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http://mass-spec.stanford.edu

Core mass spec and proteomic services include open access lab for trained users with GC/MS, LC/MS, high resolution LC/MS, and MALDI-TOF instruments, help with intact protein analysis, targeted quantitation, drug discovery support, pathway analysis, protein interactions, FFPE tissue analysis, both labeled and label-free proteomics, and more. Please contact SUMS to discuss these and other custom projects including new application development.

Proper citation: Stanford University Vincent Coates Foundation Mass Spectrometry Laboratory Core Facility (RRID:SCR_017801) Copy   

•   Source: SciCrunch Registry

https://www.bif.northwestern.edu/

Shared use and training facility. Servies include Confocal Laser Scanning Microscopy, DIC (Differential Interference Contrast Microscopy), FCS (Fluorescence Correlation Spectroscopy), FLIP (Fluorescence-Loss-In-Photobleaching), FRAP (Fluorescence Recovery After Photobleaching),FRET (Fluorescence/ Forster Resonance Energy Transfer),Live-cell Imaging,Phase Contrast Microscopy,Widefield Fluorescence Microscopy,Image Processing and Analysis. Services include poster printing, and specimen preparation. Provides training for most instruments. Instruments include Leica DM6B Fluorescent Microscope (Hogan 5-112), Leica TCS SP8 Confocal Microscope (Hogan 5-128),Leica SP5 II Confocal Microscope (Hogan 5-114),Leica Spinning Disk Confocal Microscope (Hogan 5-113),DeltaVision Deconvolution Microscope (Hogan 5-111),Olympus IX83 Inverted Fluorescent Microscope (Silverman Hall 1-567),Olympus IX53 Inverted Color Microscope (Silverman Hall 1-567), LionHeart Automated Microscope BioTeck (Hogan 5-110).

Proper citation: Northwestern University Biological Imaging Core Facility (RRID:SCR_017767) Copy   

•   Source: SciCrunch Registry

http://nufab.northwestern.edu

Central micro/nano fabrication facility of Northwestern University. Provides range of nanofabrication equipment and technical expertise. Supports research in all areas of science, engineering, medicine, and interdisciplinary fields.

Proper citation: Northwestern University Micro/Nano Fabrication Core Facility (RRID:SCR_017779) Copy   

•   Source: SciCrunch Registry

https://sites.northwestern.edu/nucapt/

Facility specializes in high resolution chemical imaging by three dimensional atom probe tomography. APT produces three-dimensional (3D) atom-by-atom elementally and isotopically resolved image with sub-nanometer spatial resolution of sample volume typically 100 x 100 x 300 nm^3, by simultaneous high resolution direct-space imaging and atom-by-atom time of flight mass spectrometry. APT is particularly suited to study nano- or nanostructured materials.

Proper citation: Northwestern University Center for Atom Probe Tomography Core Facility (RRID:SCR_017770) Copy   

•   Source: SciCrunch Registry

https://geiselmed.dartmouth.edu/dartmouse/

Core dedicated to facilitation and development of congenic mice for pre clinical projects across United States. Provides genotyping, background checks to verify purity of mice DNA.

Proper citation: Darthmouth Geisel School of Medicine DartMouse Core Facility (RRID:SCR_017756) Copy   

•   Source: SciCrunch Registry

http://www.greatlakesgenomics.uwm.edu

Core provides services which include massively parallel sequencing on Illumina MiSeq, traditional Sanger sequencing, fragment analysis, quantitative PCR, nucleic acid extractions and QC, and digital PCR. Offers various level of service for Sanger sequencing and qPCR from full service to ready to load plates. Trains researchers in laboratory techniques and provide protocols. Each MiSeq sequencing project and qPCR project is unique and specifically designed so experimental design should be discussed before collecting samples.

Proper citation: Wisconsin University Great Lakes Genomics Center Core Facility (RRID:SCR_017838) Copy   

•   Source: SciCrunch Registry

http://www.med.unc.edu/csb/sbi

Core provides consultations and collaborations on research studies requiring computational structural biology methods. Analyses available are to study of static structures, molecular dynamics studies for analyzing contribution of dynamic and collective motions to macromolecular functionality. Trains researchers in computational structural biology techniques, or works in collaborative manner with researchers.Provides access to software tools for protein and DNA sequence analysis, protein fold determination, homology modeling, active site identification, and analysis of effects of various mutations on structure and function of protein, along with additional computational analyses.

Proper citation: North Carolina University at Chapel Hill R.L. Juliano Structural Bioinformatics Core Facility (RRID:SCR_017836) Copy   

•   Source: SciCrunch Registry

http://www.scripps.edu/florida/technologies/xray/contacts.html

Core provides equipment and resources for crystallographic analysis of target macromolecules and small inorganic or organic molecules. Performes crystallization, X-ray diffraction data collection (both in-house and synchrotron sources) processing, phasing, crystallographic refinement, model building, and visualization. Structural data provide information including biological functions, 3D-folding, ligand binding (small molecule or protein), or mutational effect of target macromolecules. Services include Crystallization Screening; Data Collection Service: Diffraction experiments will be performed at in-house X-ray facility as well as synchrotron beam lines; Structure Determination and Analysis: complete data set collected at home or synchrotron will be processed for inorganic, organic, protein or nucleic acid structure determination, model building and crystallographic refinement. Other Structural Biology Related Services: core facility offers thorough analysis of macromolecular structure for publication or grant applications, also provides computational experiments such as homology modeling and in silico ligand docking.

