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https://www.biovendor.cz/

An Antibody supplier

Proper citation: BioVendor Laboratory Medicine (RRID:SCR_005143) Copy   

•   Source: SciCrunch Registry

http://www.cmhd.ca/

Multidisciplinary collaboration undertaking genome-wide mutagenesis to functionally annotate the mouse genome and develop new mouse models relevant to human disease. To achieve these goals two major research platforms are carried out: Gene trapping and ENU Mutagenesis. A new challenge is faced in the post-genomic era - the assignment of biological function to the human genome sequence and projecting that assignment into understanding of human health and disease. The Centre for Modeling Human Disease (CMHD) was established to take part in the worldwide initiative to address these challenges. At the CMHD, two fundamentally different, yet complimentary methods are employed to generate mutant mouse models of human disease: chemical mutagenesis by ethylnitrosourea (ENU), and gene trap insertional mutagenesis. The Centre contributes its resources to similar international efforts and is the first of its kind in Canada. The Center is also actively developing other mutagenic strategies including pharmacologic and genetic modifier screens to dissect disease pathways, and novel mutagenic techniques using embryonic stem cells. ENU Database * Statistics for Mouse Physiological Parameters * Search Mutants by Phenotype * Search Mutants by Heritability Gene Trap Database * Search by in vitro Expression Pattern * Search by Gene Trap Sequences CMHD Members Only (must register and login) * Search Mouse Line * Histopathology * Sperm, Tissue, Slide Archiving * CMHD Database Download CMHD Services * Phenotyping * Genetic Mapping * Pathology * Pathology Service Charges

Proper citation: CMHD - Centre for Modeling Human Disease (RRID:SCR_006101) Copy   

•   Source: SciCrunch Registry

http://cohere.open.ac.uk/

Web-based tool to create claims, hypotheses, or statements, and relate these to other claims using an open set of relationships. It is usable for science, but also for structuring online debates on other topics. The visual tool allows users to create, connect and share Ideas. Back them up with websites. Support or challenge them. Embed them to spread virally. Discover who - literally - connects with your thinking.

Proper citation: Cohere (RRID:SCR_006189) Copy   

•   Source: SciCrunch Registry

http://bioinformatics.biol.uoa.gr/human_gpdb/

A publicly accessible, relational database of human G-Proteins and their interactions with human GPCRs and Effectors. Advanced data integration techniques make Human-gpDB very rich in context since all of the bioentities are linked to a rich variety of external data sources. High quality visualization methods make the networks more informative and the extraction of information easier. Human-gpDB is currently a very useful tool for drug targeting investigation. The sequences of G-Proteins and GPCRs are classified according to a hierarchy of different classes, families and sub-families, whereas the Effectors sequences are classified in families, subfamilies and types, based on extensive literature search. The classification of GPCRs follows the IUPHAR classification, while the Effectors classification is a unique feature and is based on their function. The database currently holds information about 713 human GPCRs, 36 human G-Proteins and 99 human Effectors. The collection of the information about the interactions between these molecules was done manually and the current status of Human-gpDB reveals information about 1663 connections between GPCRs and G-Proteins and 1618 connections between G-Proteins and Effectors.

Proper citation: Human-gpDB (RRID:SCR_006223) Copy   

•   Source: SciCrunch Registry

http://www.wmkeck.org/

The W. M. Keck Foundation was established in 1954 in Los Angeles by William Myron Keck, founder of The Superior Oil Company. Our Foundation is one of the nation''s largest philanthropic organizations, with assets of more than $1billion. Mr. Keck envisioned a philanthropic institution that would provide far-reaching benefits for humanity. By taking a bold, creative approach to grantmaking, he created a legacy that the Foundation proudly upholds today. In recent years, the Foundation has focused on Science and Engineering Research; Medical Research; Undergraduate Education; and Southern California. Each of our grant programs invests in people and programs that are making a difference in the quality of life, now and for the future. Supporting pioneering discoveries in science, engineering and medical research has been our mandate for a half-century. By funding the work of leading researchers, the establishment of unique laboratories and research centers, and the purchase of sophisticated instruments, we are laying the groundwork for breakthrough discoveries and new technologies that will save lives, provide innovative solutions to complex problems and add immeasurably to our understanding of life on Earth and our place in the universe. We believe that a high-quality, well-rounded college education is vital for tomorrow''s leaders. The Foundation''s undergraduate education program promotes inventive approaches to instruction and effective involvement of students in research at colleges across the nation. Our support of Southern California-based organizations enriching the lives of our region''s residents has expanded and deepened over the years. We place a special emphasis on children, youth and their families, with the goal of providing safe, healthy, supportive environments that prepare children to succeed in school and in life.

