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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
Examl
 
Resource Report
Resource Website
50+ mentions
Examl (RRID:SCR_016087) Examl software application, source code, software resource Source code for large-scale phylogenetic analyses on whole-transcriptome and whole-genome alignments using supercomputers. phylogenetic, analysis, database, large scale, whole genome, whole transcriptome, alignment, efficiency, bio.tools, FASEB list is listed by: bio.tools
is listed by: Debian
is listed by: OMICtools
Heidelberg Institute for Theoretical Studies PMID:25819675 Free, Available for download OMICS_08024, biotools:ExaML https://bio.tools/ExaML, https://sources.debian.org/src/examl/ SCR_016087 Examl:Exascale Maximum Likelihood 2026-08-06 09:28:45 60
lncRNAdb
 
Resource Report
Resource Website
100+ mentions
lncRNAdb (RRID:SCR_015491) database, data or information resource Searchable database of comprehensive annotations of eukaryotic long non-coding RNAs. Entries are manually curated from referenced literature. reference database, eukaryotic annotation, annotation database, eukaryotic long non coding rna database, functional long noncoding rnas, bio.tools, FASEB list is listed by: bio.tools
is listed by: Debian
Open source, Acknowledgement requested, The community can contribute to this resource biotools:lncrnadb https://bio.tools/lncrnadb SCR_015491 lncRNAdb v2.0, Long Noncoding RNA Database, Long Noncoding RNA Database v2.0 2026-08-06 09:28:41 163
MethBase
 
Resource Report
Resource Website
1+ mentions
MethBase (RRID:SCR_017487) service resource, database, data or information resource Central reference methylome database created from public BS-seq datasets. Provides methylation level at individual sites, regions of allele specific methylation, hypo- or hyper-methylated regions, partially methylated regions, and detailed meta data and summary statistics. Methylome, database, public, BSseq, dataset, methylation, site, region, allele, specific, metadata, statistics, bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: University of Southern California; Los Angeles; USA
Free, Freely available BioTools:MethBase, biotools:Methbase https://bio.tools/MethBase, https://bio.tools/MethBase, https://bio.tools/MethBase SCR_017487 MethBase: a reference methylome database 2026-08-06 09:29:05 1
Signaling Pathways Project
 
Resource Report
Resource Website
10+ mentions
Signaling Pathways Project (RRID:SCR_018412) SPP database, data or information resource Web multi omics knowledgebase based upon public, manually curated transcriptomic and cistromic datasets involving genetic and small molecule manipulations of cellular receptors, enzymes and transcription factors. Integrated omics knowledgebase for mammalian cellular signaling pathways. Web browser interface was designed to accommodate numerous routine data mining strategies. Datasets are biocurated versions of publically archived datasets and are formatted according to recommendations of the FORCE11 Joint Declaration on Data Citation Principles73, and are made available under Creative Commons CC 3.0 BY license. Original datasets are available. Data integration, genetic database, gene regulatory network, cell signalling, cellular signalling network, transcriptomic data, manualy curated, cistromic data, cellular receptor, enzyme, transcrptomic factor, mammalian cellular signaling pathway, data mining strategy, dataset, , bio.tools is used by: Hypothesis Center
is listed by: Debian
is listed by: bio.tools
works with: Gene Expression Omnibus (GEO)
works with: NCBI Sequence Read Archive (SRA)
NIDDK DK097771;
NIDDK DK097748;
NIDDK DK48807;
NIDDK DK107535;
NIDDK DK56338;
NIDDK DK095686;
NIDDK DK105126;
NCI CA125123;
NHLBI HL127624;
Dan L. Duncan NCI Comprehensive Cancer Center at Baylor College of Medicine ;
CPRIT RP150578
PMID:31672983 Free, Freely available r3d100013650, biotools:Signaling_Pathways_Project https://bio.tools/Signaling_Pathways_Project, https://doi.org/10.17616/R31NJN0Y https://www.signalingpathways.org SCR_018412 2026-08-06 09:29:25 30
VeryFastTree
 
