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https://www.research.chop.edu/flow-cytometry

Core provides access to instrumentation and technical expertise. Offers services, including sample preparation, advanced multi-color analysis, and high-speed cell sorting. Our experienced staff delivers personalized training and project-specific consultations.

Proper citation: Children's Hospital of Philadelphia Flow Cytometry Core Facility (RRID:SCR_009726) Copy   

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http://eagle-i.itmat.upenn.edu/i/00000142-47d2-2012-91c7-0c6080000000

The Clinical and Translational Research Center (CTRC) offers ophthalmological testing services for children. The Ophthalmology Core at CHOP?s CTRC was established t**provide clinical and translational research services in ophthalmology for the assessment of visual function and structure. Services provided include: * Eye exams (includes visual, recognition and grating acuity; anterior segment, fundus exam, refraction) **Contrast sensitivity **Color vision testing * Optical coherence tomography (OCT) tests of the: **Anterior segment **Posterior segment ? optic nerve **Posterior segment ? retin A* Visual field measures: **Using Humphrey **Using Goldman * Full field sensitivity testing * Electroretinography * Visual evoked potential * Fundus photography * Ocular ultrasound * Professional interpretation of all tests is als**available

Proper citation: CHOP CTRC Ophthalmology Core (RRID:SCR_009724) Copy   

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http://eagle-i.itmat.upenn.edu/i/0000013a-bc4e-ecdd-d69a-d90d80000000

Core facility that provides the following services: Clinical trials consultation service, Document storage service, Investigational new drug or investigational device exemption application support service, Institutional Review Board submission service, Additional regulatory submissions support service, Protocol development service, Human subject recruitment support service, Study feasibility service, Study placement service. The Clinical Trials Office (CTO) at The Children''s Hospital of Philadelphia is a centralized office that provides resources and assistance to clinical research investigators, enabling them to carry out clinical research in a manner consistent with the Hospital''s goals ? excellent patient care, top-quality education, and innovative research. The CTO has expertise in implementing, conducting, and monitoring clinical trials and provides a variety of services that benefit both novice and experienced clinical researchers. The CTO is designed to ensure the excellence and compliance of an investigator''s clinical research trial. The Children''s Hospital of Philadelphia established the CTO in 1999 as part of the institution''s emphasis on clinical research. Since then, the CTO has experienced rapid growth. The CTO advances the quality and quantity of clinical research at Children''s Hospital and its associated network. Specifically, the CTO supports research at the Hospital by developing and completing submissions to the Hospital''s Institutional Review Board; assisting in the preparation of Investigational New Drug and Investigational Device exemption application submissions to the Federal Drug Administration; conducting clinical research studies under the guidance of principal investigators; and developing budgets and providing research training for investigators, study coordinators, and administrative staff. The CTO staff works in partnership with investigators to ensure the protection of human subjects in accordance with Good Clinical Practice, federal, state and/or local regulations and the requirements of the study sponsor.

Proper citation: CHOP Clinical Trials Office (RRID:SCR_009725) Copy   

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http://eagle-i.itmat.upenn.edu/i/00000142-3843-baeb-91c7-0c6080000000

The Nutrition Assessment Unit of the Nutrition Core is a state-of-the-art facility for the assessment of growth and body dimensions, body composition (the amount of muscle, fat and bone in the body), energy expenditure, bone density, and muscle strength. The Unit has two locations and four experienced technicians for performing research assessments.

Proper citation: CHOP CTRC Nutrition Core Nutrition Assessment (RRID:SCR_009723) Copy   

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http://cau.eagle-i.net/i/00000135-abef-4d3d-ecf8-187780000000

We are equipped for proteomics research including Cell Fractionation on one floor and tabletop Ultracentrifuges (Beckman Coulter) , Fast Protein Liquid Chromatography (FPLC), Two-Dimensional Protein Electrophoresis (Protean II, Biorad), and Gel Documentation Systems (one Bio-Rad and one Fuji Medical). Protein quantification can be done using UV-Vis spectrophotometry ( DU650, Beckman Coulter) or multimode Plate Spectrophotometers in both 96-well and 384-well micro well plate formats. Protein gels can also be visualized, digitized, and documented on Multi-Mode Imager Typhoon 9410.

