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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=2314162
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals; Cryopreserved Sperm
Alternate IDs: 2314162
Notes: A mutant rat showing abnormal tail was found in the G1 rats produced by ENU mutagenesis (phenotype-driven). National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_2314162 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=2314165
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm
Alternate IDs: 2314165
Notes: This strain was established by phenotype-driven ENU mutagenesis. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_2314165 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=2314167
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals; Cryopreserved Sperm
Alternate IDs: 2314167
Notes: This strain was established by phenotype-driven ENU mutagenesis. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_2314167 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=2314168
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm
Alternate IDs: 2314168
Notes: A mutant rat showing abnormal eyes was found in the G1 rats produced by ENU mutagenesis (phenotype-driven). National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_2314168 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=2314170
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm
Synonyms: , Kaikai, Kyo1897
Alternate IDs: 2314170
Notes: This strain was established by phenotype-driven ENU mutagenesis. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_2314170 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=2314340
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Extinct (as of 2016-10-24)
Alternate IDs: 2314340
Notes: These Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb (RGD:2290163) and F344-Tg(PGK2-sb11)Ceb (RGD:2290169).This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 10th intron of the Acoxl gene.
Proper citation: RRID:RGD_2314340 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=2311071
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 2311071
Notes: A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974???75. Part of this colony containing the mutation was moved to Indiana University Medical School (IUMS), to the laboratory of Dr. Julia Clark in 1977. Several groups of animals with diabetic lineage were identified and rederived in 1981. Inbreeding of selected pairs from this rederivation was done in the laboratory of Dr. Richard Peterson at IUMS. An inbred line of ZDF rat was established in 1985. To Genetic Models, Inc. in 1991. To Charles River in 2001. Control models for the ZDF Rat (Obese fa/fa) are the ZDF Rat (Lean fa/+) or ZDF Rat (Lean +/?). Charles River Laboratories
Proper citation: RRID:RGD_2311071 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=2314362
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm
Alternate IDs: 2314362
Notes: Hairless mutation was found in the G1 rats that established by ENU mutagenesis (phenotype driven). National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_2314362 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=2314655
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-06-21)
Alternate IDs: 2314655
Notes: Hereditary hypothalamic diabetes insipidus was first described in offspring from a Long-Evans stock of rats by Dr. Schroeder, later named Brattleboro strain. In 1964 from Dr. Lewis Kinder, Harvard University, Boston to Blue Spruce Farms, Altamont, New York. to Harlan through acquisition in 1988. Harlan
Proper citation: RRID:RGD_2314655 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150429817
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 150429817
Notes: Thehomozygous Gnal mutant rats were created by CRISPR/Cas9. Guide RNA sequences targeting the first exon of the rat Gnal gene isoform 2 were designed. The mutated allele contained a 13- bp deletion in exon1 that corresponded to
position 34 to 46 downstream of the translation start point ATG of the
Gnal splicing variant 2 was detected resulting in an early stop at position
150 and producing a truncated protein with 50 amino acids. Only 5% of homozygous Gnal knockout mice could survive till maturity
Proper citation: RRID:RGD_150429817 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=15090819
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 15090819
Notes: The homozygous rats carrying 2 defective Ahr genes. The deletion of part of exon 2 in rat Ahr gene was created by injecting TALEN mRNA containing 5'-TTCTAAACGACACAGAGACCGGCTGAACACAGAGTTAGACCGCCTGGCTA-3' to embryos of JclKud:WI.
Proper citation: RRID:RGD_15090819 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=14402419
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 14402419
Notes: The Zinc Finger Nuclease system was used to create184-bp deletion at the beginning of exon 5 thus created the premature stop coden. The embryos were from breeding of Long Evans from Janvier Labs (RjOrl:LE) and reimplanted to foster mother Dark Agouti (Janvier). Heterozygous rats are currently bred to generate heterozygous and homozygous.
Proper citation: RRID:RGD_14402419 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=15017094
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 15017094
Notes: The wpk mutation was first recognized in 1994 in a colony of outbred Wistar rats at Utrecht University (Utrecht, The Netherlands). In 1996, a breeding pair of test-proven heterozygotes were transferred to the University of Rotterdam (Rotterdam, The Netherlands), and a new subcolony was initiated. This colony has been maintained by brother-sister matings for more than five generations. Individuals heterozygous for the mutant allele were identified in each generation by test-crossing phenotypically normal offspring from known heterozygotes. A single C to T substitution in exon 12 was identified as the mutated allele in the Wpk rat. This mutation converts a proline to a leucine in the protein products(P394L).
Proper citation: RRID:RGD_15017094 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150521538
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 150521538
Notes: The CRISPR/Cas9 system targeting exons 2 to 4 was injected into Sprague Dawley embryos. The resulting mutation was complete deletion of exons 2, 3 and 4.
Proper citation: RRID:RGD_150521538 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=151356958
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 151356958
Notes: The CRISPR/Cas9 system was used to target exon 11 to create a deletion at codon F508 which was injected into Sprague-Dawley one-cell
embryos (C076 line). One rat
had an allele that contained the desired homology-directed
repair edited TTT deletion and was designated the
Phe508del founder (c.1522_1524delTTT).
Proper citation: RRID:RGD_151356958 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=40924661
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 40924661
Notes: This corpulent rat used by Rudolph L Leibel's laboratory was developed at the National Institutes of Health (NIH). It was a congenic strain initially derived by mating a male Koletsky rat that was heterozygous for the corpulent gene (cp/ +) to a female Lister Albany/NIH (LAIN) rat. This congenic carrying the recessive Leprcp (RGD:11570565) identified in in the obese spontaneously hypertensive Koletsky rat.
Proper citation: RRID:RGD_40924661 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150429828
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 150429828
Notes: Tspo-targeted genome editing in Sprague Dawley rats embryos by microinjecting
with optimized and customized ZFNs designed for targeted gene KO. Locus-specific PCR was performed to identify Rat5 founders using
the following primer pairs: CKOZFN-F: 50-AGAGCATACTCTTGCCGTCG-30 and CKOZFN-R:50-ACTCCTAAAGGGGTTGCAGG-30; Normal PCRs generated 362 bp for the WT and
273 bp for the mutant,(89 bp deletion).
Proper citation: RRID:RGD_150429828 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=126925134
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 126925134
Notes: This line was produced by mating rats carrying Il36rnf/f allele and Myh6-cre-allele. The expression of Il36rn was knockout in cardiomyocytes.
Proper citation: RRID:RGD_126925134 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=45073130
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 45073130
Notes: The CRISPR/Cas9 system was used to introduce deletions/mutations in exon 4 of the rat Fmr1 gene of outbred Sprague-
Dawley embryos. The resulting mutation is a deletion of five amino acids and a G-A mutation in the Fmr1 gene. This genetic modification results in a frame-shift starting from the second Agenet-like 2 domain in the Fmr1 protein.
Proper citation: RRID:RGD_45073130 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=126777687
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 126777687
Notes: A spontaneous mutation (ter) leading to the formation of congenital ovarian and testicular tumors was detected in the WKY/Ztm rat strain. Sequence analysis detected a point mutation in exon 4 of the rat Dnd1, which introduces a premature stop codon assumed to cause a truncation of the Dnd1 protein. This recessive ter mutation has a complete penetrance of teratocarcinogenesis and infertility of both sexes in homozygous genotype.
Proper citation: RRID:RGD_126777687 Copy
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