Tools   Select Another Resource Report Type

http://www.newmeds-europe.com/

Consortium that will develop new models and methods to enable novel treatments for schizophrenia and depression including three important missing tools that will facilitate the translation of scientific findings into benefits for patients. The project will focus on developing new animal models which use brain recording and behavioral tests to identify innovative and effective drugs for schizophrenia. The project will develop standardized paradigms, acquisition and analysis techniques to apply brain imaging, especially fMRI and PET imaging to drug development. It will examine how new genetic findings (duplication and deletion or changes in genes) influence the response to various drugs and whether this information can be used to choose the right drug for the right patient. And finally, it will try and develop new approaches for shorter and more efficient trials of new medication - trials that may require fewer patients and give faster results.

Proper citation: NEWMEDS (RRID:SCR_003872) Copy   

•   Source: SciCrunch Registry

http://gtlinker.cnb.csic.es/

Web application that filters and links enriched output data identifying sets of associated genes and terms, producing metagroups of coherent biological significance. The method uses fuzzy reciprocal linkage between genes and terms to unravel their functional convergence and associations. It can also be accessed through its web service.

Proper citation: GeneTerm Linker (RRID:SCR_006385) Copy   

•   Source: SciCrunch Registry

http://www.precisesads.eu/

A project that will study 2,500 people with various systemic autoimmune diseases (SADs), gathering data on the molecular causes of their disease as well as their clinical symptoms, enabling them to pave the way for a new classification of these diseases. The goal is to use OMICs and bioinformatics to identify new classifications for diseases known to share common pathophysiological mechanisms. Results will be shared to deliver a new molecular taxonomy of systemic autoimmune diseases. In order to achieve this, PRECISEADS is informing on a regular basis on the project implementation and results, and involving stakeholders from Europe in its activities in order to broaden the project impact and increase opportunities for cooperation.

Proper citation: PRECISESADS (RRID:SCR_003882) Copy   

•   Source: SciCrunch Registry

http://nd4bb-enable.eu/

Consortium working to advance the development of potential antibiotics against Gram-negative bacteria, such as Escherichia coli. The project creates and manages a drug discovery engine for testing and optimizing molecules that are still in the earlier stages of drug discovery but have the potential to become future drug candidates capable of treating resistant Gram-negative infections. The project will focus on the discovery and pre-clinical stages of drug development, as well as (potentially) phase 1 clinical trials. ENABLE will run several drug discovery programs in parallel and the consortium seeks external hit and lead programs to join, through a series of open calls during the project. Researchers who have interesting molecules will have the opportunity to collaborate with a diverse range of experts in microbiology, pharmacology and chemistry to help advance their molecule through the drug development process until it is an attractive candidate for clinical testing. Specifically, the project is working towards: # identifying three antibacterial lead molecules which, following extensive testing, have been identified as having promising antimicrobial activity; # identifying two antibacterial clinical candidate molecules # advancing at least one compound into preclinical and phase 1 clinical studies, i.e. early clinical safety testing in humans.

Proper citation: European Gram Negative AntiBacterial Engine (RRID:SCR_003859) Copy   

•   Source: SciCrunch Registry

http://floresta.eead.csic.es/footprintdb/index.php

Database with 2797 unique DNA-binding proteins (mostly transcription factors, TFs), 4196 Position Weight Matrices (PWMs) and 13161 DNA Binding Sites extracted from the literature and other repositories. The binding interfaces of (most) proteins in the database are inferred from the collection of protein-DNA complexes described in 3D-footprint. The database predicts transcription factors which bind a specific DNA site or motif and DNA motifs or sites likely to be recognized by a specific DNA-binding protein.

Proper citation: footprintDB (RRID:SCR_005368) Copy   

•   Source: SciCrunch Registry

http://genecodis.cnb.csic.es/

Web-based tool for the ontological analysis of large lists of genes. It can be used to determine biological annotations or combinations of annotations that are significantly associated to a list of genes under study with respect to a reference list. As well as single annotations, this tool allows users to simultaneously evaluate annotations from different sources, for example Biological Process and Cellular Component categories of Gene Ontology.

Proper citation: GeneCodis (RRID:SCR_006943) Copy   

•   Source: SciCrunch Registry

http://emperie.eu/

The European Management Platform for Emerging and Re-emerging Infectious Disease Entities (EMPERIE) consortium brings together international experts of different disciplines in an efficient and decisive collaborative network, to coordinate the response and control of an emerging new disease.

Proper citation: European Management Platform for Emerging and Re-Emerging Infectious Disease Entities (EMPERIE) (RRID:SCR_013693) Copy   

•   Source: SciCrunch Registry