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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.

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Organism Name Proper Citation Species Synonyms Notes Phenotype Affected Gene Genomic Alteration Catalog Number Background Database Database Abbreviation Availability Source References Alternate IDs Authority Record Last Update Mentions Count
LE-ROSA26em1(EF1a-TetR, Fos-iCre)/Bhope
 
Resource Report
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RRID:RGD_151356945 Rattus norvegicus Two DNA expression constructs, the bacterial tetracyclin repressor (TetR) under the expression control of human EF1a promoter and the improved Cre recombinase (iCre) under Fos promoter were joined in an antiparallel orientation in one rat ROSA26 targeting cassette. The DNA construct, together with CRISPR /Cas9 system, was injected to one cell Long-Evans (Crl:LE) rat embryos and founders were identified and bred for 8 generations at at NIDA IRP (Hope lab). 151356945 mutant Rat Genome Database (RGD) RGD Unknown 151356945 RGD 2026-10-10 01:05:07 0
LE-Fxn em2Fara-/+/Rrrc
 
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RRID:RGD_152999002 Rattus norvegicus Heterozygous KO of the Fxn gene obtained by targeting exon 4 with CRISPR/Cas9 system This strain has been deposited with RRRC Rat Resource and Research Center 152999002 mutant Rat Genome Database (RGD) RGD Unknown 152999002 RGD 2026-10-10 01:05:07 0
LE-Fxn em2Fara-/+
 
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RRID:RGD_152999000 Rattus norvegicus Heterozygous KO of the Fxn gene obtained by targeting exon 4 with CRISPR/Cas9 system This strain has been deposited with RRRC 152999000 mutant Rat Genome Database (RGD) RGD Unknown 152999000 RGD 2026-10-10 01:05:07 0
F344-Nppcem3Kyo
 
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RRID:RGD_127284870 Rattus norvegicus This strain was established by injecting Zinc-finger nucleases (ZFNs) to F344/Stm pronuclear stage embryos. Selected ZFNs were designed to target exon 1 of rat Nppc, which encodes the N-terminus of natriuretic peptide precursor C (target sequence: CGAAGCCAAGCCCGGGACaccaccGAAGGTGGGTGCTGTCGCG; nucleotides 179 - 221, NC_005108.4). The injected F344/Stm embryos were transferred into the oviducts of pseudopregnant rats. Four lines of knockout strains were estaglished. This F344-Nppcem3Kyo strain ( delta 11)was deduced to generated a frame shift and a premature stop codon (at nucleotides 275 - 277, NM_053750.1) National BioResource Project for the Rat in Japan 127284870 mutant Rat Genome Database (RGD) RGD Unknown 127284870 RGD 2026-10-10 01:05:06 0
LEW.SD-CD8am1Trg
 
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RRID:RGD_150521559 Rattus norvegicus Male SD rats were treated with the mutagen N-ethyl-N-nitrosourea (60 mg/kg intraperitoneally) at ages 9 and 10 weeks. A heterozygous mutant founder carrying a T to C transition that encoded a substitution of a proline residue (CCA) for a highly conserved serine residue (TCA) at amino acid position 94 was identified. This mutant male was mated to a LEW female and phenotyping by the expression of CD8a and CD8ab. 150521559 mutant Rat Genome Database (RGD) RGD Unknown 150521559 RGD 2026-10-10 01:05:07 0
F344-Trpc4Tn(sb)1Bni
 
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RRID:RGD_126848804 Rattus norvegicus The Sleeping Beauty transposon system was used to insert the sleeping beauty transposon into the first intron of the rat Trpc4 gene. Trpc4 knock-out (510 bp) and wild-type allele (905 bp) were confirmed using PCR and gel electrophoresis 126848804 mutant Rat Genome Database (RGD) RGD Unknown 126848804 RGD 2026-10-10 01:05:07 0
F344-Hcn1em4Kyo
 
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RRID:RGD_38676255 Rattus norvegicus TALEN (Left: ttcagAATGATTCATGGG, Right : ACGCACTCTTCAAAGCTA) targeting the exon4 of hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene was designed and mRNA coding these TALEN was microinjected into F344/NSlc embyo. A 18-bp deletion in the exon4 of Hcn1 gene. It is predicted that 6 amino-acid deleted HCN1 protein is expressed. National BioResource Project for the Rat in Japan 38676255 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2020-09-16) 38676255 RGD 2026-10-10 01:05:07 0
SD-Tbc1d1Tn(sb)1Fkh
 
