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Assessment test that measures the cognitive flexibility of patients. Two target pictures are presented that vary along two dimensions (e.g., shape and color). Participants are asked to match a series of bivalent test pictures (e.g., yellow balls and blue trucks) to the target pictures, first according to one dimension (e.g., color) and then, after a number of trials, according to the other dimension (e.g., shape). Switch trials are also employed, in which the participant must change the dimension being matched. For example, after 4 straight trials matching on shape, the participant may be asked to match on color on the next trial and then go back to shape, thus requiring the cognitive flexibility to quickly choose the correct stimulus. Scoring is based on a combination of accuracy and reaction time, and the test takes approximately 4 minutes to administer. This test is recommended for ages 3-85.
Proper citation: NIH Toolbox Dimensional Change Card Sort Test (RRID:SCR_003616) Copy
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 4, 2023.Consortium that developed brief, standardized and reliable procedures for the evaluation and diagnosis of patients with Alzheimer's disease (AD) and other dementias of the elderly. These procedures included data forms, flipbooks, guidebooks, brochures, instruction manuals and demonstration tapes, which are now available for purchase. The CERAD assessment material can be used for research purposes as well as for patient care. CERAD has developed several basic standardized instruments, each consisting of brief forms designed to gather data on normal persons as well as on cognitively impaired or behaviorally disturbed individuals. Such data permit the identification of dementia based on clinical, neuropsychological, behavioral or neuropathological criteria. Staff at participating CERAD sites were trained and certified to administer the assessment instruments and to evaluate the subjects enrolled in the study. Cases and controls were evaluated at entry and annually thereafter including (when possible) autopsy examination of the brain to track the natural progression of AD and to obtain neuropathological confirmation of the clinical diagnosis. The CERAD database has become a major resource for research in Alzheimer's disease. It contains longitudinal data for periods as long as seven years on the natural progression of the disorder as well as information on clinical and neuropsychological changes and neuropathological manifestations., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
Proper citation: CERAD - Consortium to Establish a Registry for Alzheimer's Disease (RRID:SCR_003016) Copy
http://psychology-tools.com/cast/
Assessment test developed by the Autism Research Centre at the University of Cambridge, for assessing the severity of autism spectrum symptoms in children. This assessment is usually used with children aged from 4-11 years of age.
Proper citation: Childhood Autism Spectrum Test (RRID:SCR_003322) Copy
http://psychology-tools.com/spin/
A 17-item self-administered assessment questionnaire developed by the Psychiatry and Behavioral Sciences Department at Duke University effective in screening for and measuring the severity of social anxiety disorder. Each question is answered with one of 5 responses ranging from Not at All to Extremely. Each response is assigned a score and then totaled at the end. Scoring: * 0-20 Little or No Anxiety * 21-30 Mild Anxiety * 31-40 Moderate Anxiety * 41-50 Severe Anxiety * 51-68 Very Severe Anxiety
Proper citation: Social Phobia Inventory (RRID:SCR_003673) Copy
https://pdbp.ninds.nih.gov/assets/crfs/Hamilton%20Anxiety%20Rating%20Scale%20(HAM-A).pdf
Assessment scale to assess the severity of symptoms of anxiety in adults, adolescents and children. The scale consists of 14 items, each defined by a series of symptoms, and measures both psychic anxiety (mental agitation and psychological distress) and somatic anxiety (physical complaints related to anxiety). Although the HAM-A remains widely used as an outcome measure in clinical trials, it has been criticized for its sometimes poor ability to discriminate between anxiolytic and antidepressant effects, and somatic anxiety versus somatic side effects. The HAM-A does not provide any standardized probe questions. Despite this, the reported levels of inter-rater reliability for the scale appear to be acceptable. The scale has been translated into: Cantonese for China, French and Spanish. An IVR version of the scale is available from Healthcare Technology Systems.
