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Lifebanc is the nonprofit organ and tissue recovery organization for Northeast Ohio. As one of the original seven independent organ procurement organizations in the United States, Lifebanc serves nearly four million people and works with 80 hospitals in 20 counties. We are a member of the Organ Procurement and Transplantation Network (OPTN), which has been managed by the United Network for Organ Sharing (UNOS) since 1986. We also work closely with local partners, as well as the other Organ Procurement Organizations in the state of Ohio to educate the public and healthcare professionals about the benefits of and need for organ, tissue and eye donations. These organizations include Lifeline of Ohio; LifeCenter and Life Connection of Ohio. Along with serving the public, professional community and donor hospitals, Lifebanc provides life-saving organs to two transplant centers: The Cleveland Clinic and University Hospital Case Medical Center. Recovered tissue is transplanted countless times in hospitals throughout the region. Last year, Lifebanc helped to heal and save more than 25,000 lives. Additionally, it was instrumental in helping to perform the nation''s first near-total face transplant and establishing the world-record for lungs transplanted in a year.
Proper citation: LifeBanc (RRID:SCR_004918) Copy
Indiana Organ Procurement Organization (IOPO) is the non-profit health service dedicated to advancing organ, tissue, and eye donation throughout Indiana. Its mission is to save and enhance the quality of life through organ, tissue and eye donation. IOPO''s vision is to create the most effective and influential donation and transplantation delivery model in health care. IOPO, as a health services organization, is regulated by several agencies of the US government and maintains accreditations and compliance with regulatory requirements by strict adherence to quality.
Proper citation: Indiana Organ Procurement Organization - IOPO (RRID:SCR_004912) Copy
Kentucky Organ Donor Affiliates (KODA) is dedicated to saving lives through organ and tissue donation and transplantation. An independent, non-profit organ and tissue procurement agency, KODA was formed to establish a statewide educational and procurement network. Its services include evaluation of organ/tissue donor suitability; coordination of organ recovery; organ placement; tissue recovery; family support and aftercare; hospital staff education; public education. Like all OPOs, KODA is federally designated by the U.S. Department of Health and Human Services (HHS). As a licensed tissue bank, KODA Tissue Operations is regulated by the Food & Drug Administration (FDA). KODA is a member of the United Network of Organ Sharing (UNOS), a government-chartered nationwide network operating the Organ Procurement and Transplantation Network (OPTN) under federal contract with the U.S. Department of Health and Human Services (HHS). Founded in 1987 (Originated as a combination of existing organ and tissue procurement programs at the University of Kentucky and the University of Louisville), it now serves 114 counties in Kentucky, 4 counties in southern Indianan and 2 counties in western West Virginia. (Six northern Kentucky counties are served by LifeCenter in Cincinnati). Its major clients are 112 hospitals, 3 transplant centers and a multicultural population of 4 million people.
Proper citation: Kentucky Organ Donor Affiliates (KODA) (RRID:SCR_004990) Copy
Tennessee Donor Services (TDS) is a nonprofit, independent organization authorized by the Federal Government to accept anatomical gifts for transplantation and research. Its mission is to support families in our communities who have sustained the loss of a loved one by providing an opportunity for organ, eye and tissue donation and by facilitating the recovery and transplantation of these gifts to help others in need. In our area (TN & VA), over 4,600 people now wait for an organ transplant, (heart, liver, lungs, kidneys, intestine or pancreas). Annually, our service area has approximately 300 people who donate one or more organs upon death and over 900 who donate corneas and/or tissues annually. The need for transplants far exceeds the number of donations in the area covered by TDS, and across the nation. Currently, in the United States, more than 108,000 people wait for an organ transplant. One third of them will die waiting for a transplant. TDS'' designated service area includes 84 counties in Tennessee, 10 counties in Virginia, 3 counties in Georgia and 1 county in Kentucky.