Proper citation: W. M. Keck Foundation (RRID:SCR_006103) Copy   

•   Source: SciCrunch Registry

http://riodb.ibase.aist.go.jp/brain/index.php?LANG=ENG

Atlas of magnetic resonance images and histological sections of a Japanese monkey brain, Rhesus monkey and human. The Brain Explorer allows for display, magnification, and comparison these images. Other formats include a collection of .jpg images, Quicktime VR (allow user to zoom in), and EmonV, a voxel viewer for MacOS X.

Proper citation: Brain Atlas Database of Japanese Monkey for WWW (RRID:SCR_006104) Copy   

•   Source: SciCrunch Registry

http://www.unc.edu/

The University of North Carolina at Chapel Hill, also known as UNC-Chapel Hill, Chapel Hill, North Carolina, or simply Carolina is a public research university in Chapel Hill, North Carolina. It is the flagship of the 17 campuses of the University of North Carolina system.

Proper citation: University of North Carolina at Chapel Hill; North Carolina; USA (RRID:SCR_006100) Copy   

•   Source: SciCrunch Registry

http://songbirdtranscriptome.net/

Database containing cDNA clone information of the brains of songbirds. These clones are annotated with behavioral information, as well as links to information of homologous genes of other species. The database includes over 91,000 zebra finch brain cDNAs (2009) sequenced by Duke, ESTIMA, and Rockefeller research groups. The project is a collaborative effort of the Jarvis Laboratory of Duke University, Duke Bioinformatics, and The Genomics group of RIKEN, with Erich D. Jarvis as P.I. and Kazuhiro Wada as Co-P.I. Microarrays with the cDNAs in this database are available at Duke http://mgm.duke.edu/genome/dna_micro/core/spotted.htm and through the NIH Neurosciences Microarray Consortium http://arrayconsortium.tgen.org/np2/public/overview.jsp

Proper citation: Songbird Brain Transcriptome Database (RRID:SCR_006182) Copy   

•   Source: SciCrunch Registry

https://phenome.jax.org/centers/QTLA

Raw data from various QTL (quantitative trait loci) studies using rodent inbred line crosses. Data are available in the .csv format used by R/qtl and pseudomarker programs. In some cases analysis scripts and/or results are posted to accompany the data. These data are provided as a courtesy to the genetic mapping community and may be used for purposes of developing or testing new analysis methods or software and for meta-analysis of quantitative traits. The authors of the datasets retain individual ownership of the data. As a courtesy to the authors, please alert them in advance of any publications that result from reanalysis of these data or obtain permission prior to redistribution of data or results. In all data sets and files, the marker locations have been translated to Cox build 37 coordinates unless otherwise stated. Please consider contributing your data to the QTL Archive.

Proper citation: QTL Archive (RRID:SCR_006213) Copy   

•   Source: SciCrunch Registry

http://www.healthfinder.gov/

Provides information and tools to help consumers stay healthy including resources on a wide range of health topics selected from over 1,600 government and non-profit organizations to provide the best, most reliable health information possible.

Proper citation: Healthfinder.gov (RRID:SCR_006175) Copy   

•   Source: SciCrunch Registry

http://www.nottingham.ac.uk/

Public research university in Nottingham, United Kingdom. It was founded as University College Nottingham in 1881, and was granted a royal charter in 1948.

Proper citation: University of Nottingham; Nottingham; United Kingdom (RRID:SCR_006210) Copy   

•   Source: SciCrunch Registry

http://www.gwascentral.org/

Publicly available database of summary level findings from genetic association studies in humans, including genome wide association studies (GWAS). Previously named HGBASE, HGVbase and HGVbaseG2P.

Proper citation: GWAS Central (RRID:SCR_006170) Copy   

•   Source: SciCrunch Registry

http://epigenomegateway.wustl.edu/

Software tool for visualizing and interacting with whole-genome datasets. Browser hosts Human Epigenome Atlas data produced by Roadmap Epigenomics project, but its use of advanced, multi-resolution data formats and its user-friendly interface make it possible for investigators to upload and visualize their own data as custom tracks. Developed and maintained by Epigenome Informatics Group at Washington University in St. Louis.