Resource Report
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RRID:RGD_150521708 Rattus norvegicus The Sleeping Beauty transposon-mediated mutagenesis was used to knock out the rat Tbc1d1 gene in in rat spermatogonial stem cells from Sprague Dawley. 150521708 mutant Rat Genome Database (RGD) RGD Unknown 150521708 RGD 2026-10-10 01:05:07 0
F344-Hcn1em3Kyo
 
Resource Report
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RRID:RGD_38676250 Rattus norvegicus TALEN (Left:ttcagAATGATTCATGGG, Right:ACGCACTCTTCAAAGCTA)targeting the exon4 of hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene was designed and mRNA coding these TALEN was microinjected into F344/NSlc embyo. A 13-bp deletion in the exon4 of Hcn1 gene: as a result of frameshift mutation, stop codon is produced. Decreased expression levels of Hcn1 gene and HCN1 protein. National BioResource Project for the Rat in Japan 38676250 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2020-09-16) 38676250 RGD 2026-10-10 01:05:06 0
LE-Chrna5em20(D398N)Pas
 
Resource Report
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RRID:RGD_14402421 Rattus norvegicus The Zinc Finger Nuclease system was used to knock-in SNP rs16969968 in exon 5 (D398N) thus created a missense mutation. The embryos were from breeding of Long Evans from Janvier Labs (RjOrl:LE) and reimplanted to foster mother Dark Agouti (Janvier). Heterozygous rats are currently bred to generate heterozygous and homozygous. 14402421 mutant Rat Genome Database (RGD) RGD Unknown 14402421 RGD 2026-10-10 01:05:07 0
SD-Mertkem1Cgen
 
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RRID:RGD_329322880 Rattus norvegicus The gRNA to rat Mertk gene, and Cas9 mRNA were co-injected into fertilized rat eggs to generate targeted knockout offspring. F0 founder animals were identified by PCR followed by sequence analysis, which were bred to wildtype rat to test germline transmission and F1 animal generation. This strain was derived from founder 6# carrying a 13934 deletion which included exons 3 to 5. Cyagen Biosciences (Guangzhou) Inc.Building D, 3rd Floor, 3 Juquan Road, Science City, Guangzhou, 510663, China 329322880 mutant Rat Genome Database (RGD) RGD Live Animals (as of 2023-04-24) 329322880 RGD 2026-10-10 01:05:08 0
SD-Chrna6em2Slot
 
Resource Report
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RRID:RGD_155900757 Rattus norvegicus Using CRISPR/Cas9 genomic engineering in rats via homologous end-joining in fertilized embryos, we have knocked'in a humanized CHRNA6 3'UTR in place of the natural CHRNA6 3'UTR of the Sprague Dawley rat line. This new genetically modified CHRNA6C123G humanized rat line carries a homozygous CC nucleotide modification at position 123 within the CHRNA6 gene 3'UTR. The laboratory has deposited these strains with the RRRC. 155900757 mutant Rat Genome Database (RGD) RGD Cryopreserved Embryo; Cryopreserved Sperm (as of 2023-02-09) 155900757 RGD 2026-10-10 01:05:07 0
SD-Chrna6em1Slot
 
Resource Report
Resource Website
RRID:RGD_155900755 Rattus norvegicus Using CRISPR/Cas9 genomic engineering in rats via homologous end-joining in fertilized embryos, we have knocked'in a humanized CHRNA6 3'UTR in place of the natural CHRNA6 3'UTR of the Sprague Dawley rat line. This new genetically modified CHRNA6C123G humanized rat line carries a homozygous GG nucleotide modification at position 123 within the CHRNA6 gene 3'UTR. The laboratory has deposited these strains with the RRRC. 155900755 mutant Rat Genome Database (RGD) RGD Cryopreserved Embryo; Cryopreserved Sperm (as of 2023-02-09) 155900755 RGD 2026-10-10 01:05:08 0
SD-Akt1em1Soar
 
Resource Report
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RRID:RGD_158013766 Rattus norvegicus This Akt mutant strain was created in zygotes from Holtzman Sprague-Dawley. Guided RNAs targeting exon 4 (target sequence: GCCGTTTGAGTCCATCAGCC; nucleotides 356-375) and exon 7 (target sequence: TTGTCATGGAGTACGCCAAT; nucleotides 712-731) of the Akt1 gene (NM_033230.3) were injected to the embryos to create a1332-bp deletion from exon 4 to exon7, resulting a premature stop of the protein. 158013766 mutant Rat Genome Database (RGD) RGD Unknown 158013766 RGD 2026-10-10 01:05:09 0
Taiep
 
