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 PMID:21203469  

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  2. PMID:21203469

Loss of caveolin-1 accelerates neurodegeneration and aging.

Brian P Head | Jason N Peart | Mathivadhani Panneerselvam | Takaakira Yokoyama | Matthew L Pearn | Ingrid R Niesman | Jacqueline A Bonds | Jan M Schilling | Atsushi Miyanohara | John Headrick | Sameh S Ali | David M Roth | Piyush M Patel | Hemal H Patel
PloS one | 2010

The aged brain exhibits a loss in gray matter and a decrease in spines and synaptic densities that may represent a sequela for neurodegenerative diseases such as Alzheimer's. Membrane/lipid rafts (MLR), discrete regions of the plasmalemma enriched in cholesterol, glycosphingolipids, and sphingomyelin, are essential for the development and stabilization of synapses. Caveolin-1 (Cav-1), a cholesterol binding protein organizes synaptic signaling components within MLR. It is unknown whether loss of synapses is dependent on an age-related loss of Cav-1 expression and whether this has implications for neurodegenerative diseases such as Alzheimer's disease.

Pubmed ID: 21203469

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Associated grants

  • Agency: NIA NIH HHS, United States
    Id: K25 AG026379
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL091071

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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C57BL/6Smoc-Cav1em1Smoc (tool)

RRID:IMSR_NM-KO-190930

Mus musculus with name C57BL/6Smoc-Cav1em1Smoc from IMSR.

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