Resource Report
Resource Website
1+ mentions
VeryFastTree (RRID:SCR_023594) software application, source code, software resource Software tool for speeding up estimation of phylogenetic trees for large alignments through parallelization and vectorization strategies. large alignments, phylogenetic tree, phylogenetic tree creation, bio.tools is listed by: bio.tools
is related to: FastTree
MICINN ;
Xunta de Galicia ;
ERDF
PMID:32573652
DOI:10.1093/bioinformatics/btaa582
Free, Available for download, Freely available biotools:veryfasttree https://bio.tools/veryfasttree SCR_023594 2026-08-06 09:30:12 5
ReadqPCR
 
Resource Report
Resource Website
ReadqPCR (RRID:SCR_000030) standalone software, software application, software resource A software package that provides functions to read raw RT-qPCR data of different platforms. standalone software, mac os x, unix/linux, windows, r, data import, gene expression, microtitre plate assay, qpcr, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioconductor
has parent organization: University College London; London; United Kingdom
PMID:22748112 Free, Available for download, Freely available biotools:readqpcr, OMICS_03936 https://bio.tools/readqpcr SCR_000030 ReadqPCR - Read qPCR data 2026-08-06 09:25:06 0
metabnorm
 
Resource Report
Resource Website
metabnorm (RRID:SCR_001266) standalone software, software application, software resource Software tool as mixed model normalization method for metabolomics data.Uses normalization approach based on mixed model, with simultaneous estimation of correlation matrix. Metabolomics datasets, corelation, normalization, identifying metabolites, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: SourceForge
Cancer Research UK Cambridge Institute ;
Erik and Edith Fernström foundation ;
Cancer Research UK
PMID:24711654 Free, Available for download, Freely available OMICS_03548, biotools:metabnorm https://bio.tools/metabnorm SCR_001266 2026-08-06 09:25:22 0
FANTOM DB
 
Resource Report
Resource Website
10+ mentions
FANTOM DB (RRID:SCR_002678) FANTOM DB material resource, biomaterial supply resource The FANTOM consortium is an international collaborative research project initiated and organized by the RIKEN Omics Science Center. In earlier FANTOM efforts we cloned and annotated 103,000 full-length cDNAs from mouse and distributed them to researchers throughout the world. FANTOM1-3 focused on identifying the transcribed components of mammalian cells. This work improved estimates of the total number of genes and their alternative transcript isoforms in both human and mouse, expanded gene families, and revealed that a large fraction of the transcriptome is non-coding. In addition, with the development of Cap Analysis of Gene Expression (CAGE) FANTOM3 could map a large fraction of transcription start sites and revise our models of promoter structure. This updated web resource provides the previous FANTOM results mapped to current genome builds and presents the results of FANTOM4. In FANTOM4 the focus has changed to understanding how these components work together in the context of a biological network. Using deepCAGE (deep sequencing with CAGE) we monitored the dynamics of transcription start site (TSS) usage during a time course of monocytic differentiation in the acute myeloid leukemia cell line THP-1. This allowed us to identify active promoters, monitor their relative expression and define relevant regions for carrying out transcription factor binding site predictions. Computational methods were then used to build a network model of gene expression in this leukemia and the transcription factors key to its regulation. This work gives the first picture of the wiring between genes involved in acute myeloid leukemia and provides a strategy for identifying key factors that determine cell fates. In addition to the network, FANTOM4 data was used in two additional analyses. The first identified a novel class of short RNAs associated with transcription start sites and the second focused on the role of repetitive element expression in the transcriptome. TOOLS *Genome Browser: graphical display of genomic features, such as promoters, exon structures, H3K9 acetylation, transcription factors positioning on the genome, coupled with gene and promoter activities. *EdgeExpressDB: regulatory interactions, such as transcriptional regulation, post-transcriptional silencing with miRNA, and PPI, coupled with gene and promoter activities. *SwissRegulon: FANTOM4 TF regulation is predicted using Motif Activity Response Analysis (MARA) developed by Erik van Nimwegen at Biozentrum. Follow the link to carry out MARA on your own dataset. *Custom Tracks on the UCSC Genome Browser: FANTOM4 tracks on the UCSC Genome Browser Database. *The RIKEN integrated database of mammals: Integration of FANTOM4 data with other mammalian resources, in particular, produced by RIKEN. cdna clone, mouse, mouse cdna, human, bio.tools is listed by: One Mind Biospecimen Bank Listing
is listed by: bio.tools
is listed by: Debian
is related to: CAGE
has parent organization: RIKEN Omics Science Center
PMID:20211142 Free, Available for download, Freely available nif-0000-02833, biotools:fantom http://fantom3.gsc.riken.jp/, https://bio.tools/fantom SCR_002678 FANTOM: Functional Annotation of Mouse, FANTOM2, FANTOM1, Functional Annotation of the Mammalian Genome, FANTOM4, FANTOM3, FANTOM, Functional Annotation of Mouse 2026-08-06 09:25:41 20
e-Driver
 
