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http://projectreporter.nih.gov/project_info_description.cfm?aid=8661937&icde=19363283&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC

Initiative to assemble a multicenter team of expert neuroscientists to evaluate the late effects of Traumatic brain injury (TBI), including single and repetitive TBI of varying severity, and Chronic Traumatic Encephalopathy (CTE), using histological examination of postmortem bio specimens and neuroimaging tools as a foundation to develop in vivo diagnostics. As a first aim, this proposal will bring together a team of 5 accomplished neuropathologists in neurodegenerative disease to establish consensus criteria for the post-mortem diagnosis of CTE. This team will also define the stages of CTE pathology, the features that differentiate CTE from other neurodegenerations and the effects of substance abuse, and the characteristics of posttraumatic neurodegeneration after single TBI. As a second aim, this proposal will establish a national bio specimen and data bank for TBI (Understanding Neurological Injury and Traumatic Encephalopathy (UNITE) bio bank) by developing a nationwide brain donor registry and hotline to acquire high quality bio specimens and data. The UNITE bank will use strictly standardized protocols and a web-based interface to ensure that tissue and data are readily available to qualified investigators. Comprehensive retrospective clinical data including clinical symptoms, brain trauma and substance abuse history, and medical records (including common data elements) will be entered into a secure database. Behavioral/ mood dysfunction, cognitive changes, substance abuse and traumatic exposure will be correlated with quantitative assessment of the multifocal tauopathy, Ass deposition and axonal injury. As a third aim, neuroimaging signatures of the neuropathology will be determined in post-mortem tissue using high spatial resolution diffusion tensor imaging (DTI) and autoradiography using a highly selective PET ligand for tau. Quantitative assessment of axonal injury, tau, and Ass will be correlated with ex vivo DTI abnormalities and tau ligand autoradiography. Pilot neuroimaging studies of individuals at high risk for the development of CTE will also be conducted in the final 2 years of the proposal. This proposal will determine the clinical and neuroimaging correlates of CTE and posttraumatic neurodegeneration and create the groundwork for establishing their incidence and prevalence. This study will have a tremendous impact on public health of millions of Americans and greatly increase our understanding of the latent effects of brain trauma.

Proper citation: CTE and Post-traumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging (RRID:SCR_006543) Copy   

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https://www.crukscotlandinstitute.ac.uk/advanced-technologies/mass-spectrometry.html

Core offers proteomics and metabolomics services. Provides support from experimental design to execution, sample processing, data interpretation, and assistance with presentations, manuscript preparation for publication and deposition of data in public repository and data storage on local server. Provides service analysis of post-translational modifications, such as phosphorylation, ubiquitination, acetylation, and others, with precise site localization on either single protein or for entire proteome.Uses Orbitrap Fusion Lumos coupled to Easy-nLC 1200 HPLC system. Facility instruments are operated with various acquisition methods, including classic Data Dependent Analysis (DDA) or more recent Data Independent Analysis (DIA). Acquired data from different methods are used to accurately identify and measure abundance of proteins and peptides employing different quantitation strategies: Label-free, TMT, pulsed-SILAC and Isotope-labelled Iodoacetamide (for Cysteine oxidation).Provides specialized data analysis software like MaxQuant and Mascot for DDA, Spectronaut for DIA of clinical samples and Perseus and Scaffold for data compilation, analysis, and dissemination.

Proper citation: Cancer Research UK Scotland Institute Mass Spectrometry Core Facility (RRID:SCR_027652) Copy   

•   Source: SciCrunch Registry
  

http://jjj.biochem.sun.ac.za

A systems biology tool for simulation of kinetic models from a curated model database. JWS Online is both a repository of curated biochemical pathway models and a simulation tool for these models. Users are able to view the models in the database, select a particular model, alter its parameters and perform a simulation on it. JWS Online aims to provide a service to the Systems Biology community by 1) giving access to a database of curated models of biological systems, and 2) allowing the users to run these models in a web browser via an easy to use interface, and 3) helping in reviewing of manuscripts containing kinetic models. In addition to this service role, JWS Online is an important component of an ambitious research initiative: The Silicon Cell. Whereas as a service JWS Online is a repository of published models, in the research activity models are not stored as published but are changed to reflect standardized notation of metabolites and enzymes, and a direct link between model and experimental data is provided.

