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https://www.cincinnatichildrens.org/research/cores/translational-core-laboratory/viral-vector-core

Provides research grade retroviral, lentiviral and adeno associated virus vectors. Offers generation of stable producer lines, and non-GMP quality control testing including vector titer by functional assay FACS or PCR, endotoxin, mycoplasma, and USP sterility testing.Provides standard packaging plasmids, the investigator provides the viral vector to be used for the production run.

Proper citation: Cincinnati Children's Hospital Viral Vector Core Facility (RRID:SCR_022641) Copy   

•   Source: SciCrunch Registry

https://www.cincinnatichildrens.org/research/cores/translational-core-laboratory/translational-trial-development-support-laboratory

Provides facilities and expertise to support clinical assay development from technology developed in academic laboratories.Provides assay development and testing support for early phase clinical trials with focus on cell and gene therapy.

Proper citation: Cincinnati Children's Hospital Translational Trial Development and Support Laboratory Core Facility (RRID:SCR_022640) Copy   

•   Source: SciCrunch Registry

https://www.cincinnatichildrens.org/service/p/pathology/mass-spectrometry

Provides analytical resource focusing on application of mass spectrometry and allied chromatographies to analysis of small molecules, generally of less than 1,000 daltons molecular weight, in complex clinical and biological samples.

Proper citation: Cincinnati Children's Hospital Mass Spectrometry Core Facility (RRID:SCR_022638) Copy   

•   Source: SciCrunch Registry

https://research.wayne.edu/proteomics

Protein identification and proteome analysis using Orbitrao Eclipse,Fusion and Q Exactive LC-MS/MS platforms. Affinity selection for phosphopeptides with analysis using HCD, CID and ETD. Validation and quantitation of proteins using MRM with a TSQ Vantage triple quad.

Proper citation: Wayne State University Proteomics Core Facility (RRID:SCR_022879) Copy   

•   Source: SciCrunch Registry

https://www.cincinnatichildrens.org/service/c/clinical-trials/biobank

Provides access to services for standardized and centralized acquisition, processing, storage and distribution of biospecimens for research.

Proper citation: Cincinnati Children's Hospital Discover Together Biobank Core Facility (RRID:SCR_022632) Copy   

•   Source: SciCrunch Registry

https://www.cincinnatichildrens.org/research/cores/imaging

Provides access to advanced analytical imaging and image post-processing methods for collaborators involved in basic and clinical research.

Proper citation: Cincinnati Children's Hospital Imaging Research Center Core Facility (RRID:SCR_022631) Copy   

•   Source: SciCrunch Registry

https://www.med.uvm.edu/vigr/mpsf

Provides support for design, execution, and analysis of experiments involving Next Generation Sequencing through access and use of Illumina HiSeq 1500. Sequencer performs wide range of analysis including target preparation for RNAseq, Exome Seq, ChIP seq, Methyl Seq, whole genome sequencing, and small RNA sequencing.Core is involved in all aspects of Nanopore sequencing.

Proper citation: University of Vermont Larner College of Medicine Advanced Genome Technologies Massively Parallel Sequencing Core Facility (RRID:SCR_022696) Copy   

•   Source: SciCrunch Registry

http://igm.ucsd.edu/genomics/

Provides services including sequencing library preparation and sequencing on Illumina MiSeq and NovaSeq 6000 platforms. Supports single cell sequencing on 10X Genomics Chromium Controller. Provides Illumina Infinium Beadchips, which includes variety of whole genome genotyping arrays as well as Infinium MethylationEPIC BeadChip.

Proper citation: University of California at San Diego Institute for Genomic Medicine Genomics Center Core Facilitiy (RRID:SCR_022740) Copy   

•   Source: SciCrunch Registry

https://www.unmc.edu/publichealth/centers/ccorda/index.html

Provides advance clinical, translational and public health research at UNMC and in the community and region. Provides expertise in quantitative sciences, including biostatistics, epidemiology, and health services research, and coordinates collaborative design, planning, conduct, analysis and interpretation of laboratory, clinical, and public health research studies.Provides educational training opportunities for graduate students and educational opportunities for public health, clinical, and translational investigators.

