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http://bmsr.usc.edu/software/eons/

Modeling platform to study the basic interactions between synaptic elements that allows the user to study qualitatively, and also quantitatively the relative contributions of diverse mechanisms underlying synaptic efficacy: the relevance of each and every element that comprises a synapse, the interactions between these components and their subcellular distribution, as well as the influence of synaptic geometry (presynaptic terminal, cleft and postsynaptic density). This platform consists of a graphical interface in which elements that comprise a single glutamatergic synapse (both pre- and post-synaptically), their behavior as well as the underlying synaptic geometry can be modified. For example, EONS offers the ability to study the effect of voltage-gated calcium channels density and distribution, the number and location of receptors and more. EONS is a parametric model of a generic glutamatergic synapse that takes into account pre-synaptic mechanisms, such as calcium buffering and diffusion, neurotransmitter release, diffusion and uptake in the cleft, and postsynaptic elements, such as ionotropic AMPA and NMDA receptors, their distribution and synaptic geometry, as well as metabotropic glutamate receptors. There are no complicated equations to write: all the models are predefined. This version is a great tool for first time users and students interested in learning about synapses, as well as for studying geometry and distribution hypotheses in a 2D rectangular geometry. System Requirements: EONS V1.2 is a Windows program but can be also successfully installed and run on Mac and Linux.

Proper citation: EONS (RRID:SCR_002979) Copy   

•   Source: SciCrunch Registry

http://www.rad.upenn.edu/sbia/

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on June 2, 2023. Software package used to simulate brain images with local growth / atrophy within a prescribed spherical region. Specifically, given an input image and its segmented image, the location of the center of the spherical region, and the radius of that sphere, it simulates new images that have tissue growth or shrinkage within that pre-specified brain region according to given rates (atrophy for rates less than one and growth for rates greater than one). The algorithm uses an iterative procedure that tries to achieve the given level of volumetric change for brain tissues within the region, by seeking a smooth deformation field, whose Jacobian determinants match the prescribed volume change rate within the region. Note that in the current software, the simulation of growth or atrophy for brain tissue requires that the input spherical region has to cover some CSF or background regions.

Proper citation: Atrophy Simulation Package (RRID:SCR_006046) Copy   

•   Source: SciCrunch Registry

http://rdocdb.nimh.nih.gov

A database that houses human subjects data related to mental health research. Data from 691 subjects are shared in RDoCdb and data from 100,500 subjects are shared in the NIMH Data Archive. Users can plan for data submission, share data, query data, or share their results related to a publication or finding.

Proper citation: RDoCdb (RRID:SCR_013796) Copy   

•   Source: SciCrunch Registry

http://hirisplex.erasmusmc.nl/

An interactive software tool that predicts hair and eye color based on genetics. The website includes both the IrisPlex system and the HIrisPlex system.

Proper citation: HIrisPlex system (RRID:SCR_014058) Copy   

•   Source: SciCrunch Registry

http://www.bioeden.com/

International private stem cell storage bank to collect, assess and cryogenically store living tooth cells from deciduous baby teeth. Tooth cell banking is a safe, natural and completely noninvasive method of collecting and preserving valuable stem cells which could hold the key to your child's health. Simply enroll, send us your child's tooth when it falls out, and they'll do the rest. Stem cell treatment to repair or replace damaged tissues or organs is the cornerstone of future medical science. Children's milk teeth, (baby teeth) have been identified as a rich source of these stem cells and have the potential to treat some of the worst illnesses and diseases facing people today. Stem cells from teeth (mesenchymal stem cells) are different from those found in cord blood (hematopoietic stem cells). Cord blood cells can be used to treat blood disorders such as leukemia, but stem cells from teeth are different. Stem cells from teeth can be used to grow a range of tissues including bone, nerve, fat, muscle and cartilage and may one day be used to grow entire organs. It is widely believed that stem cells will be used to treat a wide variety of diseases and injuries within the next decade. Their UK facility is regulated by the Human Tissue Authority (HTA), and they hold a full license. They are also registered with the Food and Drug Administration (FDA) in the US. BioEDEN, Ltd is ISO 9001:2008 accredited by the British Assessment Bureau. When you enroll for the BioEDEN service, you will be offered the opportunity to consent to donate any excess cells. BioEDEN will provide these cells to leading academic and clinical research centers to help further the progression of this technology to useful clinical applications. BioEDEN will only provide cells to researchers that have full ethical approval for their research and will be guided by our Advisory team as to the most appropriate research to support. The cells will be donated in accordance with strict regulatory guidelines and anonymity of the donor will be strictly assured at all times. Donation of cells is an entirely opt in service. If you choose not to give consent to donate, BioEDEN will simply store the cells for your child.

