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http://www.spl.harvard.edu/

A laboratory dedicated to advancing health care through utilizing computation and imaging to new areas of medicine.

Proper citation: BWH Surgical Planning Laboratory (RRID:SCR_000869) Copy   

•   Source: SciCrunch Registry

http://www.ohsu.edu/xd/

As the state''s only health and research university, OHSU brings together patient care, research, education of the next generation of health care providers and scientists and community service to improve the health and well-being of all Oregonians.

Proper citation: Oregon Health and Science University; Oregon; USA (RRID:SCR_009665) Copy   

•   Source: SciCrunch Registry

http://ctsaconnect.org/

THIS RESOURCE IS NO LONGER IS SERVICE. Documented on December 5th, 2022. Semantic framework to integrate information about research activities, clinical activities, and scientific resources to facilitate the production and consumption of Linked Open Data about investigators, physicians, biomedical research resources, services, and clinical activities. The goal is to enable software to consume data from multiple sources and allow the broadest possible representation of researchers'''' and clinicians'''' activities and research products. Current research tracking and networking systems rely largely on publications, but clinical encounters, reagents, techniques, specimens, model organisms, etc., are equally valuable for representing expertise. CTSAConnect will provide linkage between semantic representations of a wide range of clinical and research data using controlled vocabularies mapped to the Unified Medical Language System (UMLS) as a bridge between the two subject areas. The data sources include data from Medicaid, hospital billing systems, CTSAShareCenter, and other CTSA resource data, eagle-i and VIVO. It allows institutions to leverage existing tools and data sources by making the information they contain more discoverable and easier to integrate. For instance, with the ISF, researchers can be characterized by organizational affiliations, grant and project participation, research resources that they have generated, and publications that they have (co)-authored. Clinicians can be characterized by training and credentials, by clinical research topic, and by the kinds of procedures and specialization that can be inferred from encounter data. LOD refers to data that has been given a specific Uniform Resource Identifier (URI), for the purpose of sharing and linking data and information on the Semantic Web. While a large amount of data is published as LOD, there remains a significant gap in the representation of research resources and clinical expertise. Researchers can be characterized by the organization to which they belong, the grants and research in which they have participated, the research topics and research resources (reagents, biospecimens, animal models) they have generated, as well as the publications they have (co)-authored. Clinician profiles on the other hand, can be defined by their credentials, clinical research topics, and the kinds of procedures and specialization that can be inferred from clinical encounter data. They believe that integrating and relating this diversity of information sources and platforms requires addressing the overlap between research resources and the attributes and activities of researchers and clinicians. CTSAconnect aims to promote integration and discovery of research activities, resources, and clinical expertise. To this end, they will publish their ontologies and LOD via their website, which will also illustrate repeatable methods and examples of how to extract, consume, and utilize this valuable new LOD using freely available tools like VIVO, eagle-i, and Google APIs. CTSAconnect is a collaboration between Oregon Health & Science University, Stony Brook University, Cornell University, Harvard University, University at Buffalo, and the University of Florida, and leverages the work of eagle-i (eagle-i.net), VIVO (vivoweb.org), and ShareCenter (ctsasharecenter.org).

Proper citation: CTSAconnect (RRID:SCR_005225) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-5e5d-69c2-55da-381e80000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 27, 2023. Core facility that provides the following services: Storage services for -80 degrees C and -190 degrees C in secure facility.

The Biospecimen Repository provides long-term storage of clinical and research material in -80 degrees C and liquid nitrogen freezers located at Dana Farber''s Harbor Campus. Transportation of samples to and from Harbor Campus is provided by the facility for a small fee. Competitive prices are available on per box or per freezer basis in both segregated or non-segregated environments.

Proper citation: DFCI Biospecimen Repository Core Facility (RRID:SCR_009747) Copy   

•   Source: SciCrunch Registry

http://utep.eagle-i.net/i/00000134-a952-c738-bfc0-fe9780000000

THIS RESOURCE IS NO LONGER IN SERVCE, documented January 23, 2019. Core facility that provides the following services: Zeiss LD-5 Pascal Scanning Confocal Microscope/Assisted access, Zeiss Axioskop Epifluorescence Microscope/Assisted access, Zeiss EM-10 Transmission Electron Microscope/Assisted access, Microscopy sample preparation, Observation and photography service. The Analytical Cytology Core Facility provides assistance in the designing of protocols and the use of sophisticated, well maintained and supervised equipment. Each microscope is equipped with software for image analysis, image processing and printing of digital images. Service contracts are maintained on each of the microscopes. Computers and software are regularly upgraded. Confocal workshops are held regularly to familiarize users with new techniques and new protocols. The specific aims of the Analytical Cytology Core Facility (ACCF) are: 1. to train users in the design of protocols, the fixations, sectioning, cryofixations, immunolocalizations, the use of the Zeiss EM-10, the Zeiss Axioskop epifluorescence microscope and the Zeiss Pascal scanning confocal microscope with image analysis and image processing, 2. to support new faculty in realizing their research objectives that utilize microscopy, 3. to support the productivity of the Infectious Diseases and Immunology unit, the Toxicology unit, the Neuroscience/Metabolic Disorders unit, the Statistical Consulting Laboratory and the Bioinformatics unit by assisting faculty, undergraduate, masters, doctoral and postdoctoral students in advancing biomedical research, 4. to maintain and upgrade equipment and expertise and; 5. to provide core services anticipating self-sustaining maintenance of the core facility.

