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http://depts.washington.edu/yeastrc/
Biomedical technology research center that (1) exploits the budding yeast Saccharomyces cerevisiae to develop novel technologies for investigating and characterizing protein function and protein structure (2) facilitates research and extension of new technologies through collaboration, and (3) actively disseminates data and technology to the research community. Through collaboration, the YRC freely provides resources and expertise in six core technology areas: Protein Tandem Mass Spectrometry, Protein Sequence-Function Relationships, Quantitative Phenotyping, Protein Structure Prediction and Design, Fluorescence Microscopy, Computational Biology.
Proper citation: Yeast Resource Center (RRID:SCR_007942) Copy
Biomedical Technology Resource Center that develops image processing and analysis techniques for basic and clinical neurosciences. The NAC research approach emphasizes both specific core technologies and collaborative application projects. The core activity of the center is the development of algorithms and techniques for postprocessing of imaging data. New segmentation techniques aid identification of brain structures and disease. Registration methods are used for relating image data to specific patient anatomy or one set of images to another. Visualization tools allow the display of complex anatomical and quantitative information. High-performance computing hardware and associated software techniques further accelerate algorithms and methods. Digital anatomy atlases are developed for the support of both interactive and algorithmic computational tools. Although the emphasis of the NAC is on the dissemination of concepts and techniques, specific elements of the core software technologies have been made available to outside researchers or the community at large. The NAC's core technologies serve the following major collaborative projects: Alzheimer's disease and the aging brain, morphometric measures in schizophrenia and schizotypal disorder, quantitative analysis of multiple sclerosis, and interactive image-based planning and guidance in neurosurgery. One or more NAC researchers have been designated as responsible for each of the core technologies and the collaborative projects.
Proper citation: Neuroimage Analysis Center (RRID:SCR_008998) Copy
The data sets included in this resource are published in Kravitz et al, 2012 Distinct roles for direct and indirect pathway striatal neurons in reinforcement (Nat. Neurosci). The data shows: optogenetic activation of dopamine D1 or D2 receptor-expressing striatal projection neurons influenced reinforcement learning in mice. Stimulating D1 receptor-expressing neurons induced persistent reinforcement, whereas stimulating D2 receptor-expressing neurons induced transient punishment. These 3 recording files contain data collected in 2010 and 2011 by Lex Kravitz in Anatol Kreitzer''s lab at the Gladstone Institutes. Each file contains ~ 1 hour of awake in vivo recording data, containing the spike times for ~30 minutes of spontaneous activity, preceeded or followed by 400 laser pulses (473nm laser light, 1 sec pulses, 3 seconds inter-pulse-interval). The laser pulses were presented at 4 intensities: 0.1mW, 0.3mW, 1.0mW, and 3.0mW, and pulse times at each intensity are given in separate columns in each data file. Finally, each data file contains the identification of ''light-modulated units'' as we identified them (see methods below). Methods: Viral expression of DIO-ChR2-YFP and DIO-YFP We used double-floxed inverted (DIO) constructs to express ChR2-YFP fusions and YFP alone in Cre-expressing neurons, which virtually eliminates recombination in cells that do not express Cre-recombinase (Sohal et al, Nature, 2009). The double-floxed reverse ChR2-YFP or YFP cassette was cloned into a modified version of the pAAV2-MCS vector (Stratagene, La Jolla, CA) carrying the EF-1a promoter and the Woodchuck hepatitis virus posttranscriptional regulatory element (WPRE) to enhance expression. The recombinant AAV vectors were serotyped with AAV1 coat proteins and packaged by the viral vector core at the University of North Carolina. The final viral concentration was 4 x 10^12 virus molecules/mL (by Dot Blot, UNC vector core). This viral construct can now be ordered in single aliquots directly from UNC Vector core as product AAV-EF1a-DIO-hChR2(H134R)-EYFP, at http://genetherapy.unc.edu/services.htm) Implantation of electrode arrays for awake recordings Anaesthesia was induced with a mixture of ketamine and xylazine (100mg ketamine plus 5mg xylazine per kilogram of body weight i.p.) and maintained with isoflurane through a nose cone mounted on a stereotaxic apparatus (Kopf Instruments). The scalp was opened and a hole was drilled