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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://cran.r-project.org/web/packages/pairheatmap/
A software tool to compare two heatmaps and discover patterns within and across groups. In the context of biology, group can be defined based on gene ontology.
Proper citation: pairheatmap (RRID:SCR_003109) Copy
https://github.com/quwubin/MFEprimer/
A fast thermodynamics-based software program for checking PCR primer specificity against genomic DNA and mRNA/cDNA sequence databases.
Proper citation: MFEprimer (RRID:SCR_003066) Copy
https://github.com/timflutre/eqtlbma/wiki
Software package that implements Bayesian statistical methods to detect eQTLs jointly in multiple subgroups (e.g. tissues). Key features are to borrow information across subgroups, to explicitly model heterogeneity (qualitatively and quantitatively), and to borrow information across genes to estimate hyper-parameters from the data (empirical Bayes).
Proper citation: eQtlBma (RRID:SCR_003102) Copy
http://www.bioconductor.org/packages/release/bioc/html/triplex.html
Software package that provides functions for identification and visualization of potential intramolecular triplex patterns in DNA sequence. The main functionality is to detect the positions of subsequences capable of folding into an intramolecular triplex (H-DNA) in a much larger sequence. The potential H-DNA (triplexes) should be made of as many canonical nucleotide triplets as possible. The package includes visualization showing the exact base-pairing in 1D, 2D or 3D.
Proper citation: Triplex (RRID:SCR_003061) Copy
https://github.com/CRG-Barcelona/bwtool/wiki
A command-line utility for bigWig files designed to read bigWig files rapidly and efficiently, providing functionality for extracting data and summarizing it in several ways, globally or at specific regions. Its functionality is subdivided into subprograms that roughly fall into three categories: data extraction, analysis, and data modification, although e.g. in the case of the matrix program or the sax program, the boundary between data extraction and analysis isn't very strong. The data modification programs all have the behavior that a bigWig is inputted and a new bigWig is outputted.
Proper citation: bwtool (RRID:SCR_003035) Copy
http://cran.r-project.org/web/packages/enviPat/
Software for fast and very memory-efficient calculation of isotope patterns, subsequent convolution to theoretical envelopes (profiles) plus valley detection and centroidization or intensoid calculation. Batch processing, resolution interpolation, wrapper, adduct calculations and molecular formula parsing.
Proper citation: enviPat (RRID:SCR_003034) Copy
https://code.google.com/p/gel2de/
Software application for performing pixel-by-pixel correlation analysis on a set of gel images from two-dimensional gel electrophoresis and a set of clinical parameters for a population. The application is written in C++, and has been tested on Windows, although it in principle should compile cross platform using CMake.
Proper citation: Gel2DE (RRID:SCR_002977) Copy
http://www.bioinformatics.babraham.ac.uk/projects/chipmonk/
Software tool to visualize and analyse ChIP-on-chip array data. Main features: * Import of data from Nimblegen arrays (other formats can be added if people send us examples) * Normalization of data (both per array and per probe) * Various data plotting options to assess data quality and the effectiveness of normalization * Creation of data groups for visualization and analysis * Visualization of data against an annotated genome. * Statistical analysis of data to find probes of interest * Creation of reports containing probes, data and genome annotation Note: This project is no longer being developed, but critical bug fixes will still be provided
Proper citation: ChIPMonk (RRID:SCR_002975) Copy
https://github.com/PacificBiosciences/DevNet/wiki/SMRT-View
An open source Genome Browser that visualizes data generated by PacBio Sequencing Systems. * Users can explore and interact with all types of analysis results, including resequencing, De novo, cDNA, and barcoding. * Users can also visualize base modifications, base identification and motifs analysis results.
Proper citation: SMRT View (RRID:SCR_003029) Copy
https://github.com/PacificBiosciences/pbh5tools
Software tools for manipulating HDF5 files produced by Pacific Biosciences. Specifically, this package provides functionality for manipulating and extracting data from cmp.h5 and bas.h5 files.
Proper citation: pbh5tools (RRID:SCR_003027) Copy
https://code.google.com/p/prorata/
A quantitative proteomics software program for accurate protein abundance ratio estimation with confidence interval evaluation.
Proper citation: ProRata (RRID:SCR_002988) Copy
https://cloud.google.com/products/compute-engine
An infrastructure as a service that lets you run your large-scale computing workloads on Linux virtual machines hosted on Google's infrastructure.
Proper citation: Google Compute Engine (RRID:SCR_001011) Copy
http://sourceforge.net/projects/cuda-ec/
A fast parallel error correction tool for short reads.
Proper citation: CUDA-EC (RRID:SCR_001090) Copy
http://sourceforge.net/projects/qips/
A software package for analyzing ChIP-seq (Chromatin ImmunoPrecipitation on sequencing) data that finds enriched regions of arbitrary lengths and is therefore especially suited for analyzing ChIP-seq of histone marks or polymerase.
Proper citation: qips (RRID:SCR_001092) Copy
A high-performance visualization tool for interactive exploration of large, integrated genomic datasets written primarily in JavaScript. It supports a wide variety of data types, including array-based and next-generation sequence data, and genomic annotations.
Proper citation: JBrowse (RRID:SCR_001004) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowWorkspace.html
Software package that facilitates comparison of automated gating methods against manual gating done in flowJo. This package allows you to import basic flowJo workspaces into BioConductor and replicate the gating from flowJo using the flowCore functionality. Gating hierarchies, groups of samples, compensation, and transformation are performed so that the output matches the flowJo analysis.
Proper citation: flowWorkspace (RRID:SCR_001155) Copy
http://131.174.198.125/bioinfo/gimmemotifs/
Software that provides a de novo motif prediction pipeline, especially suited for ChIP-seq datasets. It incorporates several existing motif prediction algorithms in an ensemble method to predict motifs and clusters these motifs using the WIC similarity scoring metric., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
Proper citation: GimmeMotifs (RRID:SCR_001146) Copy
http://www.bioconductor.org/packages/release/bioc/html/rbsurv.html
Software package that selects genes associated with survival.
Proper citation: rbsurv (RRID:SCR_001175) Copy
http://crossmap.sourceforge.net/
A software program for convenient conversion of genome coordinates (or annotation files) between different assemblies. It supports most commonly used file formats including SAM/BAM, Wiggle/BigWig, BED, GFF/GTF, VCF. It is designed to liftover genome coordinates between assemblies. It?s not a program for aligning sequences to reference genome. CrossMap is not recommend for converting genome coordinates between species.
Proper citation: CrossMap (RRID:SCR_001173) Copy
https://github.com/FelixKrueger/Sherman
Software tool to simulate FastQ files for high-throughput sequencing experiments. It allows the user to introduce various "contaminants" into the sequences, such as basecall errors, SNPs, adapter fragments etc., in order to evaluate the influence of common problems observed in many Next-Gen Sequencing experiments.
Proper citation: Sherman (RRID:SCR_001294) Copy
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