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https://www.wadsworth.org/research/cores/alm

Core facility is designed for Imaging living cells or tissues, Fluorescence imaging, Image analysis. Provides imaging of adherent cells or tissue fragments,drug delivery using perfusion chamber, gas exchange for the growth media, Rose chambers for imaging, image processing and analysis software to assist in data analysis and interpretation.

Proper citation: New York State Department of Health Wadsworth Center Advanced Light Microscopy and Image Analysis Core Facility (RRID:SCR_021104) Copy   

•   Source: SciCrunch Registry

https://psxl.ku.edu/

Core laboratory with infrastructure and expertise to perform all aspects of protein and small molecule structure determination using X-ray crystallography. For protein structure determination, high-throughput methods are utilized to move projects rapidly from gene-to-structure.

Proper citation: University of Kansas Lawrence Protein Structure and X-ray Crystallography Laboratory Core Facility (RRID:SCR_021742) Copy   

•   Source: SciCrunch Registry

https://www.biotech.cornell.edu/core-facilities-brc/facilities/proteomics-metabolomics-facility

Facility provides diverse range of Mass Spectrometry based proteomics and metabolomics services.Services include sample preparation, sample analysis, and data interpretation.

Proper citation: Cornell University BRC Proteomics and Metabolomics Core Facility (RRID:SCR_021743) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/lab/nmr/

Core serves research needs of entire campus community as well as outside research entities. Facility maintains a variety of NMR spectrometers at variety of magnetic fields to support research needs.

Proper citation: Colorado University at Boulder Nuclear Magnetic Resonance Spectroscopy Core Facility (RRID:SCR_019311) Copy   

•   Source: SciCrunch Registry

https://www.biotech.cornell.edu/core-facilities-brc/facilities/epigenomics-facility

Provides service that maps protein DNA interactions genome wide, tracks experimental metadata, and implements quality controlled data processing and research based analysis pipelines. Provides epigenomic and bioinformatic research resources and services that include sample preparation services and data generation. Open source platforms enable and reinforce FAIR data practices. Core is able to receive and process cell and tissue samples for various diagnostic epigenetic assays.

Proper citation: Cornell University BRC Epigenomics Core Facility (RRID:SCR_021287) Copy   

•   Source: SciCrunch Registry

https://research.med.psu.edu/core-facilities/transmission-electron-microscopy/

Provides consultation and training in TEM imaging of biological, chemical, and materials science samples.

Proper citation: Penn State Hershey College of Medicine Transmission Electron Microscopy Core Facility (RRID:SCR_021200) Copy   

•   Source: SciCrunch Registry

https://nuance.northwestern.edu/facilities/biocryo/index.html

Provides source for characterization of biological, soft matter, and hybrid samples with TEM (Transmission Electron Microscopy), SEM (Scanning Electron Microscopy), and STEM (Scanning Transmission Electron Microscopy) at cryogenic or at ambient temperature.Provide expertise and access to equipment for cryofixation and processing of frozen hydrated samples by high pressure freezing, plunge freezing, freeze fracturing, cryo ultramicrotomy, freeze substitution, and turbo freeze-drying. Conventional samples can be processed at ambient temperature with chemical fixation, dehydration, and resin embedding, or critical point drying. Offers EDX (Energy Dispersive X-ray Spectroscopy) for elemental analysis.Offers training on instruments and sample preparation techniques.BioCryo staff mentors new users, advises on experimental design, and collaborates with researchers in experiments with challenging and unconventional samples.BioCryo Facility participates in numerous educational and outreach events, e.g. workshops, seminars, demos, and facility tours.

Proper citation: Northwestern University NUANCE BioCryo Core Facility (RRID:SCR_021288) Copy   

•   Source: SciCrunch Registry

http://web.ncifcrf.gov/atp/default.asp?LabID=12&page=labs

Comprises six service groups. Our services are available to all NIH intramural researchers, and by interagency agreements to FDA and US Army at Ft. Detrick. We are happy to consult and distribute materials to not-for-profit institutions.Clone Optimization service include DNA cloning for protein expression; Gateway-based; fluorescent, epitope, solubility, purification tags; mutagenesis; vectors for insect/ baculovirus, mammalian, E. coli, P. pastoris, K. lactis. Microbial Expression: E. coli, P. pastoris, K. lactis, 2 mL to 60 L, autoinduction and IPTG; fully instrumented fermenters.Eukaryotic Expression service include insect / baculovirus, mammalian transient and stable, monoclonal antibodies.Protein Purification service include parallel microscale for process development; affinity and native, tag and endotoxin removal; scale-up to low gram scale.Virus Technology service include custom and stock adenovirus and lentivirus production; titer determination; promoter and reporter panels in lentivirus ready to deliver.Molecular Detection: qPCR and ELISA assaysdeveloped and executed, focused on human viruses in human samples; qPCR assays for mycoplasma and human pathogenic viruses contaminating cell lines; cell line identity testing.

