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https://www.crukscotlandinstitute.ac.uk/advanced-technologies/deep-phenotyping.html

Core offers comprehensive pathologist-led spatial biology service comprising spatial proteomic, transcriptomic, and multiomic experimental design, including platform and panel selection, assay development, image acquisition, and digital image processing. The facility houses 2x Ventana Discovery Ultra autostainers, 2x 10 x Genomics Xenium platforms, a Lunaphore COMET, an Akoya PhenoImager, an Akoya PhenoCycler, an Olympus VS200 slide scanner and a Visiopharm image analysis suite.

Proper citation: CRUK Scotland Institute Deep Phenotyping Advanced Technology Core Facility (RRID:SCR_027366) Copy   

•   Source: SciCrunch Registry

https://www.crukscotlandinstitute.ac.uk/advanced-technologies/molecular-technology.html

Core provides Next Generation Sequencing (NGS) services and Single Cell services predominantly focussing on single cell RNAseq. Processes samples for variety of cancer associated projects, in both mouse and human derived materials. Offers full end-to-end service, from initial study design and planning, through sample QC, full library preparation, sequencing and data return. Offers range of standard molecular tests covering, plasmid purifications, Sanger sequencing and mycoplasma screening.

Proper citation: Cancer Research UK Scotland Institute Molecular Technology Service Core Facility (RRID:SCR_027368) Copy   

•   Source: SciCrunch Registry

https://www.augusta.edu/cancer/research/shared-resources/bioinformatics/

Georgia Cancer Center's Bioinformatics Core provides expertise in integrative computational based analysis solutions to basic, clinical, and translational research applications. Services include study design, analysis, and interpretation that may involve interaction with industry, government, and regulatory agencies in the areas of Clinical trials, Epidemiology, laboratory studies, in addition to data mining using local and national databases for hypotheses generation and scientific investigation.

Proper citation: Augusta University Bioinformatics Shared Resource Core Facility (RRID:SCR_027372) Copy   

•   Source: SciCrunch Registry

https://www.med.uvm.edu/bsr/home

Core offers bioinformatics and data modeling services. Focuses on support for reproducible, well documented, containerized, nextflow pipelines customized to address the specific research questions and biological systems of the investigators. Offers support from preprocessing -omics data, through data integration and manuscript support, based on grant support or a fee-for-service mechanism. Provides training for students and PIs in the form of individual help, seminars, and workshops.

Proper citation: University of Vermont Bioinformatics Shared Resource Core Facility (RRID:SCR_027493) Copy   

•   Source: SciCrunch Registry

https://www.lerner.ccf.org/cores/light-microscopy/

Core services include: basic light microscopy (determine appropriate staining protocols and offer training and/or assistance in acquiring transmitted and fluorescent digital images with wide-field microscopes); optical sectioning (training and assistance in the use of confocal and multi-photon microscopes); whole slide scanning (brightfield or fluorescence mode). Laser MicroDissection instruments are available for isolating small areas of tissue or single cells. Total Interference Reflection Fluorescence (TIRF) microscopy is available for visualizing and quantifying cellular events localized at the basal plasma membrane. Live cell and tissue imaging can be done on both wide-field and confocal microscopes equipped with environmental chambers for heat/CO2 control.Investigators have access to Image Processing and Analysis workstations with variety of advanced software for extracting quantitative data from their images. They can also generate images and movies for presentations, grants and publications. Core is home to 2 LI-COR Odyssey, laser-based scanning systems for gels, Westerns, in-cell Westerns, ELISA/FLISA, EMSA/Gel Shift, Protein Detection, etc.

Proper citation: Cleveland Clinic Lerner Research Institute Light Microscopy Core Facility (RRID:SCR_027477) Copy   

•   Source: SciCrunch Registry

https://www.houstonmethodist.org/academic-institute/research/cores/

Core is fee-for-service research laboratory providing internal and external users a wide spectrum of electron microscopy (EM) techniques. As part of the Houston Methodist Research Institute Department of Neurology, we routinely process samples related to the peripheral nervous system but can help with the ultrastructural study of many biological samples.

