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http://harvard.eagle-i.net/i/0000012e-5870-e12d-55da-381e80000000

The Forsyth Center for Clinical and Translational Research (CCTR) is a unique clinical facility with 6 fully-equipped dental units and associated laboratories that are specifically dedicated to conduct clinical research in oral and related systemic diseases. Clinical trials following FDA guidelines are performed at all levels, from early phase 1 trials to large, multicenter definitive clinical trials, with the goal of improving outcomes and the long-term health of patients. We routinely conduct studies in the oral environment, that include standard clinical measurement protocols for dental caries, dental calculus, gingivitis, periodontal diseases, intraoral local anesthetic evaluation, tooth restoration and tooth whitening evaluation. In addition, the clinic is equipped for obtaining and processing microbiological samples, gingival crevice fluid samples, blood and saliva samples for analysis of bacteria, inflammatory mediators, as well as for genomic and proteomic analyses. Under the new leadership of Dr. Thomas Van Dyke, Vice President of Clinical Research at The Forsyth Institute, the Center proposes new goals/efforts in discovering new techniques, testing new ideas and searching for valuable biomarkers for preventing and treating periodontal diseases and associated systemic inflammatory conditions. The CCTR is actively involved with the design and conduct of clinical research under Good Clinical Practices for submission to regulatory agencies. It has a published international reputation in evaluating intraoral local drug delivery devices, oral diagnostic systems, local anesthesia, restorative materials, tooth whitening systems and the association of oral diseases with systemic conditions. Forsyth''s Institutional Review Board is a member of the Harvard Catalyst Regulatory Group and meets on a monthly basis providing complete review of clinical protocols.

Proper citation: Harvard Forsyth Center for Clinical and Translational Research (RRID:SCR_009847) Copy   

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http://harvard.eagle-i.net/i/0000012c-60a9-25c8-c437-ff0b80000000

Core facility that provides the following services: MLV plasmid construction service, HIV plasmid construction service, Adenovirus plasmid construction service. The Harvard Gene Therapy Initiative was founded with the objective of promoting the use of gene therapy in both research and therapeutic applications and to conduct research developing new gene delivery vector technologies.

Proper citation: Harvard Gene Therapy Initiative Core (RRID:SCR_009848) Copy   

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http://harvard.eagle-i.net/i/00000135-5ed7-550c-be1e-73c480000000

The Small Molecule Mass Spectrometry Facility at the FAS Center for Systems Biology offers support for the analysis of a wide variety of analytes using mass spectrometry based techniques. We are located in the second basement (B2) level of the Northwest Laboratory building at 52 Oxford Street, Cambridge, MA 02138. We provide services for molecular formula confirmation (accurate mass measurement), structural elucidation (MS/MS) and quantitation of small molecules. In addition, we can assist you in the mass analysis of a wide variety of non-proteomics samples including metabolites, medium sized proteins and oligonucleotides. Please contact us and tell us about your samples prior to submission or use of our Open Access laboratory.

Proper citation: Harvard FAS Small Molecule Mass Spectrometry Facility (RRID:SCR_009845) Copy   

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http://harvard.eagle-i.net/i/0000012e-a1a6-4291-55da-381e80000000

Core facility that provides the following services: Progamming and sequencing classes and training. Research Computing (RC) facilitates the advancement of complex research by providing leading edge computing services across the Faculty of Arts & Sciences (FAS). RC staff maintain expertise in constantly changing computing technologies, while ''speaking the language'' of the FAS researchers, to help them use computing more effectively.

Proper citation: Harvard FAS Research Computing Core (RRID:SCR_009844) Copy   

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http://harvard.eagle-i.net/i/0000012f-e9eb-c410-de5a-673e80000000

The Neuroimaging facility has a 3-Tesla magnetic resonance imaging scanner for non-invasive human brain imaging. Our aim is to: * Provide functional and anatomic magnetic resonance imaging (MRI) to scientists studying human cognition, brain development and aging, and individual differences * Provide training for undergraduate and graduate students destined to become the next generation of neuroscientists * Pioneer innovative ways of imaging the human brain and is a first adopter of new neuroimaging technology, tools and applications * Develop and make available the data processing and visualization tools demanded by advancing neuroimaging technologies.