Proper citation: CAU CCRTD-Proteomics (RRID:SCR_009687) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-7cdd-51df-fbab-3b8480000000

Core facility that provides the following services: Data management/information technology subcore services, Statistical analysis and database consulting service, Limited statistical analysis service. The Biostatistics and Data Management Core (BDMC) at The Children''s Hospital of Philadelphia (CHOP) supports investigators from virtually all subspecialties of pediatric medicine and supports studies ranging from small, narrowly defined basic science projects to large, multi-site clinical trials. The Biostatistics and Data Management Core currently supports more than 50 funded studies and collaborates with investigators on numerous grant applications each year. The BDMC is staffed by a Scientific Director, Deputy Director, and data management/information technology managers, as well as approximately 20 additional staff members representing the disciplines of biostatistics, data management, information technology and administration. The BDMC is located on the CHOP campus (3535 Market Street), and is operated and supported by Westat, a large health research organization with extensive biostatistics, data management and information technology capabilities.

Proper citation: CHOP Biostatistics and Data Management Core (RRID:SCR_009720) Copy   

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http://harvard.eagle-i.net/i/0000012e-e30c-f348-cb22-be8c80000000

Core facility that provides the following services: Immunoassay expertise for several methodologies, Specialty hormone analysis. The Specialty Assay Research Core Lab (CLIA certified laboratory) is an analytical research core designed to provide scientific and analytical services to the Partners and non-Partners research communities. The primary objective of the core is to provide sensitive, cost-effective, and reproducible clinical research assays to investigators for endocrine, diabetes, bone markers, inflammatory and sleep medicine related research in both human and animal clinical research protocols. The core hopes to collaborate with investigators in biomarkers discovery and to offer new tools to the scientific community. The core also serves as a central laboratory for multisite studies. The SARC facility offers tests for any investigators (local or national) or industry, but preference may be given to internal users. Different rates may apply.

Proper citation: BWH Specialty Assay Research Core Laboratory (RRID:SCR_009686) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000013c-2506-8388-e81d-064c80000000

Core facility that provides the following services: PSG Procedures, PSG Data Archiving, PSG Training to Staff, PSG Data Processing and Analysis Support. The Sleep & EEG Core within the Division of Sleep Medicine (DSM) provides an integrated infrastructure and knowledge base in support of research projects that use polysomnography (PSG), quantitative EEG analysis and related methodologies. The Core consists of a team of specialists lead by the Core director and a chief PSG technologist. The Core provides support and services in different areas: # It provides basic training and certification in PSG and EEG instrumentation to technicians and investigators, particularly those conducting studies at the Center for Clinical Investigation (CCI) at Brigham and Women?s Hospital. # It acts as liaison between DSM investigators and CCI technical staff, and implements and monitors quality assurance measures. # It carries out standard vigilance state scoring of PSG recordings and different types of waking EEG and electrooculogram analyses. # It carries out spectral analysis of sleep and waking EEG. # It evaluates, acquires, and maintains PSG and EEG equipment used by investigators of the CCI. # It carries out PSG procedures such as sleep screens and multiple sleep latency tests. # It assists investigators in the analysis and interpretation of sleep and EEG data. Over the years, the Sleep & EEG Core has been a central part of many projects funded by NIH, the Air Force Office of Scientific Research (AFOSR), and the National Space Biomedical Research Institute (NSBRI) that had a main focus on the physiology of human sleep-wake regulation. Scientifically, the Core has contributed by providing investigators with important quantitative measures of homeostatic and circadian components of the human sleep-wake regulatory system.

Proper citation: BWH Sleep and EEG Core (RRID:SCR_009684) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-742b-7e73-c437-ff0b80000000

Core facility that provides the following services: DNA sequencing, Multiplex ligation-dependent probe amplification analysis, Capillary electrophoresis.

The DNA Sequencing Core mission is to provide a highly accurate, high quality DNA sequencing service to the BWH community and other users. Our turn-around-time is 36 to 72 hrs.

Proper citation: BWH DNA Sequencing Core (RRID:SCR_009682) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-b8f4-ce9f-4882-b08d80000000

Nuclear Medicine and Molecular Imaging performs non-invasive, painless imaging tests that can reveal important information about your child''s health. Nuclear medicine uses short-lived radiopharmaceuticals and specialized cameras to create images of the human body. The images show blood flow and functional and metabolic activity within organs and lesions. This technology allows early diagnosis and monitoring of disease and can often make invasive procedures unnecessary. It also complements information obtained from X-rays, computed tomography (CT), ultrasound, and magnetic resonance imaging (MRI). Some applications of nuclear medicine are used for treatment of certain specific diseases.

