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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150519896
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: CRISPR/Cas9 mediated single nucleotide deletion resulting in a frameshift that creates a premature stop and generates a null allele. This strain serves as a model for Alexander disease - nulls are of interest for traumatic brain injury and many other studies of CNS disease and astrocyte response. Rat Resource and Research Center
Proper citation: RRID:RRRC_00931 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11081177
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: A spontaneous tooth less mutation was maintained in inbred Fisher colony maintained at the University of Massachusetts Medical School. The homozygous mutant is a 10-bp insertion near the beginning of the open reading of the Csf1 gene that yields a truncated, nonfunctional protein and an early stop codon. Rat Resource and Research Center
Proper citation: RRID:RRRC_00749 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2314478
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Embryo; Cryopreserved Sperm
References:
Synonyms:
Notes: ENU induced mutation in a Sprague Dawley rat resulting in a phenotypic change at the RT1.B MHC locus such that antibody binding to the RT1.B locus is no longer present. Animals carrying this mutation fail to have OX-6 antibody binding to the RT1.B locus. The exact nature of the mutation has not been genetically characterized. Mutation was backcrossed onto the Lewis strain. Rat Resource and Research Center
Proper citation: RRID:RRRC_00392 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2292453
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm
References:
Synonyms:
Notes: this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb Rat Resource & Research Center
Proper citation: RRID:RRRC_00345 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155641248
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: The CRISPR/Case9 knock-in rats have cre recombinase-dependent expression of nanoluciferase under the control of HIV LTR promoter inserted to the rat ROSA26 locus. ROSA26 is a synonym for rat Thumpd3-as1 (RGD:6491660) and is used as an official symbol for rat strain nomenclature. Rat Resource and Research Center
Proper citation: RRID:RRRC_00925 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155641247
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: The mutated ROSA26 locus of LE-(ROSA)26 em1(LTR-nLuc)Ottc (RGD:13208223) was crossed onto Fischer344 background by backcrossing the hybrid to Fischer344 and select for the presence of mutated locus. The LE donor is CRISPR/Case9 knock-in strain that has cre recombinase-dependent expression of nanoluciferase under the control of HIV LTR promoter inserted to the rat ROSA26 locus. ROSA26 is a synonym for rat Thumpd3-as1 (RGD:6491660) and is used as an official symbol for rat strain nomenclature. now deposited at Rat Resource and Research Center
Proper citation: RRID:RRRC_00926 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2290081
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm
References:
Synonyms:
Notes: this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb Rat Resource & Research Center
Proper citation: RRID:RRRC_00367 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2290137
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Cryopreserved Sperm
References:
Synonyms:
Notes: this Sleeping Beauty mutants were derived by crossing F344-Tg(T2/Bart3)2Ceb and F344-Tg(PGK2-SB11)Ceb Rat Resource & Research Center
Proper citation: RRID:RRRC_00361 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155663560
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: CRISPR/Cas9 technology was used to insert an IRES for iCre expression after the final coding sequence of exon 6 of the rat Gcg gene, before the 3' UTR. Rat Resource and Research Center
Proper citation: RRID:RRRC_00983 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695058
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: frame shift deletion in an exon 12 of Add3 gene causing a stop codon and loss of function. SD outbred background. Rat Resource and Research Center
Proper citation: RRID:RRRC_00792 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=151667414
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: This model expresses cre-recombinase under the control of the endogenous Ckm (creatine kinase, M-type) promoter. Cre was targeted to the rat Ckm gene of LE embryos through CRISP/Cas9 system genome editing system. Rat Resource and Research Center
Proper citation: RRID:RRRC_00951 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=13208224
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: The CRISPR/Case9 knock-in rats have cre recombinase-dependent expression of Cas9 under the control of CAG promoter inserted to the rat ROSA26 locus. ROSA26 is a synonym for rat Thumpd3-as1 (RGD:6491660) and is used as an official symbol for rat strain nomenclature. Rat Resource and Research Center
Proper citation: RRID:RRRC_00833 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=7364940
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: Backcrossed STOCK-Tp53tm1(EGFP-Pac)QlyRrrc with F344 using speed congenic approach to move mutation onto F344 genetic background. Rat Resource and Research Center
Proper citation: RRID:RRRC_00661 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14398460
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: Zinc Finger Nuclease (ZFN) was utilized to knockout rat CD40 function in the embryos of SS/JrHsd rats. The target sequence (CAGCACCGACACTGCgaactcAGTGCGTGGGGCTGCCGGG) introduced an 11 bp-deletion (CTGCGAACTCA) in the third exon of the Cd40 gene, resulted in a trucated protein. Rat Resource and Research Center
Proper citation: RRID:RRRC_00840 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=152999002
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: Heterozygous KO of the Fxn gene obtained by targeting exon 4 with CRISPR/Cas9 system Rat Resource and Research Center
Proper citation: RRID:RRRC_00961 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695028
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: This strain was made by electroporation of DAc8 embryonic stem cells with a targeting vector containing 6.3kb 5' and 2.1kb 3' homology arm. The Kcnh2 gene 7th and 8th exons are replaced with a CAG-EGFP-IRES-Pac cassette. Chimeras were formed by microinjecting into F344 blastocysts. Founder animals were mated with SD rats to produce this strain. Rat Resource and Research Center
Proper citation: RRID:RRRC_00847 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150521606
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: CRISPR/Cas9 system was used to introduce a 22-bp deletion at the sgRNA2 site of exon 2 in the rat Lrp5 gene of Crl:SD embryos. Rat Resource and Research Center
Proper citation: RRID:RRRC_00880 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695053
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: 11bp deletion from genomic DNAfor the cannabinoid-1 receptor (Cnr1)using Zinc-Fingers Nucleases. Animals are resistant to the development of type-2 diabetes. Rat Resource and Research Center
Proper citation: RRID:RRRC_00800 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11087551
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: Zinc finger nuclease mediated 7bp deletion within exon 2 of the Il15 gene, resulting in a frameshift and premature stop codon. Rat Resource and Research Center
Proper citation: RRID:RRRC_00769 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14694999
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Affected Genes:
Genomic Alteration:
Availability: Unknown
References:
Synonyms:
Notes: This mutant strain was generated by injecting TALEN targeting rat Sdhb into NTac:SD embryo. The resulting mutant is a 6 bp-deletion in Sdhb. Rat Resource and Research Center
Proper citation: RRID:RRRC_00854 Copy
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