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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://www.bioconductor.org/packages/release/bioc/html/plgem.html
Software to detect differential expression in microarray and proteomics datasets. Its use has been shown to improve the detection of differentially expressed genes or proteins in these datasets.
Proper citation: plgem (RRID:SCR_001355) Copy
http://www.bioconductor.org/packages/release/bioc/html/pvca.html
Software package that contains the function to assess the batch sourcs by fitting all sources as random effects including two-way interaction terms in the Mixed Model (depends on lme4 package) to selected principal components, which were obtained from the original data correlation matrix. This package accompanies the book Batch Effects and Noise in Microarray Experiements, chapter 12.
Proper citation: PVCA (RRID:SCR_001356) Copy
http://www.bioconductor.org/packages/release/bioc/html/maSigPro.html
A regression based software package to find genes for which there are significant gene expression profile differences between experimental groups in time course microarray experiments.
Proper citation: maSigPro (RRID:SCR_001349) Copy
http://www.bioconductor.org/packages/release/bioc/html/genArise.html
An easy to use software tool for dual color microarray data. Its GUI-Tk based environment lets any non-experienced user perform a basic, but not simple, data analysis just following a wizard. In addition it provides some tools for the developer.
Proper citation: genArise (RRID:SCR_001346) Copy
http://www.bioconductor.org/packages/release/bioc/html/Harshlight.html
Software package used to detect extended, diffuse and compact blemishes on microarray chips. It automatically marks the areas in a collection of chips (affybatch objects) and a corrected AffyBatch object is returned, in which the defected areas are substituted with NAs or the median of the values of the same probe in the other chips in the collection.
Proper citation: Harshlight (RRID:SCR_001340) Copy
http://www.bioconductor.org/packages/release/bioc/html/MiChip.html
Software package that takes the MiChip miRNA microarray .grp scanner output files and parses these out, providing summary and plotting functions to analyse MiChip hybridizations. A set of hybridizations is packaged into an ExpressionSet allowing it to be used by other BioConductor packages.
Proper citation: MiChip (RRID:SCR_001341) Copy
http://www.bioconductor.org/packages/release/bioc/html/frma.html
Preprocessing and analysis software for single microarrays and microarray batches.
Proper citation: fRMA (RRID:SCR_001345) Copy
http://www.bioconductor.org/packages/release/bioc/html/arrayQualityMetrics.html
Software package that generates microarray quality metrics reports for data in Bioconductor microarray data containers (ExpressionSet, NChannelSet, AffyBatch). Reports contain both general and platform-specific sections. Both one and two color array platforms are supported.
Proper citation: arrayQualityMetrics (RRID:SCR_001335) Copy
Software library that contains functions that calculate various statistics of differential expression for microarray data, including t statistics, fold change, F statistics, SAM, moderated t and F statistics and B statistics. It also implements methodology (Differential Expression via Distance Summary) which selects differentially expressed genes by integrating and summarizing a set of statistics using a weighted distance approach.
Proper citation: DEDS (RRID:SCR_001339) Copy
A database of hierarchical classification of enzymes that relates specific sequence-structure features to specific chemical capabilities. The SFLD classifies evolutionarily related enzymes according to shared chemical functions and maps these shared functions to conserved active site features. The classification is hierarchical, where broader levels encompass more distantly related proteins with fewer shared features. It thus serves as the analysis and archive site for superfamilies targeted by the Enzyme Function Initiative, and is developed by the Babbitt Laboratory in collaboration with the UCSF Resource for Biocomputing, Visualization, and Informatics. The resource also provides a collection of tools and data for investigating sequence-structure-function relationships and hypothesizing function.
Proper citation: Structure-function linkage database (RRID:SCR_001375) Copy
https://www.ddbj.nig.ac.jp/dra/index-e.html
Archive database for output data generated by next-generation sequencing machines including Roche 454 GS System, Illumina Genome Analyzer, Applied Biosystems SOLiD System, and others. DRA is a member of the International Nucleotide Sequence Database Collaboration (INSDC) and archiving the data in a close collaboration with NCBI Sequence Read Archive (SRA) and EBI Sequence Read Archive (ERA). Please submit the trace data from conventional capillary sequencers to DDBJ Trace Archive., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
Proper citation: DDBJ Sequence Read Archive (RRID:SCR_001370) Copy
http://igb.agri.gov.il/main/index.pl
Biobank which collects, preserves, and assesses gene information related to species of plants indigenous to Israel. The Bank's goal is to conserve representative gene pools of species whose economic potential has yet to be developed.