Proper citation: University of Nebraska Medical Center Center for Collaboration on Research Design and Analysis Core Facility (RRID:SCR_022860) Copy   

•   Source: SciCrunch Registry

http://crc.pitt.edu

Supports leading edge research with free access to advanced computing hardware and software.

Proper citation: University of Pittsburgh Center for Research Computing Core Facility (RRID:SCR_022735) Copy   

•   Source: SciCrunch Registry

https://med.stanford.edu/obrienurology/research.html

Core leverages infrastructure of Stanford Urology and Pathology Departments to provide services to benefit O’Brien Center investigators in CAIRIBU Network. Procures and provides biospecimens, including fresh, freshly-frozen, and formalin-fixed paraffin-embedded (FFPE) prostate issues.Provides tissue characterization services, including histology, tissue microarrays, laser microdissection, and multiplex immunohistochemistry (IHC) using MIBI-TOF (Multiplexed Ion Beam Imaging by Time of Flight). Stores and provides access to images including prostate MRIs, whole-mount histology and IHC, and MIBI-TOF data, as well as integrated multiscale data platform.

Proper citation: Stanford University School of Medicine O’Brien Urology Research Center Biospecimen/Bioimaging Core Facility (RRID:SCR_022852) Copy   

•   Source: SciCrunch Registry

http://GeneEditing.wustl.edu/

Provides support with technologies for cell and animal model needs. Services are ranging from CRISPR reagents with or without validation, to cancer/iPS cell line modification or animal model creation. Works closely with mouse cores from design, reagent validation to genotyping, process improvement and troubleshooting, when necessary. Provides next-generation sequencing (NGS) based human cell authentication and NGS-based genotyping services and general molecular biology assistance. Offers to culture, bank and store primary fibroblasts and renal epithelial cells from patient samples for investigators, and iPSC reprogramming service is provided from fibroblasts, RECs as well as peripheral blood mononuclear cells. Provides differentiation services on growing list of cell types.

Proper citation: Washington University School of Medicine Genome Engineering and Stem Cell Center Core Facility (RRID:SCR_023243) Copy   

•   Source: SciCrunch Registry

https://asrc.gc.cuny.edu/neuroscience/facilities/live-imaging-bioenergetics-facility/

Provides Zeiss LSM880 upright two photon confocal microscope with Airyscan, FAST model and CLARITY lens; LSM880 inverted live cell imaging confocal microscope with Airyscan and FAST model; Agilent Seahorse XFe24 live cell metabolic analyzer.Supported applications include in vivo imaging of live animals, time lapse live cell imaging with high resolution optical sectioning, deep imaging of fixed CLARITY tissues, calcium imaging, photo switching and photo uncaging, Fluorescence Recovery After Photobleaching, Forster Resonance Energy Transfer, laser ablation, and measuring mitochondrial respiration and glycolysis in live cells in real time.Provides advanced imaging analysis software Imaris for data processing.

Proper citation: City University of New York Advanced Science Research Center Live Imaging and Bioenergetics Core Facility (RRID:SCR_022945) Copy   

•   Source: SciCrunch Registry

https://isotope.ucsc.edu/

Provides light stable isotope ratio analysis services to scientists from UCSC and from around the world.

Proper citation: University of California at Santa Cruz Stable Isotope Laboratory Core Facility (RRID:SCR_022947) Copy   

•   Source: SciCrunch Registry

https://www.rockefeller.edu/transgenics/

Provides services such as Pronuclear Injection, Blastocyst Injection, Embryo and Sperm Cryopreservation, Strain Recovery and Rederivation. Provides assisted reproductive techniques such as IVF and ICSI used for strain recovery. Core facility to the university for creation and maintenance of all transgenic animal models, refinement and development of new transgenic techniques, as well as training center for research personnel.

Proper citation: Rockefeller University Transgenic and Reproductive Technology Center Core Facility (RRID:SCR_023098) Copy   

•   Source: SciCrunch Registry

https://www.biocampus.cnrs.fr/index.php/en/facilities-en/browse-by-facility/platform/421-bacfly-en

Facility dedicated to expression of innovative recombinant proteins for all in vitro and in vivo studies. Innovative technology developed by the platform, called FlexiBac, uses baculovirus / insect cell expression system.

