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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
| Organism Name | Proper Citation | Species | Synonyms |
Notes |
Phenotype | Affected Gene | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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SD;DA-Tg(Thy1-APP*)14Dspb Resource Report Resource Website |
RRID:RGD_38599244 | Rattus norvegicus | Mutant human amyloid beta (APP*) combined Thy1 promoter which is specifically expressed in neurons, was induced to ES cells from DA strain rats, and chimera rats obtained from the ES cells. The F1 rats were backcrossed with Crl:CD (SD) strain rats and F3 rats was deposited to NBRP. The expression levels of mutant human APP mRNA are difficult among Lines (12>1>14>6). National BioResource Project for the Rat in Japan | 38599244 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2020-09-16) | 38599244 | RGD | 2026-11-07 12:23:30 | 0 | |||||
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CD-Tg(RNECO-180E22)737Arno Resource Report Resource Website 1+ mentions |
RRID:RGD_155663368 | Rattus norvegicus | This transgenic model line 737 was made by injecting bacterial artificial chromosome (BAC) RNECO-180E22, into Crl:CD(SD) strain embryos. The BAC clone RNECO-180E22, a kind gift of Helen Skaletsky, is derived from Rattus norvegicus strain SHR chromosome Y. | 155663368 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 155663368 | RGD | 2026-11-07 12:23:32 | 1 | |||||
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SD-Tg(Cyp3a23-3a1-Cyp3A4*-Cas9)SynblRrrc Resource Report Resource Website |
RRID:RGD_155260364 | Rattus norvegicus | rat strain in which the rat Cyp3a1 gene (Cyp3a23-3a1, RGD:628626) was inactivated by insertion of a human CYP3A4 minigene (Cyp3A4*) and the linked rat Cyp3a2 locus was simultaneously mutated by CRISPR-mediated indel introduction. Strain contains Indel 8 at the Rat 3A2 locus (55 kb away), The CYP3A4 minigene included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance. Strain contains and Active Genetic cassette which encodes a gRNA targeting the Rat 3A1 and 3A2 translation initiation site. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 URL: URL: Doi:10.1101/2022.08.30.505951 RRRC | 155260364 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2022-10-06) | 155260364 | RGD | 2026-11-07 12:23:32 | 0 | |||||
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SD-Tg(Sycp1-Cas9-eGFP)Synbl Resource Report Resource Website |
RRID:RGD_155260365 | Rattus norvegicus | This project entailed generation of a novel rat strain in which a P2A-Cas9-T2A-EGFP coding sequence was inserted at the stop codon of the rat Sycp1 gene for co-expression of Cas9 and EGFP under the control of the Sycp1 regulatory elements. Animals express Cas9 in the testis in the spermatogonial layer and in meiosis stages with 4N DNA content. Strain catalyzes high levels of Active Genetic Gene conversion when paired with certain Active Genetic cassettes. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 Donated to Rat Resource & Research Center | 155260365 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2022-10-06) | 155260365 | RGD | 2026-11-07 12:23:32 | 0 | |||||
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WKY-Tg(CD68-GFP)Kjw Resource Report Resource Website |
RRID:RGD_329955364 | Rattus norvegicus | Transgene insertion (human CD68-GFP) using Sleeping Beauty transposon system on Wistar Kyoto rats. Rat monocyte/macrophage reporter strain on a WKY background which has susceptibility to experimental glomerulonephritis. GFP expression occurs exclusively within blood monocytes and tissue macrophages. | 329955364 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 329955364 | RGD | 2026-11-07 12:23:32 | 0 | |||||
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DA;CD-Tg(RNECO-180E22)733Arno/Mcwi Resource Report Resource Website |
RRID:RGD_404976872 | Rattus norvegicus | CD-Tg(RNECO-180E22)733Arno, RGD:155663367 was backcrossed at the Medical College of Wisconsin to DA/MolTacMcwi for 6-7 generations before cryopreservation of sperm. Contact MCW rat distribution at [email protected] | 404976872 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2024-03-18) | 404976872 | RGD | 2026-11-07 12:23:33 | 0 | |||||
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W-Tg(Dbh-tTA,-cre)5_4Fusa Resource Report Resource Website |