in the skull (0.0 to +1.0mm AP, -1.0 to -2.0mm ML from bregma). Two skull screws were implanted in the opposing hemisphere. Dental adhesive (C&B Metabond, Parkell) was used to fix the skull screws in place and coat the surface of the skull. An array of 16 or 32 microwires (35-��m tungsten wires, 100-��m spacing between wires, 200-��m spacing between rows; Innovative Physiology) and one optical fiber in a ferrule was lowered into the striatum (3.0mm below the surface of the brain) and cemented in place with dental acrylic (Ortho-Jet, Lang Dental). After the cement dried, the scalp was sutured shut. Animals were allowed to recover for at least seven days before striatal recordings were made. In vivo electrophysiology Voltage signals from each recording site on the microwire array were band-pass-filtered, such that activity between 150 and 8,000Hz was analysed as spiking activity. This data was amplified, processed and digitally captured using commercial hardware and software (Plexon). Single units were discriminated with principal component analysis (OFFLINE SORTER, Plexon). Two criteria were used to ensure quality of recorded units: (1) recorded units smaller than 100��V (~3 times the noise band) were excluded from further analysis and (2) recorded units in which more than 1% of interspike intervals were shorter than 2ms were excluded from further analysis. Average waveforms were exported with OFFLINE SORTER. During the recording we coupled the array to a laser and pulsed the laser at four intensities (0.1mW, 0.3mW, 1mW, and 3mW). Laser stimulation was run in a cyclical fashion, on for 1 second, and off for 3 seconds. Each neuron received 100 pulses at each laser intensity. Identification of ChR2 expressing units in in vivo recordings For all neurons, peri-event histograms were generated for each laser intensity independently. Neurons were classified as ChR2-expressing if they exhibited a firing rate greater than 3x above the standard deviation of the 1-second preceding the laser pulse within 10msec of the laser onset. Each neuron was tested independently at each laser power, and neurons that satisfied this criteria at any one power were defined as ChR2-expression.
Proper citation: Kravitz Dataset1 (RRID:SCR_008759) Copy
Data set of connection probabilities and PSP amplitudes from Chapeton, J., Fares, T., LaSota, D., and Stepanyants, A., Efficient associative memory storage in cortical circuits of inhibitory and excitatory neurons, PNAS, 109(51): E3614E3622 (2012). Available as a PDF under Resources tab.
Proper citation: experimental studies reporting connection probabilities and/or unitary PSP amplitudes (RRID:SCR_008995) Copy
THIS RESOURCE IS NO LONGER AVAILABLE,documented on February 1st, 2022. Instrument supplier providing eye tracking capabilities for behavioral labs as well as for MRI, MEG, and EEG research environments.
Proper citation: SR Research EyeLink Eye Trackers (RRID:SCR_009602) Copy
https://confluence.crbs.ucsd.edu/display/NIF/StemCellInfo
Data tables providing an overview of information about stem cells that have been derived from mice and humans. The tables summarize published research that characterizes cells that are capable of developing into cells of multiple germ layers (i.e., multipotent or pluripotent) or that can generate the differentiated cell types of another tissue (i.e., plasticity) such as a bone marrow cell becoming a neuronal cell. The tables do not include information about cells considered progenitor or precursor cells or those that can proliferate without the demonstrated ability to generate cell types of other tissues. The tables list the tissue from which the cells were derived, the types of cells that developed, the conditions under which differentiation occurred, the methods by which the cells were characterized, and the primary references for the information.
Proper citation: National Institutes of Health Stem Cell Tables (RRID:SCR_008359) Copy
http://www.nitrc.org/projects/bstp/
A free collection of MRI brain images for testing segmentation algorithms. It is available for download to assess the accuracy, reproducibility and sensitivity of MRI segmentation software. It includes data from infants and adults as well as patients with Alzheimer's disease.
Proper citation: Brain Segmentation Testing Protocol (RRID:SCR_009445) Copy
http://snyderome.stanford.edu/
Data set generated by personal omics profiling of Dr. Michael Snyder at Stanford University. It combines genomic, transcriptomic, proteomic, metabolomic, and autoantibody profiles from a single individual over a 14 month period. The analysis revealed various medical risks, including type II diabetes. It also uncovered extensive, dynamic changes in diverse molecular components and biological pathways across healthy and diseased conditions.