Resource Report
Resource Website
1+ mentions
e-Driver (RRID:SCR_002674) standalone software, software application, software resource Software tool to identify cancer driver genes based on linear annotations of biological regions such as protein domains.Uses information on three-dimensional structures of mutated proteins to identify specific structural features. Then algorithm analyzes whether these features are enriched in cancer somatic mutations and are candidate driver genes. Identify cancer driver genes, candidate driver genes, perl, protein, mutated proteins, cancer somatic mutations, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
Cancer PMID:25064568 Free, Available for download, Freely available biotools:e-Driver, OMICS_05288 https://bio.tools/e-Driver SCR_002674 2026-08-06 09:25:41 5
MRFSEQ
 
Resource Report
Resource Website
MRFSEQ (RRID:SCR_002972) software resource, algorithm resource Algorithm based on a Markov random field (MRF) model that uses additional gene coexpression data to enhance differential gene expression prediction power. It is able to call differentially expressed (DE) genes but also assign confidence scores to each inferred DE gene. markov, algorithm, gene expression, prediction algorithm, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of California at Riverside; California; USA
PMID:23793751 Free, Available for download, Freely available biotools:mrfseq, OMICS_01309 https://bio.tools/mrfseq SCR_002972 2026-08-06 09:25:46 0
zfishbook
 
Resource Report
Resource Website
1+ mentions
zfishbook (RRID:SCR_006896) zfishbook material resource, biomaterial supply resource Collection of revertible protein trap gene-breaking transposon (GBT) insertional mutants in zebrafish with active or cryopreserved lines from initially identified lines. Open to community-wide contributions including expression and functional annotation and represents world-wide central hub for information on how to obtain these lines from diverse members of International Zebrafish Protein Trap Consortium (IZPTC) and integration within other zebrafish community databases including Zebrafish Information Network (ZFIN), Ensembl and National Center for Biotechnology Information. Registration allows users to save their favorite lines for easy access, request lines from Mayo Clinic catalog, contribute to line annotation with appropriate credit, and puts them on optional mailing list for future zfishbook newletters and updates. gene-breaking transposon, expression-tagged, revertible mutation, gene, transposon, mutation, mutant, brain, muscle, skin, secretory, cardiac, brain line, muscle line, skin line, secretory line, cardiac line, plasmid, expression, functional annotation, gene-breaking transposon line, gene-break transposon mutagenesis, cell line, annotation, embryonic zebrafish, larval zebrafish, bio.tools is listed by: One Mind Biospecimen Bank Listing
is listed by: Debian
is listed by: bio.tools
is related to: Addgene
is related to: Zebrafish International Resource Center
has parent organization: Mayo Clinic Minnesota; Minnesota; USA
Mayo Clinic Cancer Center ;
Mayo Foundation ;
NIGMS GM63904;
NIDA DA14546;
NHGRI HG006431
PMID:22067444 Free, Freely available biotools:zfishbook, nlx_151613 https://bio.tools/zfishbook SCR_006896 book, z fish book, zfishbook, fish, z 2026-08-06 09:26:42 4
PhyML
 
Resource Report
Resource Website
5000+ mentions
PhyML (RRID:SCR_014629) web application, source code, software resource Web phylogeny server based on the maximum-likelihood principle. phylogenic software, phylogeny, maximum likelihood, web server, bio.tools is used by: ProtTest
is listed by: bio.tools
is listed by: Debian
is listed by: OMICtools
is listed by: SoftCite
works with: PAML
DOI:10.1093/molbev/msq060 Public server, Source code is available on request biotools:phyml, OMICS_04241 https://bio.tools/phyml, https://sources.debian.org/src/phyml/ SCR_014629 2026-08-06 09:28:22 7740
QmRLFS-finder
 
