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https://www.lsi.umich.edu/science/centers-technologies/center-structural-biology

Comprehensive structural biology resource.Provides high throughput protein laboratory for protein engineering, protein purification facilities for small- and large-scale protein production, macromolecular crystallization and crystallography laboratories for solving crystal structures of biological molecules, and X-ray facility with access to high energy synchrotron radiation. Provides expert guidance to researchers through every stage of project, collaborating and consulting with researchers who use the facilities. Service categories are Chemical, Material and Protein Characterization, Molecular Biology. Services include Cloning, Crystallization, Differential thermal analysis, Drug development, NMR (small molecule), PCR, Protein crystallography, Protein engineering, Protein production, Structure determination, Xray.

Proper citation: University of Michigan Center for Structural Biology Core Facility (RRID:SCR_021065) Copy   

•   Source: SciCrunch Registry

https://cami.northwestern.edu/

Provides access to range of preclinical imaging modalities and support services. These include MRI, nuclear imaging (PET, SPECT, and CT), in vivo bioluminescence and fluorescence imaging, animal housing and prep spaces, and tissue culture. Image analysis services are available, as are software packages (JIM, Amira, Matlab) and a workstation for users to perform their own data analysis. Imaging services can be provided for investigators' own animal models, or animal models can be supplied by the Developmental Therapeutics Core.

Proper citation: Northwestern University Center for Advanced Molecular Imaging Core Facility (RRID:SCR_021192) Copy   

•   Source: SciCrunch Registry

https://research.med.psu.edu/core-facilities/zebrafish/

Provides Penn State research community with modern, centralized facility for housing, breeding and performing experiments with zebrafish.Provides physical and intellectual infrastructure for investigators whose research can benefit from use of zebrafish as model system.

Proper citation: Penn State Hershey College of Medicine Zebrafish Functional Genomics Core Facility (RRID:SCR_021199) Copy   

•   Source: SciCrunch Registry

https://research.med.psu.edu/core-facilities/mri/

MRI and NMR magnetic resonance imaging facility for animal and human research, providing MRI methodologies and expertise for in vivo studies Laboratory space includes biochemical, electronic and surgical suites, and fully equipped machine shop with (2) 3D printers. MRI Core facility has two MRI systems and EEG MRI-compatible system.3T Siemens PRISMA-Fit scanner equipped with True 2 Channel Tx and 64 Channel Rx. The latest RF coil set including a 64 Channel head coil and software packages with full clinical capability.7T Biospec 70/20 as small animal imaging system (Bruker Biospin, Ettlingen, Germany). Latest Hardware and Software. Avance NEO with Paravision 360. Full sensory fMRI stimulation systems:SenSaVue System for visual and auditory stimulation (Invivo Corp, FL, USA), which includes an LCD visual display, audio system, button response unit and software (E-Prime) for paradigm creation, patient management, protocol planning, precise delivery of brain stimulation, and behavioral analysis.ETT Olfactometer with full-programmable 6 independent channels for odor and trigeminal stimulation (ETT, LLC, Hershey, PA).Olfact Smell Test System (Osmic Enterprises, Inc., Cincinnati, OH) is a computerized instrument to test the smell functions of human subjects. The smell functions that can be tested are odor threshold, odor identification, and odor memory.ETT Gustatometer with full-programmable 7 independent channels for taste stimulation (ETT,LLC, Hershey, PA) Eye Link 1000 Plus system via SR Research: The EyeLink 1000 Plus Host PC performs real-time eye tracking at 250, 500,1000, or 2000 samples per second while computing true gaze position on the display viewed by the participant. The Host PC also performs on-line detection and analysis of eye-motion events such as saccades, blinks, and fixations. In addition to the sample data, these events are stored in a data file on the Host PC. They can be sent through the Ethernet link to the Display PC with a minimal delay or output as analog signals (if the optional analog/digital I/O card is installed). From the Host PC, the operator performs participant setup, monitors their performance, and can communicate with applications running on a Display PC.

Proper citation: Penn State Hershey College of Medicine MRI Core Facility (RRID:SCR_021198) Copy   

•   Source: SciCrunch Registry

https://med.psu.edu/core/specimen-processing

Process, store and ship clinical trial samples from IRB approved studies. Collect remnant samples for outside company for instrument correlation, validation and specimen type verification with IRB approved protocol. CLIA Waver for urine pregnancy, urine dipstick results for participant study treatment.