Proper citation: iPOP (RRID:SCR_008991) Copy
http://www.paris-neuroscience.fr/en/graduate-program
THIS RESOURCE IS NO LONGER IN SERVICE, documented on January 31, 2022. The Paris School of Neuroscience (ENP) is a network of outstanding neuroscience laboratories in Paris area, within major universities and research institutes. ENP aims at facilitating graduate training of selected students in the Paris area. It covers all areas of Neuroscience and associated methodologies, from fundamental to clinical and from molecular to cognitive. It brings together a majority of the outstanding teams in Neuroscience in le-de-France region. ENP forms a network of research groups, scientific and technological facilities, and research centers, with recognized expertise in Neuroscience, which is original at the international level. Pre-PhD and PhD programs are open to highly talented and motivated students, who received their undergraduate training outside of France, irrespective of their original disciplines. Pre-PhD > Up to a year of rotations in participating laboratories. This can include a Masters degree. PhD > Three year program (with possible one year extension). Training and Courses > Courses in neuroscience and relate topics ? International Conferences and seminars ? French language courses ? Individual supervision by a tutor and a thesis committee ? Annual retreat with faculty members and guest scientists. Principal activities : -Coordinating the offers of the associated universities to organize an advanced international doctoral training program -Facilitating collaborative efforts and innovative research of the participating laboratories -Attracting outstanding scientists to the le-de-France region and facilitating their setting up in Paris area -Organizing joint activities, including seminars, conferences, summer schools, workshops, symposia, etc.
Proper citation: Paris School of Neuroscience PhD Program (RRID:SCR_008355) Copy
Provides equipment for TEER measurement, nitric oxide testing, and electro-physiology applications.
Proper citation: World Precision Instruments (RRID:SCR_008593) Copy
Integrated framework for accessing grid resources that supports scientific exploration, workflow capture and replay, and a dynamic services oriented architecture. This framework provides researchers in the molecular sciences with a tool to discover remote grid application services and compose them as appropriate to the chemical and physical nature of the problem at hand. The initial set of application services include molecular quantum and classical chemistries (GAMESS, APBS, Polyrate), along with supporting services for visualization (QMView), databases, auxillary chemistry services, and documentation and education materials. * Rich-client Desktop Interface - Gemstone is a Firefox extension that provides a dynamic user interface to backend computational, data and visualization services. * Workflow Integration - Gemstone supports a workflow component based on Informnet (see http://grid-devel.sdsc.edu/informnet). They are adapting the Informnet workflow engine to support workflow publication and discovery, brokering, and fault tolerance. They are also adding support for automatic generation of workflows based on user interaction. * Strongy Typed Data Schemas - They are working extensively with CML, integrating their data schemas into workflow systems and providing bridges to the GamesXML that they defined.
Proper citation: Grid Enabled Molecular Science Through Online Networked Environments (RRID:SCR_008629) Copy
A data set designed to provide a cross-sectional description of health, mental, and social status of the oldest-old segment of the elderly population in Israel, and to serve as a baseline for a multiple-stage research program to correlate demographic, health, and functional status with subsequent mortality, selected morbidity, and institutionalization. Study data are based on a sample of Jewish subjects aged 75+, alive and living in Israel on January 1, 1989, randomly selected from the National Population Register (NPR), a complete listing of the Israeli population maintained by the Ministry of the Interior. The NPR is updated on a routine basis with births, deaths, and in and out migration, and corrected by linkage with census data. The sample was stratified by age (five 5-year age groups: 75-79, 80-84, 85-89, 90-94, 95+), sex, and place of birth (Israel, Asia-Africa, Europe-America). One hundred subjects were randomly selected in each of the 30 strata. However, there were less than 100 individuals of each sex aged 95+ born in Israel, so all were selected for the sample. The total group included 2,891 individuals living both in the community and in institutions. A total of 1,820 (76%) of the 75-94 age group were interviewed during 1989-1992. An additional cognitive exam (Folstein) and a 24-hour dietary recall interview were added in the second round. Kibbutz Residents Sample The kibbutz is a social and economic unit based on equality among members, common property and work, collaborative consumption, and democracy in decision making. There are 250 kibbutzim in Israel, and their population constitutes about 3% of the country''s total population. All kibbutz residents in the country aged 85+, both members and parents, were selected for interviewing, of whom 80.4% (n=652) were interviewed. A matched sample aged 75-84 was selected, and 85.9% (n=674) were successfully interviewed. The original interview took approximately two hours to administer, and collected extensive information concerning the socio-demographic, physical, health, functioning, life events (including Holocaust), depression, mental status, and social network characteristics of the sample. The questionnaire used for kibbutz residents in the follow-up interview is identical to that utilized in the national random sample. Data Availability: Mortality data for both the national and kibbutz samples are available for analysis as a result of the linkage to the NPR file updated as of June 2000. The fieldwork for first follow up was completed as of September 1994 and for the second follow up as of December 2002. The data file of the three phases of the study is ready for analysis. * Dates of Study: 1989-1992 * Study Features: Longitudinal, International * Sample Size: 2,891
Proper citation: Cross-Sectional and Longitudinal Aging Study (RRID:SCR_008903) Copy
https://github.com/BRAINSia/BRAINSTools/tree/master/TestData
About 1.2GB of anonymized imaging data of many different file formats used by the BRAINS suite of tools (BRAINSFit, GTRACT, BRAINS, BRAINSTracer... and others) as a common set of anonymized data for nightly regression testing.
