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https://nuance.northwestern.edu/facilities/epic/

Offers wide range of electron microscopy (both transmission and scanning), accessory instrumentation, and expertise to the scientific and engineering community through education, collaboration, and service. Provides facilities for preparation and examination of many types of bulk and thin specimens (foils/films), fine particles, and replicas, including biological materials, by transmission and scanning electron microscopy.

Proper citation: Northwestern University Electron Probe Instrumentation Center EPIC Core Facility (RRID:SCR_026361) Copy   

•   Source: SciCrunch Registry

https://um-grex.github.io/grex-docs/grex/

Core offers computing and storage resources, along with support and training. Currently, Grex system consists of over 10,000 CPU cores connected via low-latency InfiniBand interconnect, several GPU compute nodes, 2 Petabytes of high-performance Lustre storage, and tape backup system. System also provides for condominium model of hosting researcher-contributed hardware funded by Canada Foundation for Innovation (CFI) and other granting agencies.

Proper citation: University of Manitoba Grex High Performance Computing Core Facility (RRID:SCR_026342) Copy   

•   Source: SciCrunch Registry

https://trienens-institute.northwestern.edu/giantfab/

Core provides equipment to manufacture and test thin-film devices without ever exposing them to air or water, allowing measurements of device performance unaffected by environmental degradation.

Proper citation: Northwestern University GIANTFab Core Facility (RRID:SCR_026343) Copy   

•   Source: SciCrunch Registry

https://ki-sbc.mit.edu/high-throughput-sciences

Core offers automation and screening capabilities. Equipped with environmentally-controlled high-content microscopes, automated liquid handlers, plate washers and readers, and robotic platforms, HTS aims to accelerate experiments from small-scale assays to large screening campaigns.

Proper citation: Massachusetts Institute of Technology Koch Institute High Throughput Sciences Core Facility (RRID:SCR_026340) Copy   

•   Source: SciCrunch Registry

https://centers.louisville.edu/brown-cancer-center/core-facilities/biophysical-core

Biophysical Core Facility supports structural biology studies focused on characterization of biophysical properties of biomolecules and their interactions with binding partners or novel drug candidates. Offers range of biophysical techniques for initial screening of hit/lead compound binding as well as rigorous characterization of the thermodynamic and hydrodynamic properties of various biological macromolecules (most commonly proteins and nucleic acids), macromolecular association reactions, and ligand-macromolecule interactions. Biophysical techniques include differential scanning fluorimetry, microscale thermophoresis, isothermal titration calorimetry, differential scanning calorimetry, circular dichroism spectroscopy, fluorescence spectroscopy, absorbance spectroscopy and analytical ultracentrifugation.

Proper citation: University of Louisville Biophysical Core Facility (RRID:SCR_026277) Copy   

•   Source: SciCrunch Registry

https://www.med.upenn.edu/cdbacme/

Core provides custom built ad hoc optical microscopy solutions, advanced image analysis, and consultation services to researchers across the Penn campus and beyond.

Proper citation: University of Pennsylvania School of Medicine Advanced Core for Microscope Engineering Core Facility (RRID:SCR_026289) Copy   

•   Source: SciCrunch Registry

https://www.montana.edu/cryo-electron-microscopy/

Core provides single particle analysis and cryo-electron tomography. Instrumentation includes 200 kV Talos Arctica with Gatan K3 camera, 120 kV Tecnai Spirit, and Vitrobot Mark IV allowing imaging of biological structures at single nanometer to sub-nanometer resolutions, and thus enable 3D modeling of cells, viruses, proteins, nucleic acid, and other soft matter at the atomic level.

Proper citation: Montana State University Cryo-EM Core Facility (RRID:SCR_026324) Copy   

•   Source: SciCrunch Registry

https://www.montana.edu/socialdata/

Core enables collection of high-quality data for researchers employing variety of social and behavioral methods. This facility provides tools necessary for researchers to study interactions between human systems and other complex phenomena like public health and ecosystems.

Proper citation: Montana State University Social Data Collection and Analysis Services Core Facility (RRID:SCR_026326) Copy   

•   Source: SciCrunch Registry

https://physics.montana.edu/ical/

Facility supports basic and applied research and education in all science, engineering, and STEM disciplines. Specializes in complementary surface, interfacial, and bulk characterization of materials via high-resolution imaging and spectroscopy. The lab promotes interdisciplinary collaboration between research, educational, and industrial fields.

