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http://dbmi.mc.vanderbilt.edu/research/dnadatabank.html

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 11, 2023. BioVU is a research resource providing a View into biology at the level of DNA and other important macromolecules. BioVU has two major components. The first is a repository of DNA samples (extracted from discarded blood samples) that are coded solely by a Research Unique Identifier (RUI) derived from the Medical Record Number (MRN) using a one-way hash function. This is a computer algorithm that creates a transformation of each MRN such that the resulting RUI (which is in this instance is a 512 byte identifier) is unique, and has the property that it is not possible to infer or compute the MRN that generated it. As of early 2009, over 50,000 DNA samples were in the biobank, with new samples being added at the rate of approximately 700 per week. The second component of the resource is the creation of a database known as the Synthetic Derivative which is a collection of de-identified information extracted from VUMC''s electronic clinical information systems, indexed by the same one-way RUI used to track samples, and with content changed by deletion or permutation of all identifiers contained within each record. The Synthetic Derivative search interface is available to Vanderbilt researchers via the StarBRITE research portal created and maintained by the Vanderbilt Institute for Clinical and Translational Research. This user interface enables investigators meeting protocol approval criteria and other user agreement requirements to receive protocol-specific sets of data derived from DNA samples and from the Synthetic Derivative., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: Vanderbilt BioVU (RRID:SCR_004632) Copy   

•   Source: SciCrunch Registry

http://psychology-tools.com/gad-7/

A seven item assessment to measure the severity of a patient's anxiety. The test is self administered and cannot be used to replace a proper clinical assessment and additional evaluations.

Proper citation: Generalized Anxiety Disorder 7 (RRID:SCR_003666) Copy   

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https://pdbp.ninds.nih.gov/assets/crfs/Hamilton%20Anxiety%20Rating%20Scale%20(HAM-A).pdf

Assessment scale to assess the severity of symptoms of anxiety in adults, adolescents and children. The scale consists of 14 items, each defined by a series of symptoms, and measures both psychic anxiety (mental agitation and psychological distress) and somatic anxiety (physical complaints related to anxiety). Although the HAM-A remains widely used as an outcome measure in clinical trials, it has been criticized for its sometimes poor ability to discriminate between anxiolytic and antidepressant effects, and somatic anxiety versus somatic side effects. The HAM-A does not provide any standardized probe questions. Despite this, the reported levels of inter-rater reliability for the scale appear to be acceptable. The scale has been translated into: Cantonese for China, French and Spanish. An IVR version of the scale is available from Healthcare Technology Systems.

Proper citation: Hamilton Anxiety Rating Scale (RRID:SCR_003664) Copy   

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https://pmsiregistry.patientcrossroads.org/

International registry that consolidates information from individuals with Phelan-McDermid Syndrome into a single database, which will be utilized by researchers to understand Phelan-McDermid Syndrome better. In order to accelerate translational efforts (moving from basic laboratory research to meaningful health outcomes, such as therapies and treatments) related to Phelan-McDermid Syndrome, PMSF is funding the Phelan-McDermid Syndrome International Registry. The Registry is important for characterizing and understanding the syndrome better. Not only will the Registry provide valuable information for families and doctors to make the best care decisions possible, it will be important to help researchers decide what are the most important challenges to address. The Registry will also help scientists find out if there are any PMS patients who might be a good match for their research studies. Collecting information from PMS patients is very important, but protecting the privacy of people affected by PMS is also extremely important. In order to protect your privacy, Patient Crossroads (the company that designed the registry software) has designed many safeguards. Your child''s information will be de-identified so no one who looks at the data can identify you or your child. Your child''s information will be assigned a code. If a researcher is interested in learning more about your child, the researcher will ask the Patient Crossroads/PMSIR genetic counselor to contact you. A scientist will not be able to receive any identifying information about your child unless you give explicit consent for your child''s identity to be released to that researcher. BE PART OF OUR INTERNATIONAL REGISTRY The Registry will provide valuable information for families and doctors to make the best care decisions possible, and it will help researchers decide what are the most important challenges to address in PMS. Establishing the registry addresses two important scientific needs. First, scientists studying PMS need accurate, firsthand information to understand how PMS affects people. Second, scientists who are ready to start studies, such as those that test new treatments, will be able to access The Registry to identify people that may be eligible to participate in studies. In either case, your privacy is assured while the cause of research is advanced. While raw data about PMS will be available to scientists, they won''t have access to any identifying information about your child unless you agree to have your child''s identity released.

