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 PMID:22606246  

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  2. PMID:22606246

Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.

Shunsuke Nakamura | Motohiko Oshima | Jin Yuan | Atsunori Saraya | Satoru Miyagi | Takaaki Konuma | Satoshi Yamazaki | Mitsujiro Osawa | Hiromitsu Nakauchi | Haruhiko Koseki | Atsushi Iwama
PloS one | 2012

The polycomb-group (PcG) proteins function as general regulators of stem cells. We previously reported that retrovirus-mediated overexpression of Bmi1, a gene encoding a core component of polycomb repressive complex (PRC) 1, maintained self-renewing hematopoietic stem cells (HSCs) during long-term culture. However, the effects of overexpression of Bmi1 on HSCs in vivo remained to be precisely addressed.

Pubmed ID: 22606246

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C57BL/6J (tool)

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Mus musculus with name C57BL/6J from IMSR.

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B6.SJL-Ptprca Pepc/BoyJ (tool)

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Mus musculus with name B6.SJL-Ptprca Pepc/BoyJ from IMSR.

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