Resource Report
Resource Website
10+ mentions
QmRLFS-finder (RRID:SCR_014584) software application, data analytics software, software resource A software which predicts R-loop Forming Sequences (RLFSs) in nucleic acid sequences based on the experimentally supported structural models of RLFSs. The tool identifies and visualizes RLFS coordinates from natural or artificial DNA or RNA input sequences and creates standard-compliant output files for later annotation and analysis. r-loop, r loop, rlf, rlfs, dna, rna, input sequences, output files, annotation, analysis, bio.tools uses: UCSC Genome Browser
is listed by: bio.tools
is listed by: Debian
is listed by: SoftCite
Singapore Agency for Science Technology and Research PMID:26400173
PMID:25883153
Open Source biotools:qmrlfs-finder https://omictools.com/qmrlfs-finder-tool, https://bio.tools/qmrlfs-finder SCR_014584 QmRLFS finder 2026-08-06 09:28:23 13
FunRich: Functional Enrichment analysis tool
 
Resource Report
Resource Website
100+ mentions
FunRich: Functional Enrichment analysis tool (RRID:SCR_014467) standalone software, software application, data analytics software, software resource A software tool used for functional enrichment and interaction network analysis of genes and proteins. Users can search against a default background database or load customized database. The results can be depicted as venn, bar, column, pie and doughnut charts. network analysis, background database, charts, data analytics software, standalone software, bio.tools, FASEB list is listed by: bio.tools
is listed by: Debian
PMID:25921073
PMID:26149235
Public, Open Source biotools:funrich https://bio.tools/funrich SCR_014467 2026-08-06 09:28:21 338
CIBERSORT
 
Resource Report
Resource Website
1000+ mentions
CIBERSORT (RRID:SCR_016955) software application, data analytics software, software resource Software tool to provide an estimation of the abundances of member cell types in a mixed cell population, using gene expression data. Used for characterizing cell composition of complex tissues from their gene expression profiles, large scale analysis of RNA mixtures for cellular biomarkers and therapeutic targets. estimation, abundance, cell, type, mixed, population, gene, expression, data, tissue, complex, analysis, RNA, biomarker, therapeutic, target, bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: Stanford University; Stanford; California
Doris Duke Charitable Foundation ;
Damon Runyon Cancer Research Foundation ;
B&J Cardan Oncology Research Fund ;
Ludwig Institute for Cancer Research ;
NCI U01 CA154969;
NIAID U19 AI090019;
NCI T32 CA09302;
US Department of Defense ;
Siebel Stem Cell Institute ;
Thomas and Stacey Siebel Foundation
PMID:25822800 Not freely available for download or distribution, Available for non commercial users, Registration required biotools:CIbERSORt https://bio.tools/CIBERSORT SCR_016955 2026-08-06 09:28:59 1239
Myriads
 
Resource Report
Resource Website
1+ mentions
Myriads (RRID:SCR_017447) software application, data analytics software, software resource Software package for p value based multiple testing that also implements dependence test and p-value simulation. P value, multiple, testing, simulation, BRAIN Initiative, bio.tools is recommended by: BRAIN Initiative
is listed by: bio.tools
is listed by: Debian
NIMH MH111416 PMID:29186285 biotools:myriads https://bio.tools/myriads SCR_017447 SGoF+ 2026-08-06 09:29:04 1
PyRosetta
 
Resource Report
Resource Website
10+ mentions
PyRosetta (RRID:SCR_018541) standalone software, software application, software resource Interactive Python based interface to Rosetta molecular modeling suite. Stand alone Python based implementation of Rosetta molecular modeling package that allows users to write custom structure prediction and design algorithms using major Rosetta sampling and scoring functions. Molecular modeling, custom structure prediction, design algorithm, energy function, scoring function, bio.tools uses: Python Programming Language
is listed by: bio.tools
is listed by: Debian
is related to: Rosetta
has parent organization: Johns Hopkins University; Maryland; USA
NIGMS R01 GM73151;
NIGMS R01 GM078221;
NSF 0846324
PMID:20061306 Free, Freely available biotools:pyrosetta https://bio.tools/pyrosetta SCR_018541 Python Rosetta 2026-08-06 09:29:20 20
Segway - a way to segment the genome
 
