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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://www.wormbase.org/db/get?name=WBStrain00005197
Source Database: WormBase (WB)
Affected Genes: WBGene00000254(bli-4)|WBGene00001168(eef-1A.1)
Genomic Alteration: WBGene00000254(bli-4), WBGene00001168(eef-1A.1)
Availability: available
Source References: EMPTY
Synonyms: eef-1A.1(q145) III/hT2 [bli-4(e937) let-?(q782) qIs48] (I;III).
Alternate IDs: WB-STRAIN:CU6493, CGC_CU6493
Notes: Heterozygotes are WT and GFP+. Segregate non-GFP steriles (q145 homozygotes). qIs48 is an insertion of ccEx9747 with markers: myo-2::GFP expressed brightly in the pharynx throughout development, pes-10::GFP expressed in embryos, and a gut promoter driving GFP in the intestine, and is homozygous lethal.
Proper citation: RRID:WB-STRAIN:WBStrain00005197 Copy
http://www.wormbase.org/db/get?name=WBStrain00005195
Source Database: WormBase (WB)
Affected Genes: WBGene00004807(skr-1)|WBGene00006808(unc-76)
Genomic Alteration: WBGene00004807(skr-1), WBGene00006808(unc-76)
Availability: available
Source References: EMPTY
Synonyms: skr-1(sm151) I; unc-76(e911) V.
Alternate IDs: WB-STRAIN:CU6102, CGC_CU6102
Notes: Mutagen:UV/TMP|"sm151 is a semi-dominant allele of skr-1. Maintain under normal conditions. Reference: Killian DJ, et al. (2008) Dev Biol. 322(2):322-31."
Proper citation: RRID:WB-STRAIN:WBStrain00005195 Copy
http://www.wormbase.org/db/get?name=WBStrain00005193
Source Database: WormBase (WB)
Affected Genes: WBGene00011935(scrm-1)
Genomic Alteration: WBGene00011935(scrm-1)
Availability: available
Source References: PMID:33759761
Synonyms: scrm-1(tm805) I.
Alternate IDs: WB-STRAIN:CU2945, CGC_CU2945
Notes: Made_by: X. Wang & D. Xue|"Mild defect in cell corpse engulfment."|"Mutagen:UV/TMP"|"WBStrain provided so WBPaper00061198 paper added based on AFP_Strain data."
Proper citation: RRID:WB-STRAIN:WBStrain00005193 Copy
http://www.wormbase.org/db/get?name=WBStrain00005190
Source Database: WormBase (WB)
Availability: available
Source References: PMID:36774344, PMID:37118512, PMID:37577954
Synonyms: smIs34.
Alternate IDs: WB-STRAIN:CU1546, CGC_CU1546
Notes: Mutagen:Gamma rays|"smIs34 [ced-1p::ced-1::GFP + rol-6(su1006)]. Maintain under standard conditions. Reference: Zou W, et al., (2009) PLoS Genet. 5(10):e1000679."
Proper citation: RRID:WB-STRAIN:WBStrain00005190 Copy
http://www.wormbase.org/db/get?name=WBStrain00005106
Source Database: WormBase (WB)
Affected Genes: WBGene00004879(smg-1)
Genomic Alteration: WBGene00004879(smg-1)
Availability: available
Source References: PMID:31797327, PMID:32966472, PMID:33466350, PMID:35018947, PMID:37549461, PMID:38274404, PMID:38500791, PMID:38983916, PMID:39212733
Synonyms: EMPTY
Alternate IDs: WB-STRAIN:CL2355, CGC_CL2355
Notes: Associated protein: Human A peptide|"dvIs50 [pCL45 (snb-1::Abeta 1-42::3' UTR(long) + mtl-2::GFP] I. Maintain at 16C. Pan-neuronal expresion of human Abeta peptide. Constitutive intestinal expression of GFP from marker transgene. Strain shows deficits in chemotaxis, associative learning, and thrashing in liquid. Strain also has incomplete sterility due to germline proliferation defects and embryonic lethality. Maintain at 16 C to reduce selection against transgene, although this does not alter the partial sterility. Reference: Wu Y., et al. J Neurosci. 2006 Dec 13;26(50):13102-13. [NOTE: The temperature-sensitive allele cc546 causes an M1957L change in SMG-1. The lesion is an atg>ttg transversion in exon 35. Flanking sequences follow with the mutation site indicated with a capital A: ttggtggtcggttacaaaacgatattcaaga tcactggcagtcatgagtAtggttggatcagttttaggactcggtgatcg acatttggacaatttattg The lesion is detectable via SNP-snip with the mutation causing loss of an MslI site. Primers are for a 323 bp product. Digest with MslI to 86+237 in the wild type, uncut as 323 in the mutant. DJR701(f): CAGTCGTGAGCTTTGGATGCGTGC DJR702(r): TCGGGGATACGCAGATTCTTTCCC. Pedone ... Reiner G3 (2021).]"|"Mutagen:Gamma rays"|"Transgene expression: Inducible pan-neuronal + intestine (marker)"|"[2020-08-03T20:49:03.516Z WBPerson324] Ressurect Strain: Genotype: smg-1(cc546); pCL45 [Psnb-1::human Amyloid beta 1-42::3' UTR (long); Pmtl-2::GFP]"
Proper citation: RRID:WB-STRAIN:WBStrain00005106 Copy
http://www.wormbase.org/db/get?name=WBStrain00005104
Source Database: WormBase (WB)
Availability: available
Source References: PMID:35018947, PMID:37549461, PMID:37239029, PMID:38983916
Synonyms: dvIs37.
