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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
eProbalign
 
Resource Report
Resource Website
eProbalign (RRID:SCR_013247) data analysis service, production service resource, analysis service resource, service resource Data analysis service that computes maximal expected accuracy multiple sequence alignments from partition function posterior probabilities. multiple sequence alignments, partition function posterior probabilities, bio.tools uses: Probalign
is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: New Jersey Institute of Technology; New Jersey; USA
NIGMS R01 GM073082 PMID:17485479 OMICS_00975, biotools:eprobalign https://bio.tools/eprobalign SCR_013247 eProbalign web server, EProbalign 2026-08-06 09:28:06 0
Cube-DB
 
Resource Report
Resource Website
1+ mentions
Cube-DB (RRID:SCR_013233) Cube-DB database, data or information resource Cube-DB is a database of pre-evaluated conservation and specialization scores for residues in paralogous proteins belonging to multi-member families of human proteins. Protein family classification follows (largely) the classification suggested by HUGO Gene Nomenclature Committee. Sets of orhtologous protein sequences were generated by mutual-best-hit strategy using full vertebrate genomes available in Ensembl. The scores, described on documentation page, are assigned to each individual residue in a protein, and presented in the form of a table (html or downloadable xls formats) and mapped, when appropriate, onto the related structure (Jmol, Pymol, Chimera). protein, functional divergence, vertebrate, genome, ortholog, protein sequence, data set, bio.tools is listed by: 3DVC
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioinformatics Institute; Singapore; Singapore
PMID:22139934 nlx_149432, biotools:cube-db https://bio.tools/cube-db SCR_013233 Cube-DB: Detection of Functional Divergence in Human Protein Families 2026-08-06 09:28:05 3
UniCarbKB
 
Resource Report
Resource Website
10+ mentions
UniCarbKB (RRID:SCR_014410) database, data or information resource International effort which has created a glycomics knowledgebase with access to a database of information on the glycan structures of glycoproteins. It serves as and promotes an online information storage and search platform for glycomics and glycobiology research. Open access knowledgebase offers resource supported by querying interfaces, annotation technologies and the adoption of common standards to integrate structural, experimental and functional data. knowledgebase, glycomics, glycerin structure, glycoprotein, cell line, glycoproteomics knowledge platform, bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: Macquarie University; Sydney; Australia
has parent organization: University of Gothenburg; Gothenburg; Sweden
has parent organization: SIB Swiss Institute of Bioinformatics
is parent organization of: UniCarb-DB
DOI:10.1093/nar/gkt1128 Free, Freely available biotools:unicarbkb https://bio.tools/unicarbkb http://www.unicarbkb.org SCR_014410 2026-08-06 09:28:20 27
ExPASy ABCD database
 
Resource Report
Resource Website
10+ mentions
ExPASy ABCD database (RRID:SCR_017401) ABCD ExPASy, The ABCD database database, data or information resource Repository of sequenced antibodies, integrating curated information about antibody and its antigen with cross links to standardized databases of chemical and protein entities. Manually curated repository of sequenced antibodies, developed by Geneva Antibody Facility at University of Geneva, in collaboration with CALIPHO and Swiss Prot groups at SIB Swiss Institute of Bioinformatics. Database provides list of sequenced antibodies with their known targets. Each antibody is assigned unique ID number that can be used in academic publications to increase reproducibility of experiments. Sequenced antibody, manually curated, known target, ExPASy, repository, chemically defined antibodies, antibody, bio.tools is listed by: Debian
is listed by: bio.tools
is related to: ExPASy Bioinformatics Resource Portal
is related to: SIB Swiss Institute of Bioinformatics
has parent organization: University of Geneva; Geneva; Switzerland
University of Geneva ;
ProCare Foundation ;
Swiss National Science Foundation
PMID:31410491 Free, Freely available SCR_019000, biotools:AbCD_database https://bio.tools/ABCD_database SCR_017401 ExPASy ABCD (AntiBodies Chemically Defined) Database, The ABCD database, AntiBodies Chemically Defined, AntiBodies Chemically Defined Expert Protein Analysis System database, ExPASy ABCD Database, The AntiBodies Chemically Defined Database 2026-08-06 09:29:04 10
SnpSift
 
