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 PMID:18036190  

A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X.

S J Tai | R W Herzog | P Margaritis | V R Arruda | K Chu | J A Golden | P A Labosky | K A High
Journal of thrombosis and haemostasis : JTH | 2008

Activated factor X (FXa) is a vitamin K-dependent serine protease that plays a pivotal role in blood coagulation by converting prothrombin to thrombin. There are no reports of humans with complete deficiency of FX, and knockout of murine F10 is embryonic or perinatal lethal.

Pubmed ID: 18036190

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: P01 HL074124
  • Agency: NHLBI NIH HHS, United States
    Id: P01 HL074124-050004

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Human Gene Mutation Database (tool)

RRID:SCR_001888

Curated database of known (published) gene lesions responsible for human inherited disease.

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Human Gene Mutation Database (tool)

RRID:SCR_001621

Curated database of known (published) gene lesions responsible for human inherited disease.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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