RRID:RGD_598092606 | Rattus norvegicus | This strain was established by a use of the BAC transgenic method with a technical support from the C.B.S.N resource (Dr. Kazuto Kobayashi, Fukushima Medical University, Dr. Yuchio Yanagawa, Gunma University Graduate School of Medicine). This transgenic rat was transported to The Jikei University School of Medicine, and cre recombinase expression was confirmed by crossing it with a reporter rat (NBRP Rat No: 0734). These rats are maintained in The Jikei University School of Medicine. Background strain: Crlj:WI. Transgene: Dbh (dopamine beta-hydroxylase: rat), TetR (E.coli), VP16 protein minimal“F”-type activation domain (Herpes simplex virus), 2A (Thosea asigna virus), cre recombinase (P1 Phage), bGlobin polyA (rabbit), loxP (P1 phage). Detailed method (BAC transgenic method): a rat BAC clone was used (CH230-211J22). Combined mRNA for tTA and cre recombinase sequences is transcribed under the control of Dbh promoter. In translation step, the transcript is cut at the 2A peptide sequence, resulting in a separate protein production of tTA and Cre. National BioResource Project for the Rat in Japan | 598092606 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2025-03-28) | 598092606 | RGD | 2026-11-07 12:23:34 | 0 | |||||
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SD-Tg(TOR1A)Tot Resource Report Resource Website |
RRID:RGD_598154611 | Rattus norvegicus | The full length humanTOR1A wild type gene including upstream and downstream flanking regions were inserted into a pUC19 vector. Following linearization and purification the transgenes were used to generate transgenic rats by microinjection of the DNA construct into the pronucleus of rat zygotes. Transgenic rats were kept on Sprague–Dawley background and bred as hemizygotes using standard procedures. Genotypes of offspring were determined by PCR and sequencing of DNA extracted from ear biopsies. Primer pair 5′-TAAAAATGTGTATCCGAGTGGAAAT (forward) and 5′-AAGGACTGAGTGTTGTTTCTTTTC (reverse) amplified a 230 bp segment within the coding sequence of exon 5 under the following conditions: 94 °C for 1 min, 60 °C for 1 min and 72 °C for 1 min, 40 cycles. Only lines that showed stable germline transmission of the transgenes were used for further analyses. | 598154611 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 598154611 | RGD | 2026-11-07 12:23:34 | 0 | |||||
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SD-Tg(TOR1ADYT1)Tot Resource Report Resource Website |
RRID:RGD_598154612 | Rattus norvegicus | The 16.25 kbps full length human DYT1 allele of TOR1A gene including upstream and downstream flanking regions were inserted into a pUC19 vector. Following linearization and purification the transgenes were used to generate transgenic rats by microinjection of the DNA construct into the pronucleus of rat zygotes. Transgenic rats were kept on Sprague–Dawley background and bred as hemizygotes using standard procedures. Genotypes of offspring were determined by PCR and sequencing of DNA extracted from ear biopsies. Primer pair 5′-TAAAAATGTGTATCCGAGTGGAAAT (forward) and 5′-AAGGACTGAGTGTTGTTTCTTTTC (reverse) amplified a 230 bp segment within the coding sequence of exon 5 under the following conditions: 94 °C for 1 min, 60 °C for 1 min and 72 °C for 1 min, 40 cycles. Only lines that showed stable germline transmission of the transgenes were used for further analyses. | 598154612 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 598154612 | RGD | 2026-11-07 12:23:34 | 0 | |||||
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LE-Tg(Tac1-cre)3-2Koba Resource Report Resource Website |
RRID:RGD_598092579 | Rattus norvegicus | Background strain: Long-Evans rat (Iar:Long-Evans). This strain was established by injection of modified BAC (cre gene was inserted into the exon 2 of rat Tac1 gene) into Long-Evans rat's fertiled eggs. National BioResource Project for the Rat in Japan | 598092579 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2025-03-27) | 598092579 | RGD | 2026-11-07 12:23:34 | 0 | |||||
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SD-Tg(DNMT3A+) Feis Resource Report Resource Website |
RRID:RGD_405849385 | Rattus norvegicus | The hDNMT3A transgenic rats were established using zygote microinjection of a bacterial artificial chromosome (BAC). The RP11-159D24 BAC (NCBI-ID:223335, Homo sapiens, GRCh38.p2: Chr. 2: 25,202,642-25,410,145, total length: 207,504 bp) containing DNMT3A (GRCh38.p2: 25,232,961,25,342,590, total length: 109,630 bp) was injected into rat zygotes (Rattus norvegicus, Sprague-Dawley, SD). The offspring were identified with 8 PCR primer-pairs that were specific for the RP11-159D24 sequence to detect positive transgenic ones. | 405849385 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 405849385 | RGD | 2026-11-07 12:23:33 | 0 | |||||
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SD-Tg(NR3C2*)-/-Frje Resource Report Resource Website |