Proper citation: Phelan-McDermid Syndrome International Registry (RRID:SCR_004230) Copy   

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http://cbl.uh.edu/ORION/research/software

ORION is our neuron reconstruction software package developed for the morphological reconstruction of neurons from confocal and multiphoton microscopy data. It accepts raw neuron stack data as input and it is capable of reconstructing the neuron structure, visualizing the output, and exporting the reconstruction in a variety of formats. We are developing tools that will enable Neuroscientists to explore single neuron function via sophisticated image analysis. Advanced optical imaging can produce both structural and functional data and is at the forefront of experimentally exploring the fast, small-scale dynamics of living neurons. Further, compartmental modeling of neuronal function enables rapid testing of hypotheses and estimating experimentally inaccessible parameters. Combining these two techniques will afford unprecedented capabilities in the study of single neuron function. Our software utility bridges the two Neuroscience techniques by rapidly, accurately, and robustly generating, from structural image data, a cylindrical morphology model suitable for simulating neuronal function.

Proper citation: ORION Software (RRID:SCR_004389) Copy   

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http://psychology-tools.com/binge-eating-scale/

A 16 item questionnaire used to assess the presence of binge eating behavior indicative of an eating disorder that was devised specifically for use with obese individuals. The questions are based upon both behavioral characteristics (e.g., amount of food consumed) and the emotional, cognitive response, guilt or shame. Each question has 3-4 separate responses assigned a numerical value. The score range is from 0-46: * < 17 Non-Binging * 18-26 Moderate Binging * 27 and greater Severe Binging (Adapted from Wikipedia)

Proper citation: Binge Eating Scale (RRID:SCR_003694) Copy   

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http://www.1000livesplus.wales.nhs.uk/sitesplus/documents/1011/ABOS.pdf

A thirty-item diagnostic scale devised to be answered by the parents, spouse or other family member of an individual suspected of having an eating disorder. The questions address three factors; unusual eating behavior, bulimic-type behavior and hyperactivity. The ABOS however does not address the frequency of the observed behavior. The ABOS is scored on a range of from 0-60. There are three possible answers provided per question, each assigned a numerical value: two points for yes, zero for no, and one for don't know. (Adapted from Wikipedia) Scoring: * 0-10 Non-Anorexic * 11-20 Retest Required in 2 Months * 21-30 Anorexic Eating Detected, More Testing Required * 31-60 Severe Anorexia, Seek Professional Guidance. THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 27,2026.

Proper citation: Anorectic Behavior Observation Scale (RRID:SCR_003693) Copy   

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http://www.mnbb.org/

The Michigan Neonatal Biobank (Biobank) is a storage and management facility for The Michigan Department of Community Health''s archive of dried blood spot cards. A 501(c)3 non-profit charitable organization, the Biobank is contracted to serve as the repository for storage and management of the samples in a temperature controlled facility at Wayne State University''s Biobanking Center of Excellence in Tech Town. The Biobank''s roots are planted in the State''s Newborn Screening Program which began in 1965 in the Department of Community Health. Newborn screening is a public health program required by Michigan law to find babies with rare but serious disorders that require early treatment. A few drops of blood taken from the baby''s heel are sent to the State Public Health Laboratory and are tested for 49 disorders. Each year more than 200 Michigan babies are found to have a disorder detected by Newborn Screening. Once screening in the State laboratory is complete, residual dried blood spot samples that are no longer needed for testing are each assigned a unique code which assures anonymity for the sample and its donor. The samples are then sent for storage in the Michigan Neonatal Biobank.