Proper citation: Online Cellular Systems Modelling (RRID:SCR_008127) Copy   

•   Source: SciCrunch Registry
  

http://www.rbcsyd.se/

To meet the law requirements and regulations of the National Board of the Southern Health Care Region, Region Skane and Lund University agreed to establish a common biobanking center for Southern healthcare region. Regional biobanksrcentrum will develop and maintain systems for quality assurance and integrity protected using biobanks. The Regional Biobank center is responsible for matters relating to the collection, storage and use of samples stored in biobanks in the Southern healthcare region. Regional Biobank center operations consist of: * to promote the use of biobank material is in accordance with legal requirements biobank * to promote integrity protected and safe storage of repository material * to provide information about the biobank law and biobank materials used for individual sample donors, health professionals, researchers and the public * to handle requests for modified consent and desire to destroy or de test * maintaining a current and privacy protected records of repository material in the region * work to the individual''s integrity will be strengthened in relation to research on biobank material. Tissue samples available to other parties, by surrendering, or by sending tissue samples for analysis, requiring the return or destruction, after completion of the analysis. Regional Biobank Centre (RBC) for the southern healthcare region was established in 2004 and was until 2010 in the Oncology Centre. As of January 1, 2011 it is under the management of RBC Labmedicin Skane.

Proper citation: Swedish Regional Biobank (RRID:SCR_004503) Copy   

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http://ecoli.naist.jp/GB8/

A database of high-throughput data being collected to understand comprehensively the living E. coli K-12 model cell. GenoBase is a public repository for sequence information, proteome, transcription, and metabolome data. The GenoBase contains columns labeled Gene, Synonym, ECK, Genome, ID, Left, Right, Direction, Description, Comment, and Status. The table displays two rows for each gene: one row shows data for the E. coli K-12 MG1655 genome; the other shows data for the E. coli K-12 W3110 genome. Left, Right, and direction give the coordinates and orientation of the gene. Search/Clip allows the user to find information in GenoBase based on gene, position, or DNA sequence. References is currently not fully operational. Other search allows execution of an SQL query., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: GenoBase (RRID:SCR_007682) Copy   

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https://ncats.nih.gov/grdr/rdhub

A database of biospecimens collected, stored, and distributed by biorepositories in the United States and around the globe. Its goals are: To help and assist interested parties and investigators search, locate, and identify desired biospecimens needed for their research; to facilitate collaboration and sharing of material and data among investigators across the globe; to accelerate research to facilitate the discovery of new treatments, therapeutics and eventually cures for rare diseases as well as common diseases; to identify, locate and increase the awareness of existing biorepositories across the globe; and to link the RD-HUB with the Global Rare Diseases Patient Registry and Data Repository (GRDR).

Proper citation: Biospecimens/Biorepositories: Rare Disease-HUB (RD-HUB) (RRID:SCR_004327) Copy   

•   Source: SciCrunch Registry
  

http://isa-tools.org

Desktop software suite targeted to curators and experimentalists that assists in the reporting and local management of experimental metadata, engages with minimum information checklists and ontologies and formats studies for submission to international public repositories. The ISA software suite is the product of an ongoing collaboration between various research and service groups from diverse life science domains. It represents an opportunity for the wider research community to start taking data management into their own hands by supporting graduated adherence to community standards and the efficient curation of experimental metadata at source, shielded from underlying complexities. The software suite is comprised of several platform-independent Java-based software components for local use, including a relational database, built around the ISA-Tab format. The components work both as stand-alone applications and as a unified system.

Proper citation: ISA Infrastructure for Managing Experimental Metadata (RRID:SCR_002041) Copy   

•   Source: SciCrunch Registry
  

https://www.ibis-network.org/index.html

Research study of brain development in infants and children with autism. Consortium of researchers across North America that work together to discover early changes in brain development of young children with autism. Participants will travel to their closest study location to receive developmental and behavioral assessments, MRI scan of the brain. Participants will be reimbursed for travel and related expenses. Families of children at high risk for developing symptoms of autism will receive assistance with referrals for local services. check if data repository is in the papers

Proper citation: IBIS Network (RRID:SCR_017399) Copy   

•   Source: SciCrunch Registry
  

http://stellabase.org

StellaBase is a genomics database of Nematostella vectensis. It allows users to query the assembled Nematostella genome, a confirmed gene library, and a predicted genome using both keyword and homology based search functions. Data provided by these searches will elucidate gene family evolution in early animals. Unique research tools, including a Nematostella genetic stock library, a primer library, a literature repository and a gene expression library will provide support to the burgeoning Nematostella research community. Supported by: National Science Foundation (Grant No. 0212773 to JRF)

