. Main components of CFI60 infinity optical system include objective, tube lens to converge light beam, and eyepiece lens to enlarge intermediate image. Fluorescence microscope that has detachable substage, 12 volt 100 watt tungsten halide lamp, filter magazine, and choice of sextuple nosepiece or sextuple DIC nosepiece.Has objectives for brightfield, darkfield, Nomarski DIC, epi fluorescence, or phase contrast techniques.

Proper citation: Nikon: Eclipse E600 Fluorescence Microscope (RRID:SCR_018606) Copy   

•   Source: SciCrunch Registry