Proper citation: University of Texas El Paso Analytical Cytology Core Facility (RRID:SCR_010137) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/microarray-and-bioinformatics-core-mmc

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 22,2024. Core facility that provides the following services: RNA quality analysis service, qRT-PCR service, Microarray service, Bioinformatics data analysis service. The Core provides state of the art training, instrumentation, services and bioinformatics-driven data analysis to the Meharry Community in microarray experimental design, manipulation, and gene expression analysis. They also aid investigators and trainees in validation of microarray results using RNA QA/QC and real time PCR results. Finally, this Core Resource aids Meharry investigators and trainees with high performance computation in proteomics as well as genomics. Gene and protein pathways analysis and shotgun proteomics (mass spectrometry) analysis are just two more of the services that we provide. It is their aim to keep this facility up to date computationally and intellectually with state of the art Omics services to support education and research in microarray, genomics and proteomics data analysis, computational biology, and systems biology.

Proper citation: Meharry Microarray and Bioinformatics Core (RRID:SCR_012229) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/martinos-center-for-biomedical-imaging-core-facility-harvard

Core facility that provides the following services: Positron emission tomography service.

The Martinos Center''''s dual mission includes translational research and technology development. The core technologies being developed and used at the center are magnetic resonance imaging (MRI) and spectroscopy (MRS), magnetoencephalography (MEG) and electroencephalograpy (EEG), near infra-red spectroscopy (NIRS) and diffuse optical tomography (DOT), Positron Emission Tomography (PET), electrophysiology, molecular imaging, and computational image analysis. A particular area of innovation at the Center is Multimodal Functional Neuroimaging which involves the integration of imaging technologies. They are also world leaders in the development of primate neuroimaging techniques. Major areas of research at the center include, psychiatric, neurologic and neurovascular disorders, basic and cognitive neuroscience, cardiovascular disease, cancer and more. With an extensive and expanding inventory of state-of-the-art imaging facilities, a world class team of investigators and collaborators, and important government, industry and private supporters, the Martinos Center is leading the way to new advances and applications in biomedical imaging.

Proper citation: MGH Martinos Center for Biomedical Imaging Core Facility (RRID:SCR_012324) Copy   

•   Source: SciCrunch Registry

http://www.schepens.harvard.edu/graphics

Core facility that provides the following services: Web and graphic services, Web design and content management service, Photography service. Peter Mallen is a designer and illustrator who manages a full-service web and graphics studio in a moderately sized scientific research facility, Schepens Eye Research Institute. He provides a full range of graphic design, scientific illustration, web design and development, content management, and general design and production services. His products are utilized by: faculty and scientific staff (books, scientific publications, slide shows, grant applications); professional staff (Administration, Development & Public Affairs; brochures, books, pamphlets); the general public (Institute websites) as well as clients of our 250-seat state-of-the-art conference center, Starr Center for Scientific Communications.

Proper citation: Harvard SERI Graphic Services Core (RRID:SCR_012309) Copy   

•   Source: SciCrunch Registry

http://www.massgeneral.org/psychiatry/research/pngu_home.aspx

Core facility that provides the following services: SNP genotyping, qPCR for CNV detection / confirmation, Genetic analysis services, DNA extraction, quantification, sample preparation, tracking, and storage. This resource provides custom genotyping (SNP, other), qPCR for CNV detection/confirmation, DNA extraction, quantification, sample preparation, tracking, and storage, and related services to further the PNGU mission of identifying and characterizing the genetic basis of psychiatric, behavioral, and neurodevelopmental disorders and to translate these discoveries to improvements in clinical care and public health.

Proper citation: MGH Psychiatric and Neurodevelopmental Genetics Unit Core Lab (RRID:SCR_012301) Copy   

•   Source: SciCrunch Registry

http://flowcytometry.sysbio.med.harvard.edu/

Core facility that provides the following services: Sorting and analysis services. The facility houses two state-of-the-art BD analyzers with high-throughput capability, a Stratedigm benchtop analyzer, a high-speed BD cell sorter, and both Mac and PC workstations for data analysis. Sorting services are offered through the facility, as well as instrument and software training.