Proper citation: Frederick National Laboratory Protein Expression Laboratory Core Facility (RRID:SCR_021286) Copy   

•   Source: SciCrunch Registry

https://strucbiol.pbsci.ucsc.edu/

Provides instrumentation, supplies, and expertise to assist researchers in structural characterization of biological macromolecules. Resources are available for crystallization and structure determination as wells as biophysical characterization of macromolecular stability and interactions.

Proper citation: University of California Santa Cruz Macromolecular Structure Function Core Facility (RRID:SCR_021283) Copy   

•   Source: SciCrunch Registry

http://www.nersc.gov

Supercomputer user facility operated by Lawrence Berkeley National Laboratory for the United States Department of Energy Office of Science.Houses high performance computing and data systems used by scientists at national laboratories and universities around the country.

Proper citation: University of California at Berkeley National Energy Research Scientific Computing Core Facility (RRID:SCR_021318) Copy   

•   Source: SciCrunch Registry

https://gladstone.org/science/flow-cytometry-core

Core offers operation, training and consultation on both cell sorters and analyzers.Our core comprises BDFACsAria II, two BDFACSAria Fusions, Fortessa X-20 and Attune, with analyzing and sorting up to 18 colors possible. Core also offers antibody staining, protocol optimization and data analysis services.

Proper citation: Gladstone Institutes Gladstone Flow Cytometry Core Facility (RRID:SCR_021714) Copy   

•   Source: SciCrunch Registry

https://biotech.unl.edu/proteomics-and-metabolomics#tab1

Provides services using mass spectrometry, including identification and relative quantification of proteins and several advanced methods for profiling and quantitation of small molecules.Provides outreach and education program including workshops,seminars and courses.Proteomics services include Bottom-up Proteomics of whole organisms, organs, organelles, tissues, cell pellets, pulldowns, complex or single protein mixes from solutions or gels;Quantification by label-free or multiplexed labeling techniques with microscale subfractionation to increase coverage;Post Translational Modification Characterization especially phosphopeptide enrichment from whole organism digests, but also ubiquitylation, acetylation, etc.Metabolomics services include Untargeted Quantification of small molecules;Primary metabolism using GC-MS and NIST/Fiehn Libraries;Secondary metabolism using LC-MS and Progenesis QI, NIST Library, mzCloud;Targeted Quantification using HPLC or LCMS.

Proper citation: University of Nebraska Lincoln Nebraska Center for Biotechnology Proteomics and Metabolomics Core Facility (RRID:SCR_021314) Copy   

•   Source: SciCrunch Registry

https://sites.google.com/alaska.edu/genomicscorelab/home

UAF IAB Genomics Core Lab provides library preparation and sequencing services for the Illumina MiSeq sequencer, and the Oxford Nanopore Technologies GridION. For UAF researchers, we also provide training and access to specialized equipment relating to the purification, quantitation, amplification and library preparation of DNA and RNA.

Proper citation: University of Alaska Fairbanks Genomics Core Facility (RRID:SCR_021291) Copy   

•   Source: SciCrunch Registry

https://cemas.osu.edu

Centralized, coordinated imaging facility.Provides electron and ion beam analytical microscopy instruments.Full service facility from extensive sample preparation laboratories to image processing tools and support.

Proper citation: Ohio State University Center for Electron Microscopy and Analysis Core Facility (RRID:SCR_021294) Copy   

•   Source: SciCrunch Registry

https://mcgill.ca/cftrc/platforms/primary-airway-cell-biobank-pacb

Nonprofit facility providing researchers worldwide with standardized, high-quality primary airway cells from normal and large variety of airway diseased donors with different genetic backgrounds, are essential for improving our understanding of CF and other respiratory diseases and for translational research to develop new therapeutic agents.The PACB is certified by the UBC Office of Biobank Education and Research Biobank Certification Program.

Proper citation: McGill University Primary Airway Cell Biobank Core Facility (RRID:SCR_020998) Copy   

•   Source: SciCrunch Registry

https://sites.google.com/ucsc.edu/ucsccrisprcore/home

Facility that provides CRISPR services and expertise to facilitate study of gene function. Services include project consultation, sgRNA design and cloning, lentivirus production, custom CRISPR cell line generation and genome wide CRISPR screen.