RRID:RGD_632522750 | Rattus norvegicus | This is the wild type littermate of the transgenic rat strain carrying human NR3C2 (RGD:632522749). | 632522750 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 632522750 | RGD | 2026-11-07 12:23:35 | 0 | |||||
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WI-Tg(Avp-CHRM3*-mCherry)Tuch Resource Report Resource Website |
RRID:RGD_626168247 | Rattus norvegicus | A chimeric AVP-hM3Dq-mCherry BAC clone transgene construct was purified for microinjections. hM3Dq is a modified form of the human M3 muscarinic receptor (hM3; CHRM3*). It can be activated by the inert clozapine metabolite clozapine-N-oxide (CNO), engaging the Gq signaling pathway.The hM3Dq-mCherry sequence from the hM3Dq-mCherry cassette (Plasmid #44361, Addgene, Cambridge, MA, USA) was used for the transgene. Next, SV40 poly A sequence was framed to the hM3Dq-mCherry sequence. Finally, this hM3Dq-mCherry-SV40 poly A cassette was introduced into the rat Avp gene in place of the genomic start codon. Thus, hM3Dq-mCherry should be specifically expressed under the Avp promoter in the transgenic rat brain. | 626168247 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 626168247 | RGD | 2026-11-07 12:23:35 | 0 | |||||
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SD-Tg(CAG-HRAS*G12V)218Htsu Resource Report Resource Website |
RRID:RGD_10045584 | Rattus norvegicus | The transgene consisting of CAG promoter/loxP/neomycin resistant gene casette/lox/Ha-ras*G12V（HrasV12）was injected into embryos of SD rat (Jcl:SD). This strain was generated at CLEA Japan,Inc. National BioResource Project for the Rat in Japan | 10045584 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Embryo | 10045584 | RGD | 2026-11-07 12:22:47 | 0 | |||||
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Eker-Tg(Tsc2)5Hin Resource Report Resource Website |
RRID:RGD_629489 | Rattus norvegicus | Wild type Tsc2 transgene was constructed from the Tsc2 cDNA from BN rat and was microinjected into single male pronuclei. Eggs were cultured and tranferred into female wistar which were mated with Eker rats. | 629489 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 629489 | RGD | 2026-11-07 12:22:51 | 0 | |||||
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SI-Tg(Ednrb)Ywa Resource Report Resource Website |
RRID:RGD_629488 | Rattus norvegicus | A 5.8 kb fragment of the human dopamine-beta-hydroxylase (DbH) promoter used directs rat Endrb expression in sl animals. | 629488 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 629488 | RGD | 2026-11-07 12:22:51 | 0 | |||||
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LE-Tg(Drd2-IL2RA/YFP*)1Koba Resource Report Resource Website |
RRID:RGD_152977766 | Rattus norvegicus | Background strain: Iar:LE (Institute for Animal Reproduction) ( RGD:18337282). This strain was generated by injecting a modified BAC, in which a fusion protein created from the human IL2R alpha-subunit gene (IL2RA) and YFP* (enhanced yellow fluorescent protein,Venus) was inserted into the second exon of the rat Drd2 gene, into fertilized eggs of Long-Evans rats. National BioResource Project for the Rat in Japan | 152977766 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2022-07-06) | 152977766 | RGD | 2026-11-07 12:22:52 | 0 | |||||
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F344.DR-(D4Mit6-D4Mit24)-Tg(Gimap5)Mcwi Resource Report Resource Website |
RRID:RGD_1357175 | Rattus norvegicus | Wild type allele of Gimap5 from BN was microinjected into the pronuclei of fertilized eggs from a T cell lymphopenic congenic strain F344.DR-(D4Mit6-D4Mit24) | 1357175 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 1357175 | RGD | 2026-11-07 12:22:55 | 0 | |||||
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F344-Tg(ROSA26-EGFP)Eps Resource Report Resource Website |
RRID:RGD_1566459 | Rattus norvegicus | F344 embryos were microinjected with R26-EGFP trangene which comprises of 0.8 kb genomic sequence of ROSA 26 promoter fused to enhanced green fluorescent protein (EGFP). | 1566459 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 1566459 | RGD | 2026-11-07 12:22:56 | 0 | |||||
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SD-Tg(Rho*P23H)2Lav Resource Report Resource Website |
RRID:RGD_1358299 | Rattus norvegicus | This transgenic strain carries a copy of mouse Rhodopsin gene with a proline to histidine substitution at codon 23 (c.68C>A). Retinal Degeneration Rat Model Resource | 1358299 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 1358299 | RGD | 2026-11-07 12:22:56 | 0 |
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