Proper citation: CHB Nuclear Medicine and Molecular Imaging (RRID:SCR_009717) Copy   

•   Source: SciCrunch Registry

http://www.dartmouse.org

Core facility that provides the following services: Medium-density speed congenic backcross service, Medium-density genetic background check service, DNA extraction. DartMouse is a not-for-profit core facility funded by the National Institutes of Health''s National Center for Research Resources. The mission of DartMouse is to facilitate the development of congenic mice in support of pre-clinical projects across the United States. Use of DartMouse allows the generation of congenic mice in 5 generations (~1.5 years), versus the 10 generations (~3 years) required by conventional back-crossing. Facility staff provides expert advice on mouse speed congenic development, mouse genetic background analysis, and mouse genetic mapping. Investigators provide us with mouse tail clippings. From these, DartMouse isolates genomic DNA and performs and analyzes complete genome-wide scans. We return data in graphical and spreadsheet formats, and make specific recommendations on breeder selection. We operate an Illumina BeadStation 500. Chips use a 1449 SNP array covering the mouse genome with an average density of <5 cM.

Proper citation: DartMouse - Speed Congenics (RRID:SCR_009757) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-a5a7-396c-55da-381e80000000

Core facility that provides the following services: Genome-scale screening of lentiviral human and mouse shRNA libraries.

The RNAi Screening Facility provides investigators with access to RNAi reagents and high-throughput screening technology. Lentiviral-based RNAi constructs against the human and mouse genomes are provided by the RNAi Consortium of the Broad Institute, and can be used to transduce a wide range of target cells, including primary and non-dividing cells. The Facility provides reagents, equipment, and technical expertise to design, optimize, and perform cell-based, arrayed lentiviral RNAi screens. Additionally, lentiviral RNAi constructs against individual genes can be requested.

Proper citation: DFCI RNA Interference Screening Facility (RRID:SCR_009755) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-cca8-e37a-a061-4a6580000000

The Molecular Diagnostics Laboratory provides such research services as microRNA expression profiling, human cell line identity verification, mutation detection for clinical research studies, and specimen processing for clinical research studies to investigators at the Dana Farber Cancer Institute, as well as to investigators at other institutions. Consultation on experimental design and assistance with data analysis are also available.

Proper citation: DFCI Shannon McCormack Advanced Molecular Diagnostics Laboratory (RRID:SCR_009756) Copy   

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http://mbcf.dfci.harvard.edu

Core offers services for genomic next-generation sequencing library preparation, sequencing and analysis applications including RNAseq, ChIPseq, ATACseq, CRISPR screening, whole genome methylation profiling, targeted resequencing, single-cell RNAseq, exome sequencing, and more. Performs bioinformatics analysis such as integration of multi-omics datasets or specialized analyses. Genomics core technology platforms include Illumina NovaSeq6000, NextSeq500s, MiSeqs, MiniSeq. High throughput sample preparation is performed on Beckman Coulter Biomek FX and i7 systems. Low throughput samples are prepared by technical staff.

Proper citation: Dana-Farber Cancer Institute Molecular Biology Core Facility (RRID:SCR_009754) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012f-bbba-4d59-de5a-673e80000000

Core facility that provides the following services: Cell Sorting.

The Flow Cytometry Core Facility provides sterile sorting and analysis of samples in support of research at DFCI. The core has 2 high-speed cell sorters, the BD FACSAria II SORP and BD FACSAria IIu with up to 12-color simultaneous detection utilizing multi-laser platforms. Sample populations can be sterile sorted into a variety of tubes or plates. The BD FACSAria II SORP and BD FACSAria IIu are both equipped with the Automated Cell Deposition Unit (ACDU) for sterile sinlge cell sorting into 96, 384 micro titer plates. The core presently has 2 analyzers, the BD LSRFortessa SORP and BD LSRII with up to 12-color simultaneous detection utilizing multi-laser platforms. The BD LSR II is also equipped with an HTS(high throughput sampler) for analyzing samples directly from 96 well micro titer plates as well as being able to run 5ml tubes. The Facility staff is available to assist researchers with their sorting and analysis needs. Researchers who would like to utilize the analyzers are trained so that they can analyze their experiments independently. The staff will assist with data acquisition and analysis as well as interpretation. They will also assist in experiment design and implementation as well as troubleshooting. Training sessions are available for researchers who would like to run their sorting experiments independently.

Proper citation: DFCI Flow Cytometry Core Facility (RRID:SCR_009751) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-a164-eaea-55da-381e80000000

Core facility that provides the following services: Graphics services, All Research Related Photography.