Proper citation: University of California at Santa Cruz CRISPR Core Facility (RRID:SCR_021207) Copy   

•   Source: SciCrunch Registry

https://www.feinberg.northwestern.edu/sites/cam/

Core offers instrumentation and services for study of biological processes at whole animal, tissue, cellular and subcellular levels. This includes light microscopy, electron microscopy and image analysis. Light microscopy offerings include super resolution microscopy (MINFLUX, STED, NSPARC, SORA), fluorescent laser scanning and spinning disk microscopy, fluorescent lifetime imaging, automated high throughput tissue cytometry, atomic force microscopy, laser capture microdissection, mutliphoton imaging, and whole animal bioluminescent and fluorescent imaging. Electron microscopy includes sample prep and imaging for TEM, SEM, platinum replicas, immuno gold and CLEM. We also provide microinjection equipment, chambers for stable live cell observation, and anesthesia equipment. CAM provides training on numerous different instrument platforms, consultation on experiment design, as well as digital image processing and image analysis.CAM is one of two Nikon Imaging Centers in the US, allowing us access and excellent support from Nikon to develop innovative solutions for the cutting edge imaging needs of users.

Proper citation: Northwestern University Feinberg School of Medicine Center for Advanced Microscopy and Nikon Imaging Center Core Facility (RRID:SCR_020996) Copy   

•   Source: SciCrunch Registry

https://med.umn.edu/uic

Center composes network of core imaging facility locations for advanced optical imaging and basic electron microscopy located within the AHC/Medical School (1-151 Jackson Hall, Minneapolis) and College of Biological Sciences (23 Snyder Hall, St. Paul) on the University of Minnesota Twin Cities Campus.UIC cores serve internal and external research clients in design of imaging experiments, choice of and training on suitable imaging systems, and subsequent image processing, visualization and analysis.Provides advanced imaging systems including macro spectral confocal microscopy,wide-field light and fluorescence microscopy, spinning disk confocal, laser-scanning confocal microscopes, multi photon/Second Harmonic Generation microscopes, total internal reflectance microscope, laser capture micro-dissection, live cell imaging systems, scanning and transmission electron microscopy, whole animal fluorescence, bioluminescence and chemiluminescence imagers, gel, print and film scanners,poster printers, full sample preparation capabilities.

Proper citation: University of Minnesota University Imaging Centers Core Facility (RRID:SCR_020997) Copy   

•   Source: SciCrunch Registry

http://big.umassmed.edu

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 11, 2025. Interdisciplinary team of engineers and scientists, representing fields of physics, mathematics, and computer science, that combine their expertise in areas such as microscopy, lasers, optoelectronics, applied mathematics, image and signal processing, computer graphics, computer vision, statistics, software engineering, and biophysics, to develop imaging approaches for cell biology. Pioneers in high-resolution 3D imaging using wide-field fluorescence microscopy together with digital image deconvolution, and image visualization and quantitative analysis techniques, especially as applied to statistical analysis of images to determine co-localization of fluorescence markers inside cells.Research includes development and application of light microscopy and imaging in cell biology and biophysics.Developed TESM microscope that combines Total internal reflection fluorescence (TIRF) with Epi-fluorescence Structured illumination to provide new views of trafficking in near plasma membrane domain of cells.Provides custom-built, ultra-high-speed microscope system for imaging dynamics of intracellular calcium channel events, called calcium sparks, that are being found to regulate expanding array of cellular processes. Provides two photon fluorescence microscope for looking deep inside tissue, completing range from molecule to organism. Areas of ongoing technology research include high-speed, high-resolution imaging of live cells and tissues, novel image processing approaches, high-performance computing, and computer graphics.

Proper citation: University of Massachusetts Medical School Biomedical Imaging Group Core Facility (RRID:SCR_021201) Copy   

•   Source: SciCrunch Registry

http://med.uvm.edu/mic

The MIC Live Imaging and Physiology Core is a division of the Microscopy and Imaging Center of the UVM Larner College of Medicine. The Live Imaging and Physiology Core provides a wide range of imaging techniques mainly for live-cell, live-tissue and in-vivo preparations. We maintain a Noran/Prairie Technologies OZ LSCM (laser scanning confocal microscope), a DeltaVision RT restoration microscopy system, a Zeiss/BioRad 2100 dedicated multiphoton LSCM, a Zeiss LSM 7 MP dedicated multiphoton LSCM, a Nikon TIRF (total-internal reflection fluorescence) system, a Nikon/Yokogawa CSU-W1 spinning disk microscopy system, a PTI monochromator system, and a Nikon SMZ-1500 fluorescence stereoscope. Patch-clamp electronics are available for use on most microscope systems, and each system has an integrated perfusion setup.

Proper citation: University of Vermont Larner College of Medicine Microscopy Imaging Center Live Imaging and PhysiologyCore Facility (RRID:SCR_021289) Copy   

•   Source: SciCrunch Registry