Alternate IDs: WB-STRAIN:CL2331, CGC_CL2331
Notes: dvIs37 [myo-3p::GFP::A-Beta (3-42) + rol-6(su1006)]. Maintain at 16C. Roller. Diffuse and aggregated GFP expression in body wall muscle. Low brood size. Sicker at higher temperatures (e.g. 25C). Reference: Link CD, et al. (2008) Neurobiology of Disease,32(3):420-5.|"expresses the human A3-42 peptide fused to green fluorescent protein (GFP) in its body-wall muscle cells"|"Mutagen:Gamma radiation"
Proper citation: RRID:WB-STRAIN:WBStrain00005104 Copy
http://www.wormbase.org/db/get?name=WBStrain00005105
Source Database: WormBase (WB)
Affected Genes: WBGene00004879(smg-1)
Genomic Alteration: WBGene00004879(smg-1)
Availability: available
Source References: EMPTY
Synonyms: smg-1(cc546) I; dvIs38.
Alternate IDs: WB-STRAIN:CL2337, CGC_CL2337
Notes: dvIs38 [myo-3p::GFP::degron::3' UTR(long) + rol-6(su1006)]. Maintain at 16C. Rollers. Temperature-dependent expression of aggregating GFP in body wall muscle (weak at 16C, strong at 25C). Animals become paralyzed if upshifted as larvae to 25C due to expression of aggregating GFP. References: Link CD, et al. (2006) J Biol Chem. Jan 20;281(3):1808-16. Hassan WM, et al. (2014) Neurobiology of Aging. [NOTE: The temperature-sensitive allele cc546 causes an M1957L change in SMG-1. The lesion is an atg>ttg transversion in exon 35. Flanking sequences follow with the mutation site indicated with a capital A: ttggtggtcggttacaaaacgatattcaaga tcactggcagtcatgagtAtggttggatcagttttaggactcggtgatcg acatttggacaatttattg The lesion is detectable via SNP-snip with the mutation causing loss of an MslI site. Primers are for a 323 bp product. Digest with MslI to 86+237 in the wild type, uncut as 323 in the mutant. DJR701(f): CAGTCGTGAGCTTTGGATGCGTGC DJR702(r): TCGGGGATACGCAGATTCTTTCCC. Pedone ... Reiner G3 (2021).]|"Mutagen:Gamma radiation"
Proper citation: RRID:WB-STRAIN:WBStrain00005105 Copy
http://www.wormbase.org/db/get?name=WBStrain00005102
Source Database: WormBase (WB)
Affected Genes: WBGene00001752(gst-4)
Genomic Alteration: WBGene00001752(gst-4)
Availability: available
Source References: PMID:12757851, PMID:29956725, PMID:31409866, PMID:31432005, PMID:31510078, PMID:31717869, PMID:31735670, PMID:32294300, PMID:32600387, PMID:33008901, PMID:32163353, PMID:33471780, PMID:33789349, PMID:33809299, PMID:33883621, PMID:34505574, PMID:35602005, PMID:36791646, PMID:37099597, PMID:37416472, PMID:37427543, PMID:37488107, PMID:37549461, PMID:37606250, PMID:37726773, PMID:37751046, PMID:37902464, PMID:37910615, PMID:38632209, PMID:38799567, PMID:38754743, PMID:38889876, PMID:38983916, PMID:38991033, PMID:39169052, PMID:39164296, PMID:39264947, PMID:39097626, PMID:39420966, PMID:39561954, PMID:39560153
Synonyms: dvIs19 [(pAF15)gst-4p::GFP::NLS] III.