Proper citation: Tennessee Donor Services (RRID:SCR_004992) Copy
http://www.cdha.nshealth.ca/regional-tissue-bank
The Regional Tissue Bank (RTB), in Halifax Nova Scotia, is a non-profit service dedicated to providing Canadian health care teams with safe high quality allograft tissue and tissue products in support of optimal patient outcomes. It is accredited with the American Association of Tissue Bank (AATB) for all aspects of screening, procurement, processing, storage and distribution for cardiovascular, bone and skin tissues. The RTB is also in compliance with the Eye Bank Association of America (EBAA) and the draft Canadian Standards for Tissue Donation and Transplantation. It also supports autologous tissue transplantation, the bone marrow transplantation program and provides perfusion and preservation service to the Multi-Organ Transplant Program kidney and liver procurement teams. The mission of the Regional Tissue Bank is to ensure all Nova Scotians are offered the option of tissue donation and to provide safe high quality tissue products to Nova Scotian surgical programs and patients. It has expanded its activities with New Brunswick, in collaboration with Health Care Regions, to support tissue donation and transplantation in New Brunswick. The RTB also provides tissue to centers throughout Canada when requested; under the condition that meeting these requests would not disadvantage Atlantic Canadians.
Proper citation: Regional Tissue Bank (RRID:SCR_004872) Copy
http://www.utmb.edu/scccb/htbc/htbc.htm
THIS RESOURCE IS NO LONGER IN SERVCE, documented September 2, 2016.
Proper citation: University of Texas Tumor Bank (RRID:SCR_005048) Copy
TBI/Tissue Banks International is a non-profit network of medical eye and tissue banks dedicated to the relief of human suffering through transplantation. More than 100,000 patients are treated with TBI tissue annually. TBI is a recognized innovator in the field of eye and tissue banking and has led advancements in recovery, processing, and distribution of allograft tissue. Each person who chooses to become an eye and tissue donor can help more than a dozen people through their gift. Sight can be restored with a cornea, mobility enabled with a ligament, pain eased with a spinal implant made of bone, burns treated with skin, and lives saved with heart valves. The largest provider of ocular tissue in the world, TBI started as a single eye bank in 1962, and has grown to a network that covers the United States and reaches around the globe. Each year, more than 130,000 TBI tissues are used in transplant surgery, with thousands more utilized in research and medical education.
Proper citation: Tissue Banks International - TBI (RRID:SCR_005041) Copy
NDRI actively recovers a diverse range of normal and diseased human tissues for biomedical researchers. We have recently implemented a new program to make human dorsal root ganglia (DRG) available for your research studies. The dorsal root ganglia contain cell bodies of afferent (inbound) neurons, and transmit pain and temperature sensations from the body. DRGs from C5 through L5 regions will be available. DRGs will be recovered under operating room conditions with a low post mortem interval to preservation and can be shipped at 4 degrees C, snap-frozen or fixed. Detailed medical-social history information is provided for each donor. If you are interested in obtaining these specimens, please contact me at your earliest convenience. Current NDRI researchers can immediately request these samples. Non-NDRI researchers need to submit a researcher application. * The program provides a reliable source of human DRG neurons that can be utilized for: Electrophysiology analysis, Live cell imaging studies * Low PMI yields high quality samples that are suitable for rigorous molecular applications: Deep sequencing analysis, In situ hybridization, Micro-array analysis * DRGs from C5 through L5 regions will be available. * The tissue fee for this program is 500 dollars per DRG * Customizable-- the researcher determines the DRG location and quantity that is needed for their research.
Proper citation: NDRI Dorsal Root Ganglia Program (RRID:SCR_005043) Copy
LifeCenter Northwest is one of 58 federally designated nonprofit organ procurement organizations (OPO) in the United States. LifeCenter Northwest works together with families, medical professionals, and communities in Alaska, Montana, North Idaho, and Washington to save lives through organ and tissue donation. LifeCenter Northwest provides the following services: * Hospital Development ** support of donor families throughout and after the donation process ** development of strong relationships between hospitals and LifeCenter Northwest ** helping hospitals stay compliant with federal and state regulations ** ongoing education of hospital staff on donation laws and programs * Organ Recovery Services ** on-site referral response to hospitals ** evaluation of patient medical suitability for donation ** management of patient care through the allocation and recovery of organs ** placement of organs, working with the United Network for Organ Sharing (UNOS) ** coordination of transplant team transportation and arrival at donor hospitals ** surgical recovery and transportation of organs * Tissue Recovery Services ** telephone referral response to hospitals ** evaluation of patient medical suitability for donation ** surgical recovery and transportation of tissues
Proper citation: LifeCenter Northwest (RRID:SCR_004868) Copy
California Transplant Services (CTS) is a full service eye and tissue bank headquartered in Carlsbad, California. CTS is a California non-profit public benefit corporation qualified by the IRS as a section 501(c)3 public charity, licensed by the California Department of Public Health as a Tissue Bank and registered and inspected by the United States Food and Drug Administration. We were also inspected by the American Association of Tissue Banks in September of 2003 and awarded Accreditation in December 2003. California Transplant Services is a Member of the Eye Bank Association of America. We are registered in California with the Office of Charitable Trusts. Most of CTS California Transplant''s fulltime staff are Certified Tissue Bank Specialists (CTBS) by the AATB or Certified Eye Bank Technicians (CEBT) by the Eye Bank Association of America. CTS staffing includes fulltime and part time tissue procurement specialists. CTS helps tissue banks by providing 24 hour tissue placement services from it''s west coast USA distribution center. CTS has provided cornea and bone tissue placement services nationwide since 1994.
