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http://www.uab.edu/shp/drc/human-physiology-core-links

Core which incorporates and combines expertise and technology for assessment of hormones and other analytes in both humans and animal models; body composition and fat distribution; insulin sensitivity and substrate metabolism; energy expenditure; and cardiovascular function.

Proper citation: University of Alabama at Birmingham Diabetes Research Center Human Physiology Core Facility (RRID:SCR_015111) Copy   

•   Source: SciCrunch Registry

https://www.bif.northwestern.edu/

Shared use and training facility. Servies include Confocal Laser Scanning Microscopy, DIC (Differential Interference Contrast Microscopy), FCS (Fluorescence Correlation Spectroscopy), FLIP (Fluorescence-Loss-In-Photobleaching), FRAP (Fluorescence Recovery After Photobleaching),FRET (Fluorescence/ Forster Resonance Energy Transfer),Live-cell Imaging,Phase Contrast Microscopy,Widefield Fluorescence Microscopy,Image Processing and Analysis. Services include poster printing, and specimen preparation. Provides training for most instruments. Instruments include Leica DM6B Fluorescent Microscope (Hogan 5-112), Leica TCS SP8 Confocal Microscope (Hogan 5-128),Leica SP5 II Confocal Microscope (Hogan 5-114),Leica Spinning Disk Confocal Microscope (Hogan 5-113),DeltaVision Deconvolution Microscope (Hogan 5-111),Olympus IX83 Inverted Fluorescent Microscope (Silverman Hall 1-567),Olympus IX53 Inverted Color Microscope (Silverman Hall 1-567), LionHeart Automated Microscope BioTeck (Hogan 5-110).

Proper citation: Northwestern University Biological Imaging Core Facility (RRID:SCR_017767) Copy   

•   Source: SciCrunch Registry

http://nufab.northwestern.edu

Central micro/nano fabrication facility of Northwestern University. Provides range of nanofabrication equipment and technical expertise. Supports research in all areas of science, engineering, medicine, and interdisciplinary fields.

Proper citation: Northwestern University Micro/Nano Fabrication Core Facility (RRID:SCR_017779) Copy   

•   Source: SciCrunch Registry

https://sites.northwestern.edu/nucapt/

Facility specializes in high resolution chemical imaging by three dimensional atom probe tomography. APT produces three-dimensional (3D) atom-by-atom elementally and isotopically resolved image with sub-nanometer spatial resolution of sample volume typically 100 x 100 x 300 nm^3, by simultaneous high resolution direct-space imaging and atom-by-atom time of flight mass spectrometry. APT is particularly suited to study nano- or nanostructured materials.

Proper citation: Northwestern University Center for Atom Probe Tomography Core Facility (RRID:SCR_017770) Copy   

•   Source: SciCrunch Registry

https://geiselmed.dartmouth.edu/dartmouse/

Core dedicated to facilitation and development of congenic mice for pre clinical projects across United States. Provides genotyping, background checks to verify purity of mice DNA.

Proper citation: Darthmouth Geisel School of Medicine DartMouse Core Facility (RRID:SCR_017756) Copy   

•   Source: SciCrunch Registry

http://mmcri.org/ns/?page_id=221

Core provides viral vector services dedicated to development and production of viral vectors for angiogenesis, stem cell and regenerative medicine and clinical renal research. Viral vectors are produced in dedicated BL2 facility within MMCRI building. Vector systems currently being used include adenovirus, retrovirus and lentivirus. Services Available:Transfection and transduction of gene-specific viral DNA provided by principal investigators;Small, large and custom scale production of adenovirus;retrovirus and lentivirus (2nd and 3rd generation packaging);TCID50 titration of adenovirus;Titration of retrovirus and lentivirus (fluorescence marker or antibiotic resistance);Test for replication competent virus (RCV) in lentivirus preparations.

Proper citation: Maine Medical Center Research Institute Viral Vector Core Facility (RRID:SCR_017882) Copy   

•   Source: SciCrunch Registry

http://mass-spec.stanford.edu

Core mass spec and proteomic services include open access lab for trained users with GC/MS, LC/MS, high resolution LC/MS, and MALDI-TOF instruments, help with intact protein analysis, targeted quantitation, drug discovery support, pathway analysis, protein interactions, FFPE tissue analysis, both labeled and label-free proteomics, and more. Please contact SUMS to discuss these and other custom projects including new application development.