Proper citation: BioEden Tooth Cell Bank (RRID:SCR_000507) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-e341-a9f2-eb5b-b63c80000000

Core facility that provides the following services: Induced pluripotent stem cell derivation, Characterization of induced pluripotent stem cells, Hands-on training course for embryonic / induced pluripotent stem cell culture. Additionally, the Core has several established human iPS cell lines for purchase for research purposes by non-profit institutions. Please contact the director for available cell lines. The goals of the Core are: * to facilitate derivation of induced pluripotent stem (iPS) cells from somatic cells; * to provide expertise and training to researchers in embryonic stem (ES)/iPS cell culture; * and to serve as a resource for sharing iPS cell lines and iPSC technology within the UPenn and the broader scientific community.

Proper citation: Penn Induced Pluripotent Stem Cell Core Facility (RRID:SCR_002976) Copy   

•   Source: SciCrunch Registry

http://stemcells.nih.gov/research/registry/

A listing of human embryonic cell lines that are eligible for use in NIH funded research. Those lines that carry disease-specific mutations are noted as such under the line name. Total Eligible Lines = 200. The purpose of the Registry is to provide investigators with: # a unique NIH Code for each cell line that must be used when applying for NIH funding and # contact information to facilitate investigators' acquisition of stem cells. Before submitting a new grant application and supporting materials for consideration of a human embryonic stem cell line, scientists may wish to see what lines are already under consideration: * Human embryonic stem cell lines submitted to NIH that are being reviewed to determine if they may be used in NIH-supported research, http://grants.nih.gov/stem_cells/registry/pending.htm President George W. Bush required that the name of the registry be changed in his Executive Order #13435, issued on June 20, 2007. As a result of this Executive Order, the former National Institutes of Health Human Embryonic Stem Cell Registry will now be called the National Institutes of Health Human Pluripotent Stem Cell Registry. The registry will now include both human embryonic stem cells that were derived consistent with the President's policy of August 9, 2001 and human pluripotent stem cells derived from non-embryonic sources.

Proper citation: NIH Human Pluripotent Stem Cell Registry (RRID:SCR_003149) Copy   

•   Source: SciCrunch Registry

https://research.ochsner.org/clinical-research/biobank

Biospecimen and clinical data repository for researchers that includes tumor and normal tissue, blood samples, and other bio fluids. Samples are refrigerated, frozen, deep frozen, or frozen in liquid nitrogen. Four service lines are provided: ExpressBank offers access to biospecimens, which are collected under IRB-approved core protocol for future unknown research projects; Service Bank offers services such as biospecimen procurement, processing, and temporary banking; PathBank offers access to high-quality, annotated formalin-fixed paraffin-embedded (FFPE) tissues and H&E slides from Pathology department on fee-for-sample basis; and On-DemandBank allows targeted development of a temporary Biobank that strictly meets the specifications of an IRB-approved collection protocol of a sponsor on fee-for-service basis.

Proper citation: Ochsner Biobank (RRID:SCR_001396) Copy   

•   Source: SciCrunch Registry

http://www.nationalstemcellbank.org/

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 28,2023. High quality, well characterized pluripotent stem cell lines for distribution to researchers worldwide. Offerings include human embryonic and induced pluripotent stem cell lines, as well as modified cell lines tailored to specific research needs. *Human Embryonic Stem Cell Lines *Modified Cell Lines *Induced Pluripotent Stem Cells (iPS) *Clinical Grade (cGMP) Human ES Cell Banks

Proper citation: Wisconsin International Stem Cell Bank (RRID:SCR_004398) Copy   

•   Source: SciCrunch Registry

http://www.cfcsyndrome.org/biobank.shtml

CFC International holds the world''s largest collection of blood and tissue from people affected by CFC and their immediate relatives. It is the only centralized repository in the world. The CFC BioBank provides medical researchers with genetic and biological material from CFC patients and their families, so that research on CFC and other related syndromes can be performed. CFC International joined the Genetic Alliance BioBank in 2004 to make certain that your privacy and confidentiality are protected and your samples are available to any approved research project. The bank serves as a resource for researchers around the world who are willing to search to find the gene(s) responsible for the Cardio-Facio-Cutaneous Syndrome. As you know, Cardio-Facio-Cutaneous Syndrome is an extremely rare condition. Thus while access to cell lines is essential for studying the biology and genetics of the disorder, there are very few cell lines in existence. Because an integral part of CFC''s mission is to stimulate interest in CFC research, there is an increased need for cell lines. The CFC BioBank will ensure that need is met! The goals of The CFC BioBank are to promote: * Sufficient availability of cells for approved research projects * Incentive for new research projects * Study of the biochemical basis for CFC Syndrome * Discoveries leading to new treatments for children with CFC Syndrome If you are interested in donating to the CFC BioBank please call 607-772-9666, or e-mail us at bconger_at_cfcsyndrome.org and indicate your interest. Researchers with an interest in either donating CFC Syndrome cell lines or in applying to use material from the bank should also call or write.