Resource Report
Resource Website
1+ mentions
Segway - a way to segment the genome (RRID:SCR_004206) source code, software resource The free Segway software package contains a novel method for analyzing multiple tracks of functional genomics data. The method uses a dynamic Bayesian network (DBN) model, which enables it to analyze the entire genome at 1-bp resolution even in the face of heterogeneous patterns of missing data. This method is the first application of DBN techniques to genome-scale data and the first genomic segmentation method designed for use with the maximum resolution data available from ChIP-seq experiments without downsampling. Segway uses the Graphical Models Toolkit (GMTK) for efficient DBN inference. The software has extensive documentation and was designed from the outset with external users in mind. genome annotation, source code, bayesian network model, bayesian, chip seq, dbn, bio.tools is used by: ENCODE
is listed by: Debian
is listed by: bio.tools
has parent organization: University of Washington; Seattle; USA
has parent organization: University of Toronto; Ontario; Canada
PMID:22426492 Free nlx_22911, biotools:segway https://www.pmgenomics.ca/hoffmanlab/proj/segway/, https://bitbucket.org/hoffmanlab/segway/, https://bio.tools/segway http://noble.gs.washington.edu/proj/segway/ SCR_004206 Segway 2026-08-06 09:26:03 8
Biopieces
 
Resource Report
Resource Website
10+ mentions
Biopieces (RRID:SCR_005783) Biopieces source code, software toolkit, software resource A collection of bioinformatics tools that can be pieced together in a very easy and flexible manner to perform both simple and complex tasks. The Biopieces work on a data stream in such a way that the data stream can be passed through several different Biopieces, each performing one specific task: modifying or adding records to the data stream, creating plots, or uploading data to databases and web services. The Biopieces are executed in a command line environment where the data stream is initialized by specific Biopieces which read data from files, databases, or web services, and output records to the data stream that is passed to downstream Biopieces until the data stream is terminated at the end of the analysis. The advantage of the Biopieces is that a user can easily solve simple and complex tasks without having any programming experience. Moreover, since the data format used to pass data between Biopieces is text based, different developers can quickly create new Biopieces in their favorite programming language - and all the Biopieces will maintain compatibility. Finally, templates exist for creating new Biopieces in Perl and Ruby. There are currently ~190 Biopieces (March 2014). bioinformatics, tool, framework, biopieces, language independent, bio.tools, FASEB list is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Google Project Hosting
Danish Agency for Science Technology and Innovation 272-06-0325 GNU General Public License, v2 nlx_149253, biotools:biopieces, OMICS_01036 http://code.google.com/p/biopieces/, https://bio.tools/biopieces SCR_005783 www.biopieces.org, biopieces - Biopieces is a bioinformatic framework of tools easily used and easily created 2026-08-06 09:26:24 40
VIDA
 
Resource Report
Resource Website
100+ mentions
VIDA (RRID:SCR_007111) VIDA data set, data or information resource VIDA contains a collection of homologous protein families derived from open reading frames from complete and partial virus genomes. For each family, users can get an alignment of the conserved regions, functional and taxonomy information, and links to DNA sequences and structures. * Search homologous protein families from particular virus families * Links to complete genome sequence: Arteriviridae, Coronaviridae, Herpesviridae, Poxviridae The Virus Database at University College London has been developed as a system to organize animal virus open reading frame sequences. All known and predicted protein sequences from complete and partial genomes of particular virus families are extracted from GenBank and filtered to remove 100% redundancy. On the basis of sequence similarity the sequences are then clustered into homologous protein families (HPFs). The families are enriched with annotations including function and functional classification, related protein structures, taxonomy, length of the proteins, boundaries of the conserved region/s, virus-specific gene name and links to EMBL entries and SWISSPROT., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. genomics, non-vertebrate, viral genome, homologous protein, hpf, viral genome, virus, bio.tools, FASEB list is listed by: Debian
is listed by: bio.tools
has parent organization: University College London; London; United Kingdom
BBSRC ;
MRC
PMID:11125070 THIS RESOURCE IS NO LONGER IN SERVICE nif-0000-03628, biotools:vida https://bio.tools/vida http://www.biochem.ucl.ac.uk/bsm/virus_database/VIDA.html SCR_007111 Virus Database at University College London, Virus Database, VIDA Virus Database 2026-08-06 09:26:45 193

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