Proper citation: Houston Methodist HMRI Neurology Electron Microscopy Core Facility (RRID:SCR_027479) Copy   

•   Source: SciCrunch Registry

https://rcgd.isr.umich.edu/research/facilities/zajonc-lab/

Core provides researchers with facilities to conduct experimental research, particularly within the Research Center for Group Dynamics (RCGD) and across the U-M campus. The labs offer adaptable room configurations, specialized software like E-Prime and z-Tree, and shared access to cutting-edge technology, including a new Virtual Reality (VR) Lab, to support a range of interdisciplinary research projects focused on human social behavior and dynamics.

Proper citation: University of Michigan Robert B. Zajonc Experimental Lab Core Facility (RRID:SCR_027478) Copy   

•   Source: SciCrunch Registry

https://icahn.mssm.edu/research/resources/deans-cores/neuropathology

Provides access to collection of human postmortem brain tissues, including fresh, frozen, and formalin-fixed paraffin-embedded (FFPE) specimens, along with detailed clinical histories and neuropathological assessments. Available histology services include processing and embedding, slide sectioning for FFPE and cryosections, immunohistochemistry (IHC), immunofluorescence (IF), and advanced RNA assays such as RNAscope, BaseScope, and miRscope. High-resolution digital slide imaging is performed using the GT450 scanner. CoRE scientists also collaborate with investigators and trainees to support project development, method optimization and troubleshooting, data analysis.

Proper citation: Icahn School of Medicine at Mount Sinai Neuropathology Brain Bank and Research CoRE Facility (RRID:SCR_027565) Copy   

•   Source: SciCrunch Registry

https://icahn.mssm.edu/research/human-immune-monitoring-center

Core provides team of experts in the characterization of immune profiles and treatment responses across a diverse range of diseases, such as cancer, autoimmunity, allergy, and neuro-immune disorders. Offers equipment in the field for research at Genomic, cellular and proteomic analysis. Develops assays to balance innovation with protocols and operating procedures to ensure data quality and reproducibility.

Proper citation: Icahn School of Medicine at Mount Sinai Human Immune Monitoring Center Core Facility (RRID:SCR_027571) Copy   

•   Source: SciCrunch Registry

https://medicine.tulane.edu/microbiology-immunology/flow-cytometry-and-cell-sorting-facility

Tulane University School of Medicine Department of Microbiology/Immunology Flow cytometry and cell sorting shared resource facility. Provides education, training and services, Applications include analysis and sorting of immune subsets and fluorescent-reporter expressing cells, DNA content, multi-plex bead assays and functional assays. Expert assistance with experimental design and data analysis, as well as instrument training, are available at no charge.

Proper citation: Tulane University School of Medicine Flow Cytometry and Cell Sorting Core Facility (RRID:SCR_027605) Copy   

•   Source: SciCrunch Registry

https://www.mayo.edu/research/core-resources/antibody-hybridoma-core/overview

Core can generate custom monoclonal antibodies in mouse and hamster systems. Can also produce large amounts of antibodies (of all species) and recombinant proteins in-vitro. Purification is also available for various systems.

Proper citation: Mayo Clinic Antibody Hybridoma Core Facility (RRID:SCR_027544) Copy   

•   Source: SciCrunch Registry

http://confocal.uconn.edu

Facility provides training and access to advanced light microscopy systems at an hourly rate. In addition, we are available to consult with and support users at every stage of a project including: experimental design, sample preparation, image acquisition, analysis, and data preparation.

Proper citation: University of Connecticut Advanced Light Microscopy Core Facility (RRID:SCR_027547) Copy   

•   Source: SciCrunch Registry

https://research.manchester.ac.uk/en/equipments/core-facility-for-advanced-metal-development

Core supports all processing of metal related activity and houses equipment in the areas of thermomechanical processing, additive manufacturing, mechanical testing (including testing under a variety of environments), thermomechanical simulation/testing and heat treatment.