Alternate IDs: WB-STRAIN:CL2166, CGC_CL2166
Notes: dvIs19 [(pAF15)gst-4p::GFP::NLS] III. Oxidative stress-inducible GFP.|"Reference WBPaper00054805 added based on published strain data identified by Textpresso literature search."|"Reference WBPaper00057197 added based on published strain data identified by Textpresso literature search."|"Reference WBPaper00057259 added based on published strain data identified by Textpresso literature search."|"Reference WBPaper00058621 added based on published strain data identified by Textpresso literature search."|"Reference WBPaper00058851 added based on published strain data identified by Textpresso literature search."|"Supplementary_genotype (dvIs19[pAF15(gst-4::GFP::NLS)])"|"Supplementary_genotype dvIs19 [(pAF15)gst-4p::GFP::NLS] III"|"Supplementary_genotype dvIs19[(pAF15)gst-4p::GFP::NLS]"|"Supplementary_genotype gst-4::GFP dvIs19 [(pAF15)gst-4p::GFP::NLS] III"|"Supplementary_genotype gst-4p::GFP"|"WBStrain mapped, WBPaper00059548 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00060449 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00060456 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00060486 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00060545 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00060669 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00060692 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00060778 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00060797 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00060840 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00060896 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00060924 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00060976 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061045 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061159 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061220 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061236 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061385 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061436 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061452 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061495 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061547 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061584 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061641 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061671 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061869 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061871 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061890 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061895 added based on AFP_Strain data."|"WBStrain mapped, WBPaper00061902 added based on AFP_Strain data."|"WBStrain provided so WBPaper00059545 paper added based on AFP_Strain data."|"WBStrain provided so WBPaper00060797 paper added based on AFP_Strain data."
Proper citation: RRID:WB-STRAIN:WBStrain00005102 Copy
http://www.wormbase.org/db/get?name=WBStrain00005103
Source Database: WormBase (WB)
Affected Genes: WBGene00004879(smg-1)
Genomic Alteration: WBGene00004879(smg-1)
Availability: available
Source References: EMPTY
Synonyms: smg-1(cc546) I; dvIs179.
Alternate IDs: WB-STRAIN:CL2179, CGC_CL2179
Notes: dvIs179 [myo-3p::GFP::3' UTR(long) + rol-6(su1006)]. Maintain at 16C. Superficially wild-type Roller; expression of GFP in body wall muscles increases with temperature. References: Link CD, et al. (2006) J Biol Chem. Jan 20;281(3):1808-16. Hassan WM, et al. (2014) Neurobiology of Aging. [NOTE: The temperature-sensitive allele cc546 causes an M1957L change in SMG-1. The lesion is an atg>ttg transversion in exon 35. Flanking sequences follow with the mutation site indicated with a capital A: ttggtggtcggttacaaaacgatattcaaga tcactggcagtcatgagtAtggttggatcagttttaggactcggtgatcg acatttggacaatttattg The lesion is detectable via SNP-snip with the mutation causing loss of an MslI site. Primers are for a 323 bp product. Digest with MslI to 86+237 in the wild type, uncut as 323 in the mutant. DJR701(f): CAGTCGTGAGCTTTGGATGCGTGC DJR702(r): TCGGGGATACGCAGATTCTTTCCC. Pedone ... Reiner G3 (2021).]|"Mutagen:Gamma radiation"
Proper citation: RRID:WB-STRAIN:WBStrain00005103 Copy
http://www.wormbase.org/db/get?name=WBStrain00005122
Source Database: WormBase (WB)
Affected Genes: WBGene00001648(goa-1)
Genomic Alteration: WBGene00001648(goa-1)
Availability: available
Source References: PMID:34622282
Synonyms: goa-1(knu751) I.