Proper citation: WashU Epigenome Browser (RRID:SCR_006208) Copy   

•   Source: SciCrunch Registry

http://www.umd.be/BRCA1/

The UMD-BRCA1/BRCA2 databases have been set up in a joined national effort through the network of 16 diagnostic laboratories to provide up-to-date information about mutations of the BRCA1 and BRCA2 genes identified in patients with breast and/or ovarian cancer. These databases currently contain published and unpublished information about the BRCA1/BRCA2 mutations reported in French diagnostic laboratories. This database includes 28 references and 5530 mutations (1440 different mutations and 786 protein variants) The databases of BRCA1 and BRCA2 mutations were built using the Universal Mutation Database tool. For each mutation, information is provided at several levels: * at the gene level: exon and codon number, wild type and mutant codon, mutation event, mutation name and, * at the protein level: wild type and mutant amino acid, binding domain, affected domain. If you want to submit a mutation, please contact R. Lidereau., S. Caputo. or E. Rouleau.

Proper citation: UMD-BRCA1/ BRCA2 databases (RRID:SCR_006128) Copy   

•   Source: SciCrunch Registry

http://www.hdfoundation.org/home.php

The Hereditary Disease Foundation (HDF) aims to cure genetic illness by supporting basic biomedical research. The HDF was started by Dr. Milton Wexler in 1968 when his wife was diagnosed with Huntington''s disease (HD). The Foundation uses a variety of strategies - workshops, grants, fellowships, and targeted research contracts - to solve the mysteries of genetic disease and develop new treatments and cures. Huntington''s disease is a fatal, dominantly inherited, genetic, neurological disorder causing involuntary movements, severe emotional disturbance and progressive cognitive loss over ten to twenty years. Each child of an affected parent has a 50% risk of inheriting HD, usually in the third or fourth decade of life, though children as young as two years and adults in their eighties may also develop symptoms. The Hereditary Disease Foundation uses Huntington''s disease as a model for hereditary disease research because it is triggered by a mutation of one single gene. Progress toward treatment or a cure could be instrumental in finding ways to treat other illnesses with more complex genetics, including Parkinson''s, Alzheimer''s, Lou Gehrig''s disease (ALS), depression, schizophrenia, and cancer. The Hereditary Disease Foundation has given over $50 million to support pioneering research in genetics, gene therapy, molecular and cell biology, cell survival and death, animal models, neurophysiology, neuropharmacology and other areas relevant to understanding inherited diseases. * Milton Wexler Workshop Program: A centerpiece of the Foundation is the interdisciplinary Workshop Program which sponsors Workshops held many times during the year. Milton Wexler began the Program to bring scientists together from different academic disciplines to brainstorm - without prepared lectures or slides - and explore new directions for research. They often share unpublished data. * Funding Opportunities ** The Basic Research Grants Program supports projects that contribute to identifying and understanding the fundamental defects in Huntington''s disease and related disorders. ** The John J. Wasmuth Postdoctoral Fellowships are named in honor of the late John Jacob Wasmuth, an essential member of the Huntington''s Disease Collaborative Research Group. Our hope is that those granted fellowships bearing his name will seek John''s level of imagination, rigor, creativity and spirit. ** The Lieberman Award is presented annually to a worthy scientist, thanks to the generosity of Harry Lieberman, a trustee of the Hereditary Disease Foundation. ** The Milton Wexler Postdoctoral Fellowship Award is named after the founder of the Hereditary Disease Foundation. The Hereditary Disease Foundation restricts this annual award to research highly relevant to curing Huntington''s disease. * Giving to the Hereditary Disease Foundation - Donations are accepted by check, credit card, etc.

Proper citation: Hereditary Disease Foundation (RRID:SCR_006088) Copy   

•   Source: SciCrunch Registry

http://isaac.bioapps.biozentrum.uni-wuerzburg.de/isaac/modules/genome/species.xhtml

Web based tool to enable the analysis of sets of genes, transcripts and proteins under different biological viewpoints and to interactively modify these sets at any point of the analysis. Detailed history and snapshot information allows tracing each action. One can switch back to previous states and perform new analyses. Sets can be viewed in the context of genomes, protein functions, protein interactions, pathways, regulation, diseases and drugs. Additionally, users can switch between species with an automatic, orthology based translation of existing gene sets. Sets as well as results of analyses can be exchanged between members of groups.