Proper citation: Scripps Research Institute - Florida X ray Crystallography Core Facility (RRID:SCR_017835) Copy   

•   Source: SciCrunch Registry

http://www.einstein.yu.edu/departments/genetics/resources/molecular-cytogenetics-core.aspx

Core provides tools for preparation of human and murine samples suitable for molecular genetic and cytogenetic analysis of entire genome. These tools include establishment of EBV transformed cell lines; isolation of DNA and mRNA from variety of tissue culture samples as well as primary biopsies; preparation of metaphase chromosomes suitable for fluorescence in situ hybridization (FISH) and Spectral Karyotyping (SKY) or whole chromosome paints for human and mouse genome. Core personnel is trained to hybridize commercial probes and to designed locus specific probes for regions of interest to investigators. All probes are custom designed and in house generated.

Proper citation: Albert Einstein College of Medicine Molecular Cytogenetics Core Facility (RRID:SCR_017815) Copy   

•   Source: SciCrunch Registry

https://umiamihealth.org/sylvester-comprehensive-cancer-center/research/research-resources/shared-resources/flow-cytometry-shared-resource

Core provides analytical and preparative flow cytometers, to facilitate range of experiments in biology of both normal and cancer cells. Experimental analyses, including:Complex, 19 fluorescence parameter immuno-phenotyping;DNA content, ploidy and cell cycle analysis; 17 fluorescence parameter cell sorting and single-cell flow cloning; High speed (10,000 � 30,000+ cells per second) and efficiency (95%+ purity) cell sorting;Assessment of apoptosis;Molecular cytogenetics;Cell function studies;Micro-biological applications;Multiplexed and micro-particle-based analysis;Mass cytometry analysis and imaging;Fluidigm Helios plasma mass cytometer. Cells are labeled with antibodies conjugated to heavy metal markers, vaporized in plasma and detected with time-of-flight mass spectrometry;Fluidigm Hyperion solid tissue imager provides simultaneous imaging of labeled solid tissue sections, for mass cytometry analysis. FCSR has bank of metal reagent kits (for custom antibody conjugation), available for purchase at favorable rates compared to those available commercially. The bank has 35 unique labeling metals, for users to create custom reagents and panels. Please contact FCSR for further information and pricing. Robotic automated cell transfer A.L.S. CellCelector automated cell transfer robot. For automated transfer of single cells and colonies from culture plates, without pre-treatment. Integral bio-safety cabinet for BSL-2 cultures.

Proper citation: Miami University SCCC Flow Cytometry Core Facility (RRID:SCR_017817) Copy   

•   Source: SciCrunch Registry

http://neuralsci.org/neuracell

Core facility provides neural stem cells (NSC) and everything you need to grow them, custom lentiviral shRNA and over-expression vectors, consult based characterization service where we can assess how your products or reagents affect stem cell performance and behavior. Services include:Cell Supply,Adult SVZ Neural Stem Cells,Any Age Embryonic stem cells from any region of the brain,Human Retinal Pigmented Epithelial cells,RPE iPSCs,iPSCs,Neural Progenitor Cells (NPCs),Custom Orders,Media/ Dissociation Reagents,High-performance Media formulated according to optimal cell growth conditions,Complete Defined Media for Neural Stem Cell Culture,Complete Defined Media for Human Retinal Pigmented Epithelial Culture,Cell characterization. Performs assays to verify how stem cell populations behave in response to certain environments, plastics, reagents, etc., using trade secret assays via FACS and cell culture techniques. This can be used for neural stem cells as well as embryonic stem cells.Cell banking solutions shall ensure that their integrity is maintained, and that sufficient supply is readily available. We will also expand cells, harvest cells, generation the freezing medium and thaw cells to test performance. Provides Generation of custom lentiviral shRNA constructs,Generation of custom lentiviral over-expression constructs,Supply of NSC lines already expressing these shRNA or over-expression constructs.

Proper citation: Neural Stem Cell Institute NeuraCell Core Facility (RRID:SCR_017821) Copy   

•   Source: SciCrunch Registry

http://www.ucdmc.ucdavis.edu/cancer/research/sharedresources/flowcytometry.html

Core provides access to expertise and instrumentation for analytical flow cytometry, cell sorting and laser scanning cytometry.Cell sorting and analytical cytometers are located at three sites in Davis and Sacramento for research use on recharge basis. Provides cell sorters for assisted sorting on appointment basis and provides training to investigators in acquiring data on analytic cytometers.Can advise on experiment design for flow cytometry, provides training to enable independent use of analytical cytometers, and familiarize investigators with popular data analysis software tools such as BD Diva and CellQuest, FlowJo, ModFit and iBrowser.

