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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
pNovo+
 
Resource Report
Resource Website
1+ mentions
pNovo+ (RRID:SCR_002860) software resource A de novo peptide sequencing algorithm using complementary higher-energy collisional dissociation (HCD) and electron transfer dissociation (ETD) tandem mass spectra. mass spectrometry, proteomics, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Chinese Academy of Sciences; Beijing; China
PMID:23272783 Free, Freely available biotools.pNovo_3, OMICS_02470 https://bio.tools/pNovo_3 SCR_002860 2026-08-01 12:01:57 7
pairheatmap
 
Resource Report
Resource Website
pairheatmap (RRID:SCR_003109) software resource A software tool to compare two heatmaps and discover patterns within and across groups. In the context of biology, group can be defined based on gene ontology. standalone software, r, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: CRAN
PMID:24016862 Free, Available for download, Freely available biotools:pairheatmap, OMICS_04853 https://www.rdocumentation.org/packages/pairheatmap/versions/1.0.1/topics/pairheatmap SCR_003109 pairheatmap: A tool for comparing heatmaps 2026-08-01 12:02:02 0
MFEprimer
 
Resource Report
Resource Website
10+ mentions
MFEprimer (RRID:SCR_003066) software resource A fast thermodynamics-based software program for checking PCR primer specificity against genomic DNA and mRNA/cDNA sequence databases. standalone software, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
PMID:22689644 Free, Available for download, Freely available biotools:mfeprimer-2.0, OMICS_02355 https://www.mfeprimer.com/ SCR_003066 MFEprimer-2.0 2026-08-01 12:02:01 19
eQtlBma
 
Resource Report
Resource Website
1+ mentions
eQtlBma (RRID:SCR_003102) software resource Software package that implements Bayesian statistical methods to detect eQTLs jointly in multiple subgroups (e.g. tissues). Key features are to borrow information across subgroups, to explicitly model heterogeneity (qualitatively and quantitatively), and to borrow information across genes to estimate hyper-parameters from the data (empirical Bayes). standalone software, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of Chicago; Illinois; USA
PMID:23671422 Free, Available for download, Freely available biotools:eqtlbma, OMICS_04875 https://bio.tools/eqtlbma SCR_003102 2026-08-01 12:02:26 5
Triplex
 
Resource Report
Resource Website
10+ mentions
Triplex (RRID:SCR_003061) software resource Software package that provides functions for identification and visualization of potential intramolecular triplex patterns in DNA sequence. The main functionality is to detect the positions of subsequences capable of folding into an intramolecular triplex (H-DNA) in a much larger sequence. The potential H-DNA (triplexes) should be made of as many canonical nucleotide triplets as possible. The package includes visualization showing the exact base-pairing in 1D, 2D or 3D. software package, mac os x, unix/linux, windows, r, gene regulation, sequence matching, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Bioconductor
PMID:23709494 Free, Available for download, Freely available OMICS_06259, biotools:triplex http://www.fi.muni.cz/~lexa/triplex/, https://bio.tools/triplex SCR_003061 triplex - Search and visualize intramolecular triplex-forming sequences in DNA 2026-08-01 12:02:25 10
bwtool
 
Resource Report
Resource Website
10+ mentions
bwtool (RRID:SCR_003035) software resource A command-line utility for bigWig files designed to read bigWig files rapidly and efficiently, providing functionality for extracting data and summarizing it in several ways, globally or at specific regions. Its functionality is subdivided into subprograms that roughly fall into three categories: data extraction, analysis, and data modification, although e.g. in the case of the matrix program or the sax program, the boundary between data extraction and analysis isn't very strong. The data modification programs all have the behavior that a bigWig is inputted and a new bigWig is outputted. standalone software, unix/linux, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:2448936 Free, Available for download, Freely available biotools:bwtool, OMICS_05125 https://bio.tools/bwtool SCR_003035 2026-08-01 12:02:00 21
SMRT View
 
Resource Report
Resource Website
1+ mentions
SMRT View (RRID:SCR_003029) software resource An open source Genome Browser that visualizes data generated by PacBio Sequencing Systems. * Users can explore and interact with all types of analysis results, including resequencing, De novo, cDNA, and barcoding. * Users can also visualize base modifications, base identification and motifs analysis results. standalone software, unix/linux, mac os x, windows, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
Free, Freely available biotools:smrt_view, OMICS_05137 https://bio.tools/smrt_view SCR_003029 SMRT-View 2026-08-01 12:02:24 9
ProRata
 
Resource Report
Resource Website
1+ mentions
ProRata (RRID:SCR_002988) software resource A quantitative proteomics software program for accurate protein abundance ratio estimation with confidence interval evaluation. standalone software, mass spectrometry, proteomics, stable isotope labeling, quantitative proteomics, proteomics, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Google Code
PMID:17037911 GNU General Public License, v3 biotools:prorata, OMICS_02502 https://bio.tools/prorata SCR_002988 ProRata: A quantitative proteomics program for accurate protein abundance ratio estimation with confidence interval evaluation, prorata - Quantitative Proteomics Software 2026-08-01 12:01:59 9
rbsurv
 