Proper citation: Montpellier Bacfly Core Facility (RRID:SCR_023096) Copy   

•   Source: SciCrunch Registry

https://mssr.cnsi.ucla.edu/

Services include use of high throughput screening technology, compounds in various libraries, siRNA sets of druggable genome for mouse and human and database of results from screens. For compounds screens, data points are in singlets.For functional genomics screens we use duplicates. We typically utilize 384 well plates but are flexible in this regard. We can accomodate any plate type ranging from 96 to 1536 well plates. Specialty plates can be handled on needed base. We have special rates for consumables with many vendors based on volume we use. These reduced rates are passed on directly to our screeners.

Proper citation: University of Califorania at Los Angeles California NanoSystems Institute Molecular Screening Shared Resource Core Facility (RRID:SCR_022956) Copy   

•   Source: SciCrunch Registry

https://www2.uottawa.ca/faculty-medicine/core-facilities/gem

Facility assists researchers in mammalian genome editing and molecular biology, including CRISPR genetic libraries and screens as well as custom viral vector/particle production. Projects are customized to researchers needs, from full service cell line creation to design and cloning.Supported by Canadian Foundation for Innovation.

Proper citation: University of Ottawa Genome Editing and Molecular Biology Core Facility (RRID:SCR_022954) Copy   

•   Source: SciCrunch Registry

https://www.dfhcc.harvard.edu/research/core-facilities/mouse-engineering/

Core provides services for generation of transgenic and knockout mice.Provides Nikon Diaphot microscope equipped with Nomarski Optics and Narishige micromanipulators for microinjections, Nikon surgical microscopes for egg isolation and transfer, sutter needle puller and de Fonbrune microforge. Facility maintains mice necessary for egg donors, egg recipients, and vasectomized males.Core offers electroporation of targeting vectors into ES cells. Provides investigators with DNA to identify ES cells carrying desired recombination events and ES cell expansion for microinjection into blastocysts.Services also include CRISPR injections, sperm and embryo cryopreservation, and reanimation with fresh or frozen sperm via IVF or thawing and implanting embryos.

Proper citation: Harvard Medical School Dana Farber Harvard Cancer Center Mouse Engineering Core Facility (RRID:SCR_022950) Copy   

•   Source: SciCrunch Registry

http://www.sylvester.org/CMSR

Provides small animal cancer modeling services to foster cancer research and to accelerate discovery of tailored anti-tumor therapies, including preclinical data for drug development, proof of principle for novel therapies, preclinical imaging, and disease biomarker studies. Services include facilitating in vivo modeling of human disease using mouse models; supporting preclinical in vivo efficacy and toxicity studies; devising treatment protocols; using noninvasive imaging for diagnosis and evaluation of responses to treatment; and performing histopathological analysis of targeted cancer therapies. Specific services include (1) support for the development of experimental murine models of cancer, including with cell line and patient-derived xenografts (PDXs), genetically engineered mouse models, and humanized models; (2) support for devising and implementing treatment protocols in a pre-clinical setting using murine models of human disease (e.g., drug toxicology and efficacy studies, drug formulation and delivery, and related assessments, like cell blood count, clinical chemistry, and flow cytometry analysis); and (3) diagnosis and evaluation of responses to treatment, using noninvasive small animal imaging for diagnosis and evaluation of responses to treatment, including in vivo bioluminescence and fluorescence optical imaging, high-frequency ultrasound imaging, structural and functional nuclear imaging, and magnetic resonance imaging (MRI); and (b) research histopathological analysis of targeted cancer therapies, including H&E and immunohistochemistry (IHC) sectioning, staining, scanning and analysis, and data storage of digital slide images. The CMSR also offers consultation, training, educational workshops and seminars. CMSR radiotherapy services support both small animal total body and image-guided radiation treatment delivery with sub-millimetric accuracy for development of radiation therapy regimens in a preclinical setting.

Proper citation: University of Miami Sylvester Comprehensive Cancer Center Cancer Modeling Shared Resource Core Facility (RRID:SCR_022891) Copy   

•   Source: SciCrunch Registry