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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.

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Organism Name Proper Citation Species Synonyms Notes Phenotype Affected Gene Genomic Alteration Catalog Number Background Database Database Abbreviation Availability Source References Alternate IDs Authority Record Last Update Mentions Count
WIC-Cspg4em1Kyst
 
Resource Report
Resource Website
RRID:RGD_38676464 Rattus norvegicus By CRISPR/Cas9 system, mutation was introduced in Cspg4 gene of Wistar-Imamichi rat. 7 bp deletion on Exon1. National BioResource Project for the Rat in Japan 38676464 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2020-09-18) 38676464 RGD 2026-10-17 01:54:08 0
SD-Ighmem2Ang
 
Resource Report
Resource Website
RRID:RGD_150523757 Rattus norvegicus Microinjection of Sprague-Dawley rat zygotes with ZFN mRNA specific for the JH locus resulted in the generation of a mutant animal with a 2465 bp DNA deletion, spanning the entire locus 150523757 mutant Rat Genome Database (RGD) RGD Unknown 150523757 RGD 2026-10-17 01:54:08 0
SS.BN-(D13Hmgc41-D13Rat101)-Renem2Mcwi
 
Resource Report
Resource Website
RRID:RGD_27095885 Rattus norvegicus This strain was produced by injecting ZFNs targeting the sequence acccttcatgctggccaagtttgacggggttctgggcatg into SS.BN(D13Hmgc41-D13Rat101)/Mcwi rat embryos. The resulting mutation is a net 4-bp frameshift deletion in exon 5. Contact MCW rat distribution at [email protected] 27095885 mutant Rat Genome Database (RGD) RGD Unknown 27095885 RGD 2026-10-17 01:54:08 0
SD-Wfs1em1Ptsn
 
Resource Report
Resource Website
RRID:RGD_149735334 Rattus norvegicus Rat Wfs1 exon 5-specific zinc-finger nucleases (ZNFs) and microinjection-ready mRNA were injected to embryos harvested from female Sprague-Dawley rats (Crl: CD(SD) )rats. Thereafter, microinjected egg cells were transferred to the oviduct of pseudopregnant Sprague-Dawley recipients.Three different Wfs1 mutant rat lines were created: Wfs1em1 ( Wfs1-ex5-KO232), Wfs1em2 (Wfs1-ex5-KO266) and Wfs1em3 (Wfs1-ex5-INS244). Wfs1em1 rats carry a 184 bp deletion, resulting 27 amino acids deletion in exon 5 (aa212-238) and a new GCC codon(alanine). 149735334 mutant Rat Genome Database (RGD) RGD Unknown 149735334 RGD 2026-10-17 01:54:07 0
OFA(SD)-Dsg4hr/Crl
 
Resource Report
Resource Website
RRID:RGD_150521602 Rattus norvegicus This Iffa Credo ( IC) hairless strain was a spontaneous recessive mutant identified in a colony of Crl:OFA(SD) at 1974. A large intracellular out-of-frame deletion in Dsg4 of IC mutant rats was identified. The intragenic deletion spanning exons 2?10 that results in a significant down-regulation of Dsg4 message. 150521602 mutant Rat Genome Database (RGD) RGD Unknown 150521602 RGD 2026-10-17 01:54:08 0
BN.ZUC-Leprfa
 
Resource Report
Resource Website
RRID:RGD_40924656 Rattus norvegicus Established as congenics by introducing fa from 13M/Vc to BN/Crl 40924656 mutant Rat Genome Database (RGD) RGD Unknown (as of 2021-01-19) 40924656 RGD 2026-10-17 01:54:07 0
LE-ROSA26em1(EF1a-TetR, Fos-iCre)/Bhope
 
Resource Report
Resource Website
RRID:RGD_151356945 Rattus norvegicus Two DNA expression constructs, the bacterial tetracyclin repressor (TetR) under the expression control of human EF1a promoter and the improved Cre recombinase (iCre) under Fos promoter were joined in an antiparallel orientation in one rat ROSA26 targeting cassette. The DNA construct, together with CRISPR /Cas9 system, was injected to one cell Long-Evans (Crl:LE) rat embryos and founders were identified and bred for 8 generations at at NIDA IRP (Hope lab). 151356945 mutant Rat Genome Database (RGD) RGD Unknown 151356945 RGD 2026-10-17 01:54:08 0
LE-Fxn em2Fara-/+/Rrrc
 