Alternate IDs: WB-STRAIN:COP1863, CGC_COP1863
Notes: Hyperactive, protruding vulva. knu751 is an A221D point mutation associated with GNAO1-associated epileptic encephalopathy. This strain may not be distributed to commercial or for-profit entities. Please contact [email protected] for more information.|"Made_by: NemaMetrix"|"WBStrain provided so WBPaper00062031 paper added based on AFP_Strain data."
Proper citation: RRID:WB-STRAIN:WBStrain00005122 Copy
http://www.wormbase.org/db/get?name=WBStrain00005123
Source Database: WormBase (WB)
Affected Genes: WBGene00011352(rskn-1)
Genomic Alteration: WBGene00011352(rskn-1)
Availability: available
Source References: EMPTY
Synonyms: rskn-1(knu796) I.
Alternate IDs: WB-STRAIN:COP1918, CGC_COP1918
Notes: Made_by: NemaMetrix|"Superficially wild-type. knu796 is a K216E point mutation mimicking a patient allele associated with Coffin-Lowry syndrome. This strain may not be distributed to commercial or for-profit entities. Please contact [email protected] for more information."
Proper citation: RRID:WB-STRAIN:WBStrain00005123 Copy
http://www.wormbase.org/db/get?name=WBStrain00005120
Source Database: WormBase (WB)
Affected Genes: WBGene00003561(ncr-1)
Genomic Alteration: WBGene00003561(ncr-1)
Availability: available
Source References: EMPTY
Synonyms: ncr-1(knu4) X.
Alternate IDs: WB-STRAIN:COP677, CGC_COP677
Notes: Cholesterol-sensitive. Smaller broods and sizes upon serial cholesterol deprivation. This strain may not be distributed to commercial or for-profit entities. Please contact [email protected] for more information.|"Made_by: NemaMetrix"
Proper citation: RRID:WB-STRAIN:WBStrain00005120 Copy
http://www.wormbase.org/db/get?name=WBStrain00005119
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: PMID:37039075, PMID:37118512
Synonyms: unc-119(ed3) III; knuSi221.
Alternate IDs: WB-STRAIN:COP262, CGC_COP262
Notes: fib-1 translational marker|"knuSi221 [fib-1p::fib-1(genomic)::eGFP::fib-1 3' UTR + unc-119(+)]. Single copy insertion. fib-1 promoter, genomic sequence, and 3'UTR was inserted into pCFJ151 (ttTi5606) targeting vector and inserted into ttTi5605. Allen AK, Nesmith JE, and A Golden. 2014 G3:4(12)2329-43."|"Made_by: Knudra Transgenics"
Proper citation: RRID:WB-STRAIN:WBStrain00005119 Copy
http://www.wormbase.org/db/get?name=WBStrain00005115
Source Database: WormBase (WB)
Affected Genes: WBGene00004804(skn-1)|WBGene00004879(smg-1)
Genomic Alteration: WBGene00004804(skn-1), WBGene00004879(smg-1)
Availability: available
Source References: EMPTY
Synonyms: smg-1(cc546) I; dvIs19 III; skn-1(zu67)/nT1 [unc-?(n754) let-?] (IV;V); dvIs27 X.
Alternate IDs: WB-STRAIN:CL6180, CGC_CL6180
Notes: dvIs19 [(pAF15) gst-4p::GFP::NLS] III. dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)] X. Roller with weak constitutive GFP expression. Balanced strain, segregates Rol Uncs [skn-1(zu67) heterozygotes], Rol nonUncs [skn-1(zu67) homozygotes] and dead eggs. Maintain by picking Rol Uncs. Paralyzed if upshifted as larvae to 25C. References: Dostal, V and Link CD (2010) J Vis Exp. Oct 9;(44). Dostal V, Roberts CM, Link CD (2010) Genetics Nov;186(3):857-66. [NOTE: The temperature-sensitive allele cc546 causes an M1957L change in SMG-1. The lesion is an atg>ttg transversion in exon 35. Flanking sequences follow with the mutation site indicated with a capital A: ttggtggtcggttacaaaacgatattcaaga tcactggcagtcatgagtAtggttggatcagttttaggactcggtgatcg acatttggacaatttattg The lesion is detectable via SNP-snip with the mutation causing loss of an MslI site. Primers are for a 323 bp product. Digest with MslI to 86+237 in the wild type, uncut as 323 in the mutant. DJR701(f): CAGTCGTGAGCTTTGGATGCGTGC DJR702(r): TCGGGGATACGCAGATTCTTTCCC. Pedone ... Reiner G3 (2021).]|"Mutagen:Gamma radiation"
Proper citation: RRID:WB-STRAIN:WBStrain00005115 Copy
http://www.wormbase.org/db/get?name=WBStrain00005114
Source Database: WormBase (WB)
Availability: available
Source References: PMID:37957360, PMID:39212733
Synonyms: dvIs62 X.
