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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano
Genomic Alteration: Rosa26tm1
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Notes: This strain expresses both mutant cyclin D1T286A and a cherry reporter under the regulation of a tetracycline-responsive bi-directional minimal CMV promoter (TRE-Tight; tetO). The cyclin D1-T286A mutant cannot be phosphorylated by GSK-3beta and is resistant to polyubiquitination. Therefore, cyclin D1-T286A remains nuclear throughout the cell cycle and has an extended half-life relative to wild-type cyclin D1. This strain represents an effective tool for generating inducible tissue-specific cyclin D1T286A mutants with a cherry reporter.
Proper citation: RRID:BCBC_1221 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: RMCE
Affected Genes: SRY-box containing gene 17
Genomic Alteration: Sox17tm1
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Notes: Sox17CreERT2 mice may be used either to track Sox17-expressing cells or their progeny or to conditionally inactivate genes in Sox17-expressing cells at specific time points by tamoxifen injection. This line is complementary to Sox17-CreGFP and may avoid possible interferences of expression in the extra-embryonic visceral endoderm. We plan to analyze the effects of a direct activation/deletion of the Wnt pathway in the endoderm by crossing the Sox17-CreERT2 with the gain- and loss-of-function of beta-catenin.
Proper citation: RRID:BCBC_1101 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: RMCE
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Proper citation: RRID:BCBC_4058 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano
Genomic Alteration: Rosa26tm1
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Notes: This mouse line was made by RMCE in the Rosa26[LCA] allele and has a cyan fluorescent protein (CFP, Cerulean) expressed under the control of the ROSA26 promoter. The CFP sequence is preceded by a translational enhancer and followed by intron-containing rabbit beta-globin polyA sequences. This mouse has ubiquitously expressed CFP protein and can be used for transplantation and other experiments where tracing of source cells is required.
Proper citation: RRID:BCBC_4054 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: TG
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Notes: Mice hemi- or homozygous for the transgene are viable, fertile, normal size, and do not display any behavioral abnormalities. Expression of the bicistronic transgene is directed by a heptameric tetO repeat linked to the CMV minimal promoter (collectively the tetracycline-response element). The mice do not express lacZ until a tetracycline-gransactivator (tTA) protein is produced; thereafter Ptf1a and lacZ genes are highly expressed. This mouse was designed to be mated to an apancreatic targeted mutant with tTAoff in place of the Ptf1a coding sequence (see BCBC strain M321). The combined genetic alterations provide normal pancreatic development and function until doxycycline-administration render the mice conditionally null of Ptf1a. This approach allows embryonic developmental arrest at desired stages or cessation of gene function in adult mice for the pancreas, cerebellum, retina, dorsal spinal cord and possibly hypothalamus. This transgenic mouse may be useful in studies of pancreatic endocrine/exocrine development and function, diabetes, and and certain defects of the CNS. This transgenic can also be bred with other tTA strains for conditional mutation analysis.
Proper citation: RRID:BCBC_216 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: TM
Affected Genes: Neurogenin 3
Genomic Alteration: Ngn3EYFP/+
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Notes: A targeting construct was designed to insert an IRES-EYFP and a floxed puro downstream of the coding sequence. Crossing with mice expressing Cre in the germ line excised the puromycin resistance gene. Coding region for Ngn3 is kept intact consequentely homozygous mice express Ngn3 protein , do not develop diabetes and behave like wild-types. in these mice, Ngn3-positive progenitors express EYFP and can be purified by FACS.
Proper citation: RRID:BCBC_215 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: TM
Affected Genes: Recombination signal binding protein for immunoglobulin kappa J region-like
Genomic Alteration: Rbpjltm1
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Notes: This mouse strain has the Rbpjl gene region spanning exons 7, 8, and 9 replaced with lacZ in-frame. A pgk-neo resistance cassette has been removed by Cre-loxP deletion from the founder. Mice heterozygous and homozygous for the lacZ replacement are viable, fertile, of normal size, and do not display any behavioral abnormalities. In mature mice, the pancreas is one-third smaller than normal, due to less acinar tissue. Expression of the lacZ, measured by bet-galactosidase histostaining is very low.
Proper citation: RRID:BCBC_219 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: TG
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Notes: A transgenic alteration consisting of a SacI fragment containing the glucagon promoter, inserted at SacI of pBS-beta globin-Cre, resulting in Cre expression in pancreatic lineage cells.
Proper citation: RRID:BCBC_177 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: RMCE
Affected Genes: gene trap ROSA 26, Philippe Soriano
Genomic Alteration: Rosa26tm1
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Notes: This mouse contains a bidirectional Tet0-regulated fusion gene that has been inserted into adisabled Rosa26 loxed cassette acceptor allele by RMCE. In one direction the tetO/CMV promoter drives expression of a red fluorescent protein (Cherry) while in the other direction it drives MafA expression.
Proper citation: RRID:BCBC_2702 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: TG
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Notes: This strain relies on the recombination of floxed DNA in insulin-producing beta cells.