Proper citation: HMS Systems Biology Flow Cytometry Facility (RRID:SCR_012696) Copy   

•   Source: SciCrunch Registry

http://www.neurodiscovery.harvard.edu/resources/atrc.html

Core facility that provides provides state-of-the-art molecular pathology resources to the Harvard community including laser capture microscopy, DNA/RNA/miRNA quality/expression analysis, Luminex FlexMap 3D multiplex bead cytometry, and real-time PCR. The ATRC is a fee-for-use facility. For NeuroDiscovery members, the first 10 hours of training, consultation and instrument use is free. This initial period is intended to provide a first time user with preliminary data/proof of concept regarding their project, and is generally sufficient when investigators work under the aegis of ATRC staff. Thereafter, the base fee varies depending on activity and the extent of your proposed work. Project-based charge-back agreements for large projects can be negotiated with the ATRC Director, Dr. Charles Vanderburg. Although priority is given to NeuroDiscovery members investigating neurodegenerative diseases and the CNS, the facility is also available to any academic investigators within the Harvard medical community and the greater-Boston research community. Under special arrangements the facility may also be made available to the commercial sector. Please contact ATRC Director, Dr. Charles Vanderburg, for details.

Proper citation: HNDC Advanced Tissue Resource Center (RRID:SCR_012670) Copy   

•   Source: SciCrunch Registry

http://bioinformatics.hms.harvard.edu/

Core facility that offers consultations on basic questions in research computing, bioinformatics and computational biology during the initial stages of study design and grant proposals as well as for ongoing, funded studies requiring external expertise. Core has experience in large-scale data management, database design and software development. Staff members can provide assistance in quality assurance and analysis of gene expression arrays, genome-wide SNP arrays, CNV studies and different aspects of second-generation sequencing technologies such as ChIP-seq, RNA-Seq or resequencing efforts. Services also include provision of external information generated from public database, data curation and assistance on choosing the right data format and annotation standard to ensure best practices in data management and submission are being maintained.

Proper citation: Harvard Chan Bioinformatics Core (RRID:SCR_012655) Copy   

•   Source: SciCrunch Registry

http://dartmouth.eagle-i.net/i/0000012b-00c3-e398-6a59-ec4e80000000

Core facility that provides the following services: Custom design and development of equipment, tools and instruments for scientific research.

Proper citation: Dartmouth Department of Physics: Apparatus Shop Core Laboratory (RRID:SCR_009738) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-7276-7824-55da-381e80000000

Core facility that provides the following services: Whole genome amplification service, Genotyping service using Illumina GoldenGate and Infinium technologies, SNP Analysis using OpenArray Genotyping, SNP Analysis using Taqman, Custom Illumina GoldenGate genotyping, Illumina Infinium genotyping.

The mission of the High-Throughput Polymorphism Detection Core is to provide services to investigators conducting molecular analyses of somatic DNA collected as part of a wide range of investigations. This Core provides high-throughput assays of specific gene mutations and polymorphisms (SNPs) in the many situations where previously defined specific nucleotide alterations are of interest.

Proper citation: DF/HCC High-Throughput Polymorphism Detection Core (RRID:SCR_009736) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-c90c-c8fc-4882-b08d80000000

Core facility that provides the following services: Hematopoietic progenitor cell (HPC) components processing, Tumor cell vaccine generation, Dendritic cell vaccine generation, Validation consultation.

The (Connell and O''Reilly Families) Cell Manipulation Core Facility (CMCF), at Dana-Farber Cancer Institute (DFCI) was created in 1996 to be the manufacturing facility that produces safe and effective novel cellular component therapy that meets regulatory guidelines for clinical use and also facilitates research to be translated from the bench to the bedside. The goal of this facility is to assist DF/HCC investigators in developing new cell-based therapies for cancer and to support clinical research studies designed to evaluate the toxicity and efficacy of these novel treatments. In November 2004, CMCF moved to a newly constructed 6,700 square feet facility on the third floor and ground floor of the Jimmy Fund Building (JFB) at DFCI. The new facility is dedicated to the production of clinical grade cellular products for patients who participate in clinical trials conducted by DF/HCC investigators. All procedures are performed in environmentally controlled conditions according to current Good Manufacturing Practices (cGMP) for cell and tissue processing. The third floor accommodates all of the production areas while space on the ground floor is devoted to the long-term storage of cellular products, tissues and samples in liquid nitrogen and mechanical freezers. The CMCF is available to both clinical and laboratory investigators at all DF/HCC institutions and will provide services to patients at all DF/HCC affiliated hospitals. The staff of the CMCF are committed to working with DF/HCC investigators at all levels of clinical trial development and execution, including pre-clinical development, trial design, DF/HCC and FDA review, data management, quality control, internal and external audits as well as reports and publications. The Cell Manipulation Core Facility (CMCF) has been accredited by the Foundation for the Accreditation of Cellular Therapy (FACT). The CMCF services as a Regulatory Core for Center for Human Cell Therapy and is also a member of the Joint Program in Transfusion Medicine.

