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Core offers histological and immunohistochemical services.Our staff includes ASCP certified Histologists and American Board of Pathology certified Pathologists who provide service, assistance, and quality control. Provided services include grossing specimens, frozen and fixed tissue sectioning, routine H&E and specialized histochemical staining, cytospin preparations, IHC/IF and antibody optimizations using investigator provided antibodies. Provides training for immunohistochemical and histochemical techniques.
Proper citation: Medical College of Wisconsin Children's Research Institute Histology Core Facility (RRID:SCR_028288) Copy
Core offers services in the field of bulk, single cell, spatial omics, FACs sorting and sequencing.
Proper citation: University College London Single Cell and Spatial Omics Platform Core Facility (RRID:SCR_028322) Copy
https://www.mayo.edu/research/core-resources/genome-analysis-core/overview
Core provides genomics services including next-generation sequencing, gene expression, and genotyping. It enables studies on human disease mechanisms, cancer, and rare diseases.
Proper citation: Mayo Clinic Genome Analysis Core Facility (RRID:SCR_028327) Copy
https://www.etsmtl.ca/laboratoires/lacime/equipement
Core provides equipment for the fabrication and advanced characterization of cyber-physical microdevices, particularly printed cyber-physical microdevices. Provide students and researchers with environment where engineers receive training with advanced skills in the analog, digital and mixed domains.
Proper citation: ÉTS Montréal LaCIME Scientific Platform Core Facility (RRID:SCR_028326) Copy
https://mcw.ilab.agilent.com/service_center/5692/?tab=about
Core provides guided access to novel technologies for complete dissection of energy flux in rodents and other small animals. Our expert staff assist in development, testing, and standardization of metabolic technologies and workflows to leverage both mouse and rat models of interest. Facility offers 16-cage multiplexed metabolic phenotyping system (Promethion, Sable Systems International) that provides detailed mechanistic dissection of resting metabolic rate (RMR), physical activity, and ingestive behaviors of rodents in home style cage designs across the light cycle. CRMPC combines RMR assessments with direct/combined calorimetry (total heat dissipation) to enable assessment of anaerobic forms of energy expenditure (gut microbiome). Additional services include body composition analysis (via NMR), bone content and density analysis (via DEXA), metabolic caging, indirect calorimetry, bioimpedance spectroscopy, thermal imaging. Staff provide guidance for experimental design, execution of studies, statistical analysis of resulting data, and regulatory assistance and compliance.
Proper citation: Medical College of Wisconsin Comprehensive Rodent Metabolic Phenotyping Core Facility (RRID:SCR_028283) Copy
https://www.roswellpark.org/shared-resources/gene-targeting-transgenic
Core provides investigators in the Western New York area with genetically modified animals for their research through gene targeting and transgenic methodologies.
Proper citation: Roswell Park Comprehensive Cancer Center Gene Targeting and Transgenic Core Facility (RRID:SCR_028287) Copy
High-resolution 3D X-ray microscope (micro-CT) designed for non-destructive, submicron imaging of internal structures in materials science, electronics, and life sciences. It allows researchers to visualize 3D details at 500 nm resolution without cutting samples, using "Resolution at a Distance" (RaaD™) technology to image large or complex items.
Proper citation: Zeiss Xradia 620 Versa X-ray microscope (RRID:SCR_028320) Copy
https://med.uc.edu/depart/eh/cores/genomics/home
Facility focused on next-generation sequencing services. Offers advanced capabilities in next-generation sequencing, single-cell sequencing, and genomics and epigenomics services.
Proper citation: University of Cincinnati Genomics, Epigenomics and Sequencing Core Facility (RRID:SCR_028318) Copy
Core provides instrumentation, training, and high-level scientific and technical expertise relating to conventional and spectral cytometry, cell sorting, small particle analysis, ELISA/ELISpot, PBMC processing and cryopreservation, and multiplex assays.
Proper citation: Nationwide Children's Hospital Flow Cytometry and Immune Monitoring Core Facility (RRID:SCR_028319) Copy
Core oversees the operation of research animal facilities at the University of Vermont. Animal facilities houses mainly mice and rats. Animal models facilitate discovery in the areas of infectious disease, endocrinology and metabolic disease, cancer and chemotherapy, immunology and respiratory disease, among others. The University of Vermont's Animal Care program is fully accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC, International).
Proper citation: University of Vermont Office of Animal Care Management Core Facility (RRID:SCR_028379) Copy
https://www.research.chop.edu/biostatistics-data-management)
Core offers biostatistics and data management services, expertise in the design of experiments, planning of clinical protocols, analysis and interpretation of data, and presentation and dissemination of results. Services include designing case report forms, developing databases, creating data management plans, developing metrics to report on study progress, and delivering high quality datasets for analysis. Core offers free limited consulting for data management and statistical questions. Offers experience with the submission of a Biologics License Application (BLA). Core is available to investigators seeking guidance with clinical trial start-up, oversight, and regulatory submission.