Proper citation: InterSpecies Analysing Application using Containers (RRID:SCR_006243) Copy   

•   Source: SciCrunch Registry

http://unice.fr/

THIS RESOURCE IS NO LONGER IN SERVICE, documented on August 19, 2021.University of Nice Sophia Antipolis was university located in Nice, France and neighboring areas. It was founded in 1965 and was organized in eight faculties, two autonomous institutes and engineering school. It was merged in 2019 into the University of C�te d'Azur.

Proper citation: University of Nice Sophia Antipolis; Nice; France (RRID:SCR_006114) Copy   

•   Source: SciCrunch Registry

http://athina.biol.uoa.gr/bioinformatics/PRED-GPCR/

A prediction tool for GPCR Family Classification from sequence alone based on a probabilistic method that uses family-specific profile Hidden Markov Models. The PRED-GPCR system is based on a probabilistic method that uses family specific profile HMMs in order to determine to which GPCR family a query sequence belongs or resembles. The approach proposed in this method exploits the descriptive power of profile HMMs along with an exhaustive discrimination assessment method to select only highly selective and sensitive profiles, for each family. The collection of these profiles constitutes a signature library, which is scanned, for significant matches with a given query sequence. The output report for a query sequence consists of two sections: * A ranked list of the profile HMM matches, below the selected individual motif E-value cutoff, along with their corresponding family. * A ranked list of the Combined P-values, E-values as well as the number of profiles matched for each family. To cross-evaluate your results you can browse through Swiss-Prot, Trembl, Pfam and Prosite family related entries.

Proper citation: PRED-GPCR (RRID:SCR_006196) Copy   

•   Source: SciCrunch Registry

http://cran.r-project.org/web/packages/fcros/

A fold change ranks ordering statistics based software for detecting differentially expressed genes.

Proper citation: FCROS (RRID:SCR_006195) Copy   

•   Source: SciCrunch Registry

http://www.mouseimaging.ca/

A unique resource and comprehensive imaging facility combining the latest state-of-the-art digital medical imaging technologies for the characterization of mouse functional genomics. The goals of the Mouse Imaging Centre are: * To provide a variety of medical imaging technologies adapted to studying genetically modified mice. These technologies include magnetic resonance (MR) imaging, micro computed tomography (micro-CT), ultrasound biomicroscopy (UBM), and optical projection tomography (OPT). * To screen large numbers of mice for models of human diseases. * To image an individual mouse over time to observe development, disease progression and responses to experimental treatment. * To develop an exciting team of investigators with expertise in imaging techniques, computer science, engineering, imaging processing, developmental biology and mouse pathology. * To work by collaboration with researchers throughout the world. When we look for human diseases in the human population, we make extensive use of medical imaging. Therefore, it makes sense to have available the same imaging capabilities as we investigate mice for models of human disease. The Mouse Imaging Centre (MICe) has developed high field magnetic resonance imaging microscopy, ultrasound biomicroscopy, micro computed tomography, and optical techniques. With these imaging tools, MICe is screening randomly mutagenized mice to look for phenotypes that represent human diseases and is taking established human disease models in mice and using imaging to follow the progression of disease and response to treatment over time. It is clear that imaging has a major contribution to make to phenotyping genetic variants and to characterizing mouse models. MICe is staffed by an exciting new team of about 30 investigators with expertise in imaging techniques, computer science, engineering, imaging processing, developmental biology and mouse pathology. The Mouse Imaging Centre (MICe) is not a fee-for-service facility but works through collaborations. Services include: * Projects involving MicroCT are available as a fee for service. * We will eventually move to the same model above with MRI. * Ultrasound Biomicroscopy is used for cardiac, embryo and cancer studies and is available as fee for service at $100 per study or in some cases on a collaborative basis. * Optical Projection Tomography has only limited availability on a collaborative basis. Mouse Atlas As our images are inherently three-dimensional, we will be able to make quantitative measures of size and volume. With this in mind, we are developing a mouse atlas showing the normal deviation of organ sizes. This atlas is an important resource for biologists as it has the potential to eliminate the need to sacrifice as many controls when making comparisons with mutants. Mouse Atlas Examples: * Variational Mouse Brain Atlas * Cerebral Vascular Atlas of the CBA Mouse * Neuroanatomy Atlas of the C57Bl/6j Mouse * Vascular Atlas of the Developing Mouse Embryo * Micro-CT E15.5 Mouse Embryo Atlas

Proper citation: MICe - Mouse Imaging Centre (RRID:SCR_006145) Copy   

•   Source: SciCrunch Registry