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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=598092607
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2025-03-28)
Alternate IDs: 598092607
Notes: This strain was established by a use of the BAC transgenic method with a technical support from the C.B.S.N resource (Dr. Kazuto Kobayashi, Fukushima Medical University, Dr. Yuchio Yanagawa, Gunma University Graduate School of Medicine). This transgenic rat was transported to The Jikei University School of Medicine, and cre recombinase expression was confirmed by crossing it with a reporter rat (NBRP Rat No: 0734). These rats are maintained in The Jikei University School of Medicine. Background strain: Crlj:WI.
Transgene: Dbh (dopamine beta-hydroxylase: rat), TetR (E.coli), VP16 protein minimal“F”-type activation domain (Herpes simplex virus), 2A (Thosea asigna virus), cre recombinase (P1 Phage), bGlobin polyA (rabbit), loxP (P1 phage). Detailed method (BAC transgenic method): a rat BAC clone was used (CH230-211J22). Combined mRNA for tTA and cre recombinase sequences is transcribed under the control of Dbh promoter. In translation step, the transcript is cut at the 2A peptide sequence, resulting in a separate protein production of tTA and Cre. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_598092607 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=598092605
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2025-03-28)
Alternate IDs: 598092605
Notes: This strain was established by a use of the BAC transgenic method with a technical support from the C.B.S.N resource (Dr. Kazuto Kobayashi, Fukushima Medical University, Dr. Yuchio Yanagawa, Gunma University Graduate School of Medicine). This transgenic rat was transported to The Jikei University School of Medicine, and cre recombinase expression was confirmed by crossing it with a reporter rat (NBRP Rat No: 0734). These rats are maintained in The Jikei University School of Medicine. Background strain: Crlj:WI.
Transgene: Dbh (dopamine beta-hydroxylase: rat), TetR (E.coli), VP16 protein minimal“F”-type activation domain (Herpes simplex virus), 2A (Thosea asigna virus), cre recombinase (P1 Phage), bGlobin polyA (rabbit), loxP (P1 phage). Detailed method (BAC transgenic method): a rat BAC clone was used (CH230-211J22). Combined mRNA for tTA and cre recombinase sequences is transcribed under the control of Dbh promoter. In translation step, the transcript is cut at the 2A peptide sequence, resulting in a separate protein production of tTA and Cre. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_598092605 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=597538592
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 597538592
Notes: For the generation of transgenic rats, the authors used a 190-kb fused AF163864 PAC/AC097478 BAC clone (Yamakado et al., 2012, PMID:22475625). It contained the entire human SNCA sequence (GenBank AF163864), with 30-kb upstream regulatory promoter sequences and a 45-kb flanking downstream region, cloned into pBACe3.6 vector as described previously. Transgenic rats were obtained by injecting the purified BAC fragment into fertilized Sprague–Dawley oocytes at a concentration of 1.5 µg/ml. A founder line displaying the highest integration number of BAC DNA construct was crossedbred to homozygosity.
Proper citation: RRID:RGD_597538592 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=405849386
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 405849386
Notes: This is the wild type littermate of the hDNMT3A transgenic rats which were established using zygote microinjection of a bacterial artificial chromosome (BAC). The RP11-159D24 BAC (NCBI-ID:223335, Homo sapiens, GRCh38.p2: Chr. 2: 25,202,642-25,410,145, total length: 207,504 bp) containing DNMT3A (GRCh38.p2: 25,232,961,25,342,590, total length: 109,630 bp) was injected into rat zygotes (Rattus norvegicus, Sprague-Dawley, SD). The offspring were identified with 8 PCR primer-pairs that were specific for the RP11-159D24 sequence to detect positive transgenic ones and wild type littermates that did not carry the human transgene.
Proper citation: RRID:RGD_405849386 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=617256277
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2025-07-23)
Alternate IDs: 617256277
Notes: Cryopreserved sperm was obtained and recovered for SD-Tg(Camk2a-cre/ERT2)ZiRrrc (RRRC_00688; RGD ID: 13446407), and then back-crossed to the outbred Long-evans (LE) strain for 8 generations. This transgenic strain is a tamoxifen inducible Cre recombinase animal in the Long-evans strain, with targeted cre/ERT2 fusion protein expression in neural populations, and is suitable for crossing with loxP models also in the LE strain. Rat Resource and Research Center
Proper citation: RRID:RGD_617256277 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=632522749
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 632522749
Notes: This transgenic rat strain carrying human NR3C2 was developed on a Sprague-Dawley albino background. The transgene was constructed with the human NR3C2 (also know as MR) under the proximal P1 promotor in the 5′-flanking regions of exons 1alpha.