Proper citation: Penn State Hershey College of Medicine Clinical Research Biospecimen Core Facility (RRID:SCR_021194) Copy   

•   Source: SciCrunch Registry

https://www.etsu.edu/com/mbcf/

Core provides Genomics, Transcriptomics and Proteomics Services to researchers.

Proper citation: East Tennessee State University Quillen College of Medicine Molecular Biology Core Facility (RRID:SCR_021106) Copy   

•   Source: SciCrunch Registry

https://www.coresri.org/facilities?facility_id=16

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 19,2022. Core offers contemporary imaging, molecular biology, histology, flow cytometry, cell sorting, and real-time gene expression. Provides technologies and training including specialized microscope facility.

Proper citation: Brown Alpert Medical School Women and Infants Hospital of Rhode Island Kilguss Research Institute Molecular Biology and Imaging Core Facility (RRID:SCR_021348) Copy   

•   Source: SciCrunch Registry

https://www.wadsworth.org/research/cores/alm

Core facility is designed for Imaging living cells or tissues, Fluorescence imaging, Image analysis. Provides imaging of adherent cells or tissue fragments,drug delivery using perfusion chamber, gas exchange for the growth media, Rose chambers for imaging, image processing and analysis software to assist in data analysis and interpretation.

Proper citation: New York State Department of Health Wadsworth Center Advanced Light Microscopy and Image Analysis Core Facility (RRID:SCR_021104) Copy   

•   Source: SciCrunch Registry

https://psxl.ku.edu/

Core laboratory with infrastructure and expertise to perform all aspects of protein and small molecule structure determination using X-ray crystallography. For protein structure determination, high-throughput methods are utilized to move projects rapidly from gene-to-structure.

Proper citation: University of Kansas Lawrence Protein Structure and X-ray Crystallography Laboratory Core Facility (RRID:SCR_021742) Copy   

•   Source: SciCrunch Registry

https://www.biotech.cornell.edu/core-facilities-brc/facilities/proteomics-metabolomics-facility

Facility provides diverse range of Mass Spectrometry based proteomics and metabolomics services.Services include sample preparation, sample analysis, and data interpretation.

Proper citation: Cornell University BRC Proteomics and Metabolomics Core Facility (RRID:SCR_021743) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/lab/nmr/

Core serves research needs of entire campus community as well as outside research entities. Facility maintains a variety of NMR spectrometers at variety of magnetic fields to support research needs.

Proper citation: Colorado University at Boulder Nuclear Magnetic Resonance Spectroscopy Core Facility (RRID:SCR_019311) Copy   

•   Source: SciCrunch Registry

https://www.biotech.cornell.edu/core-facilities-brc/facilities/epigenomics-facility

Provides service that maps protein DNA interactions genome wide, tracks experimental metadata, and implements quality controlled data processing and research based analysis pipelines. Provides epigenomic and bioinformatic research resources and services that include sample preparation services and data generation. Open source platforms enable and reinforce FAIR data practices. Core is able to receive and process cell and tissue samples for various diagnostic epigenetic assays.

Proper citation: Cornell University BRC Epigenomics Core Facility (RRID:SCR_021287) Copy   

•   Source: SciCrunch Registry

https://research.med.psu.edu/core-facilities/transmission-electron-microscopy/

Provides consultation and training in TEM imaging of biological, chemical, and materials science samples.

Proper citation: Penn State Hershey College of Medicine Transmission Electron Microscopy Core Facility (RRID:SCR_021200) Copy   

•   Source: SciCrunch Registry

https://nuance.northwestern.edu/facilities/biocryo/index.html

Provides source for characterization of biological, soft matter, and hybrid samples with TEM (Transmission Electron Microscopy), SEM (Scanning Electron Microscopy), and STEM (Scanning Transmission Electron Microscopy) at cryogenic or at ambient temperature.Provide expertise and access to equipment for cryofixation and processing of frozen hydrated samples by high pressure freezing, plunge freezing, freeze fracturing, cryo ultramicrotomy, freeze substitution, and turbo freeze-drying. Conventional samples can be processed at ambient temperature with chemical fixation, dehydration, and resin embedding, or critical point drying. Offers EDX (Energy Dispersive X-ray Spectroscopy) for elemental analysis.Offers training on instruments and sample preparation techniques.BioCryo staff mentors new users, advises on experimental design, and collaborates with researchers in experiments with challenging and unconventional samples.BioCryo Facility participates in numerous educational and outreach events, e.g. workshops, seminars, demos, and facility tours.