Proper citation: California Transplant Services (RRID:SCR_004788) Copy
http://www.rtix.com/about/donor-services/
RTI Donor Services is a not-for-profit, American Association of Tissue Banks (AATB) accredited organization, working with organ and tissue agencies to provide responsible stewardship of the gift of donation. By working with RTI Donor Services, you will receive the benefit of the science, safety and innovation of RTI Biologics, Inc. (RTI). While RTI Biologics and RTI Donor Services are separate but affiliated organizations, our missions are symbiotic ����?? both are aimed at improving the lives of others with a focus on maximizing the gift of tissue donation, providing safe tissue implants for recipients, and providing education and support programs to donor families and the donation community. Please visit http://www.rtidonorservices.org/about_rti_donor_services for more information.
Proper citation: RTI Donor Services (RRID:SCR_004895) Copy
http://www.broadinstitute.org/cancer/cga/oncotator
A tool for annotating human genomic point mutations and indels with data relevant to cancer researchers. Genomic Annotations, Protein Annotations, and Cancer Annotations are aggregated from many resources. A standalone version of Oncotator is being developed.
Proper citation: Oncotator (RRID:SCR_005183) Copy
A comprehensive collection of human transcription factor binding sites models. DNA sequences of TF binding regions obtained by both pregenomic and high-throughput methods were collected from existing databases and other public data. The ChIPMunk software was used to construct positional weight matrices. Four motif discovery strategies were tested based on different motif shape priors including flat and periodic priors associated with DNA helix pitch. A quality rating was manually assigned to each model based on known binding preferences. An appropriate TFBS model was selected for each TF, with similar models selected for related TFs. In any case only one model per TF was selected unless there was additional evidence for two distinct binding models or different stable modes of dimerization. All TFBS models and initial binding segments data used for motif discovery were mapped to UniPROT IDs.
Proper citation: HOCOMOCO (RRID:SCR_005409) Copy
http://wiringthebrain.blogspot.com/
This blog highlights and comments on current research and hypotheses relating to how the brain wires itself up during development, how the end result can vary in different people and what happens when it goes wrong. It includes discussions of the genetic and neurodevelopmental bases of traits such as intelligence and personality characteristics, as well as of conditions such as schizophrenia, autism, dyslexia, epilepsy, synaesthesia and others.
Proper citation: Wiring the Brain (RRID:SCR_005528) Copy
http://research.nhgri.nih.gov/skippy/index.shtml
A Web-based tool that allows users to input a set of exonic variants to score them for a number of features (such as changes in splicing regulatory elements) that have been shown to be predictive of known genome variations that cause exon skipping or activation of ectopic splice sites. In this way, variants can be either prioritized for further splicing-based functional analysis or the results can be used as further genomic evidence in cases in which the causative variant is already known.