Resource Report
Resource Website
RRID:RGD_152999002 Rattus norvegicus Heterozygous KO of the Fxn gene obtained by targeting exon 4 with CRISPR/Cas9 system This strain has been deposited with RRRC Rat Resource and Research Center 152999002 mutant Rat Genome Database (RGD) RGD Unknown 152999002 RGD 2026-10-17 01:54:08 0
LE-Fxn em2Fara-/+
 
Resource Report
Resource Website
RRID:RGD_152999000 Rattus norvegicus Heterozygous KO of the Fxn gene obtained by targeting exon 4 with CRISPR/Cas9 system This strain has been deposited with RRRC 152999000 mutant Rat Genome Database (RGD) RGD Unknown 152999000 RGD 2026-10-17 01:54:08 0
F344-Nppcem3Kyo
 
Resource Report
Resource Website
RRID:RGD_127284870 Rattus norvegicus This strain was established by injecting Zinc-finger nucleases (ZFNs) to F344/Stm pronuclear stage embryos. Selected ZFNs were designed to target exon 1 of rat Nppc, which encodes the N-terminus of natriuretic peptide precursor C (target sequence: CGAAGCCAAGCCCGGGACaccaccGAAGGTGGGTGCTGTCGCG; nucleotides 179 - 221, NC_005108.4). The injected F344/Stm embryos were transferred into the oviducts of pseudopregnant rats. Four lines of knockout strains were estaglished. This F344-Nppcem3Kyo strain ( delta 11)was deduced to generated a frame shift and a premature stop codon (at nucleotides 275 - 277, NM_053750.1) National BioResource Project for the Rat in Japan 127284870 mutant Rat Genome Database (RGD) RGD Unknown 127284870 RGD 2026-10-17 01:54:07 0
LEW.SD-CD8am1Trg
 
Resource Report
Resource Website
RRID:RGD_150521559 Rattus norvegicus Male SD rats were treated with the mutagen N-ethyl-N-nitrosourea (60 mg/kg intraperitoneally) at ages 9 and 10 weeks. A heterozygous mutant founder carrying a T to C transition that encoded a substitution of a proline residue (CCA) for a highly conserved serine residue (TCA) at amino acid position 94 was identified. This mutant male was mated to a LEW female and phenotyping by the expression of CD8a and CD8ab. 150521559 mutant Rat Genome Database (RGD) RGD Unknown 150521559 RGD 2026-10-17 01:54:08 0
F344-Trpc4Tn(sb)1Bni
 
Resource Report
Resource Website
RRID:RGD_126848804 Rattus norvegicus The Sleeping Beauty transposon system was used to insert the sleeping beauty transposon into the first intron of the rat Trpc4 gene. Trpc4 knock-out (510 bp) and wild-type allele (905 bp) were confirmed using PCR and gel electrophoresis 126848804 mutant Rat Genome Database (RGD) RGD Unknown 126848804 RGD 2026-10-17 01:54:08 0
F344-Hcn1em4Kyo
 
Resource Report
Resource Website
RRID:RGD_38676255 Rattus norvegicus TALEN (Left: ttcagAATGATTCATGGG, Right : ACGCACTCTTCAAAGCTA) targeting the exon4 of hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene was designed and mRNA coding these TALEN was microinjected into F344/NSlc embyo. A 18-bp deletion in the exon4 of Hcn1 gene. It is predicted that 6 amino-acid deleted HCN1 protein is expressed. National BioResource Project for the Rat in Japan 38676255 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2020-09-16) 38676255 RGD 2026-10-17 01:54:08 0
SD-Tbc1d1Tn(sb)1Fkh
 
Resource Report
Resource Website
RRID:RGD_150521708 Rattus norvegicus The Sleeping Beauty transposon-mediated mutagenesis was used to knock out the rat Tbc1d1 gene in in rat spermatogonial stem cells from Sprague Dawley. 150521708 mutant Rat Genome Database (RGD) RGD Unknown 150521708 RGD 2026-10-17 01:54:08 0
F344-Hcn1em3Kyo
 