Proper citation: StellaBase: Nematostella vactensis genomics database (RRID:SCR_005153) Copy   

•   Source: SciCrunch Registry
  

https://www.nih.gov/allofus-research-program/biobank

A biobank is a repository that stores and manages biological samples known as biospecimens for use in research. The Precision Medicine Initiative (PMI) Cohort Program biobank has been awarded to Mayo Clinic in Rochester, Minnesota. The biobank will support the collection, analyses, storage and distribution of biospecimens for research use. Data from laboratory analyses of biospecimens will be combined with an array of other lifestyle and health information provided by volunteers to help researchers continue to unravel individual differences that contribute to disease and response to treatments.

Proper citation: AllofUs Research Program Biobank (RRID:SCR_015679) Copy   

•   Source: SciCrunch Registry
  

https://charite3r.charite.de/en/3r_service/primary_tissue_pipeline

Specialized service at Charité – Universitätsmedizin Berlin that provides researchers with fresh, high-quality primary human biospecimens. By bypassing standard supply chains, it connects operating and clinical wards directly to research laboratories, supporting human-based methods to reduce reliance on animal experimentation. Operates as a central contact point, taking care of the logistics from project initiation to sample transfer. It coordinates with surgical clinics, pathology departments, and tissue repositories. Alongside the living biospecimens, the pipeline helps safely transfer relevant, pseudonymized patient data to research groups.

Proper citation: Charité Primary Tissue Pipeline (RRID:SCR_028446) Copy   

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https://med.stanford.edu/cancer/research/shared-resources/tissue-procurement.html

Procures and provides needed tissue specimens to Stanford Cancer Institute investigators to support cancer related research. Services include collecting and banking freshly frozen tumor and normal tissue from surgical material and autopsy specimens;Providing fresh tumor tissue for viable cell studies;Processing and banking blood from cancer patients;Maintaining tissue database with links to clinicopathological data;Providing histological staining and pathological review;Coordinating patient consent and assuring regulatory compliance.Provides portal to virtual bank which links inventories of specialized satellite repositories, including collections of hematological and neurosurgical specimens.

Proper citation: Stanford University School of Medicine Cancer Institute Tissue Procurement Shared Resource Core Facility (RRID:SCR_023387) Copy   

•   Source: SciCrunch Registry
  

http://floresta.eead.csic.es/footprintdb/index.php

Database with 2797 unique DNA-binding proteins (mostly transcription factors, TFs), 4196 Position Weight Matrices (PWMs) and 13161 DNA Binding Sites extracted from the literature and other repositories. The binding interfaces of (most) proteins in the database are inferred from the collection of protein-DNA complexes described in 3D-footprint. The database predicts transcription factors which bind a specific DNA site or motif and DNA motifs or sites likely to be recognized by a specific DNA-binding protein.

Proper citation: footprintDB (RRID:SCR_005368) Copy   

•   Source: SciCrunch Registry
  

https://ogrdb.airr-community.org/

Reference database of inferred immune receptor genes. Public repository used by immunologists and computational biologists to publish, review, and maintain adaptive immune receptor (antibody and T-cell receptor) genes. Curated database of Ig and TR receptor germline sequences. Provides sets for use in receptor repertoire annotation and analysis, in formats suitable for widely-used analysis tools. Enables reproducible, evidence-based analysis of immune receptor diversity across populations and species, supporting both fundamental immunology research and precision medicine applications.

Proper citation: Open Germline Receptor Database (RRID:SCR_028635) Copy   

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http://www.nitrc.org/projects/vmagnotta/

A Diffusion Tensor fiber tracking software suite that includes streamline tracking tools. The fiber tracking includes a guided tracking tool that integrates apriori information into a streamlines algorithm. This suite of programs is built using the NA-MIC toolkit and uses the Slicer3 execution model framework to define the command line arguments. These tools can be fully integrated with Slicer3 using the module discovery capabilities of Slicer3. NOTE: All new development is being managed in a github repository. Please visit, https://github.com/BRAINSia/BRAINSTools

Proper citation: GTRACT (RRID:SCR_009651) Copy   

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http://purl.bioontology.org/ontology/DIAGONT

A computational diagnostic ontology containing 91 elements, including classes and sub-classes, which are required to conduct SR-MA (Systematic Review - Meta Analysis) for diagnostic studies, that will assist in standardized reporting of diagnostic articles. They also report high percentage of agreement among five observers as a result of the inter-observer agreement that they conducted among them to tag 13 articles using the diagnostic ontology. Moreover, they extend their existing repository CERR-N (Center of Excellence in Research Reporting in Neurosurgery) to include diagnostic studies.