Proper citation: Montana State University Imaging and Chemical Analysis Laboratory Core Facility (RRID:SCR_026325) Copy   

•   Source: SciCrunch Registry

https://cancer.ucsf.edu/research/cores/lca/lca-flowcytometry

Provides access and training on two FACS Calibur benchtop cytometers, one FACS Canto II multi-laser digital cytometer, one FACS Aria II cell sorter, one FACS Aria III cell sorter, and one Sony SH800 cell sorter. These systems are primarily used for the rapid analysis and sorting of single-cell suspensions. To analyze the light scatter and fluorescence characteristics of a cell population, one of the benchtop machines is appropriate. For more complex assays requiring more than four differentiating markers, then the high-end multi-laser Canto II system would work well. To rapidly retrieve or sort a particular sub-group of cells from a mixed sample, then a cell sorter would be required.

Proper citation: UCSF Helen Diller Family Comprehensive Cancer Center Flow and Cell Sorting Core Facility (RRID:SCR_026372) Copy   

•   Source: SciCrunch Registry

https://www.chop.edu/centers-programs/gastrointestinal-epithelium-modeling-gem-program

Core is component of the GEM Program collaborative research effort focused on accelerating discovery and innovation using patient tissue-derived organoids. GEM Core staff generate and maintain living biobank of tissue-derived organoids with matched original tissue and blood specimens and provide access to specialized training, protocols, and reagents.

Proper citation: Children's Hospital of Philadelphia Research Institute CHOP Gastrointestinal Epithelium Modeling Core Facility (RRID:SCR_026402) Copy   

•   Source: SciCrunch Registry

https://www.augusta.edu/cancer/research/shared-resources/genomics/

Core offers services from sample processing from both fresh and frozen, as well as fixed cells or tissues to library preparation and next-generation sequencing (NGS) for bulk DNA/RNA sequencing and single-cell/nuclei sequencing. For single-cell studies, core is equipped with Chromium X system from 10X Genomics. Sequencing capabilities include Illumina Novaseq6000 and NextSeq 500. Offers single cell spatial transcriptomics with CosMx SMI platform. Other equipped includes CytAssit instrument from 10X genomics for VISIUM spatial transcriptomic and QIAConnect from Qiagen for nucleic acid and protein extraction.

Proper citation: Augusta University Integrated Genomics Shared Resource Core Facility (RRID:SCR_026483) Copy   

•   Source: SciCrunch Registry

https://research.vcu.edu/cores/structural-biology/

Provides access to equipment, offering researchers capability to determine 3D structure of macromolecules and macromolecular complexes. Provides services for structure-based drug design, protein-ligand or DNA binding studies, testing mutational effects on target macromolecules, and finding the absolute stereochemistry of chiral compounds. Offers training, technical support, and collaborative opportunities, which are crucial for structural biologists and other researchers studying structure of biological macromolecules and other materials.Core encompasses X-ray crystallography, Cryo-Electron Microscopy (Cryo-EM), and Nuclear Magnetic Resonance (NMR) facilities, and is also closely associated with the School of Pharmacy Molecular Modeling facility.

Proper citation: Virginia Commonwealth University VCU Structural Biology Core Facility (RRID:SCR_026455) Copy   

•   Source: SciCrunch Registry

https://www.lerner.ccf.org/cores/flow-cytometry/

Core provides investigators with resource for quantitative studies of cells, extracellular vesicles, and single-cell gene transcriptome analyses. Offers sample acquisition and analysis, cell sorting, and consultation for experimental design, interpretation and troubleshooting.

Proper citation: Cleveland Clinic Research Flow Cytometry Core Facility (RRID:SCR_026460) Copy   

•   Source: SciCrunch Registry

https://www.salk.edu/science/core-facilities/omics/

Core offers single-cell and spatial omics services. Provides consultation, expert guidance in experimental design, and technologies tailored for innovative research in genomics. Facility is equipped with 10x Genomics Chromium X and Xenium systems, Vizgen MERSCOPE, Bruker/NanoString GeoMx Digital Spatial Profiler, and nCounter MAX.

Proper citation: Salk Institute Single-Cell and Spatial Omics Core Facility (RRID:SCR_026396) Copy   

•   Source: SciCrunch Registry

https://quant.institutducerveau.org

Core provides expertise in optical microscopy, electron microscopy, and image analysis for neuroscience research. The platform is open to all researchers. Offers access to advanced technologies, including electron microscopy, confocal microscopy, two-photon imaging, and super-resolution microscopy.

Proper citation: Paris Brain Institute Quantitative Cellular and Molecular Imaging Core Facility (RRID:SCR_026393) Copy   

•   Source: SciCrunch Registry

https://research.vcu.edu/cores/barc/

Core offers comprehensive instrumentation and technical support for all aspects of in vitro and in vivo pre-clinical non-human anatomical and molecular imaging. Studies may be conducted on samples prepared to exhibit characteristic features for a particular imaging modality. Within the intact environment, physiological and pathophysiological activity may be observed through imaging or numerous biological pathways and interactions involved in injury and disease progression, such as traumatic brain injury, cardiac disease, tumorigenesis, and therapeutic interventions.