Proper citation: University of California Davis Flow Cytometry Shared Resource Laboratory Core Facility (RRID:SCR_017826) Copy   

•   Source: SciCrunch Registry

http://hihg.med.miami.edu/cgt/gene-expression

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 27,2025. CGT gene expression core utilizes Affymetrix GeneChip Arrays and Illumina BeadChips to identify gene expression variation in single genes, targeted set of genes, or entire genomes. Affymetrix GeneChip Arrays Human Gene ST,Human Transcriptome Array 2.0, Human Exon ST, Human miRNA, Illumina Expression, HumanHT-12 v4 BeadChip.

Proper citation: University of Miami Miller School of Medicine Gene Expression Core Facility (RRID:SCR_017825) Copy   

•   Source: SciCrunch Registry

https://chemistry.as.miami.edu/research-facilities/x-ray-crystallography-resources/index.html

Core provides upgraded Bruker SMART 1000 CCD single crystal diffractometer to SMART APEX II CCD Area Detector, and its low-temperature LT3 device to KRYO-FLEX low-temperature device. Instrument which is equipped with Mo radiation source is used for small molecule crystal structure determination.

Proper citation: Miami University X-Ray Crystallography Resources Core Facility (RRID:SCR_017824) Copy   

•   Source: SciCrunch Registry

https://med.virginia.edu/flow-cytometry-facility/

Services include unassisted and assisted sample acquisition, cell sorting, mass cytometry (CyTOF), Luminex cytokine assays, antibody conjugation and data analysis.

Proper citation: University of Virginia School of Medicine Flow Cytometry Core Facility (RRID:SCR_017829) Copy   

•   Source: SciCrunch Registry

http://www.molbio1.princeton.edu/macro/

Facility helps with structure determination and analysis on service basis, but also encourages users with prior experience to use facilities independently. Offers services for setting up crystallization trials, x-ray data collection, structure determination and structure analysis. Assists in interpretation of existing structures available in Protein Data Bank and assists in homology modeling.

Proper citation: Princeton University Macromolecular Crystallography Core Facility (RRID:SCR_017833) Copy   

•   Source: SciCrunch Registry

https://med.psu.edu/core/mass-spectrometry

Core provides mass spectrometry analyses and identification of proteins, peptides, oligonucleotides, carbohydrates and small molecules.Other services include separations of complex protein and/or peptide mixtures; protein expression analysis (iTraq, SILAC, SWATH/DIA label-free); quantitation of protein, cytokine, amino acid and other small-molecule levels; bioinformatics; spot-cutting and robotics; and gel imaging and analysis., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: Penn State College of Medicine Mass Spectrometry and Proteomics Core Facility (RRID:SCR_017831) Copy   

•   Source: SciCrunch Registry

https://voices.uchicago.edu/cscenter/

Facility provides high throughput cell- and non-cell-based screening. Has number of validated cell lines and variety of small molecule or siRNA screening libraries available to investigators.

Proper citation: University of Chicago Cellular Screening Center Core Facility (RRID:SCR_017914) Copy   

•   Source: SciCrunch Registry

https://him.uchicago.edu/

Facility serves as specialized laboratory performing correlative assays for cancer-based clinical trials. Participates in project development to assist in assay selection and optimization prior to study initiation. Offers pick-up service for specimens from patients at U of C Hospital or outpatient clinics, and process samples as indicated for assays being performed. For some studies, isolation and freezing of peripheral blood lymphocytes for analysis at later date is performed, while for others immediate staining of whole blood for specific cell surface markers of interest is carried out. Prepares clinical grade products, such as peptide vaccines, for administration into patients.Assays performed include ELISA, ELISPOT, tetramer binding assays, detection of cell surface markers by flow cytometry, and biochemical assays such as Western Blots, RNA extraction from tumor biopsies and either real time RT-PCR for specific transcripts or preparation of samples for gene expression profiling. Facility is equipped with MACSQuant Flow Cytometer, ELISA microplate reader, ELISPOT reader, PCR thermocyclers, CO2 incubators, biosafety cabinets, centrifuges, and equipment for Western blot analysis. Performs assays on human samples but consideration will be given to expanding these services to mouse-model systems.

Proper citation: University of Chicago Human Immunologic Monitoring Core Facility (RRID:SCR_017916) Copy   

•   Source: SciCrunch Registry

http://mmcri.org/ns/?page_id=221

Core provides viral vector services dedicated to development and production of viral vectors for angiogenesis, stem cell and regenerative medicine and clinical renal research. Viral vectors are produced in dedicated BL2 facility within MMCRI building. Vector systems currently being used include adenovirus, retrovirus and lentivirus. Services Available:Transfection and transduction of gene-specific viral DNA provided by principal investigators;Small, large and custom scale production of adenovirus;retrovirus and lentivirus (2nd and 3rd generation packaging);TCID50 titration of adenovirus;Titration of retrovirus and lentivirus (fluorescence marker or antibiotic resistance);Test for replication competent virus (RCV) in lentivirus preparations.

Proper citation: Maine Medical Center Research Institute Viral Vector Core Facility (RRID:SCR_017882) Copy   

•   Source: SciCrunch Registry