Proper citation: Michigan Neonatal Biobank (RRID:SCR_004541) Copy   

•   Source: SciCrunch Registry

http://www4.parinc.com/Products/Product.aspx?ProductID=EDI-3

A self-report questionnaire used to assess the presence of eating disorders, anorexia nervosa, bulimia nervosa, and eating disorder not otherwise specified including Binge Eating Disorder (BED). The original questionnaire consisted of 64 questions, divided into eight subscales. There have been two subsequent revisions by Garner; Eating disorder inventory-two (EDI-2) and Eating disorder inventory-three (EDI-3). (Adapted from Wikipedia) The EDI-3 consists of 91 items organized into 12 primary scales: Drive for Thinness, Bulimia, Body Dissatisfaction, Low Self-Esteem, Personal Alienation, Interpersonal Insecurity, Interpersonal Alienation, Interoceptive Deficits, Emotional Dysregulation, Perfectionism, Asceticism, and Maturity Fears.

Proper citation: Eating Disorder Inventory (RRID:SCR_003696) Copy   

•   Source: SciCrunch Registry

http://www.scid4.org/

A diagnostic exam used to determine DSM-IV Axis I disorders (SCID-I) (major mental disorders) and Axis II disorders (SCID-II) (personality disorders). An Axis I SCID assessment with a psychiatric patient usually takes between 1 and 2 hours, depending on the complexity of the subject's psychiatric history and their ability to clearly describe episodes of current and past symptoms. A SCID with a non-psychiatric patient takes 1/2 hour to 1-1/2 hours. A SCID-II personality assessment takes about 1/2 to 1 hour. The instrument was designed to be administered by a clinician or trained mental health professional. (Adapter from Wikipedia)

Proper citation: Structured Clinical Interview for DSM-IV (RRID:SCR_003682) Copy   

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http://www.dementiatoday.com/wp-content/uploads/2012/06/MiniMentalStateExamination.pdf

A 30 question assessment test to screen patients for cognitive impairment that is commonly used in medicine to screen for dementia. It is also used to estimate the severity of cognitive impairment and to follow the course of cognitive changes in an individual over time, thus making it an effective way to document an individual's response to treatment. It takes about 10 minutes and examines functions including arithmetic, memory and orientation.

Proper citation: Mini-Mental State Examination (RRID:SCR_003681) Copy   

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http://psychology-tools.com/major-depression-inventory/

A 12 item self-report mood assessment developed by the World Health Organisation that is able to generate an ICD-10 or DSM-IV diagnosis of clinical depression in addition to an estimate of symptom severity. Scoring: * Mild depression: A score of 4 or 5 in two of the first three items. Plus a score of at least 3 on two or three of the last seven items. * Moderate depression: A score of 4 or 5 in two or three of the first three items. Plus a score of at least 3 on four of the last seven items. * Severe depression: A score of 4 or 5 in all of the first three items. Plus a score of at least 3 on five or more of the last seven items. * Major depression: The number of items is reduced to nine, as Item 4 is part of Item 5. Include whichever of the two items has the highest score (item 4 or 5). A score on at least five items is required, to be scored as follows: the score on the first three items must be at least 4, and on the other items at least 3. Either Item 1 or 2 must have a score of 4 or 5.

Proper citation: Major Depression Inventory (RRID:SCR_003688) Copy   

•   Source: SciCrunch Registry

http://www.teenmentalhealth.org/images/resources/CAPN_11Item_KADS.pdf

A psychological self-rating scale developed by Dalhousie University professor of psychiatry Stan Kutcher, to assess the level of depression in adolescents. While there are some variations, the 11-item version of the KADS is the most commonly used and most thoroughly verified for efficacy in monitoring outcomes in adolescents who are receiving treatment for major depressive disorder. Its items are worded using standard and colloquial terminology, and responses are scored on a simple 4 choice scale. There are ten questions about depression symptom frequency that the patient rates on a straight 4 point scale according to the following choices: hardly ever, much of the time, most of the time, all the time, and one question relating to the severity of suicidal ideation. Scores on the test range from 0 to 33. Unlike some rating scales, there is no threshold for sub-clinical presentation, or ranges for mild, moderate, and severe symptoms. Higher scores simply indicate more severe current depression symptoms. (Adapted from Wikipedia)

Proper citation: Kutcher Adolescent Depression Scale (RRID:SCR_003687) Copy   

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http://www.fresno.ucsf.edu/pediatrics/downloads/edinburghscale.pdf