Proper citation: RRID:RGD_632522749 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1357417
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 1357417
Notes: 14.5 kb lambda clone of the rat Npy gene was subcloned with a polylinker that had NotI and EcoRI restriction sites. This transgene that was released by NotI digestion contained ~5kb 5'and ~1kb 3' and was injected into the pronuclei of fertilized SD rats. Founders were mated with SD females. F1 animals were mated with SD females till line 400 hemizygous animals were developed that had 5 copies of the Npy gene.
Proper citation: RRID:RGD_1357417 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1357182
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 1357182
Notes: Wild type Tsc2 transgene was constructed from the Tsc2 cDNA from BN rat and was microinjected into single male pronuclei. Eggs were cultured and tranferred into female wistar which were mated with Eker rats.
Proper citation: RRID:RGD_1357182 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1559030
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryopreserved Sperm
Alternate IDs: 1559030
Notes: A 4.5 kb fragment of human ATP7B cDNA was blunt-end ligated into the pCXN2 vector that contained the CAG promoter to generate pCXN2ATP7B which was microinjected into the pronuclei of LEC/Crlj. The transgenic founders were identified by the PCR analysis of the tail-DNA. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_1559030 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1554305
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Embryo
Alternate IDs: 1554305
Notes: lacZ cDNA was inserted in the EcoRI site of the pCAGGS expression vector. This DNA was microinjected into the DA/Crlj. The expression of the transgene was determined by beta-gal staining. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_1554305 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1642994
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 1642994
Notes: This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SS rat embryos.
Proper citation: RRID:RGD_1642994 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1642995
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 1642995
Notes: This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SS rat embryos.
Proper citation: RRID:RGD_1642995 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1642992
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 1642992
Notes: This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SS rat embryos.
Proper citation: RRID:RGD_1642992 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1642993
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 1642993
Notes: This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SD rat embryos.
Proper citation: RRID:RGD_1642993 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1642989
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2019-04-04)
Alternate IDs: 1642989
Notes: This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SS rat embryos.
Proper citation: RRID:RGD_1642989 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=2290057
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Cryopreserved Sperm
Alternate IDs: 2290057
Notes: The Sleeping Beauty transposon construct, T2/Bart3 consists of inverted terminal repeats separated by a gene trap cassette. The gene trap cassette consists of two splice acceptors, one from adenovirus and one from the mouse Hox9a gene, situated in opposite orientations. Each splice acceptor is followed by stop codons in each reading frame and a polyadenylation signal. Furthermore, the T2/Bart3 transposon harbors a mouse tyrosinase minigene which rescues the phenotype of albino rats, but demonstrates position effect variegated expression.
Proper citation: RRID:RGD_2290057 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=1642990
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 1642990
Notes: This transgenic strain contains the enhanced green fluorescent protein gene drived by ubiquitous CAG promoter. This vector contains long terminal repeats with self-inactivating mutation, a central polypurine tract of HIV-1, a human cytomegalovirus and a composite intron from rabbit beta-globin. This transgenic strain was made by injecting the lentivirus vector containing the eGFP construct (lentiviral-CAG-eGFP) into SD rat embryos.
Proper citation: RRID:RGD_1642990 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=2302132
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 2302132
Notes: Trangenic line generated by microinjecting 2.8 kb fragment of smooth muscle 22 alpha promoter and cDNA for human ACE2 gene into SHRSP embryos
Proper citation: RRID:RGD_2302132 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=2290298
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 2290298
Notes: SHR embryos were microinjected with mouse Thy1 promoter and cDNA coding for human tau protein truncated at amino acid positions 151-391
Proper citation: RRID:RGD_2290298 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=2290299
Source Database: Rat Genome Database (RGD)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: 2290299
Notes: SHR embryos were microinjected with mouse Thy1 promoter and cDNA coding for human tau protein truncated at amino acid positions 151-391
Proper citation: RRID:RGD_2290299 Copy
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