Resource Report
Resource Website
RRID:RGD_38676250 Rattus norvegicus TALEN (Left:ttcagAATGATTCATGGG, Right:ACGCACTCTTCAAAGCTA)targeting the exon4 of hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene was designed and mRNA coding these TALEN was microinjected into F344/NSlc embyo. A 13-bp deletion in the exon4 of Hcn1 gene: as a result of frameshift mutation, stop codon is produced. Decreased expression levels of Hcn1 gene and HCN1 protein. National BioResource Project for the Rat in Japan 38676250 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2020-09-16) 38676250 RGD 2026-10-17 01:54:07 0
LE-Chrna5em20(D398N)Pas
 
Resource Report
Resource Website
RRID:RGD_14402421 Rattus norvegicus The Zinc Finger Nuclease system was used to knock-in SNP rs16969968 in exon 5 (D398N) thus created a missense mutation. The embryos were from breeding of Long Evans from Janvier Labs (RjOrl:LE) and reimplanted to foster mother Dark Agouti (Janvier). Heterozygous rats are currently bred to generate heterozygous and homozygous. 14402421 mutant Rat Genome Database (RGD) RGD Unknown 14402421 RGD 2026-10-17 01:54:08 0
SD-Mertkem1Cgen
 
Resource Report
Resource Website
RRID:RGD_329322880 Rattus norvegicus The gRNA to rat Mertk gene, and Cas9 mRNA were co-injected into fertilized rat eggs to generate targeted knockout offspring. F0 founder animals were identified by PCR followed by sequence analysis, which were bred to wildtype rat to test germline transmission and F1 animal generation. This strain was derived from founder 6# carrying a 13934 deletion which included exons 3 to 5. Cyagen Biosciences (Guangzhou) Inc.Building D, 3rd Floor, 3 Juquan Road, Science City, Guangzhou, 510663, China 329322880 mutant Rat Genome Database (RGD) RGD Live Animals (as of 2023-04-24) 329322880 RGD 2026-10-17 01:54:09 0
SD-Chrna6em2Slot
 
Resource Report
Resource Website
RRID:RGD_155900757 Rattus norvegicus Using CRISPR/Cas9 genomic engineering in rats via homologous end-joining in fertilized embryos, we have knocked'in a humanized CHRNA6 3'UTR in place of the natural CHRNA6 3'UTR of the Sprague Dawley rat line. This new genetically modified CHRNA6C123G humanized rat line carries a homozygous CC nucleotide modification at position 123 within the CHRNA6 gene 3'UTR. The laboratory has deposited these strains with the RRRC. 155900757 mutant Rat Genome Database (RGD) RGD Cryopreserved Embryo; Cryopreserved Sperm (as of 2023-02-09) 155900757 RGD 2026-10-17 01:54:08 0
SD-Chrna6em1Slot
 
Resource Report
Resource Website
RRID:RGD_155900755 Rattus norvegicus Using CRISPR/Cas9 genomic engineering in rats via homologous end-joining in fertilized embryos, we have knocked'in a humanized CHRNA6 3'UTR in place of the natural CHRNA6 3'UTR of the Sprague Dawley rat line. This new genetically modified CHRNA6C123G humanized rat line carries a homozygous GG nucleotide modification at position 123 within the CHRNA6 gene 3'UTR. The laboratory has deposited these strains with the RRRC. 155900755 mutant Rat Genome Database (RGD) RGD Cryopreserved Embryo; Cryopreserved Sperm (as of 2023-02-09) 155900755 RGD 2026-10-17 01:54:09 0
SD-Akt1em1Soar
 
Resource Report
Resource Website
RRID:RGD_158013766 Rattus norvegicus This Akt mutant strain was created in zygotes from Holtzman Sprague-Dawley. Guided RNAs targeting exon 4 (target sequence: GCCGTTTGAGTCCATCAGCC; nucleotides 356-375) and exon 7 (target sequence: TTGTCATGGAGTACGCCAAT; nucleotides 712-731) of the Akt1 gene (NM_033230.3) were injected to the embryos to create a1332-bp deletion from exon 4 to exon7, resulting a premature stop of the protein. 158013766 mutant Rat Genome Database (RGD) RGD Unknown 158013766 RGD 2026-10-17 01:54:09 0

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