Proper citation: SKIPPY (RRID:SCR_005430) Copy
http://mirdsnp.ccr.buffalo.edu/
A database of manually curated dSNPs on the 3''UTRs of human genes from available publications in PubMed. The advanced web interface allows users to perform proximity searches between miRNA target sites and dSNPs by gene name, miRbase ID, target prediction algorithm, disease, and any nucleotide distance between dSNPs and miRNA target sites. The web interface displays detailed sequence views showing the relationship between dSNPs, miRNA target sites, and SNPs. An interactive visualization tool shows the chromosomal distribution of dSNPs, miRNA target sites (from TargetScan), and SNPs. miRdSNP provides a comprehensive data source of dSNPs and robust tools to capture their spacial relationship with miRNA target sites on the 3''UTRs of human genes. miRdSNP enables researchers to further explore the molecular mechanism of gene dysregulation for dSNPs at posttranscriptional level.
Proper citation: miRdSNP (RRID:SCR_005303) Copy
http://www.neuroepigenomics.org/methylomedb/
A database containing genome-wide brain DNA methylation profiles for human and mouse brains. The DNA methylation profiles were generated by Methylation Mapping Analysis by Paired-end Sequencing (Methyl-MAPS) method and analyzed by Methyl-Analyzer software package. The methylation profiles cover over 80% CpG dinucleotides in human and mouse brains in single-CpG resolution. The integrated genome browser (modified from UCSC Genome Browser allows users to browse DNA methylation profiles in specific genomic loci, to search specific methylation patterns, and to compare methylation patterns between individual samples. Two species were included in the Brain Methylome Database: human and mouse. Human postmortem brain samples were obtained from three distinct cortical regions, i.e., dorsal lateral prefrontal cortex (dlPFC), ventral prefrontal cortex (vPFC), and auditory cortex (AC). Human samples were selected from our postmortem brain collection with extensive neuropathological and psychopathological data, as well as brain toxicology reports. The Department of Psychiatry of Columbia University and the New York State Psychiatric Institute have assembled this brain collection, where a validated psychological autopsy method is used to generate Axis I and II DSM IV diagnoses and data are obtained on developmental history, history of psychiatric illness and treatment, and family history for each subject. The mouse sample (strain 129S6/SvEv) DNA was collected from the entire left cerebral hemisphere. The three human brain regions were selected because they have been implicated in the neuropathology of depression and schizophrenia. Within each cortical region, both disease and non-psychiatric samples have been profiled (matching subjects by age and sex in each group). Such careful matching of subjects allows one to perform a wide range of queries with the ability to characterize methylation features in non-psychiatric controls, as well as detect differentially methylated domains or features between disease and non-psychiatric samples. A total of 14 non-psychiatric, 9 schizophrenic, and 6 depression methylation profiles are included in the database.
Proper citation: MethylomeDB (RRID:SCR_005583) Copy
A database of human molecular interaction networks that integrates human protein-protein and transcriptional regulatory interactions from 15 distinct resources and aims to give direct and easy access to the integrated data set and to enable users to perform network-based investigations. The database includes tools (i) to search for molecular interaction partners of query genes or proteins in the integrated dataset, (ii) to inspect the origin, evidence and functional annotation of retrieved proteins and interactions, (iii) to visualize and adjust the resulting interaction network, (iv) to filter interactions based on method of derivation, evidence and type of experiment as well as based on gene expression data or gene lists and (v) to analyze the functional composition of interaction networks.
Proper citation: Unified Human Interactome (RRID:SCR_005805) Copy
http://llama.mshri.on.ca/funcassociate/
A web-based tool that accepts as input a list of genes, and returns a list of GO attributes that are over- (or under-) represented among the genes in the input list. Only those over- (or under-) representations that are statistically significant, after correcting for multiple hypotheses testing, are reported. Currently 37 organisms are supported. In addition to the input list of genes, users may specify a) whether this list should be regarded as ordered or unordered; b) the universe of genes to be considered by FuncAssociate; c) whether to report over-, or under-represented attributes, or both; and d) the p-value cutoff. A new version of FuncAssociate supports a wider range of naming schemes for input genes, and uses more frequently updated GO associations. However, some features of the original version, such as sorting by LOD or the option to see the gene-attribute table, are not yet implemented. Platform: Online tool
Proper citation: FuncAssociate: The Gene Set Functionator (RRID:SCR_005768) Copy
http://snps-and-go.biocomp.unibo.it/snps-and-go/
A server for the prediction of single point protein mutations likely to be involved in the insurgence of diseases in humans.
Proper citation: SNPsandGO (RRID:SCR_005788) Copy
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