Proper citation: BRAINSTestData (RRID:SCR_009517) Copy
http://www.rand.org/labor/FLS/MHSS.html
A data set of the health and socioeconomic factors that affect the elderly in Matlab, a region of rural Bangladesh. The survey captures measurements and statistics such as adult survival, health status, health care utilization, resource flows between generations and the impact of community services and infrastructure on adult health care. Data was collected through surveys that touch on four topics: household and individual information; determinants of natural fertility; migration out of the community; and community and provider survey of healthcare and education infrastructure.
Proper citation: Matlab Health and Socio-Economic Survey (RRID:SCR_008942) Copy
A dataset of a longitudinal study of over 3,000 Mexican-Americans aged 65 or over living in five southwestern states. The objective is to describe the physical and mental health of the study group and link them to key social variables (e.g., social support, health behavior, acculturation, migration). To the extent possible, the study was modeled after the existing EPESE studies, especially the Duke EPESE, which included a large sample if African-Americans. Unlike the other EPESE studies that were restricted to small geographic areas, the Hispanic EPESE aimed at obtaining a representative sample of community-dwelling Mexican-American elderly residing in Texas, New Mexico, Arizona, Colorado, and California. Approximately 85% of Mexican-American elderly reside in these states and data were obtained that are generalizable to roughly 500,000 older people. The final sample of 3,050 subjects at baseline is comparable to those of the other EPESE studies. Data Availability: Waves I to IV are available through the National Archive of Computerized Data on Aging (NACDA), ICPSR. Also available through NACDA is the ����??Resource Book of the Hispanic Established Populations for the Epidemiologic Studies of the Elderly����?? which offers a thorough review of the data and its applications. All subjects aged 75 or older were interviewed for Wave V and 902 new subjects were added. Hemoglobin A1c test kits were provided to subjects who self-reported diabetes. Approximately 270 of the kits were returned for analyses. Wave V data are being validated and reviewed. A tentative timeline for the archiving of Wave V data is November 2006. Wave VI interviewing and data collection is scheduled to begin in Fall 2006. * Dates of Study: 1993-2006 * Study Features: Longitudinal, Minority oversamples, Anthropometric Measures * Sample Size: ** 1993-4: 3,050 (Wave I) ** 1995-6: 2,438 (Wave II) ** 1998-9: 1,980 (Wave III) ** 2000-1: 1,682 (Wave IV) ** 2004-5: 2,073 (Wave V) ** 2006-7: (Wave VI) Links: * ICPSR Wave 1: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/2851 * ICPSR Wave 2: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/3385 * ICPSR Wave 3: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/4102 * ICPSR Wave 4: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/4314 * ICPSR Wave 5: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/25041 * ICPSR Wave 6: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/29654
Proper citation: Longitudinal Study of Elderly Mexican American Health (RRID:SCR_008941) Copy
http://www.usciences.edu/default.aspx
Proper citation: University of Sciences in Philadelphia; Pennsylvania; USA (RRID:SCR_008023) Copy
http://cnef.ehe.osu.edu/#sthash.WuGubz1D.dpuf