Alternate IDs: WB-STRAIN:CL6049, CGC_CL6049
Notes: Associated protein: Human TDP-43|"dvIs62 [snb-1p::hTDP-43/3' long UTR + mtl-2p::GFP] X. Temperature-sensitive. Maintain at 16 to minimize selection against transgene. Uncoordinated from hatching; phenotype is stronger at higher temperatures. Intestinal GFP expression. Reference: Ash PE, et al. Hum Mol Genet. 2010 Aug 15;19(16):3206-18."|"Mutagen:UV/TMP"|"Supplementary_genotype dvIs62 [snb-1p::hTDP-43/3'long UTR + mtl-2p::GFP] X"|"Transgene expression: Inducible pan-neuronal + intestine (marker)"
Proper citation: RRID:WB-STRAIN:WBStrain00005114 Copy
http://www.wormbase.org/db/get?name=WBStrain00005126
Source Database: WormBase (WB)
Affected Genes: WBGene00011050(agl-1)
Genomic Alteration: WBGene00011050(agl-1)
Availability: available
Source References: EMPTY
Synonyms: agl-1(knu864) II.
Alternate IDs: WB-STRAIN:COP2008, CGC_COP2008
Notes: Made_by: NemaMetrix|"Superficially wild-type. knu864 is a S1444R point mutation associated with Cori Disease. This strain may not be distributed to commercial or for-profit entities. Please contact [email protected] for more information."
Proper citation: RRID:WB-STRAIN:WBStrain00005126 Copy
http://www.wormbase.org/db/get?name=WBStrain00005124
Source Database: WormBase (WB)
Availability: available
Source References: EMPTY
Synonyms: K09E4.4(knu858) II.
Alternate IDs: WB-STRAIN:COP2002, CGC_COP2002
Notes: knu858 is a Y146C point mutation representative of a patient mutation associated with MPSIIIB disease. This strain may not be distributed to commercial or for-profit entities. Please contact [email protected] for more information.|"Made_by: NemaMetrix"
Proper citation: RRID:WB-STRAIN:WBStrain00005124 Copy
http://www.wormbase.org/db/get?name=WBStrain00005144
Source Database: WormBase (WB)
Affected Genes: WBGene00004862(sma-9)
Genomic Alteration: WBGene00004862(sma-9)
Availability: available
Source References: EMPTY
Synonyms: sma-9(qc3) X.
Alternate IDs: WB-STRAIN:CS67, CGC_CS67
Notes: Small body size. Crumpled spicules. Male ray 8-9 fusion.
Proper citation: RRID:WB-STRAIN:WBStrain00005144 Copy
http://www.wormbase.org/db/get?name=WBStrain00005145
Source Database: WormBase (WB)
Affected Genes: WBGene00001864(him-5)|WBGene00004857(sma-3)
Genomic Alteration: WBGene00001864(him-5), WBGene00004857(sma-3)
Availability: available
Source References: EMPTY
Synonyms: sma-3(wk30) III; him-5(e1490) V; qcEx24.
Alternate IDs: WB-STRAIN:CS119, CGC_CS119
Notes: qcEx24 [GFP::sma-3 + rol-6(su1006)]. Rollers. Pick rollers to maintain. Array rescues body size phenotype. Reference: Wang J, Tokarz R, Savage-Dunn C. Development. 2002 Nov;129(21):4989-98.
Proper citation: RRID:WB-STRAIN:WBStrain00005145 Copy
http://www.wormbase.org/db/get?name=WBStrain00005143
Source Database: WormBase (WB)
Affected Genes: WBGene00004862(sma-9)
Genomic Alteration: WBGene00004862(sma-9)
Availability: available
Source References: EMPTY
Synonyms: sma-9(wk55) X.
Alternate IDs: WB-STRAIN:CS1, CGC_CS1
Notes: Small body size. Crumpled spicules. Male ray 8-9 fusion.
Proper citation: RRID:WB-STRAIN:WBStrain00005143 Copy
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