Proper citation: DF/HCC Cell Manipulation Core Facility (RRID:SCR_009734) Copy   

•   Source: SciCrunch Registry

http://cdrewu.eagle-i.net/i/00000135-20a3-3d3f-f836-7d1b80000000

The AXIS Biomedical Informatics function is dedicated to providing investigators at Charles Drew University (CDU) with state-of-the-art informatics solutions for their research projects. AXIS Biomedical Informatics comprises a multi-disciplinary team of researchers with backgrounds and interest in clinical medicine, biomedical informatics, medical geography and geographical information systems, computer science, sociotechnical theories and qualitative methods.

Proper citation: CDU AXIS Biomedical Informatics function (RRID:SCR_009699) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-f066-ba26-2162-17a280000000

Core facility that provides the following services: Metabolite identification service, PK data analysis and interpretation service.

The Cancer Pharmacology Core provides DF/HCC investigators with the necessary expertise and resources to design and undertake pharmacokinetic studies in the context of phase I and phase II clinical trials, and preclinical investigations. The core has the ability to implement and validate previously developed analytical methods to quantify drugs and their metabolites in biological fluids as well as the capability to modify or develop entirely new assays when warranted. The core also offers comprehensive analysis of pharmacokinetic data as an additional service, including the estimation of pharmacokinetic parameters and identifying their relationship to pathophysiological variables and pharmacodynamic effects.

Proper citation: DF/HCC Cancer Pharmacology Core (RRID:SCR_009732) Copy   

•   Source: SciCrunch Registry

http://ccny-cuny.eagle-i.net/i/00000137-568a-3b40-bb24-040880000000

LSR II A State-of-the-Art RCMI Flow Cytometry Core is located in MR613 with full time technical support, provided by the Flow Technician Mr. Jeffrey Walker. Mr. Walker is BD trained and certified in both analysis and sorting and has extensive experience in sorting both lymphocytes and larger epithelial cells, as well as with specialized applications including cell cycle analysis and calcium flux. Mr. Walker provides training for regular users wishing to perform independent analysis, and is responsible for all sorting.

Proper citation: CCNY Fluorescence Activated Cell Sorting (RRID:SCR_009696) Copy   

•   Source: SciCrunch Registry

http://cau.eagle-i.net/i/00000135-abf1-2607-ecf8-187780000000

CCRTD houses several major instruments to support structural studies of biological molecules, cells, modern cell, and molecular visualization applications. We have an Inverted Digitized Microscope (Zeiss) of general use, plus an advanced Fluorescence-enabled Inverted Digitized Microscope with Z-stacking and Live Cell Imaging modules (Zeiss). For advanced applications including In Situ Hybridization (ISH) and Immunohistochemistry (IHC), in addition to Zeiss microscope above we offer Confocal Fluorescent Microscope (Nikon). The latter is currently undergoing a major upgrade of computer system, software, and optics including addition of lasers.

Proper citation: CAU CCRTD-Structural Biology (RRID:SCR_009694) Copy   

•   Source: SciCrunch Registry

http://cau.eagle-i.net/i/00000135-abe7-77c7-ecf8-187780000000

CCRTD Core Facilities house major equipment for DNA and RNA-based applications. We offer polymerase chain reaction ( PCR ) instruments including Real-Time PCR machine (I-Cycle, Bio-Rad), Liquid Scintillation Counter (Beckman Coulter), Lyophilizer and Freeze-Dryer for biological samples, Cell Porator, high-speed and ultra-high-speed Centrifuges, ultra-sensitive Balances, and other supporting equipment. DNA and RNA quantification can be carried out on Spectrophotometers, both single-cuvette (DU650, Beckman Coulter) and 96-well plate based. DNA and RNA can be visualized, digitized, and quantified using Gel Documentation system (Bio-Rad) or Multi-Mode Imager Typhoon 9410, in fluorescent, luminescent, UV, or visible wavelengths; time-resolved fluorescence option is available on BioTek Plate Imager. For X-Ray imaging, we maintain an Automated X-Ray processor and Dark Room; radioisotope imaging is also supported on Typhoon 9410.

Proper citation: CAU CCRTD-Molecular Biology (RRID:SCR_009692) Copy   

•   Source: SciCrunch Registry