Medical Arts Core DFCI offers complete services for Publications, Presentations and Advertising as follows: Custom/Computer Graphics illustrations, Design and Consulting full productions services, Photoshop training. Posters Productions/Brochure Printing on best selection of paper, canvas material and Backlit poster films. Lamination, LCD announcements creation and posting. Research Related Photography Equipment: * iMAC and PC computers * Posters printer * LCD electronic announcements TV units * Backlit Display units * Laminator * Scanner * Digital camera

Proper citation: DFCI Medical Arts Core Facility (RRID:SCR_009752) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-58a1-825b-55da-381e80000000

Core facility that provides the following services: Data collection, data entry and analysis, Database design, data management and process tracking, Qualitative data collection, management and analysis.

The Survey and Data Management Core (SDMC) provides efficient, high-quality survey data collection and management services and consultation to support the research needs of investigators and staff throughout the Harvard Medical research community. The Core, housed within the Center for Population Sciences at the Dana-Farber Cancer Institute, is dedicated to rigorous quantitative and qualitative survey data collection and management.

Proper citation: DFCI Survey and Data Management Core (RRID:SCR_009750) Copy   

•   Source: SciCrunch Registry

http://tumormetrics.org/

Core facility that provides the following services: Reporting and database management service of radiological data for clinical trials, Radiologic exam quality control service.

The mission of the Tumor Imaging Metrics Core (TIMC) is to provide standardized, consistent, longitudinal radiological measurements to evaluate therapeutic response for DF/HCC clinical trials. The TIMC - * Makes reliable, quantitative, longitudinal measurements (such as RECIST, WHO, SWOG, standardized uptake value (SUV) etc.) of lesions from serial MRI, CT, PET, and PET/CT scan images * Presents results of analyses on a password-protected secure web-based report * Provides an independent service, with verifiable measurement of treatment response for patients enrolled in cancer center trials * Serves as a centralized, computerized resource to facilitate efficient internal or external auditing Reliable tracking of changes in lesion size or metabolism is essential for clinical trials that use radiological measurements as surrogate endpoints. The Tumor Imaging Metrics Core provides a service for managing these images, making measurements in a routine, reliable, and centralized way, and making results available to investigators efficiently.

Proper citation: DF/HCC Tumor Imaging Metrics Core Facility (RRID:SCR_009744) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-5de9-9aff-55da-381e80000000

Core facility that provides the following services: Histopathology analysis service, Histopathologic diagnosis training service, Cryosectioning service, Rodent necropsy service, Paraffin sectioning service, Bacteria, fungi, and inclusion bodies histological staining service, Rodent tissue processing, Carbohydrate and mucoproteins histological staining service, Connective tissue and muscle histological staining service, Cytoplasmic granules histological staining service, Fats and lipids histological staining service, Hematologic and nuclear elements histological staining service, Nerve cells and fibers histological staining service, Equipment training service, Equipment access service.

The Rodent Histopathology Core was founded in 1999 as one of the pathology cores within the Dana-Farber/Harvard Cancer Center. The Core was established to provide high quality professional, technical, and educational pathology services. The ultimate goal of the facility has been to support investigator research that leads to the identification of pathologic processes in mice and can be directly translatable to human disease. The core provides an essential and unique service to the many Center members and labs invested in mouse research. While many commercial and academic histology services are available, no other service is available that offers comparable high quality service with rapid turn around time and highly experienced professional supervision. The educational mission of the Core also adds an important dimension.

Proper citation: DF/HCC Rodent Histopathology Core Facility (RRID:SCR_009742) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9c6c-06ee-55da-381e80000000

PSL is a consultative Core with components in each of the five DF/HCC hospitals. We have established a web-based network of autonomous, distributed, searchable databases, which contain de-identified, coded, pathologic information on post-diagnostic, excess human materials (including frozen or paraffin-embedded tissues and bodily fluids). Standardized specimen core dataset includes age, gender, anatomic location, tissue type, and diagnoses. Access to the PSL is through the password-protected Harvard eCommons. Two types of generic PSL uses are envisioned: (1) Center members with eCommons accounts can quickly retrieve aggregated tissue availability information to determine the feasibility of a proposed study. (2) Approved investigators can discover and review materials from suitable, de-identified and coded cases online and then request the samples they want.

Proper citation: DF/HCC Pathology Specimen Locator (RRID:SCR_009741) Copy   

•   Source: SciCrunch Registry