Resource Report
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RRID:RGD_155631259 Rattus norvegicus These mutants were found in Sprague-Dawley rats at University of Puebla in 1989. A spontaneous neurological mutation was detected in a colony of Sprague Dawley rats. The animals developed a progressive neurological syndrome characterized by tremor (which appeared at the age of 1 month), ataxia (at 4 months), immobility episodes (after 5-6 months), audiogenic seizures and hindlimb paralysis (after 10 months). Cross breeding experiments indicate that this is an autosomal recessive mutation, The rat line was named taiep (tremor, ataxia, tonic immobility episodes, epilepsy and paralysis) rats. 155631259 mutant Rat Genome Database (RGD) RGD Unknown 155631259 RGD 2026-10-10 01:05:09 0
SD-Pde3aem1Bdr
 
Resource Report
Resource Website
RRID:RGD_155631293 Rattus norvegicus The rat mutant was generated by pronuclear microinjection of Sprague-Dawley rat zygotes with a mixture of Cas9/Cas9 system to target the region in the rat Pde3a gene homologous to the human T445N mutation. The rat model exhibits a 9-bp deletion within the conserved 15-bp regulatory region that leads to the loss of 3 amino acids (aa 441-443 analogous to human PDE3A aa 444-446). 155631293 mutant Rat Genome Database (RGD) RGD Unknown 155631293 RGD 2026-10-10 01:05:08 0
SD-Pde3aem2Bdr
 
Resource Report
Resource Website
RRID:RGD_155631295 Rattus norvegicus The rat mutant was generated by pronuclear microinjection of Sprague-Dawley rat zygotes with a mixture of Cas9/Cas9 system to target the region in the rat Pde3a gene homologous to the human T445N mutation. The rat model exhibits a 20-bp deletion within the conserved 15-bp regulatory region that leads to n a frameshift and thus in a truncated and functionally deleted protein (functional DEL). 155631295 mutant Rat Genome Database (RGD) RGD Unknown 155631295 RGD 2026-10-10 01:05:09 0
F344-Txn1 em1Kyo
 
Resource Report
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RRID:RGD_288084582 Rattus norvegicus This CRISPR/Cas9 induced mutation Phe54Leu is induced in embryos of F344/NSlc. The genome editing system targeting exon 3 of Txn1 gene ( (c. 160 T > C) was delivered into embryos by electroporation. The two-cell stage embryos were transferred into the oviducts of pseudopregnant females. The rat called Txn1-F54L rat, replicates Adem rats (RGD:288084580) which carried Phe54Leu mutation in the same gene.These two strains exhibit similar phenotype. 288084582 mutant Rat Genome Database (RGD) RGD Unknown 288084582 RGD 2026-10-10 01:05:07 0
WI-Tfap2cem1(tdTomato)Nips
 
Resource Report
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RRID:RGD_151665772 Rattus norvegicus The targeting vector was designed to replace the stop codon of Tfap2c with T2A-tdTomato. The adeno-associated virus carrying the targeting vector was infected to Crlj:WI (RGD ID: 2312504) rat 1 cell zygotes followed by the introduction of CRISPR/Cas9 ribonucleoprotein complex by electroporation. After incubation overnight, the zygotes were transferred into oviducts of pseudo-pregnant rats. The pups were judged correct gene-targeting by genomic PCR. These rat strains are being maintained by crossing the founder rats with Crlj:WI rats. The tdTomato fluorescence faithfully label Tfap2c expressing cells. Section of Mammalian Transgenesis Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi 444-8787, Japan. or Division of Mammalian Embryology, Center for Stem Cell Biology and Regenerative Medicine, The Institute for Medical Science, The University of Tokyo, Tokyo108-8639, Japan. 151665772 mutant Rat Genome Database (RGD) RGD Cryopreserved Embryo; Cryopreserved Sperm (as of 2022-04-01) 151665772 RGD 2026-10-10 01:05:07 0
SS-Nlrp3em1Mcwi
 
Resource Report
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RRID:RGD_13800848 Rattus norvegicus CRISPR/Cas9 system was used to introduce a mutation in the Nlrp3 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 10-bp deletion of exon 1 in the Nlrp3 gene. Contact MCW rat distribution at [email protected] 13800848 mutant Rat Genome Database (RGD) RGD Unknown 13800848 RGD 2026-10-10 01:05:09 0

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