Resource Report
Resource Website
1+ mentions
rbsurv (RRID:SCR_001175) rbsurv software resource Software package that selects genes associated with survival. microarray, gene, survival, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioconductor
Free, Available for download, Freely available biotools:rbsurv, BioTools:rbsurv, OMICS_02088 https://bio.tools/rbsurv, https://bio.tools/rbsurv, https://bio.tools/rbsurv SCR_001175 rbsurv - Robust likelihood-based survival modeling with microarray data 2026-08-01 12:01:24 1
Sherman
 
Resource Report
Resource Website
100+ mentions
Sherman (RRID:SCR_001294) Sherman software resource Software tool to simulate FastQ files for high-throughput sequencing experiments. It allows the user to introduce various "contaminants" into the sequences, such as basecall errors, SNPs, adapter fragments etc., in order to evaluate the influence of common problems observed in many Next-Gen Sequencing experiments. perl, bisulfite sequencing, high-throughput sequencing, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Babraham Institute
Free, Available for download, Freely available biotools:sherman, OMICS_02041 http://www.bioinformatics.babraham.ac.uk/projects/sherman/ SCR_001294 Sherman - bisulfite-treated Read FastQ Simulator 2026-08-01 12:01:37 122
GenomicTools
 
Resource Report
Resource Website
GenomicTools (RRID:SCR_001205) GenomicTools software resource A flexible computational platform, comprising both a command-line set of tools and a C++ API, for the analysis and manipulation of high-throughput sequencing data such as DNA-seq, RNA-seq, ChIP-seq and MethylC-seq. It implements a variety of mathematical operations between sets of genomic regions thereby enabling the prototyping of computational pipelines that can address tasks from preprocessing and quality control to meta-analyses. The user can create average read profiles across transcriptional start sites or enhancer sites, quickly prototype customized peak discovery methods for ChIP-seq experiments, perform genome-wide statistical tests such as enrichment analyses, design controls via appropriate randomization schemes, among other applications. In addition to enabling rapid prototyping, the platform is designed to analyze large-datasets in a single-pass fashion in order to minimize memory and intermediate file requirements. The platform supports the widely used BED format to facilitate visualization as well as integration with existing platforms and pipelines such as Galaxy or BioConductor. high-throughput sequencing, rna-seq, chip-seq, genomics, sequencing, hi-c, epigenetics, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Google Code
PMID:22113082 Free, Available for download, Freely available biotools:genomictools, OMICS_02144 https://bio.tools/genomictools SCR_001205 GenomicTools: a computational platform for developing high-throughput analytics in genomics. 2026-08-01 12:01:34 0
PARalyzer
 
Resource Report
Resource Website
1+ mentions
PARalyzer (RRID:SCR_001208) PARalyzer software resource Software tool to generate a high resolution map of interaction sites between RNA-binding proteins and their targets. The algorithm utilizes the deep sequencing reads generated by the newly developed PAR-CLIP (Photoactivatable-Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation) protocol. The use of photoactivatable nucleotides in the PAR-CLIP protocol results in a more efficient crosslinking between the RNA-binding protein and its target relative to other CLIP methods; in addition a nucleotide substitution occurs at the site of crosslinking during Illumina library preparation. PARalyzer utilizes this nucleotide substition in a kernel density estimate classifier to generate the high resolution set of Protein-RNA interaction sites. interaction, rna-binding protein, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Duke University; North Carolina; USA
PMID:21851591 THIS RESOURCE IS NO LONGER IN SERVICE biotools:paralyzer, OMICS_02137 https://bio.tools/paralyzer SCR_001208 PAR-CLIP data analyzer, PARalyzer (PAR-CLIP data analyzer) 2026-08-01 12:01:42 6
ProbRNA
 
Resource Report
Resource Website
1+ mentions
ProbRNA (RRID:SCR_001288) ProbRNA software resource Software for computational identification of protein binding sites on RNAs using high-throughput RNA structure-probing data. high-throughput sequencing, probe, rna structure, rna, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Chinese University of Hong Kong; Hong Kong; China
PMID:24376038 THIS RESOURCE IS NO LONGER IN SERVICE biotools:probrna, OMICS_02195 https://bio.tools/probrna SCR_001288 2026-08-01 12:01:37 1
Sequedex
 
Resource Report
Resource Website
1+ mentions
Sequedex (RRID:SCR_001233) Sequedex software resource THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 18,2025.Software to classify the function and phylogeny of reads as short as 30 bp. It is flexible, which can utilize multiple data modules and downstream analysis scripts. It is fast, reading in signature lists of 5-500 million peptide signatures in 1-15 minutes, and subsequently processes genomic fragments at the rate of 6 Gbp/hr. It parallelizes without significant increase in memory requirements until I/O bound on multiple input files; parallelization works well on 64 processors. phylogenetic, function, profile, metagenomics, synthetic, dna sequence, classification, java, linux, mac os, genomic analysis, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Los Alamos National Laboratory
PMID:22925230 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_02110, biotools:sequedex https://bio.tools/sequedex SCR_001233 2026-08-01 12:01:25 1
PeakAnalyzer
 