Proper citation: Hamilton Anxiety Rating Scale (RRID:SCR_003664) Copy
A diagnostic exam used to determine DSM-IV Axis I disorders (SCID-I) (major mental disorders) and Axis II disorders (SCID-II) (personality disorders). An Axis I SCID assessment with a psychiatric patient usually takes between 1 and 2 hours, depending on the complexity of the subject's psychiatric history and their ability to clearly describe episodes of current and past symptoms. A SCID with a non-psychiatric patient takes 1/2 hour to 1-1/2 hours. A SCID-II personality assessment takes about 1/2 to 1 hour. The instrument was designed to be administered by a clinician or trained mental health professional. (Adapter from Wikipedia)
Proper citation: Structured Clinical Interview for DSM-IV (RRID:SCR_003682) Copy
http://www.dementiatoday.com/wp-content/uploads/2012/06/MiniMentalStateExamination.pdf
A 30 question assessment test to screen patients for cognitive impairment that is commonly used in medicine to screen for dementia. It is also used to estimate the severity of cognitive impairment and to follow the course of cognitive changes in an individual over time, thus making it an effective way to document an individual's response to treatment. It takes about 10 minutes and examines functions including arithmetic, memory and orientation.
Proper citation: Mini-Mental State Examination (RRID:SCR_003681) Copy
http://www.biostat.wustl.edu/~adrc/cdrpgm/
A numeric scale used to quantify the severity of symptoms of dementia (i.e. its stage). Using a structured-interview protocol, a qualified health professional assesses a patient's cognitive and functional performance in six areas: memory, orientation, judgment and problem solving, community affairs, home and hobbies, and personal care. Scores in each of these are combined to obtain a composite score ranging from 0 through 3. (Adapted from Wikipedia)
Proper citation: Clinical Dementia Rating (RRID:SCR_003678) Copy
Orbitrap Exploris 120 LC-MS spectrometry instruments
Proper citation: Thermo Fisher: Orbitrap Exploris 120 high-resolution mass spectrometer (RRID:SCR_027370) Copy
https://microscopecentral.com/products/olympus-bx41-microscope
Olympus BX41 is clinical and research grade microscope. Can be customized. Offered as pre-configured with your choice of viewing head - binocular, ergo binocular, or trinocular. This has Plan N 4x, 10x, 40x, 100x oil objectives but others can be provided if needed. Comes with XY mechanical stage with slide holder and focusable condenser.
Proper citation: Olympus: BX41 Clinical Microscope (RRID:SCR_027355) Copy
Target-to-Clinic Contract Research Organization (CRO) headquartered in San Diego, CA USA. ChemDiv executes pre-clinical discovery chemistry and biology for drug development and clinical trials for international portfolio of companies across the entire range of targets with small molecule and biotech drugs. The company operates multiple research and development (R&D) subsidiaries in Russia, Ukraine and China as well as business operations around the world.
Proper citation: ChemDiv (RRID:SCR_027402) Copy
https://www.beckman.com/landing/ppc/liquid-handlers/synthetic-biology
Non-contact liquid handler that uses Acoustic Droplet Ejection (ADE) technology to precisely transfer nanoliter-sized droplets of liquid for high-throughput applications in pharmaceutical research, drug discovery, and various areas of genomics and biology. Echo 555 / 550 Liquid Handler: 2.5 nL increment; Flow rate:0.25 – 1 µL/sec; Ideal for reactions of 0.05 – 1 µL; Supports 384 and 1536-well source plate formats; Used for transfer of small molecules for high throughput screening.
Proper citation: Bechman Coulter: Labcyte Echo 550 acoustic liquid handler (RRID:SCR_027476) Copy
https://www.qd-taiwan.com/siteDocs/productBrochures/NanoTemper_NT115_series.pdf
Instrument used to quantify biomolecular interactions and measure their binding affinity using MicroScale Thermophoresis. Can determine the strength of binding between all types of biomolecules, from single ions to large complexes, in various complex samples and buffer conditions.
Proper citation: NanoTemper: Monolith NT.115 (RRID:SCR_027500) Copy
Concordia University is a public English-language research university located in Montreal, Quebec, Canada. Founded in 1974 following the merger of Loyola College and Sir George Williams University, Concordia is one of the three universities in Quebec where English is the primary language of instruction.