A dataset, 1970-2009, containing equivalently defined variables for the British Household Panel Study (BHPS), the Household Income and Labour Dynamics in Australia (HILDA), the Korea Labor and Income Panel Study (KLIPS) (new this year), the Panel Study of Income Dynamics (PSID), the Russia Longitudinal Monitoring Survey (RLMS-HSE) (new this year), the Swiss Household Panel (SHP), the Canadian Survey of Labour and Income Dynamics (SLID), and the German Socio-Economic Panel (SOEP). The data are designed to allow cross-national researchers not experienced in panel data analysis to access a simplified version of these panels, while providing experienced panel data users with guidelines for formulating equivalent variables across countries. The CNEF permit researchers to track yearly changes in the health and economic well-being of older people relative to younger people in the study countries. The equivalent file provides a set of constructed variables (for example pre- and post-government income and United States and international household equivalence weights) that are not directly available on the original surveys. Since the Cross-National Equivalent File 1970-2009 can be merged with the original surveys, PSID-CNEF users can easily incorporate these constructed variables into current analyses. The most recent release of the Equivalent File includes: * BHPS data from 1991 to 2005 on over 21,000 individuals and approximately 6,000 households. * GSOEP data from 1984 to 2007 on over 20,000 individuals and approximately 6,000 households in Germany. * HILDA data from 2001 to 2006 on over 19,000 individuals and 7,000 households. * PSID data from 1980 to 2005 on over 33,000 individuals and approximately 7,000 households. * SHP data from 1999 to 2006 on 12,900 individuals and 5,000 households. * SLID data from 1993 to 2006 on over 95,000 individuals and approximately 32,000 households. With one exception, the CNEF country data are available on CD-ROM from Cornell University for a fee. The Canadian SLID data are not distributed on the CD but are available to CNEF registered researchers through special arrangements with Statistics Canada. Complete instructions for obtaining CNEF data may be accessed on the project website. * Dates of Study: 1980-2007 * Study Features: International, Longitudinal * Sample Size: ** BHPS: 21,000+ ** PSID: 33,000+ ** SLID: 95,000+ ** GSOEP: 20,000+ ** HILDA: 19,000+ ** SHP: 12,900+ NACDA link: http://www.icpsr.umich.edu/icpsrweb/NACDA/studies/00145/detail
Proper citation: Cross-National Equivalent Files (RRID:SCR_008935) Copy
http://harvard.eagle-i.net/i/0000013c-fd63-dfbb-ea7a-a3a980000000
Core facility that provides the following services: Circulating Tumor Cell analysis, Circulating Tumor Cell Purification. The Circulating Tumor Cell Core Facility uses immunomagnetic technology developed by Veridex, LLC (Raritan, NJ) to isolate rare tumor cells from whole blood. Isolated tumor cells can then be counted or used for downstream analysis such as molecular studies or flow cytometry.
Proper citation: BWH Circulating Tumor Cell Core (RRID:SCR_008258) Copy
fNIR Imager 1100 is a new generation portable functional near-infrared (fNIR) imaging research tool capable of monitoring brain?s hemodynamics and thereby the cognitive state of the subject in natural environments. Neuroimaging Solution for Natural Environments: * fNIR is the only stand-alone and field-deployable technology able to determine localized brain activity. * fNIR can be readily integrated with other physiological and neurobehavioral measures that assess human brain activity, including eye tracking, pupil reflex, respiration and electrodermal activity. fNIR can also complement other techniques. * Studies have shown a positive correlation between a participant's performance and fNIR responses as a function of task load. * It has also been shown that fNIR can effectively monitor attention and working memory in real-life situations.
Proper citation: fNIR Devices (RRID:SCR_009623) Copy
http://www.nitrc.org/projects/eegdataanimal
A collection of 32-channel data from 14 subjects (7 males, 7 females) acquired using the Neuroscan software. Subjects are performing a go-nogo categorization task and a go-no recognition task on natural photographs presented very briefly (20 ms). Each subject responded to a total of 2500 trials. Data is CZ referenced and is sampled at 1000 Hz (total data size is 4Gb; more details are given later).
Proper citation: EEG human categorization data (RRID:SCR_009468) Copy
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