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https://www.lerner.ccf.org/cores/electron-microscopy/

Transmission (TEM), Scanning (SEM), 2D tile scanning SEM and 3DSEM electron microscopy are available in the Core for imaging and analyzing specimens at the ultrastructural level. Possible samples include fresh tissue specimens, cultured cells growing on a substrate, cells in suspension or subcellular fractions (for purity determinations). Sub-cellular localization of antigens within cells by immunogold labeling can be performed, as well as negative staining for visualizing samples such as microparticles and exosomes. Elemental analysis (EDAX) is also available together with SEM.

Proper citation: Cleveland Clinic Lerner Research Institute Electron Microscopy Core Facility (RRID:SCR_027161) Copy   

•   Source: SciCrunch Registry

https://www.mayo.edu/research/core-resources/cytometry-cell-imaging-core/overview

Core provides researchers with access to equipment in three main pipelines: Cell and tissue imaging resources, including microscopes and a slide scanner; Flow cytometry, including analytical flow cytometry and cell sorting; Mass cytometry (CyTOF). Provides consultation services including panel and experiment design, sample preparation tips and technical troubleshooting, training for independent use on select equipment, data acquisition and cell sorting.

Proper citation: Mayo Clinic Florida Cytometry and Cell Imaging Core Facility (RRID:SCR_027292) Copy   

•   Source: SciCrunch Registry

https://augusta.corefacilities.org/service_center/show_external/5130?name=transgenic-genome-editing-core

Core provides services in gene editing using CRISPR/Cas9 approach, services on preserving lines by cryopreservation of sperms, and resurrecting mouse lines using in vitro fertilization (IVF) or embryo transfer. Additional services include rederivation to create pathogen-free mouse lines, developing molecular reagents for genetic engineering, and providing expert advice on mouse genetics and breeding schemes.

Proper citation: Augusta University Transgenic and Genome Editing Core Facility (RRID:SCR_027269) Copy   

•   Source: SciCrunch Registry

https://www.augusta.edu/mcg/discovery/vdi/visual-function-assessment-core.php#content-third

Core provides equipment, expertise, and training for researchers to assess rodent vision in vivo. Offers technical expertise, training, and instrumentation for in vivo visual function assessment in animal models including rodents.

Proper citation: Augusta University Visual Function Assessment Core Facility (RRID:SCR_027277) Copy   

•   Source: SciCrunch Registry

https://www.cio.mx/microscopia_LMO.php

Core offers services in Confocal/Multiphotonic Microscopy, Raman Microscopy, Fluorescence/Pseudo Dark Field Microscopy,AFM. Available to students and researchers working and interested in research areas including optics, biology, materials, chemistry, and health sciences.

Proper citation: Government of Mexico Science and Technology Center for Research in Optics (CIO) Optical Microscopy Laboratory Core Facility (RRID:SCR_027310) Copy   

•   Source: SciCrunch Registry

https://wertheim.scripps.ufl.edu/cores-and-technologies/metabolic-core/

Core for In Vivo and In Vitro metabolic phenotyping. Provides validated in vitro and in vivo tests. Phenotyping applications span from mitochondrial and cellular metabolism to whole body animal physiology. Provides instrument training, experimental design, data analysis. Studies can be performed by staff, but IACUC-approved Animal Use Protocols are also available to help investigators use resources on their own.

Proper citation: University of Florida Scripps Institute for Biomedical Innovation and Technology Metabolic Core Facility (RRID:SCR_027279) Copy   

•   Source: SciCrunch Registry

https://www.mayo.edu/research/core-resources/cytometry-cell-imaging-core/overview

Cytometry and Cell Imaging Core provides researchers with access to equipment in three main pipelines:Cell and tissue imaging resources, including microscopes and a slide scanner;Flow cytometry, including analytical flow cytometry and cell sorting.;Mass cytometry (CyTOF).Core provides instrument training, help with experimental design and technical support. Core specializes in antibody-based techniques.Provides expertise in cell sorting, imaging and high-parameter analysis of cells and tissues.

Proper citation: Mayo Clinic Cytometry and Cell Imaging Core Facility (RRID:SCR_027312) Copy   

•   Source: SciCrunch Registry

https://pathology.weill.cornell.edu/translational-pathology

Core provides tissue-based and clinical laboratory assays, biospecimens, consultative pathology services, multiparametric imaging, mass spectrometry, molecular pathology, mouse models and advanced cellular therapeutics for basic, translational, and clinical research.

Proper citation: Weill Cornell Medicine Center for Translational Pathology Core Facility (RRID:SCR_027311) Copy   

•   Source: SciCrunch Registry

https://www.ucl.ac.uk/pharmacy/about/facilities/mass-spectrometry

Core offers services including high throughput, high mass accuracy tandem mass spectrometry coupled with liquid chromatography. Research within the facility ranges from basic biomolecular science and biochemical studies through to proteomics, metabolomics and drug-protein and drug-nucleic acid interactions.

Proper citation: University College London School of Pharmacy Mass Spectrometry Core Facility (RRID:SCR_027307) Copy   

•   Source: SciCrunch Registry

https://www.augusta.edu/mcg/pathology/research/index.php

Core offers pathology services to prepare and stain animal and human tissue for basic and clinical research.