Resource Report
Resource Website
500+ mentions
SnpSift (RRID:SCR_015624) source code, software toolkit, software resource Software toolkit for filtering and manipulating annotated files. After annotation, the software's filter function can find relevant genomic variants in large data files. annotation, filtering, genomic variant, single nucleotide polymorphism, bio.tools is listed by: bio.tools
is listed by: Debian
works with: SnpEff
PMID:22728672 Open Source, Free, Available for download biotools:snpsift https://bio.tools/snpsift SCR_015624 SnpEff 2026-08-06 09:28:40 591
Open Trials
 
Resource Report
Resource Website
1+ mentions
Open Trials (RRID:SCR_015570) database, data or information resource Database that contains data such as registry entries, portions of regulatory documents describing individual trials, structured data on methods and results, and researchers and papers from and/or related to clinical trials. The initiative aims to locate, match, and share all publicly accessible data and documents, on all trials conducted, on all medicines and other treatments, globally. clinical trial, clinical trial database, clinical trial data, open database, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: University of Oxford; Oxford; United Kingdom
Laura and John Arnold Foundation ;
Wellcome Trust ;
World Health Organisation ;
West of England Academic Health Science Network
Open source biotools:opentrials https://bio.tools/opentrials SCR_015570 2026-08-06 09:28:40 3
Genome Aggregation Database
 
Resource Report
Resource Website
1000+ mentions
Genome Aggregation Database (RRID:SCR_014964) gnomAD database, data or information resource Database that aggregates exome and genome sequencing data from large-scale sequencing projects. The gnomAD data set contains individuals sequenced using multiple exome capture methods and sequencing chemistries. Raw data from the projects have been reprocessed through the same pipeline, and jointly variant-called to increase consistency across projects. database, genome, , bio.tools, FASEB list is listed by: bio.tools
is listed by: Debian
is related to: Broad Institute Genomics Platform
has parent organization: Broad Institute
has parent organization: Broad Institute of MIT and Harvard
Broad Institute Open source, Available to the biomedical community, The community can contribute to this resource biotools:gnomad https://github.com/macarthur-lab/gnomad_browser/issues, https://bio.tools/gnomad SCR_014964 gnomAD 2.0, gnomAD Browser, gnomAD version 2.0, Exome Aggregation Consortium 2026-08-06 09:28:29 4229
Examl
 
Resource Report
Resource Website
50+ mentions
Examl (RRID:SCR_016087) Examl software application, source code, software resource Source code for large-scale phylogenetic analyses on whole-transcriptome and whole-genome alignments using supercomputers. phylogenetic, analysis, database, large scale, whole genome, whole transcriptome, alignment, efficiency, bio.tools, FASEB list is listed by: bio.tools
is listed by: Debian
is listed by: OMICtools
Heidelberg Institute for Theoretical Studies PMID:25819675 Free, Available for download OMICS_08024, biotools:ExaML https://bio.tools/ExaML, https://sources.debian.org/src/examl/ SCR_016087 Examl:Exascale Maximum Likelihood 2026-08-06 09:28:45 60
lncRNAdb
 
Resource Report
Resource Website
100+ mentions
lncRNAdb (RRID:SCR_015491) database, data or information resource Searchable database of comprehensive annotations of eukaryotic long non-coding RNAs. Entries are manually curated from referenced literature. reference database, eukaryotic annotation, annotation database, eukaryotic long non coding rna database, functional long noncoding rnas, bio.tools, FASEB list is listed by: bio.tools
is listed by: Debian
Open source, Acknowledgement requested, The community can contribute to this resource biotools:lncrnadb https://bio.tools/lncrnadb SCR_015491 lncRNAdb v2.0, Long Noncoding RNA Database, Long Noncoding RNA Database v2.0 2026-08-06 09:28:41 163
MethBase
 