Proper citation: Stanford University Vincent Coates Foundation Mass Spectrometry Laboratory Core Facility (RRID:SCR_017801) Copy   

•   Source: SciCrunch Registry

https://www.brown.edu/research/facilities/flow-cytometry-and-sorting/home

Core provides technical assistance to Brown researchers by performing flow cytometry-based analysis and sorting. Facility has 4-laser, 19-parameter BD FACSAria IIIu for flow and sorting applications, as well as 3-laser, 15-parameter BD FACSCelesta equipped with high throughput system for analysis of samples from 96 well plates.

Proper citation: Brown University Flow Cytometry and Sorting Core Facility (RRID:SCR_017886) Copy   

•   Source: SciCrunch Registry

http://cells.nmh.org/

Core offers researchers, clinicians and biotech companies regulatory compliant labs and services to manufacture minimally manipulated and complex biotechnology products.

Proper citation: Northwestern University and Northwestern Memorial Health Mathews Center for Cellular Therapy Core Facility (RRID:SCR_017881) Copy   

•   Source: SciCrunch Registry

http://www.umb.edu/genomicscore

Center for Personalized Cancer Therapy Genomics Core offers sequencing services on Illumina HiSeq 2500 (v4; 1TB enabled) and Illumina MiSeq platforms, library preparation from DNA and RNA and sample QC services.Please create an iLab account to be able to use services.

Proper citation: University of Massachusetts Boston Advancing Personalized Cancer Medicine Through Research Genomics Core Facility (RRID:SCR_017858) Copy   

•   Source: SciCrunch Registry

https://www.brown.edu/research/facilities/bioimaging/

Core provides equipment and training dedicated to high resolution imaging in life sciences. Facility includes Transmission Electron Microscope, a Scanning Electron Microscope, three Fluorescence Microscopes, Fluorescence Stereomicroscope, four Confocal Laser Scanning Microscopes,Multiphoton Microscope, and software for image analysis.Maintains equipment for sample preparation, including critical point dryer, sputter coater, and microtomes for ultrathin sectioning. Listed within CoresRI.org.

Proper citation: Brown University Leduc Bioimaging Core Facility (RRID:SCR_017861) Copy   

•   Source: SciCrunch Registry

http://www.mayo.edu/research/core-resources/immunochemical-core/overview

Provides immunochemical, chemistry and immune testing to clinical and basic science researchers, develops and validates new assays, and improves current assay methodology. Services include Assay development, Automated chemistry analysis, Immunoassay analysis, Small molecule analysis,Mass Spectrometry, LC-MS/MS and HRAM LC-MS,Enzyme-linked immunosorbent (ELISA), Meso Scale Discovery (MSD), Luminex, and radioimmunoassay (RIA) procedures for various analytes.

Proper citation: Mayo Clinic Immunochemical Core Facility (RRID:SCR_017867) Copy   

•   Source: SciCrunch Registry

http://www.lrgc.ca/

Core provides Next Generation Sequencing and Bioinformatics services.Services include:RNA assessment using Agilent 2100 Bioanalyzer,Next Generation Sequencing:Single cell RNA-seq,DNA-seq,RNA-seq,miRNA-seq,ChIP-seq,Microbiome (16S rRNA),ATAC-seq,Data Analysis (Partek Flow, Transcription Analysis Console).

Proper citation: London Regional Genomics Centre Core Facility (RRID:SCR_017865) Copy   

•   Source: SciCrunch Registry

http://cryogenics.facilities.northwestern.edu/

Facility provides liquid helium and liquid nitrogen to researchers and laboratories at Northwestern University.

Proper citation: Northwestern University Cryogenics Core Facility (RRID:SCR_017869) Copy   

•   Source: SciCrunch Registry

http://sites.northwestern.edu/stemcell/

Core provides iPSC technology services.Specialize in creating custom patient-derived iPSCs, providing training in stem cell culture, project consultation, CRISPR gene editing services, cell banking, and facility usage.