Proper citation: Virginia Commonwealth University VCU Bioimaging and Applied Research Core Facility (RRID:SCR_026429) Copy   

•   Source: SciCrunch Registry

https://www.skinresearch.northwestern.edu/cores/stem-core.html

Core provides services in human skin tissue procurement, isolation, and culture of human and murine skin-derived primary cells, 3D organotypic skin cultures, tissue processing, and basic histologic stains. The Core trains researchers in the development and use of these various techniques.

Proper citation: Northwestern University School of Medicine SBDRC Skin Tissue Engineering and Morphology Core Facility (RRID:SCR_026414) Copy   

•   Source: SciCrunch Registry

http://biomicro.mit.edu

Integrated genomics/bioinformatics facility located at MIT. Provides Illumina HiSeq2000, NextSeq500 and MiSeq sequencing instruments as well as PacBio Sequel and Oxford Minion. Provides services in preparing Illumina libraries for high-throughput sequencing samples using several different methods, supports technologies including Agilent BioAnalyzer, AATI Fragment Analyzer, AATI FemtoPulse, Roche LC480 qPCR machines, automated liquid handling through Tecan Evo150s, TTP Labtech Mosquito HV. Supports 10X Chromium and single cell work using NamoCell single cell dispenser and custom oligo synthesis using Dr.Oligo 192. Supports informatics and bioIT tools. Core administers ~2PB of data storage on several platforms, including 600TB Isilon server. Hosts 400 processor Dell cluster and Dell Quad Core 2950 application server for Illumina sequencing and bioinformatic applications. All application servers and storage servers are interconnected by 1gigabyte private networks or by fiber optic lines and are administered by IT staff that are part of the BioMicro Center. Servers are configurable to provide secure data storage for clinical data if required.

Proper citation: Massachusetts Institute of Technology MIT BioMicro Center Core Facility (RRID:SCR_026413) Copy   

•   Source: SciCrunch Registry

http://www.cas.miamioh.edu/cbfg/

Core provides training and equipment. Instruments include Pacific Biosciences VEGA benchtop long-read system, Oxford Nanopore Technologies minION and an Illumina MiSeq Next Generation Sequencing instrumentation, ABI Capillary Electrophoresis Genetic Analyzer (3130xl); an Eppendorf epMotion 5073m NGS liquid handling workstation; Promega MaxwellRSC Nucleic Acid extraction robot; real-time qPCR instruments (Rotor-Gene Q with HRM, Bio-Rad CFX Connect, QuantStudio 7 Flex [384/96 well interchangeable blocks]), and Bio-Rad ddPCR QX200 system, laser Attune NxT Flow Cytometer for analysis, laser BD FACS Melody Flow Cytometer for sorting, UV NanoDrop spectro photometers (ND1000, ND2200), and NanoDrop (ND3300) Fluorospectrophotometer; Promega Quantus, Agilent Bioanalyzer 2100; Covaris M220 Ultrasonic Nucleic Acid Shearer, a Sage BluePippin, seven 96 well gradient capable PCR thermal cyclers, two thermally controlled table top centrifuges capable of accepting 96-well plates used for DNA template preparation; two Eppendorf ThermoMixer C mixing units (384 well PCR to 50 mL tube format), two benchtop micro-centrifuges, Molecular Devices SpectraMax iD5 microplate reader, KTA-FPLC with UV detector and fractions collector, UV-1600PC UV-VIS Spectrophotometer with Sipper module, AlphaInnotechHP Gel Imaging System, Bio-Rad ChemiDoc MP Imaging System, Bio-Rad Dodeca-Cell Criterion PAGE system, several Bio-Rad Mini-Protean Gel Apparatus, Bio-Rad IEF Focusing Cells; numerous power-packs for gel electrophoresis, DNA gel boxes, pipettors, multi-channel pipettors. Provides computers (Linux & Win10), including four Ubuntu O/S based workstations for genome assembly and related bioinformatics analyses. CBFG maintains paid licenses for CLC Genomics Workbench, CLC Main Workbench, BioBam OmicsBox, SnapGene, FlowJo 10, SoftMax 7.1, Biogazelle qBasePLUS, and CANOCO.

Proper citation: Miami University Center for Bioinformatics and Functional Genomics Core Facility (RRID:SCR_026415) Copy   

•   Source: SciCrunch Registry