Resource Report
Resource Website
1+ mentions
MethBase (RRID:SCR_017487) service resource, database, data or information resource Central reference methylome database created from public BS-seq datasets. Provides methylation level at individual sites, regions of allele specific methylation, hypo- or hyper-methylated regions, partially methylated regions, and detailed meta data and summary statistics. Methylome, database, public, BSseq, dataset, methylation, site, region, allele, specific, metadata, statistics, bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: University of Southern California; Los Angeles; USA
Free, Freely available BioTools:MethBase, biotools:Methbase https://bio.tools/MethBase, https://bio.tools/MethBase, https://bio.tools/MethBase SCR_017487 MethBase: a reference methylome database 2026-08-06 09:29:05 1
Signaling Pathways Project
 
Resource Report
Resource Website
10+ mentions
Signaling Pathways Project (RRID:SCR_018412) SPP database, data or information resource Web multi omics knowledgebase based upon public, manually curated transcriptomic and cistromic datasets involving genetic and small molecule manipulations of cellular receptors, enzymes and transcription factors. Integrated omics knowledgebase for mammalian cellular signaling pathways. Web browser interface was designed to accommodate numerous routine data mining strategies. Datasets are biocurated versions of publically archived datasets and are formatted according to recommendations of the FORCE11 Joint Declaration on Data Citation Principles73, and are made available under Creative Commons CC 3.0 BY license. Original datasets are available. Data integration, genetic database, gene regulatory network, cell signalling, cellular signalling network, transcriptomic data, manualy curated, cistromic data, cellular receptor, enzyme, transcrptomic factor, mammalian cellular signaling pathway, data mining strategy, dataset, , bio.tools is used by: Hypothesis Center
is listed by: Debian
is listed by: bio.tools
works with: Gene Expression Omnibus (GEO)
works with: NCBI Sequence Read Archive (SRA)
NIDDK DK097771;
NIDDK DK097748;
NIDDK DK48807;
NIDDK DK107535;
NIDDK DK56338;
NIDDK DK095686;
NIDDK DK105126;
NCI CA125123;
NHLBI HL127624;
Dan L. Duncan NCI Comprehensive Cancer Center at Baylor College of Medicine ;
CPRIT RP150578
PMID:31672983 Free, Freely available r3d100013650, biotools:Signaling_Pathways_Project https://bio.tools/Signaling_Pathways_Project, https://doi.org/10.17616/R31NJN0Y https://www.signalingpathways.org SCR_018412 2026-08-06 09:29:25 30
LTRsift
 
Resource Report
Resource Website
LTRsift (RRID:SCR_024098) portal, software resource, data or information resource, organization portal Software graphical desktop tool for semi-automatic postprocessing of de novopredicted LTR retrotransposon annotations, such as the ones generated by LTRharvestand LTRdigest. Interface displays LTR retrotransposon candidates, their putative families and their internal structure in a hierarchical fashion allowing the user to "sift" through results of de novo prediction software. It also offers customizable filtering and classification functionality. semi-automatic postprocessing, de novopredicted LTR retrotransposon annotations, retrotransposon annotations, LTR retrotransposon candidates families and their internal structure, is listed by: Debian PMID:23131050 Free, Available for download, Freely available, OMICS_11266 https://sources.debian.org/src/ltrsift/ SCR_024098 ltrsift, LTRSIFT 2026-08-06 09:30:19 0
Vascular Modeling Toolkit
 
Resource Report
Resource Website
50+ mentions
Vascular Modeling Toolkit (RRID:SCR_001893) vmtk software application, software toolkit, software resource Software collection of libraries and tools for 3D reconstruction, geometric analysis, mesh generation and surface data analysis for image-based modeling of blood vessels. 3d reconstruction, geometric analysis, mesh generation, surface data analysis, image-based modeling, blood vessel, reconstruction, 3d is listed by: Debian
is listed by: OMICtools
is related to: VMTK in 3D Slicer
PMID:19002516
PMID:19447701
DOI:10.1109/TMI.2009.2021652
Free, Available for download, Freely available nlx_155869, OMICS_13947 https://sources.debian.org/src/vmtk/ SCR_001893 vmtk - the Vascular Modeling Toolkit 2026-08-06 09:25:29 85
ReadqPCR
 