Proper citation: Diagnostic Ontology (RRID:SCR_010307) Copy   

•   Source: SciCrunch Registry
  

https://microscopydb.io/

Community-driven, centralized online repository of online microscopy resources. Searchable database for training and education materials, hardware and software tools, community forums, job postings (including internships, PhDs, and postdocs), and upcoming events like conferences, workshops, and webinars. The goal of MicroscopyDB is to make it easier for everyone to find online information related to microscopy. Contains links to existing online microscopy resources (educational materials, jobs etc.). Coordinated by BioImaging North America (BINA) with pilot funding from a grant awarded via the Chan Zuckerberg Initiative (CZI).

Proper citation: MicroscopyDB (RRID:SCR_029186) Copy   

•   Source: SciCrunch Registry
  

http://dataver.net/

DataVer is the premier data management verification service for scientific data. DataVer''s data management plan (DMP) Compliance Review and the companion Star Ratings will bring transparency to the investigator''s compliance with data management and sharing guidelines on a grant by grant basis. DataVer will accomplish this through 1) open publication of its review standards and procedures that it applies to all submitted grants and 2) openly report the results of its findings through its web portal so anyone can look up the compliance history of an investigator or lab. The Data Management Plan. The NIH and the NSF typically require a DMP detailing data types and quantity, its storage duration, and plans for making the data accessible to fellow scientists. The DMP is supposed to meet their published guidelines outlining the data management and sharing requirements to which the PI must agree as a condition of funding. The compliance record to date is less than ideal.. Institutional funders may not require a specific DMP as such but many have specific requirements for data management and post-grant data availability. While a specific DMP as such may not be produced for these grants, the data management and sharing is expected to comport with the funders'' guidelines. To date, there are no standardized or uniform means to track or assess the compliance of the investigator with the DMP or published guidelines. While individual institutions have tasked program managers with monitoring the compliance, the process is not uniform and the data stays within the specific institute, unavailable for other granting institutes or foundations. What DataVer does. DataVer offers two services with variations. First, it offers a DMP (or funder guideline) compliance review. For this DataVer compares the actual data management and data sharing of the grant funded data to the approved DMP and with the guidelines its funding agency(s). Second, DataVer rates the actual usability and accessibility of the data based on its own published standards on a three star rating scale. This indicates at a glance how well the data is organized and whether it''s available for reuse by an outside investigator. These procedures give the funders and the scientific community accurate, standardized and timely reports on an investigators'' data storage and data sharing in a publicly available database. We at DataVer believe this light, cast on actual data openness, will further encourage increased care in data management and archiving as well as increased data sharing. This openness and transparency will be a positive means to increase data management plan and guideline compliance, and will stimulate increased attention to the accessibility and usability of the data, so important to its reuse. We will offer a means by which universities, investigators, research facilities, and data repositories can obtain a compliance certification for consistently setting a high standard of data accessibility and usability across multiple grants. This certification is a means by which these stakeholders can demonstrate their achievement in support of data sharing. Grantors will be able to see an institution or facility''s pattern of compliance when deciding where to spend their limited resources.

Proper citation: DataVer (RRID:SCR_005954) Copy   

•   Source: SciCrunch Registry
  

http://www.mousephenotype.org/

Center that produces knockout mice and carries out high-throughput phenotyping of each line in order to determine function of every gene in mouse genome. These mice will be preserved in repositories and made available to scientific community representing valuable resource for basic scientific research as well as generating new models for human diseases.

Proper citation: International Mouse Phenotyping Consortium (IMPC) (RRID:SCR_006158) Copy   

•   Source: SciCrunch Registry
  

http://dbserv2.informatik.uni-leipzig.de:8080/onex/

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 6,2023. Web-based application that integrates versions of 16 life science ontologies including the Gene Ontology, NCI Thesaurus and selected OBO ontologies with data leading back to 2002 in a common repository to explore ontology changes. It allows to study and apply the evolution of these integrated ontologies on three different levels. It provides global ontology evolution statistics and ontology-specific evolution trends for concepts and relationships and it allows the migration of annotations in case a new ontology version was released

Proper citation: OnEx - Ontology Evolution Explorer (RRID:SCR_000602) Copy   

•   Source: SciCrunch Registry