Proper citation: Cardio-Facio-Cutaneous Syndrome International Biobank (RRID:SCR_004552) Copy   

•   Source: SciCrunch Registry

http://www.ukstemcellbank.org.uk/

The UK Stem Cell Bank was established to provide a repository of human embryonic, fetal and adult stem cell lines as part of the UK governance for the use of human embryos for research. Its role is to provide quality controlled stocks of these cells that researchers worldwide can rely on to facilitate high quality and standardized research. It is also ready to prepare stocks of ''clinical grade'' cell lines as seed stocks for the development of therapies. The bank exists to establish and make available fully characterized and quality-controlled cell banks. These will be supplied to scientific research teams and eventually to pharmaceutical companies, to enable the development of broad-ranging cell therapies. The bank will support the development of stem cell therapy in the UK by: * Creating and growing a supply of well-characterized stem cell lines for researchers in the UK and abroad. This will allow the research teams to establish the basis for therapeutic applications. * Creating, a bank of stem cell lines, under conditions consistent for the preparation of pharmaceutical products which provide cultures that could be supplied for the production of medicines for human use. For researchers deriving human embryonic stem cell lines in the UK, it is a condition of the Human Fertilization and Embryology Authority (HFEA) license that a sample of all human embryonic stem cell lines derived in the UK must be deposited in the UK Stem Cell Bank. The UK Stem Cell Bank does not collect, process, store or distribute Umbilical Cord Blood either for its own use or on behalf of others. A catalog of currently available stem cells is available or you may search for a particular stem cell.

Proper citation: UK Stem Cell Bank (RRID:SCR_004738) Copy   

•   Source: SciCrunch Registry

http://www.stjames.ie/Departments/DepartmentsA-Z/C/Cryobiology/DepartmentOverview/

The Cryobiology laboratory is a stem cell processing laboratory, preparing clinical grade haemopoietic (bone marrow or peripheral blood) stem cells for transplant. The Laboratory supports the National Adult Stem Cell Transplant Programme based in St James Hospital treating Leukemia and related disorders. Approximately 100 Transplants are carried out annually. The Tissue Establishment is part of a network of hospitals carrying out stem cell transplant. Stem cells are imported from abroad and exported world wide for stem cell transplantation. The Laboratory is a GMP Tissue Establishment and is licensed by the Irish Medicines Board to process cells under the EU tissue directive.

Proper citation: St. James Hospital Cryobiology Laboratory Stem Cell Facility (RRID:SCR_004458) Copy   

•   Source: SciCrunch Registry

http://www.genethon.fr/en/rd-2/dna-and-cell-bank/

Since its creation in 1990, the mission of the Genethon''s DNA and Cell Bank is to promote advances in genetic research by providing the scientific community with a high quality cell and human tissue products resource. Europe''s leading bank for genetic diseases, it serves the whole of the medical and scientific community. Each year, Genethon''s DNA and Cell Bank: * Produces approximately 2,000 lymphoblastoid cell lines * Performs approximately 3,000 DNA extractions * Prepares primary myoblast and fibroblast cultures from approximately 100 biopsies Genethon has developed a computer database for ensuring sample management and traceability, which has been submitted to and approved by the CNIL. The Genethon DNA and Cell Bank has been AFNOR certified, according to French biological research center standard NF S 96-900. The activities of the DNA and Cell Bank are as follows: * Collecting blood or DNA from patients affected with genetic diseases and their families with the minimum identification data necessary for the monitoring and follow-up of samples. * Processing the samples in order to make them available to the scientific community and perpetuating DNA preservation (serum isolation and DNA extraction), isolating lymphocytes and establishing lymphoblastoid B lines and primary cultures (mainly myoblasts and fibroblasts). * Storing samples for future research and preserving the genetic heritage by ensuring the long-term physical security of the preserved samples. * Distributing samples as necessary for ongoing research while complying with the principles and laws of bioethics and using the best available technologies at minimum cost.All these activities are carried out following Standard Operating Procedures (SOP) validated by the Quality Assurance department at Genethon. The Bank is open to researchers in France or abroad wishing to store samples or use the services provided (extraction, establishment of cell lines etc.). Each sample received at Genethon is coded in order to guarantee confidentiality, in accordance with the rules established by the CNIL (French Data Protection Authority). All requests for collaboration with the DNA and Cell Bank should be made in writing to Dr Safaa SAKER-DELYE.