Resource Report
Resource Website
ReadqPCR (RRID:SCR_000030) standalone software, software application, software resource A software package that provides functions to read raw RT-qPCR data of different platforms. standalone software, mac os x, unix/linux, windows, r, data import, gene expression, microtitre plate assay, qpcr, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioconductor
has parent organization: University College London; London; United Kingdom
PMID:22748112 Free, Available for download, Freely available biotools:readqpcr, OMICS_03936 https://bio.tools/readqpcr SCR_000030 ReadqPCR - Read qPCR data 2026-08-06 09:25:06 0
metabnorm
 
Resource Report
Resource Website
metabnorm (RRID:SCR_001266) standalone software, software application, software resource Software tool as mixed model normalization method for metabolomics data.Uses normalization approach based on mixed model, with simultaneous estimation of correlation matrix. Metabolomics datasets, corelation, normalization, identifying metabolites, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: SourceForge
Cancer Research UK Cambridge Institute ;
Erik and Edith Fernström foundation ;
Cancer Research UK
PMID:24711654 Free, Available for download, Freely available OMICS_03548, biotools:metabnorm https://bio.tools/metabnorm SCR_001266 2026-08-06 09:25:22 0
FANTOM DB
 
Resource Report
Resource Website
10+ mentions
FANTOM DB (RRID:SCR_002678) FANTOM DB material resource, biomaterial supply resource The FANTOM consortium is an international collaborative research project initiated and organized by the RIKEN Omics Science Center. In earlier FANTOM efforts we cloned and annotated 103,000 full-length cDNAs from mouse and distributed them to researchers throughout the world. FANTOM1-3 focused on identifying the transcribed components of mammalian cells. This work improved estimates of the total number of genes and their alternative transcript isoforms in both human and mouse, expanded gene families, and revealed that a large fraction of the transcriptome is non-coding. In addition, with the development of Cap Analysis of Gene Expression (CAGE) FANTOM3 could map a large fraction of transcription start sites and revise our models of promoter structure. This updated web resource provides the previous FANTOM results mapped to current genome builds and presents the results of FANTOM4. In FANTOM4 the focus has changed to understanding how these components work together in the context of a biological network. Using deepCAGE (deep sequencing with CAGE) we monitored the dynamics of transcription start site (TSS) usage during a time course of monocytic differentiation in the acute myeloid leukemia cell line THP-1. This allowed us to identify active promoters, monitor their relative expression and define relevant regions for carrying out transcription factor binding site predictions. Computational methods were then used to build a network model of gene expression in this leukemia and the transcription factors key to its regulation. This work gives the first picture of the wiring between genes involved in acute myeloid leukemia and provides a strategy for identifying key factors that determine cell fates. In addition to the network, FANTOM4 data was used in two additional analyses. The first identified a novel class of short RNAs associated with transcription start sites and the second focused on the role of repetitive element expression in the transcriptome. TOOLS *Genome Browser: graphical display of genomic features, such as promoters, exon structures, H3K9 acetylation, transcription factors positioning on the genome, coupled with gene and promoter activities. *EdgeExpressDB: regulatory interactions, such as transcriptional regulation, post-transcriptional silencing with miRNA, and PPI, coupled with gene and promoter activities. *SwissRegulon: FANTOM4 TF regulation is predicted using Motif Activity Response Analysis (MARA) developed by Erik van Nimwegen at Biozentrum. Follow the link to carry out MARA on your own dataset. *Custom Tracks on the UCSC Genome Browser: FANTOM4 tracks on the UCSC Genome Browser Database. *The RIKEN integrated database of mammals: Integration of FANTOM4 data with other mammalian resources, in particular, produced by RIKEN. cdna clone, mouse, mouse cdna, human, bio.tools is listed by: One Mind Biospecimen Bank Listing
is listed by: bio.tools
is listed by: Debian
is related to: CAGE
has parent organization: RIKEN Omics Science Center
PMID:20211142 Free, Available for download, Freely available nif-0000-02833, biotools:fantom http://fantom3.gsc.riken.jp/, https://bio.tools/fantom SCR_002678 FANTOM: Functional Annotation of Mouse, FANTOM2, FANTOM1, Functional Annotation of the Mammalian Genome, FANTOM4, FANTOM3, FANTOM, Functional Annotation of Mouse 2026-08-06 09:25:41 20
e-Driver
 