Proper citation: Harvard FAS Center for Brain Science - Neuroimaging Core Facility (RRID:SCR_009842) Copy   

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http://harvard.eagle-i.net/i/0000012f-e9ed-31bd-de5a-673e80000000

CBS hosts an optical imaging facility that houses advanced devices for widespread use by neuroscientists and is developing the next generation of optical techniques. The optical imaging is intended to be an extension of individual labs, housed in shared space. By pooling equipment, highly skilled technical management of the tools is available, allowing for routine technological upgrades, quicker troubleshooting, and expert advice. In addition, the joint space leads to camaraderie amongst users, and allows new technical advances in one lab to spread rapidly to other labs. This core facility also frees up space in individual labs that can be used in other ways. Finally, the shared equipment lowers barriers to adoption of the latest technology. This core facility provides: * Laser scanning microscopes with motorized stages for high throughput reconstructions of the nervous system * A histology suite for brain sectioning and tissue preparation * Stereo fluorescence macroscopes * The newest tools for high-resolution optical microscopy * Ultra-fast optical scanning microscopes

Proper citation: Harvard FAS Center for Brain Science - Imaging Core Facility (RRID:SCR_009840) Copy   

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http://harvard.eagle-i.net/i/0000012f-e9f0-3cf3-de5a-673e80000000

CBS houses a core facility with a transmission electron microscope (TEM) and several scanning electron microscopes. The SEMs are part of ongoing research that will lead to a three-dimensional electron microscopy facility, to image neural circuits with the highest possible resolution.

Proper citation: Harvard FAS Center for Brain Science - Electron Microscopy Core Facility (RRID:SCR_009838) Copy   

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http://harvard.eagle-i.net/i/0000012e-5e6d-9119-55da-381e80000000

The Flow and Imaging Cytometry Resource provides research flow and imaging cytometry services to all investigators in the PCIMM at Children''s Hospital, Boston and Immune Disease Institute, HMS and the local scientific community on a case-by-case basis. With state of the art instrumentation, such as the standard configuration 3-lasers FACSAria located in BL2+-facility, 20-parameters 4-lasers FACSAria SORP and DIVA FACSVantage SE TurboSort?, the facility offers high speed cell sorting and complex analytical services, development of collaborative projects as well as consulting on design and development of new protocols and methods.

Proper citation: Harvard PCMM Flow and Imaging Cytometry Resource (RRID:SCR_009839) Copy   

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http://www.dartmouse.org

Core facility that provides the following services: Medium-density speed congenic backcross service, Medium-density genetic background check service, DNA extraction. DartMouse is a not-for-profit core facility funded by the National Institutes of Health''s National Center for Research Resources. The mission of DartMouse is to facilitate the development of congenic mice in support of pre-clinical projects across the United States. Use of DartMouse allows the generation of congenic mice in 5 generations (~1.5 years), versus the 10 generations (~3 years) required by conventional back-crossing. Facility staff provides expert advice on mouse speed congenic development, mouse genetic background analysis, and mouse genetic mapping. Investigators provide us with mouse tail clippings. From these, DartMouse isolates genomic DNA and performs and analyzes complete genome-wide scans. We return data in graphical and spreadsheet formats, and make specific recommendations on breeder selection. We operate an Illumina BeadStation 500. Chips use a 1449 SNP array covering the mouse genome with an average density of <5 cM.

Proper citation: DartMouse - Speed Congenics (RRID:SCR_009757) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-a5a7-396c-55da-381e80000000

Core facility that provides the following services: Genome-scale screening of lentiviral human and mouse shRNA libraries.

The RNAi Screening Facility provides investigators with access to RNAi reagents and high-throughput screening technology. Lentiviral-based RNAi constructs against the human and mouse genomes are provided by the RNAi Consortium of the Broad Institute, and can be used to transduce a wide range of target cells, including primary and non-dividing cells. The Facility provides reagents, equipment, and technical expertise to design, optimize, and perform cell-based, arrayed lentiviral RNAi screens. Additionally, lentiviral RNAi constructs against individual genes can be requested.

Proper citation: DFCI RNA Interference Screening Facility (RRID:SCR_009755) Copy   

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http://harvard.eagle-i.net/i/0000012c-cca8-e37a-a061-4a6580000000

The Molecular Diagnostics Laboratory provides such research services as microRNA expression profiling, human cell line identity verification, mutation detection for clinical research studies, and specimen processing for clinical research studies to investigators at the Dana Farber Cancer Institute, as well as to investigators at other institutions. Consultation on experimental design and assistance with data analysis are also available.

Proper citation: DFCI Shannon McCormack Advanced Molecular Diagnostics Laboratory (RRID:SCR_009756) Copy   

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http://mbcf.dfci.harvard.edu

Core offers services for genomic next-generation sequencing library preparation, sequencing and analysis applications including RNAseq, ChIPseq, ATACseq, CRISPR screening, whole genome methylation profiling, targeted resequencing, single-cell RNAseq, exome sequencing, and more. Performs bioinformatics analysis such as integration of multi-omics datasets or specialized analyses. Genomics core technology platforms include Illumina NovaSeq6000, NextSeq500s, MiSeqs, MiniSeq. High throughput sample preparation is performed on Beckman Coulter Biomek FX and i7 systems. Low throughput samples are prepared by technical staff.