Proper citation: Genethon DNA and Cell Bank (RRID:SCR_004639) Copy   

•   Source: SciCrunch Registry

http://www.bclq.org/en/index.html

The primary objective of the Quebec Leukemia Cell Bank is to support basic and clinical blood cancer research. It also serves to provide an infrastructure and services aimed at facilitating the work of researchers in various fields, such as oncology, hematology and immunology in particular. Several researchers have already benefited from this infrastructure in the course of their work. The main missions of the Quebec Leukemia Cell Bank are : * To set up a bank of well-characterized human blood tumor cells. The constitutional DNA is also stored for the majority of samples. A computerized databank includes all laboratory tests performed on these specimens, as well as the corresponding clinical data. Before this bank was created, the absence of access to adequate blood tumor specimens severely hampered our researchers'' efforts to competitively pursue their work. Also, the availability of these specimens now makes it possible to establish an essential link between the basic and clinical research communities. * Provide chromosomal analysis by conventional cytogenetics and spectral karyotyping (SKY) for human and mouse cells. * Contribute to the training of specialized staff and students. The Quebec Leukemia Cell Bank is a provincial program that groups together hematologists, researchers and clinical scientists from four Quebec universities (Universit�������� Laval, McGill, Sherbrooke, Montr��������al) and Quebec research centers. The cell bank has been in operation since 2001. The purpose of this website is to raise awareness about our cell bank so we can continue to help an increasing number of researchers.

Proper citation: Quebec Leukemia Cell Bank (RRID:SCR_004916) Copy   

•   Source: SciCrunch Registry

http://www.ihwg.org/

The IHWG Cell and DNA Bank was established as a shared resource to support the scientific projects of the 13th International Histocompatibility Workshop (IHWS). The Research Cell Bank (RCB), located in Fred Hutchinson Cancer Research Center in Seattle, WA, maintains the IHWG inventory. This comprehensive inventory includes B-Lymphoblastoid Cell Lines (B-LCL) from previous International Workshops, HLA heterozygous and homozygous donors, selected families, and individuals of diverse population groups. The RCB maintains stocks of purified DNA derived from these cell lines, as well as DNA reference panels that provide an extensive array of HLA and HLA-related sequence polymorphisms. The RCB also provides cloned HLA genes and B-LCL transfected with selected HLA genes, which are available on a limited basis.

Proper citation: International Histocompatibility Cell and DNA Bank (RRID:SCR_004871) Copy   

•   Source: SciCrunch Registry

https://neuinfo.org/about/sources/nlx_143622-1

International registry of biomaterial supply resources both for transplantation and research. Contributions to this resource are welcome. The database is searchable through NIF and is updated regularly.

Proper citation: One Mind Biospecimen Bank Listing (RRID:SCR_004193) Copy   

•   Source: SciCrunch Registry

http://www.biorep.it/en

Offer biorepository services to public and private research institutes, to the highest standards of quality and safety with the aim of contributing to the advancement of medical research and scientific discovery. The BioRep Cell Repository establishes, maintains and distributes cell line cultures as well as DNA derived from these cultures. The scientific and business affiliation between BioRep and Coriell allows access to more than a million types of cell vials, stored in liquid nitrogen. Cells that have been stored for nearly 50 years, are still viable and available for research purposes today. Thanks to an exclusive agreement with the Coriell Institute for Medical Research, the oldest and largest biorepository of the world, BioRep is specialized in cell lines preparation, in nucleic acid extraction and long term storage in liquid nitrose (-196 degrees C) and in refrigerators (-80 degrees C) of any kind of biosamples, using procedures and standards developed by the Coriell in over 50 years of activity. BioRep and Coriell together constitute one of the few Global Biorepository able to serve the pharmaceutical industries for world wide clinical trials. BioRep facility is specifically designed to give the utmost efficiency and security by implementing Coriell procedures and standards. The BioRep Tissue Repository provides safe and secure storage of tissue specimens as required for medical research and scientific investigation. All tissues are preserved with the most current preservation techniques and processes. In addition to the storage service, BioRep provides Cell Biology, Molecular Biology, Microbiology services developed in ISO 9001:2008 certified laboratories.