Proper citation: Augusta University Medical College of Georgia Pathology Research Services Core Facility (RRID:SCR_027309) Copy   

•   Source: SciCrunch Registry

https://www.iqm.unicamp.br/institucional/infraestrutura/cemuiq/liem/

Core features several high- and low-resolution mass spectrometers, coupled with liquid and gas chromatographs, as well as an ICP-MS. In addition, we have liquid chromatographs available that operate with other types of detectors. The laboratory collaborates with activities carried out at the Institute of Chemistry, in external academic sectors, and also within private enterprise.

Proper citation: State University of Campinas Institute of Chemistry Laboratory of Mass Spectrometry and Chromatography Core Facility (RRID:SCR_027240) Copy   

•   Source: SciCrunch Registry

https://wertheim.scripps.ufl.edu/cores-and-technologies/animal-models

Mouse Behavior Core provides equipment and software for measuring mouse behavior. The MBC can support mouse phenotyping/drug discovery test batteries as well as more focused behavioral projects.

Proper citation: Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation and Technology Mouse Behavior Core Facility (RRID:SCR_027254) Copy   

•   Source: SciCrunch Registry

https://icahn.mssm.edu/research/resources/deans-cores/microscopy

Facility provides access to imaging equipment and analysis tools. It houses widefield, laser scanning confocal, spinning disk confocal, multi-photon, light-sheet, and super-resolution microscopes, along with two transmission electron microscopes and high-content screener. Offers centralized workstation for image processing, high-performance computing capabilities, and data storage. Provides access to several commercial software programs for image analysis and data quantification. Services include consultations for sample preparation, training on the microscopes, full imaging support, and assistance with analysis strategies. Provides several services related to transmission electron microscopy: tissue/cell processing, image acquisition training or assistance, and image analysis support. CoRE scientists can collaborate with investigators to develop novel imaging methods and analysis approaches.

Proper citation: Icahn School of Medicine at Mount Sinai Microscopy and Advanced Bioimaging Core Facility (RRID:SCR_027237) Copy   

•   Source: SciCrunch Registry

https://www.uni.lu/lcsb-en/facilities/scientific-platforms/

Core offers advanced single and combined services including genomics, imaging, metabolomics and lipidomics, in vivo disease modelling, cell-based alternative methods, drug screening, and bioinformatics, providing researchers with essential tools for scientific exploration. Expert staff members offer advice on experimental design, data processing, and troubleshooting, as well as training to facilitate the use of our technologies.

Proper citation: University of Luxembourg Model Biobank and Tissue Analytics Platform Core Facility (RRID:SCR_027442) Copy   

•   Source: SciCrunch Registry

https://www.uni.lu/lcsb-en/facilities/scientific-platforms/bioinformatics-platform/

Offers advanced single and combined services including genomics, imaging, metabolomics and lipidomics, in vivo disease modelling, cell-based alternative methods, drug screening, and bioinformatics, providing researchers with essential tools for scientific exploration. Staff members offer advice on experimental design, data processing, and troubleshooting, as well as training to facilitate the use of our technologies.

Proper citation: University of Luxembourg LCSB Bioinformatics Platform Core Facility (RRID:SCR_027443) Copy   

•   Source: SciCrunch Registry

https://its.umich.edu/advanced-research-computing/

Core provides access to and support for advanced computing resources including high performance computing, active and archive storage, cloud computing, and secure computing environments for sensitive data.

Proper citation: University of Michigan Advanced Research Computing Core Facility (RRID:SCR_027337) Copy   

•   Source: SciCrunch Registry

https://www.lerner.ccf.org/therapeutics-discovery/

Core to promote translation of basic science discoveries by Cleveland Clinic researchers into new therapeutics. Through collaboration with investigators we de-risk promising approaches and illuminate fundamental biology using small molecule chemical probes. We have established a pipeline of innovative research programs directed toward improving patient care with a true bench-to-bedside vision. To achieve these goals, we use state of the art technologies in small molecule library screening, fragment-based methods, X-ray crystallography, computational tools, and target validation towards generating starting points for nascent hit-to-lead and lead optimization campaigns.

Proper citation: Cleveland Clinic Lerner Research Institute Center for Therapeutics Discovery Core Facility (RRID:SCR_027386) Copy   

•   Source: SciCrunch Registry

https://www.northampton.ac.uk/business/facilities/northampton-advanced-imaging-facility-naif/

Core provides services for advanced imaging and flow cytometry. Equipment, training and services are available for both internal users and external users from other academic institutions and industry.

Proper citation: University of Northampton Advanced Imaging Core Facility (RRID:SCR_026057) Copy   

•   Source: SciCrunch Registry

https://www.iqm.unicamp.br/institucional/infraestrutura/cemuiq/libio/

Core belongs to the Institute of Chemistry of UNICAMP and are structured to accommodate works involving pathogenic bacteria and fungi or genetically modified organisms (GMO). Part of CTNBio (Brazilian National Technical Council of Biosafety) accredited areas and have research activities monitored by CIBio -IQ (Internal Commission of Biosafety).

Proper citation: State University of Campinas LIBio-IQ Biosefaty Laboratories Core Facility (RRID:SCR_027390) Copy   

•   Source: SciCrunch Registry

https://www.iqm.unicamp.br/institucional/infraestrutura/cemuiq/lirx/

Institutional Laboratory of X-ray facility is equipped with instruments that work with following analytical techniques: single crystal X-ray diffraction (SCXRD), X-ray fluorescence (XRF), and small-angle X-ray scattering (SAXS).

Proper citation: State University of Campinas LIRX-IQ X-Ray Institutional Laboratory Core Facility (RRID:SCR_027392) Copy   

•   Source: SciCrunch Registry