A 10 item assessment scale developed to identify women who have postpartum depression (PPD). Items of the scale correspond to various clinical depression symptoms, such as guilt feeling, sleep disturbance, low energy, anhedonia, and suicidal ideation. Overall assessment is done by total score, which is determined by adding together the scores for each of the 10 items. Higher scores indicate more depressive symptoms. The EPDS may be used within 8 weeks postpartum and it also can be applied for depression screening during pregnancy. (Adapted from Wikipedia) Scoring: * 0-9 Not Likely to Have Depression * 10-30 Likely to Have Depression

Proper citation: Edinburgh Postnatal Depression Scale (RRID:SCR_003685) Copy   

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https://www.forsyth.org/research/services/

Core offers micro 3D X-ray imaging of small samples in high resolution and provides images and quantitative analyses of internal structures of ex vivo samples without any destructive procedures.Scanco CT40 system allows for visualization, measurement, and quantification of the structure of mineralized specimens. Contrast reagents permit visualization of soft tissue structures such as blood vessels.System creates 3D model from stack of 2D X-ray images taken around single axis of rotation. High-resolution scanner can capture detail at resolution of 6 to 32 microns. Non- destructive nature of this technology allows investigators to carry out complementary analyses of the same sample. There are two dedicated workstations for analyzing microCT data, the SCANCO analysis software or the Amira software package with XImagePAQ extension.

Proper citation: Forsyth Institute Micro Computed Tomography Core Facility (RRID:SCR_021180) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/lab/cufemm/

Facility features electron microscopes housed in vibration, static-free, and temperature-controlled environment.

Proper citation: Colorado University at Boulder Facility for Electron Microscopy of Materials Core Facility (RRID:SCR_019306) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/facility/mimic/

Facility provides specialized services for assessment of material properties, chemistry and structure across multiple length scales with emphasis on assessment of biological tissues, biomaterials, and biologically inspired systems.

Proper citation: Colorado University at Boulder Materials Instrumentation and Multimodal Imaging Core Facility (RRID:SCR_019307) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/sharedinstrumentation/core-facilities/biofrontiers-sequencing-core

Core instruments include Agilent Bioanalyzer 2100 system provides sizing, quantitation and quality control of DNA, RNA and proteins, Illumina MiSeq sequencer, able to sequence prepared Illumina DNA or RNA libraries at low- to mid- output (0.75 to 13 Gbp per run), Illumina NextSeq sequencer capable of sequencing Illumina DNA or RNA libraries, QuantStudio 6 Real-Time PCR uses fluorescence detection method for quantitative and qualitative analysis of nucleic acid sequences including gene expression, regulation and variation, Qubit Fluorimeter 3.0 capable of measuring DNA or RNA concentrations with high accuracy.

Proper citation: Colorado University at Boulder BioFrontiers Next-Gen Sequencing Facility Core Facility (RRID:SCR_019308) Copy   

•   Source: SciCrunch Registry

http://smrc.colorado.edu/facilities/xrd_saxs.html

Provides cutting edge capabilities for probing large lengthscale structures such as polymers, biological macromolecules, meso- and nano-porous materials, and molecular self-assemblies.Techniques that can be applied to study materials include SAXS, GISAXS, WAXS, and GIWAXS. The 30W Xenocs Genix 3D x-ray source and state-of-the-art Dectris Eiger R 1M detector provide an excellent way to probe almost any material of interest. In-situ x-ray studies may be carried out using temperature controlled sample holders in both SAXS and GISAXS modes..

Proper citation: Colorado University at Boulder Soft Materials Research Center X-Ray Diffraction Facility Core Facility (RRID:SCR_019304) Copy   

•   Source: SciCrunch Registry

https://biotech.wisc.edu/age/

Provides services and expertise to unlock genome editing tools to advance your research. Routinely generates new genome edited models, particularly mouse, rats, swine, and cell lines, as well as supports in vivo editing, novel preclinical therapeutic strategies, pooled lentiCRISPR screening, and other applications.

Proper citation: University of Wisconsin-Madison Advanced Genome Editing Laboratory (RRID:SCR_021070) Copy   

•   Source: SciCrunch Registry