Proper citation: BioRep (RRID:SCR_004907) Copy   

•   Source: SciCrunch Registry

http://www.healthsystem.virginia.edu/internet/tissueprocure/

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 11,2024. Tissue Culture Facility provides mycoplasma testing, baculovirus titer measurements, growing of cultured cells and cell storage, to University of Virginia researchers. The Facility also supplies cell culture reagents and supplies. Training and access to facilities is also available. Products and services are only available to users at the University of Virginia.

Proper citation: University of Virginia Tissue Culture Facility (RRID:SCR_004508) Copy   

•   Source: SciCrunch Registry

http://hcc.musc.edu/research/resources/biorepository/

The Hollings Cancer Center Tissue Biorepository & Research Pathology Services Shared Resource provides investigators with a centralized infrastructure that promotes biomedical research involving the use and study of human biospecimens. The shared resource is comprised of four integrated components: Biospecimens and data bank, Laser Capture Microdissection, Tissue Microarray, and Research Pathology Services. These components, along with extensive staff expertise, offer a comprehensive means by which researchers can utilize valuable human biospecimens and cutting edge technology to support basic, translational and clinical research. Services: * Biospecimen and Data Bank ** Collecting, processing, and banking of tissue, saliva, urine, blood, plasma, serum, and other tissue derivatives; including those for protocol driven studies ** Retrieval of banked specimens linked to clinicopathologic data, while maintaining patient confidentiality, for research use ** Quality control of collected tissue by the Tissue Biorepository Director, a trained pathologist: verification of diseased state and assessment of tumor purity, etc ** Quality control of DNA/RNA/protein isolated from collected tissue using the Agilent Bioanalyzer * Laser Capture Microdissection ** Identification, localization, and microdissection of targeted cell populations (from human and animal tissue sources) ** Extraction of DNA/RNA/protein from microdissected samples. ** Quality analysis and quality control of isolated nucleic acid using Agilent Bioanalyzer * Tissue Microarray ** Create custom and standard TMAs ** Consultation and technical support in the construction and analyses of TMA * Research Pathology Services ** Macrodissection of tissue prior to isolation of DNA/RNA/protein to increase tumor purity ** Immunohistochemistry and In-situ hybridization ** Quantitative image analysis on conventional and TMA sections, including tissue scoring, Ki-67 labeling index, microvascular density counting, and tissue microarray scoring, etc. * Bio-molecular Assessment ** Cellular DNA, RNA and protein prepared by the Tissue Repository from banked specimens or any other biomolecules submitted by investigators can be qualitatively assessed by Agilent Bioanalyzer, prior to use for downstream applications such as microarray and/or qRT-PCR analysis

Proper citation: Hollings Cancer Center Tissue Biorepository and Research Pathology Services Shared Resource (RRID:SCR_004626) Copy   

•   Source: SciCrunch Registry

http://www.karmanos.org/cordblood

The J.P. McCarthy Cord Stem Cell Bank at the Karmanos Cancer Institute is a public, non-profit stem cell bank with over 1,200 umbilical cord blood units in its inventory. The bank was founded in 2001 and is one of only 21 internationally recognized cord stem cell banks affiliated with the National Marrow Donor Program. The only bank of its kind in Michigan, it was created in anticipation of providing life-saving hope to people who have been diagnosed with cancer and serious blood disorders. Karmanos collects, processes and stores donated umbilical cord blood that becomes a readily available source of hematopoietic stem cells for transplant in children and adults with leukemia, lymphoma, sickle cell disease or other life-threatening conditions. The J.P. McCarthy Cord Blood Bank and Carls Processing Laboratory is also accredited by the Foundation for the Accreditation of Cellular Therapy (FACT). The accreditation signifies the highest standards of practice in collection, processing and transplantation. Karmanos is the only FACT accredited cord blood bank in Michigan and one of only nine in the United States. In the Detroit Metropolitan area, the number of hospitals participating in the collection of cord blood is rapidly increasing. Please consider donating your baby''s cord blood if you are delivering at one of our participating hospitals: Henry Ford Wyandotte Hospital in Wyandotte, MI, Providence Park Hospital in Novi, MI, St. Joseph Mercy Hospital in Ann Arbor

Proper citation: JP McCarthy Cord Stem Cell Bank (RRID:SCR_004540) Copy   

•   Source: SciCrunch Registry