Resource Report
Resource Website
1+ mentions
e-Driver (RRID:SCR_002674) standalone software, software application, software resource Software tool to identify cancer driver genes based on linear annotations of biological regions such as protein domains.Uses information on three-dimensional structures of mutated proteins to identify specific structural features. Then algorithm analyzes whether these features are enriched in cancer somatic mutations and are candidate driver genes. Identify cancer driver genes, candidate driver genes, perl, protein, mutated proteins, cancer somatic mutations, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
Cancer PMID:25064568 Free, Available for download, Freely available biotools:e-Driver, OMICS_05288 https://bio.tools/e-Driver SCR_002674 2026-08-06 09:25:41 5
MRFSEQ
 
Resource Report
Resource Website
MRFSEQ (RRID:SCR_002972) software resource, algorithm resource Algorithm based on a Markov random field (MRF) model that uses additional gene coexpression data to enhance differential gene expression prediction power. It is able to call differentially expressed (DE) genes but also assign confidence scores to each inferred DE gene. markov, algorithm, gene expression, prediction algorithm, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of California at Riverside; California; USA
PMID:23793751 Free, Available for download, Freely available biotools:mrfseq, OMICS_01309 https://bio.tools/mrfseq SCR_002972 2026-08-06 09:25:46 0
Full-Length cDNA Database
 
Resource Report
Resource Website
1+ mentions
Full-Length cDNA Database (RRID:SCR_007666) database, data or information resource Full-Length cDNA Database is a resource for cDNA libraries of arhtropods and parasites. The arthropod species covered are Anopheles stephensi, Glossina morsitans (Tsetse fly), and Dermatophagoides farinae (House dust mite), while the parasitic species included are Plasmodium falciparum (Malaria), Toxoplasma gondii, Cryptosporidium parvum, Babesia bovis (Babesia), and Echinococcus multilocularis. A specialized database of each species is available as a link from the home page. This database has been constructed and maintained since 2001 by a Grant-in-Aid for Publication of Scientific Research Results from the Japan Society for the Promotion of Science. Anopheles stephensi, Glossina morsitans, Tsetse fly, Dermatophagoides farinae, House dust mite, Plasmodium falciparum, Malaria, Toxoplasma gondii, Cryptosporidium parvum, Babesia bovis, Babesia, Echinococcus multilocularis, cDNA, cDNA library, arthropod genome, parasite genome echinococcus multilocularis, anopheles stephensi, arthropod genome, babesia, babesia bovis, cdna, cdna library, cryptosporidium parvum, dermatophagoides farinae, glossina morsitans, house dust mite, malaria, parasite genome, plasmodium falciparum, toxoplasma gondii, tsetse fly, bio.tools is listed by: bio.tools
is listed by: Debian
biotools:full-parasites, nif-0000-02856 https://bio.tools/full-parasites SCR_007666 Full-Length cDNA Database 2026-08-06 09:26:55 6
IMG
 
Resource Report
Resource Website
500+ mentions
IMG (RRID:SCR_007733) IMG database, data or information resource Datasets and tools for comparative analysis and annotation of all publicly available genomes from three domains of life in a uniquely integrated context. Plasmids that are not part of a specific microbial genome sequencing project and phage genomes are also included in order to increase its genomic context for comparative analysis. The user interface (see User Interface Map) allows navigating the microbial genome data space along its three key dimensions (genes, genomes, and functions), and groups together the main comparative analysis tools. Microbial genome data analysis in IMG usually starts with the definition of an analysis context in terms of selected genomes, functional annotations, and/or genes, followed by the individual or comparative analysis of genomes, functional annotations, or genes. genome, microorganism, annotation, bio.tools, FASEB list is listed by: 3DVC
is listed by: bio.tools
is listed by: Debian
has parent organization: DOE Joint Genome Institute
nif-0000-03009, biotools:img https://bio.tools/img SCR_007733 Integrated Microbial Genomes 2026-08-06 09:27:00 652

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