Proper citation: Northwestern University NUANCE BioCryo Core Facility (RRID:SCR_021288) Copy   

•   Source: SciCrunch Registry

http://web.ncifcrf.gov/atp/default.asp?LabID=12&page=labs

Comprises six service groups. Our services are available to all NIH intramural researchers, and by interagency agreements to FDA and US Army at Ft. Detrick. We are happy to consult and distribute materials to not-for-profit institutions.Clone Optimization service include DNA cloning for protein expression; Gateway-based; fluorescent, epitope, solubility, purification tags; mutagenesis; vectors for insect/ baculovirus, mammalian, E. coli, P. pastoris, K. lactis. Microbial Expression: E. coli, P. pastoris, K. lactis, 2 mL to 60 L, autoinduction and IPTG; fully instrumented fermenters.Eukaryotic Expression service include insect / baculovirus, mammalian transient and stable, monoclonal antibodies.Protein Purification service include parallel microscale for process development; affinity and native, tag and endotoxin removal; scale-up to low gram scale.Virus Technology service include custom and stock adenovirus and lentivirus production; titer determination; promoter and reporter panels in lentivirus ready to deliver.Molecular Detection: qPCR and ELISA assaysdeveloped and executed, focused on human viruses in human samples; qPCR assays for mycoplasma and human pathogenic viruses contaminating cell lines; cell line identity testing.

Proper citation: Frederick National Laboratory Protein Expression Laboratory Core Facility (RRID:SCR_021286) Copy   

•   Source: SciCrunch Registry

https://strucbiol.pbsci.ucsc.edu/

Provides instrumentation, supplies, and expertise to assist researchers in structural characterization of biological macromolecules. Resources are available for crystallization and structure determination as wells as biophysical characterization of macromolecular stability and interactions.

Proper citation: University of California Santa Cruz Macromolecular Structure Function Core Facility (RRID:SCR_021283) Copy   

•   Source: SciCrunch Registry

http://www.nersc.gov

Supercomputer user facility operated by Lawrence Berkeley National Laboratory for the United States Department of Energy Office of Science.Houses high performance computing and data systems used by scientists at national laboratories and universities around the country.

Proper citation: University of California at Berkeley National Energy Research Scientific Computing Core Facility (RRID:SCR_021318) Copy   

•   Source: SciCrunch Registry

https://gladstone.org/science/flow-cytometry-core

Core offers operation, training and consultation on both cell sorters and analyzers.Our core comprises BDFACsAria II, two BDFACSAria Fusions, Fortessa X-20 and Attune, with analyzing and sorting up to 18 colors possible. Core also offers antibody staining, protocol optimization and data analysis services.

Proper citation: Gladstone Institutes Gladstone Flow Cytometry Core Facility (RRID:SCR_021714) Copy   

•   Source: SciCrunch Registry

https://biotech.unl.edu/proteomics-and-metabolomics#tab1

Provides services using mass spectrometry, including identification and relative quantification of proteins and several advanced methods for profiling and quantitation of small molecules.Provides outreach and education program including workshops,seminars and courses.Proteomics services include Bottom-up Proteomics of whole organisms, organs, organelles, tissues, cell pellets, pulldowns, complex or single protein mixes from solutions or gels;Quantification by label-free or multiplexed labeling techniques with microscale subfractionation to increase coverage;Post Translational Modification Characterization especially phosphopeptide enrichment from whole organism digests, but also ubiquitylation, acetylation, etc.Metabolomics services include Untargeted Quantification of small molecules;Primary metabolism using GC-MS and NIST/Fiehn Libraries;Secondary metabolism using LC-MS and Progenesis QI, NIST Library, mzCloud;Targeted Quantification using HPLC or LCMS.

Proper citation: University of Nebraska Lincoln Nebraska Center for Biotechnology Proteomics and Metabolomics Core Facility (RRID:SCR_021314) Copy   

•   Source: SciCrunch Registry

https://sites.google.com/alaska.edu/genomicscorelab/home

UAF IAB Genomics Core Lab provides library preparation and sequencing services for the Illumina MiSeq sequencer, and the Oxford Nanopore Technologies GridION. For UAF researchers, we also provide training and access to specialized equipment relating to the purification, quantitation, amplification and library preparation of DNA and RNA.

Proper citation: University of Alaska Fairbanks Genomics Core Facility (RRID:SCR_021291) Copy   

•   Source: SciCrunch Registry