Proper citation: University of Manchester Advanced Metal Development Core Facility (RRID:SCR_027557) Copy   

•   Source: SciCrunch Registry

https://nmrcore.uhnresearch.ca/

NMR Core Facility is equipped with NMR spectrometers allowing researchers to Characterize bio-molecular structures at the atomic resolution with exquisite details;Identify protein interactions with binding partners in order to understand their architecture;Study protein dynamic;Study protein post-translational modifications acting as molecular switches;Study structure-function relationships of biological proteins to gain insight into biological processes in relation to human disease;Screening of High-throughput drug-like leads for novel therapeutic targets;Study Metabolites of interest.Core facility houses high-field NMR spectrometers equipped with cryogenically cooled probes (1H or 13C optimized) for enhanced sensitivity.

Proper citation: University Health Network Nuclear Magnetic Resonance Core Facility (RRID:SCR_027548) Copy   

•   Source: SciCrunch Registry

https://mccaingubiobank.ca/

Core supports biomarker discovery and enhancing future cancer research in the areas of genomics, proteomics and epidemiology. Provides serialized collections of biospeciments throughout patient prognosis. Clinical time point collections are based on input from our expert surgical, medical, and radiation oncologist teams.

Proper citation: University Health Network McCain GU Biobank (RRID:SCR_027521) Copy   

•   Source: SciCrunch Registry

https://jdmiresearch.ca/

Core services include Imaging Modalities:MRI,PET-MRI,CT,PET-CT,Ultrasound / X-Ray,Interventional / Biopsies;Consultation:Pre-grant submission consultations,Pre-trial launch consultations / site initiation visists,Feasibility assessments MRI physics consultation; Protocol Development / Site Feasibility:Industry site feasibility questionnaires, Protocol development of medical imaging studies and clinical trials; Post-Processing of Images:Tumour measurements, Volumetric measurements.

Proper citation: University Health Network Joint Department of Medical Imaging Research Office JDMI RO Core Facility (RRID:SCR_027520) Copy   

•   Source: SciCrunch Registry

https://pmlivingbiobank.uhnresearch.ca/

Core provides services for the use of Xenograft (PDX) models listed in open global catalogue of PDX models for comprehensive search and attribute filtering support for clinico-pathological and molecular data. Molecular data and visualization of profiled models could be accessed through the institute's portal.

Proper citation: University Health Network Princess Margaret Living PDX Core Facility (RRID:SCR_027523) Copy   

•   Source: SciCrunch Registry

https://www.pmgenomics.ca/pmgenomics/

Core is dedicated to providing access to cost-effective and high quality genomics services including standard and custom-tailored DNA sequencing using Illumina technologies, epigenomics, panel-based profiling (Luminex and Nanostring) and functional genomics. Single cell genomics applications on variety of popular platforms.

Proper citation: University Health Network Princess Margaret Genomics Centre PMGC Core Facility (RRID:SCR_027524) Copy   

•   Source: SciCrunch Registry

https://www.clf.stfc.ac.uk/Pages/Octopus-new.aspx

National imaging facility that offers access to single molecule imaging, confocal microscopy, superresolution imaging, light sheet microscopy, optical trapping and cryoscanning electron microscopy. Offers expert guidance and advice for light and electron microscopy experiments alongside advanced instruments for fluorescence and electron microscopy.

Proper citation: Science and Technology Facilities Council Central Laser Facility OCTOPUS Microscopy Core Facility (RRID:SCR_027515) Copy   

•   Source: SciCrunch Registry

https://uhnbiospecimenservices.com/

Core provide services for the enhancement and progression of novel and innovative research and discovery. Provides human biospecimen samples such as: fresh frozen and formalin fixed paraffin embedded (FFPE) tissue, compartmentalized blood components such as serum, plasma, and whole blood peripheral blood mononuclear cells (PBMCs) and other biofluids, including saliva and urine; Tissue microarray (TMA) construction and quantitative image analysis of TMA sections, Laser capture microdissection (LCM), digital slide scanning, quantitative image, and pathological/clinical analysis for various tumour sites and DNA/RNA extraction; support and guidance to researchers and biobanks on accessing, collecting, and using human biospecimens and associated data for health research.

Proper citation: University Health Network Biospecimen Services Core Facility (RRID:SCR_027519) Copy   

•   Source: SciCrunch Registry