Proper citation: RRID:BCBC_179 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: TM
Affected Genes: recombination activating gene 1
Genomic Alteration: Rag1tm1Mom
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Notes: Backcrossing of the Rag1 null allele onto the NOD/Lt strain background (NOD-Rag1null mice) provided a radio-resistant and longer-lived model for human-cell engraftment. Mutations in X-chromosome-linked Il2rg gene cause X-linked severe combined immunodeficiency (XSCID). Immunodeficient NOD-Rag1null IL2rg nullmice tolerated much higher levels of irradiation conditioning than did NOD-Prkdcscid IL2rg null mice.
Proper citation: RRID:BCBC_212 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: TM, OTH
Affected Genes: recombination activating gene 1
Genomic Alteration: MGI:97848)
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Notes: The NOD-Rag1null Prf1null Ins2Akita mouse is the first immunodeficient, spontaneously hyperglycemic mouse strain described that is based on the Ins2Akita mutation. This strain is suitable as hosts for human islet and human beta stem and progenitor cell transplantation in the absence of the need for pharmacological induction of diabetes. This strain of mice also has low levels of innate immunity and can be engrafted with a human immune system for the study of human islet allograft rejection.
Proper citation: RRID:BCBC_211 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: TG
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Notes: All islet endocrine cells inherit a recombination event, if a segment of DNA is loxP-flanked. Transgene encoding Cre recombinase under the control of a human Neurogenin3 promoter.
Proper citation: RRID:BCBC_180 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: TM
Affected Genes: insulin promoter factor 1, homeodomain transcription factor
Genomic Alteration: Ipf1tm1Cvw
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Proper citation: RRID:BCBC_182 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: TM
Affected Genes: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A
Genomic Alteration: Mafatm1.1
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Notes: Mafa is a basic leucine-zipper containing member of the large Maf transcription factor family.It is part of the RIPE3b1 activator complex and functions as a key activator of insulin and pdx-1 gene transcription. Mafalox mice may be used to generate both global and cell-specific Mafa null mice, depending on which cre-expressing transgenic mouse is used. Removal of Mafa gene might have a profound effect on beta cell function; thus we can closely monitor the expression of islet hormones, transcription functions and the glucose sensing machinery immunohistochemically. The experiment will provide us with the information about the role of Mafa plays in vivo in islet beta cells and the developing pancreas, thus helping us to understand how transcription activator contribute to the pathogenesis and the treatment of diabetes.
Proper citation: RRID:BCBC_228 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: TG
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Proper citation: RRID:BCBC_185 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: TG
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Notes: Hemizygous mice show expression of EGFP in beta lineage cells of the pancreas.
Proper citation: RRID:BCBC_188 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: TM
Affected Genes: Pancreatic and duodenal homeobox 1
Genomic Alteration: Pdx1tmd1Macd
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Notes: Mice homozygous for the targeted mutation fail to develop a pancreas. Heterozygous mice have normal pancreatic development, but have partially impaired glucose tolerance in adulthood. The substitution of the targeted Ipf1/Pdx1 gene with tTAoff inactivates the endogenous allele and places tTAoff expression under the control of the endogenous transcriptional regulatory sequences of the Pdx1 locus. Identical to the endogenous allele, mutant locus expression is detectable in the pancreas and adjacent duodenum but not in other visceral organs or salivary glands. This mutant may be useful to direct tetracycline-regulated expression of responder transgenes in studies of pancreatic endocrine/exocrine development and function and diabetes. This mutant can also be bred with other tetO/TRE strains for pancreas-specific applications. This mutant was originally designed to be mated with mice engineered with a heptameric tetracycline operator (tetO)-controlled bicistronic transgene coding for a normal PDX1 protein and with a beta-galactosidase or EGFP reporter (see BCBC mouse M561). The combined modifications allow normal pancreatic development and function until doxycycline-administration renders the mouse conditionally null of the Pdx1 gene. This configuration for conditional expression of Pdx1is most effective when the transgene locus is homozygous. This allows embryonic developmental arrest at desired stages or cessation of function in adult mice by tetracycline administration.
Proper citation: RRID:BCBC_220 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
Genetic Background: TM
Affected Genes: Arx
Genomic Alteration: Arxtm1Pgr
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Notes: These mice were created by insertion of the LacZ gene (with nuclear localization signal) into the Arx locus by homologous recombination in embryonic stem cells. The Arx gene is localized on the X chromosome. Knockout mice die after birth with due to hypoglycemia. Therefore male mice die at day 2 past birth. The colony has to be propagated with female mice. Arx-deficient mice do not produce alpha cells in the islets of Langerhans.
Proper citation: RRID:BCBC_225 Copy
The record is no longer available at this source.
Source Database: BCBC, Beta Cell Biology Consortium
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Notes: These NSG-Abo DR4 mice lack expression of the murine Prkdc gene, the X-linked Il2rg gene, and MHC class II, but express the human leukocyte antigen DR4 gene. These mice may be useful for targeting human CD4+ T cells in transplantation studies in the absence of xeno-GVHD.More details are available at http://jaxmice.jax.org/strain/017637.html.
Proper citation: RRID:BCBC_4612 Copy
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