Proper citation: Israel Plant Gene Bank (RRID:SCR_001403) Copy
http://www.usc.edu/dept/biomed/UTRC/
Biomedical technology research center focusing on the development of very high frequency (above 20 MHz) ultrasonic transducers/arrays for applications in medicine and biology that include ophthalmology, dermatology, vascular surgery, and small animal imaging. The research is pursued simultaneously in three directions: novel piezoelectric materials, very high frequency single element transducers and linear arrays, and finite element modeling and material property measurements. The Center also serves the community through collaborative efforts with investigators having a research interest in high-frequency ultrasound imaging. In addition, it performs the function of training and information dissemination by offering conferences, seminars and specialized courses at the University of Southern California. The Center has set forth a number of goals which define its mission: * Conduct novel research and development of very high frequency (>20MHz) ultrasonic transducers, arrays and imaging applications * Collaborate with other academic institutions, non-profit organizations, and small businesses supported by the NIH to further the development of these high-frequency applications and provide the expertise in transducers necessary for project success * Serve as an educational center for training scientists and engineers interested in ultrasonic transducer technology One of the primary goals of the Center is to provide service to outside investigators and small business. Often an investigator or company has a specific application in mind but is without the expertise to develop the necessary ultrasonic device. Investigators at academic institutions, research institutes, or small businesses supported by NIH grants who have a need for medical ultrasound transducers and are interested in a collaborative effort should contact Dr. Hyung Ham Kim or Dr. K. Kirk Shung. Ultrasound transducers and components can be fabricated either completely by center personnel or in a joint effort with other investigators. In addition, collaborators are encouraged to visit the facility for additional training in fabrication and assembly.
Proper citation: Resource Center for Medical Ultrasonic Transducer Technology (RRID:SCR_001404) Copy
https://bioconductor.org/packages//2.13/bioc/html/virtualArray.html
Software package that permits the user to combine raw data of different microarray platforms into one virtual array. It consists of several functions that act subsequently in a semi-automatic way. Doing as much of the data combination and letting the user concentrate on analyzing the resulting virtual array.
Proper citation: virtualArray (RRID:SCR_001361) Copy
Public state university in West Bengal, India. There is a focus on interdisciplinary learning and research; the university features a variety of centers such as school of education technology, cognitive sciences, and natural product studies.
Proper citation: Jadavpur University; West Bengal; India (RRID:SCR_001366) Copy
http://www.bioconductor.org/packages/release/bioc/html/rama.html
Software package for robust estimation of cDNA microarray intensities with replicates. It uses a Bayesian hierarchical model for the robust estimation. Outliers are modeled explicitly using a t-distribution, and the model also addresses classical issues such as design effects, normalization, transformation, and nonconstant variance.
Proper citation: RAMA (RRID:SCR_001358) Copy
https://bioportal.bioontology.org/ontologies/NCBI_NMOsp_1_2_2
NeuroMorpho.Org light species ontology is a customized taxonomy for species available in NeuroMorpho.Org. This file is created from the existing resources like NCBI Taxonomy, NIF organism, Rat strain ontology, and Jax mice catalogue. The OBO file can be explored and downloaded from the NCBO bioportal service. The current NCBI_NMOsp_v1.2.2.obo file consists of 887 concepts of which 24 unique classes are mapped onto species & strains data in NeuroMorpho.Org database.
Proper citation: NeuroMorpho.Org light species ontology (RRID:SCR_001394) Copy
http://www.bioconductor.org/packages/release/bioc/html/MANOR.html
Software packqge for importation, normalization, visualization, and quality control functions to correct identified sources of variability in array-CGH (Comparative genomic hybridization) experiments.
Proper citation: MANOR (RRID:SCR_001305) Copy
http://www.bioconductor.org/packages/release/bioc/html/limmaGUI.html
Software package for a Graphical User Interface for the limma Microarray package.
Proper citation: limmaGUI (RRID:SCR_001306) Copy
http://www.bioconductor.org/packages/release/bioc/html/ffpe.html
Software to identify low-quality data using metrics developed for expression data derived from Formalin-Fixed, Paraffin-Embedded (FFPE) data. Also a function for making Concordance at the Top plots (CAT-plots).
Proper citation: ffpe (RRID:SCR_001307) Copy
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