Proper citation: Children's Hospital of Philadelphia CHOP Biostatistics and Data Management Core Facility (RRID:SCR_028410) Copy
https://www.research.chop.edu/cag-sequencing-core
Cores Sequencing operations are integrated with Biorepository and Bioinformatics teams to keep all stages of a collaborators studies connected. Core offers genomics services in NovaSeq, Single Cell 10xGenomics, various library preparations including bulk RNAseq, Whole Genome/Whole Exome, and Sanger Sequencing including fragment analysis.
Proper citation: Children's Hospital of Philadelphia CHOP CAG Sequencing Core Facility (RRID:SCR_028416) Copy
https://www.research.chop.edu/zebrafish
Core offers zebrafish research services and provides fish husbandry. Services include experiments designing and performing, teaching zebrafish techniques.Provides special expertise in disease modeling by creation of mutant and transgenic lines, analysis of disease phenotypes, and drug testing.
Proper citation: Children's Hospital of Philadelphia CHOP Aquatic Zebrafish Core Facility (RRID:SCR_028414) Copy
https://www.roswellpark.org/shared-resources/bioinformatics
Core provides bioinformatics assistance for design, analysis and interpretation of genomics, proteomics and other studies for better understanding of cancer biology, thereby facilitating translation of cancer omics discoveries to cancer treatment. Provides services in design of experiments, raw omics data processing, data analysis and interpretation, data mining and integration, informatics infrastructure for data sharing and management, review and prepare grants and manuscripts, software evaluation, new method and database development,bioinformatics education and training for investigators.
Proper citation: Roswell Park Comprehensive Cancer Center Bioinformatics Shared Resource BIOINF Core Facility (RRID:SCR_028370) Copy
Genomics core is a self-supporting core facility specializing in Sanger sequencing, SNP/fragment analysis, and Next Generation DNA Sequencing using Illumina's MiSeq platform. Provides sequencing services.
Proper citation: University of Tennessee at Knoxville Genomics Core Facility (RRID:SCR_028374) Copy
https://www.umassmed.edu/research/cores/bioimage-dms-core/
Core helps research scientists and imaging core facilities produce, handle, safeguard, and share high-quality bioimage data. Ensures compliance with standards for image data management and sharing. Helps to plan experiments, track experimental conditions, and produce data.BioImage DMS eases the burden of data publication and sharing when the project is published.
Proper citation: University of Massachusetts Chan Medical School BioImage Data Management and Sharing Core Facility (RRID:SCR_028375) Copy
https://www.roswellpark.org/shared-resources/biomedical-research-informatics
Core provides consultations and services for investigators and study teams in the areas of clinical research, informatics, and data science. BRISR helps researchers harness internal and external data resources and provide informatics-driven solutions for clinical and translational research. Offers the infrastructure and processes to establish and monitor data standards, quality integration and distribution, educational and training opportunities. Provide services in three main areas: (1) Clinical data management and delivery for research, (2) Custom software development for research, and (3) Artificial intelligence analysis for clinical and bioinformatics research.
Proper citation: Roswell Park Comprehensive Cancer Center Biomedical Research Informatics Shared Resource BRISR Core Facility (RRID:SCR_028372) Copy
https://chop.ilab.agilent.com/sc/4963/research-viral-vector-core/?tab=about
Core provides premium recombinant adeno-associated viral (AAV) and lentiviral vectors to support basic research and preclinical studies. Provides expertise in producing custom vector constructs at multiple scales, rigorous quality control standards, and technical support. Services enable gene transfer and accelerate translational research and therapeutic development.
Proper citation: Children's Hospital of Philadelphia CHOP Research Vector Core Facility (RRID:SCR_028409) Copy
http://www.research.chop.edu/pathology
Core provides histopathology, Immunohistochemistry, tissue microarray, and imaging services. Staff offer experience in all aspects of tissue processing, histological techniques, antibody work-up, and morphologic analysis. Offers tools to facilitate high throughput analysis of tissue sections and imaging. The Pathology Core is located in the A Level of Colket Translational Research Building (CTRB) Room A410. Staff is available for consultation, troubleshooting, and assistance in planning and interpreting experiments histopathology and related techniques.
Proper citation: Children's Hospital of Philadelphia CHOP Pathology Core Facility (RRID:SCR_028406) Copy
https://chop.ilab.agilent.com/sc/5542/comparative-medicine-services-core/?tab=about
Core provides support for nonclinical research programs. Offers expertise to design, conduct, and oversee a wide range of animal studies. Services include Grant and funding application support, Budget development and financial planning, Experimental design and study planning, Study protocol drafting, implementation, and management, IACUC protocol guidance and consultation, Standard Operating Procedure (SOP) development, management, and archiving, Training delivery and documentation, Study execution and data generation, Secure archiving of study materials and data. Core offers expertise in Pharmacokinetic studies, Biodistribution studies, Toxicology and reproductive toxicology studies, Medical device testing, Surgical model development.
Proper citation: Children's Hospital of Philadelphia CHOP Comparative Medicine Services Core Facility (RRID:SCR_028407) Copy
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