Proper citation: Concordia University; Montreal; Canada (RRID:SCR_027512) Copy
http://www.pstnet.com/software.cfm?ID=96
Designed for use in an MRI simulator, MoTrak software uses Ascension Technology?s Flock of Birds. The sensor attaches to the subject?s head and determines the position of the head in space relative to the transmitter. The sensor records angular rotations as well as positional displacements from an initially calibrated position. This information is displayed and logged by the program in real-time, allowing observation of head motion in an MRI simulator. In the simulator, the participant can simultaneously be habituated to the MRI environment, while being trained to remain still via feedback from the MoTrak system.
Proper citation: MoTrak Head Motion Tracking System (RRID:SCR_009607) Copy
http://www.ncbi.nlm.nih.gov/tools/cobalt/cobalt.cgi?link_loc=BlastHomeAd
COBALT is a multiple sequence alignment tool that finds a collection of pairwise constraints derived from conserved domain database, protein motif database, and sequence similarity, using RPS-BLAST, BLASTP, and PHI-BLAST. Pairwise constraints are then incorporated into a progressive multiple alignment. A Linux executable for COBALT, and CDD and PROSITE data used is available at ftp://ftp.ncbi.nlm.nih.gov/pub/agarwala/cobalt/ COBALT has reasonable runtime performance and alignment accuracy comparable to or exceeding that of other tools for a broad range of problems.
Proper citation: COBALT: Constraint-based Multiple Alignment Tool (RRID:SCR_004152) Copy
Neuronavigation system for use in human cognitive neuroscience (TMS, EEG, NIRS) and for non-human neurosurgical applications.
Proper citation: Brainsight (RRID:SCR_009539) Copy
http://www.edanzediting.com/journal_advisor
A training service which offers English editorial support for primarily non-native English speaking scientific researchers. Users answer a questionairre concerning their progress with their manuscript and Edanz suggests which of its services users should utilize. Services include Journal Advisor, English Editing, Expert Scientific Review, Cover Letter Development, Review Editing, Abstract Development, Response Letter Edit and Manuscript Check, Author-guided Rewriting, and Reviewer Recommendation. Edanz also offers training workshops and seminars for non-native English speakers.
Proper citation: Edanz's journal advisor (RRID:SCR_014013) Copy
Bibliography covering all publications related to the fast-growing field of biomedical literature and text mining. This forum for collecting, compiling and sharing is a one-stop resource, letting researchers find out who-does-what in the area and where it is published, bridging across the many discipline-specific venues in which biomedical text-mining papers are published. If you know of a relevant paper that is missing from BLIMP, or have an accepted-for-publication paper, PhD/MSc thesis or a technical report, that you believe is relevant to biomedical text mining, fill in the submission form. The fast-growing field of biomedical literature mining is highly-interdisciplinary. Publications appear in forums ranging from the SIGIR conferences (the ACM Special Interest group on Information Retrieval) to journals such as Nature and Science, with the whole range of bioinformatics forums in-between. To substantially contribute, one must know what was/is being done in this diverse area, and place the work in context - both biologically and computationally. Instead of starting a journal fully dedicated to biomedical literature mining, thus creating yet another publication venue, this site offers an alternative: It holds in one place a compilation of references to relevant papers that have been published or accepted for publication.
Proper citation: BLIMP: Biomedical LIterature Mining Publications (RRID:SCR_007112) Copy
https://timothyspringer.org/files/tas/files/biacore3000-instrument.pdf
Biacore 3000 processing unit is an established, label-free system for detailed studies of biomolecular interactions. The system delivers comprehensive characterization of the interaction, answers questions about the rate constants, affinity, specificity, and determines the active concentration of components. The ability to recover and transfer interaction partners directly to MALDI targets for identification and further characterization makes the system highly applicable to fast identification of unknown interactants.
Proper citation: GE: Biacore 3000 Real Time Biomolecular Interaction Analyzer (RRID:SCR_018044) Copy
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