Proper citation: Northwestern University Stem Cell Core Facility (RRID:SCR_017873) Copy   

•   Source: SciCrunch Registry

http://rppc.mccormick.northwestern.edu/

Core provides quality controlled recombinant proteins. rPPC operates based on the two service models: Training model where Northwestern researchers use specialized bioreactor systems and participate in hands-on-training activities and Production model where staff carry out expression (mg to gm scale) and purification of recombinant or synthetic biologics, including potential therapeutic proteins and peptides, among others. Main focus of rPPC is to be user-facility;facility has parallel bioreactor systems for multiplexed lab-scale cultivation of microbial, insect, and mammalian cells. rPPC also serves as a production facility, providing low-cost recombinant biologics for researchers at Northwestern University.Services include: TRANSFECTION/TRANSFORMATION, ANALYTICAL (SMALL SCALE) EXPRESSION IN E.COLI AND MAMMALIAN CELLS,PROTEIN EXPRESSION IN E. COLI (LARGE SCALE),PROTEIN EXPRESSION IN MAMMALIAN CELL SYSTEM (LARGE SCALE),PROTEIN EXPRESSION IN INSECT CELL SYSTEM,GENERATION OF MOUSE HYBRIDOMA, PRODUCING MONOCLONAL ANTIBODIES, per one fusion,RESCUING AND CULTIVATING EUKARYOTIC CELLS,DOWNSTREAM PROCESSING OF GROWN CULTURE (BEFORE PROTEIN PURIFICATION),RECOMBINANT PROTEIN PURIFICATION,TAG CLEAVAGE WITH TEV. PROTEASE,LARGE SCALE mAb PRODUCTION ,DNA PLASMID PROPAGATION AND PURIFICATION,SDS-PAGE ANALYSIS,WESTERN BLOT ANALYSIS, INSTRUMENT TIME SHARING TECHNICAL/INSTRUMENT ASSISTANCE TIME,PROTEIN RECOVERING FROM INCLUSION BODIES.

Proper citation: Northwestern University Recombinant Protein Production Core Facility (RRID:SCR_017872) Copy   

•   Source: SciCrunch Registry

http://www.greatlakesgenomics.uwm.edu

Core provides services which include massively parallel sequencing on Illumina MiSeq, traditional Sanger sequencing, fragment analysis, quantitative PCR, nucleic acid extractions and QC, and digital PCR. Offers various level of service for Sanger sequencing and qPCR from full service to ready to load plates. Trains researchers in laboratory techniques and provide protocols. Each MiSeq sequencing project and qPCR project is unique and specifically designed so experimental design should be discussed before collecting samples.

Proper citation: Wisconsin University Great Lakes Genomics Center Core Facility (RRID:SCR_017838) Copy   

•   Source: SciCrunch Registry

http://www.med.unc.edu/csb/sbi

Core provides consultations and collaborations on research studies requiring computational structural biology methods. Analyses available are to study of static structures, molecular dynamics studies for analyzing contribution of dynamic and collective motions to macromolecular functionality. Trains researchers in computational structural biology techniques, or works in collaborative manner with researchers.Provides access to software tools for protein and DNA sequence analysis, protein fold determination, homology modeling, active site identification, and analysis of effects of various mutations on structure and function of protein, along with additional computational analyses.

Proper citation: North Carolina University at Chapel Hill R.L. Juliano Structural Bioinformatics Core Facility (RRID:SCR_017836) Copy   

•   Source: SciCrunch Registry

http://www.scripps.edu/florida/technologies/xray/contacts.html

Core provides equipment and resources for crystallographic analysis of target macromolecules and small inorganic or organic molecules. Performes crystallization, X-ray diffraction data collection (both in-house and synchrotron sources) processing, phasing, crystallographic refinement, model building, and visualization. Structural data provide information including biological functions, 3D-folding, ligand binding (small molecule or protein), or mutational effect of target macromolecules. Services include Crystallization Screening; Data Collection Service: Diffraction experiments will be performed at in-house X-ray facility as well as synchrotron beam lines; Structure Determination and Analysis: complete data set collected at home or synchrotron will be processed for inorganic, organic, protein or nucleic acid structure determination, model building and crystallographic refinement. Other Structural Biology Related Services: core facility offers thorough analysis of macromolecular structure for publication or grant applications, also provides computational experiments such as homology modeling and in silico ligand docking.

Proper citation: Scripps Research Institute - Florida X ray Crystallography Core Facility (RRID:SCR_017835) Copy   

•   Source: SciCrunch Registry

https://www.med.unc.edu/csb/nmr/

Core to support academic and industrial users. Spectrometer time is available to trained users for an hourly fee. Lab manager trains new users, consults to determine whether NMR will be useful in their research, and helps design experimental plan to obtain information they need. Manager also operates spectrometer for users whose experiments do not justify time and expense of individual training.

Proper citation: North Carolina University at Chapel Hill School of Medicine Biomolecular NMR Laboratory Core Facility (RRID:SCR_017841) Copy   

•   Source: SciCrunch Registry