Resource Report
Resource Website
1+ mentions
PeakAnalyzer (RRID:SCR_001194) PeakAnalyzer software resource A set of standalone software programs for the automated processing of any genomic loci, with an emphasis on datasets consisting of ChIP-derived signal peaks. The software is able to identify individual binding / modification sites from enrichment loci, retrieve peak region sequences for motif discovery, and integrate experimental data with different classes of annotated elements throughout the genome. PeakAnalyzer requires a peak file and a feature annotation file in BED or GTF format. Complete annotation files for the current builds of the human (HG19) and mouse (MM9) genomes are provided with the software distribution. genome, chip, signal peak, binding site, modification site, enrichment loci, peak region, sequence, motif, chip-seq, chip-chip, c++, java, linux, mac os x, windows, bed, gtf, annotation, r, high-throughput sequencing, chromatin binding, modification loci, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: European Bioinformatics Institute
PMID:20691053 Free, Available for download, Freely available biotools:peakanalyzer, OMICS_02156 https://bio.tools/peakanalyzer SCR_001194 2026-08-01 12:01:34 3
BreakSeq
 
Resource Report
Resource Website
1+ mentions
BreakSeq (RRID:SCR_001186) BreakSeq software resource Software for scanning reads from short-read sequenced genomes against a human breakpoint library to accurately identify structural variants (SVs). The library of breakpoints at nucleotide resolution were assembled from collating and standardizing ~2,000 published structural variants (SVs). For each breakpoint, its ancestral state (through comparison to primate genomes) was inferred and its mechanism of formation (e.g., nonallelic homologous recombination, NAHR). structural variant, breakpoint, nucleotide, fasta, gff, bowtie, genomic variation, junction mapping, insertion sequence, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Yale University; Connecticut; USA
PMID:20037582 THIS RESOURCE IS NO LONGER IN SERVICE biotools:breakseq, OMICS_02168 https://bio.tools/breakseq SCR_001186 Breakpoint Library and BreakSeq 2026-08-01 12:01:24 1
SLOPE
 
Resource Report
Resource Website
SLOPE (RRID:SCR_001185) SLOPE software resource Software that consists of two command-line utilities, slope_align (which finds the best split-read alignments to the reference genome) and slope_cluster (which clusters and outputs the alignments)., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. c++, alignment, cluster, command-line, reference genome, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of Utah; Utah; USA
PMID:20876606 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_02169, biotools:slope https://bio.tools/slope SCR_001185 2026-08-01 12:01:34 0
Genometa
 
Resource Report
Resource Website
Genometa (RRID:SCR_001181) Genometa software resource A Java based bioinformatics program which allows rapid analysis of metagenomic short read datasets. Millions of short reads can be accurately analysed within minutes and visualised in the browser component. A large database of diverse bacteria and archaea has been constructed as a reference sequence. The approach is based upon the established open source visualisation tool IGB and supported by the rapid alignment program bowtie. The Picard toolset for SAM files is also made use of. metagenomic, classify, windows, linux, java, bio.tools, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Hannover Medical School; Lower Saxony; Germany
PMID:22927906 Free, Available for download, Freely available biotools:genometa, OMICS_02175 https://bio.tools/genometa SCR_001181 Genometa - Rapid analysis of metagenomic short reads 2026-08-01 12:01:34 0
piCALL
 
Resource Report
Resource Website
1+ mentions
piCALL (RRID:SCR_001242) piCALL software resource Software to detect short insertion / deletion variants (and SNPs) from population sequence data, i.e. sequence reads generated from a population of individuals. It uses a probabilistic model to utilize sequence reads from a population of individuals to automatically account for context-specific sequencing errors associated with indels. piCALL is implemented in C for use on Linux platforms and can be applied to sequence data from different sequencing platforms. However, the method requires each individual in a dataset to be sequenced using the same platform. The reads for each individual should be aligned to the same reference genome sequence. Note that the program will not be able to call indels from individual sequence datasets or data from a small number of individuals. c, genotyping, indel, population, high-throughput sequencing, insertion, deletion, variant, single nucleotide polymorphism, linux, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Scripps Research Institute
PMID:21653520 OMICS_02098, biotools:picall https://bio.tools/picall http://polymorphism.scripps.edu/~vbansal/software/piCALL/ SCR_001242 2026-08-01 12:01:44 1
mapDamage
 
Resource Report
Resource Website
100+ mentions
mapDamage (RRID:SCR_001240) mapDamage software resource Software for tracking and quantifying DNA damage patterns among ancient DNA sequencing reads generated by Next-Generation Sequencing platforms. python, r, illumina, windows, perl, dna damage, dna sequencing, next-generation sequencing, dna, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of Copenhagen; Copenhagen; Denmark
PMID:23613487
PMID:21659319
DOI:10.1093/bioinformatics/btt193
Free, Available for download, Freely available OMICS_02099, biotools:mapdamage https://bio.tools/mapdamage, https://sources.debian.org/src/mapdamage/ SCR_001240 mapDamage 2.0, mapDamage: tracking and quantifying damage patterns in ancient DNA sequences, mapDamage2.0 2026-08-01 12:01:35 363

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