Proper citation: Dana-Farber Cancer Institute Molecular Biology Core Facility (RRID:SCR_009754) Copy   

•   Source: SciCrunch Registry

http://howard.eagle-i.net/i/00000134-a517-7b98-bf4c-ca4080000000

Core facility that provides the following services: Access to clinical physiology equipment. The Biobehavioral Core Laboratory houses the facilities for clinical exercise physiology and psycho-physiological research. The Clinical Exercise Physiology Research facility is equipped with a Cosmed Quark b2 metabolic cart and Cosmed electrocardiogram (ECG) equipment that is programmed into a Burdick Treadmill. This is used for performing graded exercise tests to assess risk for cardiovascular disease and functional work capacity training. An Ergoline 500 medical ergometer is used for exercise testing when a cycle ergometer is needed. In addition, the laboratory has 3 other treadmills that are used exercise intervention training programs. The Psychophysiology component consists of 3 computers (Dell Desktop Pentium 4, Gateway Pentium 4, and Toshiba Portege Tablet PC Pentium III). One desktop is used for data acquisition, one for data analysis and the third for internet usage. There is a surveillance camera (Security Labs) that is used to monitor participants as they take part in study tasks. To collect impedance cardiograph data, the HIC-2002 Impedance Cardiograph is used along with the COP ?Win 5.10 USB version cardiac output program for windows. This equipment is designed to measure a variety of cardiovascular measures (heart rate, stroke volume, cardiac output, pre-ejection period, left ventricular ejection time, total ejection period, and heather index). The Dinamap Vital Signs Monitor (Model 1846 SX) is used to assess systolic blood pressure and diastolic blood pressure. Lastly, a number of psychological tasks are also included in the lab such as the Automatic Mirror Tracer (Model 5403), the Peabody Picture Vocabulary Test (3 rd Edition Form IIIA and Form IIIB) and the Wisconsin Card Sorting Task for Windows.

Proper citation: Howard Biobehavioral Core Laboratory (RRID:SCR_009862) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-0220-1cee-b2b9-4d8780000000

Core facility that provides the following services: Illumina Gene Expression, Affymetrix gene expression. The Partners HealthCare Center for Personalized Genetic Medicine Microarray Facility is a full service facility dedicated to providing analysis for DNA or RNA samples. We provide support for high density microarrays to the Harvard Partners research community, including Harvard medical School, hospitals in the Partners Healthcare network, investigators in the Dana-Farber/Harvard Cancer Center, and the Harvard School of Public Health. Our services are open to both the PHS and non-PHS community.

Proper citation: Harvard PCPGM Microarray Facility (RRID:SCR_009860) Copy   

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http://harvard.eagle-i.net/i/0000012c-bca3-4116-02c0-2b6880000000

The West Quad Computing Group (WQCG) serves the research community of the BCMP and Cell Biology departments at Harvard Medical School. We provide support for your advanced computing needs, including design and maintenance of computational clusters, large data-set management, web and database backed applications, and workstation support, including workstations connected to research equipment. Please see Resources for more information, including a sample of some of our recent projects. We work in collaboration with the HMS Information Technology department. Please contact us using our support form for all of your computer support needs.

Proper citation: HMS West Quad Computing Group (RRID:SCR_009814) Copy   

•   Source: SciCrunch Registry

http://famu.eagle-i.net/i/00000137-3c2f-98f1-f0f1-ede280000000

Core facility that provides the following services: Animal handling training service, Animal surgery.

Proper citation: FAMU Animal care facility (RRID:SCR_009779) Copy   

•   Source: SciCrunch Registry

https://sites.dartmouth.edu/toxmetal/program-resources/trace-element-analysis/

Analysis of elemental composition of biological tissues and fluids by Inductively Coupled Plasma Mass spectrometry. Analysis of Arsenic species in urine and blood by chromatography-ICP-MS. Laser ablation analysis of tissue sections for imaging of elemental distributions.

Proper citation: Dartmouth Trace Element Analysis Core Facility (RRID:SCR_009777) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000012c-3d04-56dc-96ed-bdf580000000

TRAC is affiliated with the the Irradiation and Small Animal Imaging Shared Resource, which together provides irradiation services for basic and translational researchers and state-of-the-art non-invasive in vivo imaging of cultured cells and small animals. Services are used by Dartmouth investigators to irradiate cells in culture and small experimental animals. A separate set of irradiation devices is available through Norris Cotton Cancer Center for clinical and experimental irradiation of human patients.

Proper citation: Dartmouth Translational Research Animal Core (RRID:SCR_009778) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000013a-2c63-ce13-5088-2eef80000000

The SBGrid Core team provides research computing sysadmin support to structural biology laboratories in the Boston area.

Proper citation: HMS SBGrid Core (RRID:SCR_009811) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000013f-c93f-101f-0b49-0d2b80000000

Core facility that provides the following services: Research Consulation: Informatics Research.

The Biomedical Informatics Core (BIC) offers clinical and translational investigators support on informatics tools for cohort discovery, data integration, data management, text mining and visual analytics. In addition, the BIC provides consultative services on integration of data systems and on procedures for research data security.

Proper citation: Dartmouth SYNERGY: Biomedical Informatics Core (RRID:SCR_009771) Copy   

•   Source: SciCrunch Registry